The LabelHash Server

Top 150 matches

For each match you can click on the "[pdb]" link to download a PDB file with the matching chain aligned with the motif.
Download a zip file with PDB files for all the matches and the motif itself.

PDB ID		LRMSD / p-value	Matching Residues	EC	Gene Ontology annotations
PDB ID		LRMSD / p-value	Matching Residues	EC	Biological Process	Cellular Component	Molecular Function
1adjA histidyl-trna synthetase	[pdb]	0.137 1.65e-05	81^GLU 83^THR 112^ARG 130^GLU 264^TYR 311^ARG	6.1.1.21	translation tRNA aminoacylation for protein translation histidyl-tRNA aminoacylation	cytoplasm	nucleotide binding aminoacyl-tRNA ligase activity histidine-tRNA ligase activity ATP binding ligase activity
1httD histidyl-trna synthetase	[pdb]	0.361 5.47e-05	83^GLU 85^THR 113^ARG 131^GLU 264^TYR 311^ARG	6.1.1.21	translation tRNA aminoacylation for protein translation histidyl-tRNA aminoacylation translation tRNA aminoacylation for protein translation histidyl-tRNA aminoacylation translation tRNA aminoacylation for protein translation histidyl-tRNA aminoacylation	cytoplasm cytoplasm cytoplasm	nucleotide binding aminoacyl-tRNA ligase activity histidine-tRNA ligase activity ATP binding ligase activity nucleotide binding aminoacyl-tRNA ligase activity histidine-tRNA ligase activity ATP binding ligase activity nucleotide binding aminoacyl-tRNA ligase activity histidine-tRNA ligase activity ATP binding ligase activity
3o53B protein lrim1	[pdb]	0.795 9.36e-05	108^ASP 106^THR 89^SER 124^GLU 101^LEU 152^ASN	0.0.0.0			protein binding
2q09A imidazolonepropionase	[pdb]	0.899 0.000162	374^ASP 136^THR 38^ARG 133^GLU 165^LEU 57^GLN	0.0.0.0	histidine metabolic process histidine catabolic process to glutamate and formamide	cytoplasm	hydrolase activity hydrolase activity acting on carbon-nitrogen (but not peptide) bonds hydrolase activity acting on carbon-nitrogen (but not peptide) bonds
3p24A bft-3	[pdb]	0.915 0.000188	47^ASP 50^THR 42^SER 54^ASP 105^LEU 70^ASN	0.0.0.0	proteolysis	extracellular matrix	metalloendopeptidase activity peptidase activity metallopeptidase activity zinc ion binding
2oogC glycerophosphoryl diester phosphodiesterase	[pdb]	0.939 0.000219	89^ASP 170^THR 60^ARG 180^GLU 225^LEU 159^ARG	0.0.0.0	glycerol metabolic process lipid metabolic process glycerol metabolic process lipid metabolic process		phosphoric diester hydrolase activity glycerophosphodiester phosphodiesterase activity phosphoric diester hydrolase activity glycerophosphodiester phosphodiesterase activity
3netB histidyl-trna synthetase	[pdb]	0.939 0.000219	98^ASP 100^THR 128^ARG 146^ASP 302^TYR 350^ARG	6.1.1.21	translation tRNA aminoacylation for protein translation histidyl-tRNA aminoacylation	cytoplasm	nucleotide binding aminoacyl-tRNA ligase activity histidine-tRNA ligase activity ATP binding ligase activity
3lkdB type i restriction-modification systemmethyltransferase subunit	[pdb]	0.957 0.000241	255^GLU 285^THR 232^SER 289^ASP 340^LEU 277^ASN	0.0.0.0	DNA methylation methylation		nucleic acid binding DNA binding methyltransferase activity N-methyltransferase activity site-specific DNA-methyltransferase (adenine-specific) activity transferase activity
3d8bB fidgetin-like protein 1	[pdb]	0.992 0.000304	500^ASP 545^THR 464^SER 550^GLU 563^LEU 527^GLN	0.0.0.0	ATP metabolic process		nucleotide binding magnesium ion binding ATP binding hydrolase activity nucleoside-triphosphatase activity metal ion binding
2pt3A lactoperoxidase	[pdb]	1.03 0.000396	393^ASP 557^THR 360^ARG 555^ASP 269^LEU 570^ASN	1.11.1.7	response to oxidative stress defense response to bacterium hydrogen peroxide catabolic process oxidation-reduction process	extracellular region extracellular space	peroxidase activity oxidoreductase activity heme binding metal ion binding
3db9A upf0317 protein atu3911	[pdb]	1.05 0.000455	85^ASP 77^THR 24^ARG 72^ASP 80^LEU 94^ARG	0.0.0.0
3k2xA 2-c-methyl-d-erythritol 2,4-cyclodiphosphatesynthase	[pdb]	1.05 0.000455	97^ASP 99^THR 128^ARG 149^GLU 107^LEU 80^ARG	4.6.1.12	isoprenoid biosynthetic process terpenoid biosynthetic process		2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity lyase activity metal ion binding
3h66B serine/threonine-protein phosphatase 5	[pdb]	1.07 0.000504	242^ASP 243^THR 425^ARG 249^ASP 286^LEU 472^GLN	3.1.3.16	protein dephosphorylation mitosis positive regulation of I-kappaB kinase/NF-kappaB cascade response to morphine protein heterooligomerization	nucleus cytoplasm cytosol neuron projection neuronal cell body	phosphoprotein phosphatase activity protein serine/threonine phosphatase activity signal transducer activity binding protein binding hydrolase activity protein domain specific binding metal ion binding
3norA thij/pfpi family protein	[pdb]	1.07 0.000504	20^ASP 22^THR 105^SER 26^ASP 38^LEU 145^ARG	0.0.0.0
1yz6A probable translation initiation factor 2 alphasubunit	[pdb]	1.09 0.000593	227^ASP 229^THR 225^ARG 211^ASP 234^TYR 201^ARG	0.0.0.0	translation	eukaryotic translation initiation factor 2 complex	RNA binding translation initiation factor activity
1yz7A probable translation initiation factor 2 alphasubunit	[pdb]	1.1 0.000665	227^ASP 229^THR 225^ARG 211^ASP 234^TYR 201^ARG	0.0.0.0	translation	eukaryotic translation initiation factor 2 complex	RNA binding translation initiation factor activity
1uzgB major envelope protein e	[pdb]	1.12 0.000748	126^GLU 198^THR 220^SER 201^ASP 262^LEU 120^GLN	2.1.1.56, 3.4.21.91, 2.7.7.48	transcription RNA-dependent viral reproduction RNA metabolic process viral infectious cycle viral genome replication evasion by virus of host immune response methylation	membrane integral to membrane virion viral nucleocapsid viral capsid viral envelope host cell membrane virion part	nucleotide binding nucleic acid binding RNA binding RNA helicase activity double-stranded RNA binding catalytic activity RNA-directed RNA polymerase activity serine-type endopeptidase activity helicase activity mRNA (guanine-N7-)-methyltransferase activity mRNA (nucleoside-2'-O-)-methyltransferase activity structural molecule activity ATP binding methyltransferase activity transferase activity nucleotidyltransferase activity hydrolase activity nucleoside-triphosphatase activity
3hazA proline dehydrogenase	[pdb]	1.12 0.000748	603^ASP 601^THR 356^ARG 823^ASP 593^LEU 522^ARG	0.0.0.0	glutamate biosynthetic process proline biosynthetic process proline catabolic process metabolic process oxidation-reduction process		1-pyrroline-5-carboxylate dehydrogenase activity proline dehydrogenase activity oxidoreductase activity
1fi1A ferrichrome-iron receptor	[pdb]	1.12 0.000791	670^ASP 645^THR 715^ARG 630^ASP 72^TYR 167^LYS	0.0.0.0	transport ion transport iron ion transport detection of virus siderophore transport entry of virus into host cell	plasma membrane cell outer membrane membrane integral to membrane	receptor activity transporter activity iron ion binding siderophore transmembrane transporter activity toxin binding virion binding cofactor binding
1dbiA ak.1 serine protease	[pdb]	1.13 0.000791	34^GLU 97^THR 126^SER 83^GLU 235^LEU 103^ARG	0.0.0.0	proteolysis	extracellular region	serine-type endopeptidase activity peptidase activity serine-type peptidase activity hydrolase activity metal ion binding
2pifA upf0317 protein pspto_5379	[pdb]	1.13 0.000791	84^ASP 76^THR 23^ARG 71^ASP 79^LEU 93^ARG	0.0.0.0
3iemC ribonuclease ttha0252 rna (5'-r((ssu)p(ssu)p(ssu)p(ssu)p(ssu)p(ssu))-3')	[pdb]	1.13 0.000838	162^ASP 188^THR 145^SER 402^GLU 341^TYR 67^ARG	0.0.0.0	rRNA processing	cytoplasm	RNA binding nuclease activity endonuclease activity hydrolase activity metal ion binding
1qe0A histidyl-trna synthetase	[pdb]	1.14 0.000888	80^GLU 82^THR 112^ARG 130^GLU 262^TYR 312^ARG	6.1.1.21	translation tRNA aminoacylation for protein translation histidyl-tRNA aminoacylation	cytoplasm	nucleotide binding aminoacyl-tRNA ligase activity histidine-tRNA ligase activity ATP binding ligase activity
3itqB prolyl 4-hydroxylase, alpha subunit domainprotein	[pdb]	1.14 0.000941	96^GLU 92^THR 101^SER 87^ASP 56^LEU 142^ARG		oxidation-reduction process		iron ion binding oxidoreductase activity oxidoreductase activity acting on paired donors
4pgaB glutaminase-asparaginase	[pdb]	1.15 0.000997	104^GLU 102^THR 167^SER 68^GLU 75^LEU 139^ASN	3.5.1.38	cellular amino acid metabolic process asparagine metabolic process	periplasmic space	asparaginase activity hydrolase activity glutamin-(asparagin-)ase activity
2jd4B laminin subunit alpha-1	[pdb]	1.16 0.00106	2788^GLU 2797^THR 2721^ARG 2799^ASP 2758^LEU 2855^GLN	0.0.0.0	morphogenesis of an epithelial sheet cell adhesion cell surface receptor linked signaling pathway tissue development regulation of cell adhesion regulation of cell migration neuron projection development establishment of epithelial cell apical/basal polarity regulation of embryonic development epithelial tube branching involved in lung morphogenesis branching involved in salivary gland morphogenesis	extracellular region proteinaceous extracellular matrix basement membrane basal lamina laminin-1 complex laminin-3 complex extracellular space extracellular matrix	receptor binding extracellular matrix structural constituent protein binding glycosphingolipid binding
2xdqB light-independent protochlorophyllide reductase subunit b light-independent protochlorophyllide reductase subunit n	[pdb]	1.16 0.00106	136^ASP 138^THR 223^ARG 123^ASP 17^LEU 335^LYS	0.0.0.0	photosynthesis chlorophyll biosynthetic process photosynthesis dark reaction pigment biosynthetic process oxidation-reduction process photosynthesis chlorophyll biosynthetic process photosynthesis		oxidoreductase activity oxidoreductase activity acting on iron-sulfur proteins as donors oxidoreductase activity
3nz4B phenylalanine ammonia-lyase	[pdb]	1.16 0.00112	178^ASP 233^THR 170^ARG 354^ASP 134^LEU 106^ARG		L-phenylalanine catabolic process biosynthetic process phenylpropanoid metabolic process	cytoplasm	catalytic activity lyase activity ammonia-lyase activity
1k5gI gtp-binding nuclear protein ran ran-specific gtpase-activating protein ran gtpase activating protein 1	[pdb]	1.16 0.00112	66^GLU 98^THR 40^SER 125^GLU 91^LEU 131^ASN	0.0.0.0	nucleocytoplasmic transport chromosome segregation chromatin silencing at centromere Ran protein signal transduction kinetochore organization chromatin silencing at telomere DNA metabolic process RNA export from nucleus protein export from nucleus transport intracellular protein transport nucleocytoplasmic transport cell cycle mitotic spindle organization mitosis signal transduction protein transport androgen receptor signaling pathway interspecies interaction between organisms positive regulation of transcription DNA-dependent cell division signal transduction	cytoplasm cytosol nuclear membrane perinuclear region of cytoplasm nucleus nuclear pore nucleoplasm cytoplasm cytosol melanosome chromatin nucleus cytoplasm	GTPase activator activity Ran GTPase activator activity nucleotide binding chromatin binding transcription coactivator activity GTPase activity protein binding GTP binding androgen receptor binding GDP-dissociation inhibitor activity GTPase activator activity protein binding Ran GTPase binding
2zi8A probable biphenyl-2,3-diol 1,2-dioxygenase bphc	[pdb]	1.16 0.00112	219^GLU 138^THR 254^SER 140^GLU 8^TYR 249^ASN	0.0.0.0	cellular aromatic compound metabolic process aromatic compound catabolic process oxidation-reduction process response to cholesterol		catalytic activity ferrous iron binding oxidoreductase activity oxidoreductase activity acting on single donors with incorporation of molecular oxygen
1iq0A arginyl-trna synthetase	[pdb]	1.17 0.00112	108^GLU 349^THR 111^SER 347^GLU 136^LEU 333^ARG	0.0.0.0	translation tRNA aminoacylation for protein translation arginyl-tRNA aminoacylation translation tRNA aminoacylation for protein translation arginyl-tRNA aminoacylation	cytoplasm cytoplasm	nucleotide binding aminoacyl-tRNA ligase activity arginine-tRNA ligase activity ATP binding ligase activity nucleotide binding aminoacyl-tRNA ligase activity arginine-tRNA ligase activity ATP binding ligase activity
2wyaC hydroxymethylglutaryl-coa synthase,mitochondrial	[pdb]	1.17 0.00112	294^ASP 291^THR 405^SER 319^ASP 273^TYR 369^LYS	2.3.3.10	steroid biosynthetic process cholesterol biosynthetic process response to nutrient metabolic process isoprenoid biosynthetic process lipid biosynthetic process sterol biosynthetic process response to drug response to peptide hormone stimulus	mitochondrion mitochondrial inner membrane mitochondrial matrix	catalytic activity hydroxymethylglutaryl-CoA synthase activity transferase activity
1abrA abrin-a	[pdb]	1.18 0.00125	65^ASN 53^LEU 63^ARG 69^LEU 24^MET 153^SER	0.0.0.0	defense response pathogenesis negative regulation of translation positive regulation of endocytosis	cellular_component	sugar binding galactose binding hydrolase activity rRNA N-glycosylase activity
1wovA heme oxygenase 2	[pdb]	1.18 0.00125	20^GLU 22^THR 233^SER 210^GLU 225^LEU 138^LYS	1.14.99.3	heme oxidation photosynthesis oxidation-reduction process		heme oxygenase (decyclizing) activity oxidoreductase activity metal ion binding
2j22A fucolectin-related protein	[pdb]	1.18 0.00133	91^ASP 104^THR 88^SER 101^GLU 119^LEU 24^GLN	0.0.0.0	cell adhesion
1d2vC myeloperoxidase	[pdb]	1.18 0.00133	378^ASP 541^THR 345^ARG 539^ASP 254^LEU 555^ASN	1.11.1.7	anti-apoptosis defense response response to oxidative stress low-density lipoprotein particle remodeling hydrogen peroxide catabolic process oxidation-reduction process	extracellular space nucleus lysosome stored secretory granule	chromatin binding peroxidase activity heparin binding oxidoreductase activity heme binding metal ion binding
3lg3B isocitrate lyase	[pdb]	1.2 0.0014	290^GLU 234^THR 320^SER 188^ASP 286^LEU 95^GLN	0.0.0.0	metabolic process carboxylic acid metabolic process		catalytic activity isocitrate lyase activity lyase activity
3am9A xanthine dehydrogenase/oxidase	[pdb]	1.2 0.0014	309^GLU 311^THR 335^ARG 291^GLU 319^LEU 362^ASN	1.17.3.2, 1.17.1.4	lactation xanthine catabolic process regulation of epithelial cell differentiation oxidation-reduction process	extracellular region cytoplasm peroxisome	catalytic activity xanthine dehydrogenase activity xanthine oxidase activity binding iron ion binding electron carrier activity oxidoreductase activity protein homodimerization activity molybdopterin cofactor binding metal ion binding flavin adenine dinucleotide binding iron-sulfur cluster binding 2 iron
1pznC dna repair and recombination protein rad51	[pdb]	1.2 0.00148	238^ASP 282^THR 204^ARG 135^GLU 151^LEU 216^GLN	0.0.0.0	DNA metabolic process DNA repair DNA recombination response to DNA damage stimulus		nucleotide binding DNA binding damaged DNA binding protein binding ATP binding DNA-dependent ATPase activity nucleoside-triphosphatase activity
2isaB catalase	[pdb]	1.2 0.00148	294^GLU 65^THR 217^SER 81^ASP 116^TYR 261^GLN	0.0.0.0	response to oxidative stress hydrogen peroxide catabolic process oxidation-reduction process		catalase activity peroxidase activity iron ion binding oxidoreductase activity heme binding metal ion binding
3pga3 glutaminase-asparaginase	[pdb]	1.21 0.00157	104^GLU 102^THR 167^SER 68^GLU 75^LEU 139^ASN	3.5.1.38	cellular amino acid metabolic process asparagine metabolic process	periplasmic space	asparaginase activity hydrolase activity glutamin-(asparagin-)ase activity
3cpgA uncharacterized protein	[pdb]	1.21 0.00157	69^ASP 26^THR 97^ARG 24^GLU 33^LEU 86^LYS	0.0.0.0
1w27A phenylalanine ammonia-lyase 1	[pdb]	1.21 0.00157	205^ASP 262^THR 197^ARG 383^ASP 161^LEU 136^ARG	4.3.1.24	L-phenylalanine catabolic process biosynthetic process phenylpropanoid metabolic process	cytoplasm	catalytic activity lyase activity ammonia-lyase activity
2eryA ras-related protein r-ras2	[pdb]	1.21 0.00165	87^GLU 85^THR 176^ARG 80^GLU 67^LEU 150^LYS	0.0.0.0	signal transduction small GTPase mediated signal transduction Ras protein signal transduction cellular process positive regulation of cell migration	intracellular endoplasmic reticulum plasma membrane membrane	nucleotide binding GTPase activity protein binding GTP binding
3chjA alpha-14 giardin	[pdb]	1.21 0.00165	115^GLU 113^THR 82^ARG 156^ASP 240^LEU 91^ARG	0.0.0.0	cell projection organization	cilium flagellum cell projection	calcium ion binding calcium-dependent phospholipid binding calcium ion binding calcium-dependent phospholipid binding
3gf8A putative polysaccharide binding proteins (duf1812)	[pdb]	1.22 0.00165	111^ASP 113^THR 109^SER 124^ASP 63^TYR 237^ARG	0.0.0.0
1n35A 5'-r(pgpgpgpgpg)-3' 5'-r(apupupapgpcpcpcpcp*c)-3' minor core protein lambda 3	[pdb]	1.22 0.00174	700^GLU 704^THR 696^SER 709^GLU 719^LEU 770^LYS	2.7.7.48	transcription RNA-dependent viral genome replication	virion viral nucleocapsid viral capsid	nucleotide binding RNA binding RNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity hydrolase activity
1qycA phenylcoumaran benzylic ether reductase pt1	[pdb]	1.22 0.00174	275^ASP 277^THR 267^SER 280^GLU 217^LEU 134^LYS	0.0.0.0	metabolic process		catalytic activity binding
1ug9A glucodextranase	[pdb]	1.22 0.00174	57^GLU 41^THR 138^SER 71^GLU 117^LEU 182^ASN	0.0.0.0	carbohydrate metabolic process polysaccharide metabolic process carbohydrate catabolic process		catalytic activity glucan 1,4-alpha-glucosidase activity hydrolase activity hydrolyzing O-glycosyl compounds
1kmyA 2,3-dihydroxybiphenyl 1,2-dioxygenase	[pdb]	1.22 0.00174	214^GLU 139^THR 248^SER 141^GLU 8^TYR 243^ASN	1.13.11.39	cellular aromatic compound metabolic process aromatic compound catabolic process xenobiotic catabolic process oxidation-reduction process		catalytic activity iron ion binding ferrous iron binding oxidoreductase activity oxidoreductase activity acting on single donors with incorporation of molecular oxygen incorporation of two atoms of oxygen biphenyl-2,3-diol 1,2-dioxygenase activity
7ceiB protein (colicin e7 immunity protein)	[pdb]	1.23 0.00184	542^GLU 565^THR 496^ARG 533^ASP 472^LEU 518^ASN	0.0.0.0	pathogenesis cytolysis defense response to bacterium bacteriocin immunity	extrachromosomal circular DNA	nucleic acid binding nuclease activity endonuclease activity protein binding hydrolase activity metal ion binding protein binding toxin binding
2r5eB kynurenine aminotransferase	[pdb]	1.23 0.00193	222^GLU 190^THR 252^SER 200^ASP 195^LEU 315^ASN	0.0.0.0	biosynthetic process		catalytic activity transaminase activity transferase activity transferase activity transferring nitrogenous groups 1-aminocyclopropane-1-carboxylate synthase activity
4reqC methylmalonyl-coa mutase	[pdb]	1.24 0.00203	553^ILE 516^ALA 558^LYS 513^VAL 532^SER 129^LEU	5.4.99.2	metabolic process lactate fermentation to propionate and acetate metabolic process		catalytic activity methylmalonyl-CoA mutase activity isomerase activity intramolecular transferase activity cobalamin binding metal ion binding catalytic activity methylmalonyl-CoA mutase activity isomerase activity intramolecular transferase activity cobalamin binding metal ion binding
3i09A periplasmic branched-chain amino acid-binding protein	[pdb]	1.24 0.00203	44^ASP 34^THR 300^SER 74^ASP 98^LEU 294^LYS	0.0.0.0
3lc0A histidyl-trna synthetase	[pdb]	1.25 0.00214	126^GLU 128^THR 156^ARG 174^ASP 318^TYR 334^ARG	0.0.0.0	translation tRNA aminoacylation for protein translation histidyl-tRNA aminoacylation	cytoplasm	nucleotide binding aminoacyl-tRNA ligase activity histidine-tRNA ligase activity ATP binding ligase activity
3fe1B heat shock 70 kda protein 6	[pdb]	1.26 0.00237	208^ASP 206^THR 210^SER 234^ASP 17^TYR 353^GLN	0.0.0.0	response to stress response to unfolded protein		nucleotide binding ATP binding
1pbkA fkbp25	[pdb]	1.26 0.00237	217^GLU 136^THR 114^SER 146^ASP 162^LEU 110^LYS	5.2.1.8	protein folding	nucleus	peptidyl-prolyl cis-trans isomerase activity receptor activity FK506 binding isomerase activity
2pxwB gfp-like fluorescent chromoprotein fp506	[pdb]	1.26 0.00237	221^GLU 205^THR 70^ARG 207^GLU 169^LEU 17^ARG	0.0.0.0	bioluminescence protein-chromophore linkage
1z7mD atp phosphoribosyltransferase atp phosphoribosyltransferase regulatory subunit	[pdb]	1.27 0.00237	84^LEU 86^TYR 112^ARG 130^GLU 294^LEU 283^GLN	0.0.0.0	histidine biosynthetic process translation tRNA aminoacylation for protein translation histidyl-tRNA aminoacylation cellular amino acid biosynthetic process histidine biosynthetic process cellular amino acid biosynthetic process	cytoplasm cytoplasm	nucleotide binding aminoacyl-tRNA ligase activity histidine-tRNA ligase activity ATP binding nucleotide binding ATP phosphoribosyltransferase activity ATP binding transferase activity transferase activity
2b6nA proteinase k tripeptide	[pdb]	1.27 0.00237	14^ASP 26^THR 16^ARG 29^ASP 82^TYR 253^LYS	0.0.0.0	proteolysis negative regulation of catalytic activity		serine-type endopeptidase activity peptidase activity serine-type peptidase activity hydrolase activity identical protein binding
2h0bA neurexin-1-alpha	[pdb]	1.27 0.00237	307^GLU 309^THR 305^SER 447^GLU 333^LEU 299^ASN	0.0.0.0	cell adhesion synaptic transmission neurotransmitter secretion synapse assembly	membrane integral to membrane presynaptic membrane	calcium channel regulator activity protein binding metal ion binding
3kn1A golgi phosphoprotein 3	[pdb]	1.27 0.0025	130^ASP 128^THR 176^ARG 125^ASP 99^LEU 169^GLN	0.0.0.0	cell proliferation regulation of mitochondrion organization positive regulation of TOR signaling cascade	cytoplasm mitochondrion mitochondrial intermembrane space endosome Golgi apparatus trans-Golgi network cytosol plasma membrane membrane Golgi cisterna membrane	protein binding
1wraA teichoic acid phosphorylcholine esterase/cholinebinding protein e (cbpe)	[pdb]	1.27 0.0025	228^ASP 109^THR 260^SER 58^ASP 188^LEU 302^ARG	0.0.0.0			hydrolase activity
1fj7A nucleolin rbd1	[pdb]	1.27 0.0025	51^ASP 15^THR 39^SER 13^GLU 5^LEU 58^ARG	0.0.0.0		nucleus nucleolus cytoplasm ribonucleoprotein complex	nucleotide binding nucleic acid binding DNA binding RNA binding telomeric DNA binding
3exgG pyruvate dehydrogenase e1 component subunitalpha, somatic form, mitochondrial pyruvate dehydrogenase e1 component subunit beta,mitochondrial	[pdb]	1.28 0.00263	76^PRO 237^ASN 98^ALA 235^VAL 255^LYS 37^TYR	0.0.0.0	acetyl-CoA biosynthetic process from pyruvate glycolysis tricarboxylic acid cycle metabolic process regulation of acetyl-CoA biosynthetic process from pyruvate oxidation-reduction process glycolysis metabolic process regulation of acetyl-CoA biosynthetic process from pyruvate oxidation-reduction process	mitochondrion mitochondrial matrix pyruvate dehydrogenase complex mitochondrion mitochondrial matrix intracellular membrane-bounded organelle	catalytic activity pyruvate dehydrogenase (acetyl-transferring) activity oxidoreductase activity pyruvate dehydrogenase (acetyl-transferring) activity protein binding oxidoreductase activity oxidoreductase activity
3gyrA phenoxazinone synthase	[pdb]	1.28 0.00263	458^GLU 497^THR 520^SER 500^ASP 601^TYR 480^GLN	0.0.0.0	antibiotic biosynthetic process oxidation-reduction process		copper ion binding oxidoreductase activity metal ion binding
2hn1A magnesium and cobalt transporter	[pdb]	1.28 0.00263	176^ASP 173^THR 181^SER 168^ASP 156^LEU 128^GLN	0.0.0.0	cobalt ion transport magnesium ion transport metal ion transport transmembrane transport	membrane	cobalt ion transmembrane transporter activity magnesium ion transmembrane transporter activity metal ion transmembrane transporter activity
2c6uA clec1b protein	[pdb]	1.28 0.00263	217^GLU 136^THR 107^ARG 173^GLU 129^TYR 150^LYS	0.0.0.0	defense response cell surface receptor linked signaling pathway	integral to plasma membrane membrane integral to membrane	receptor activity transmembrane receptor activity binding sugar binding
2vpxF nrfc protein hypothetical membrane spanning protein thiosulfate reductase	[pdb]	1.28 0.00277	62^ILE 171^ALA 3^PHE 168^SER 102^GLY 157^VAL	0.0.0.0	oxidation-reduction process		electron carrier activity metal ion binding iron-sulfur cluster binding 4 iron 4 sulfur cluster binding binding oxidoreductase activity molybdenum ion binding metal ion binding
1xecB decorin	[pdb]	1.29 0.00277	58^ASP 80^THR 39^SER 103^GLU 75^LEU 110^ASN	0.0.0.0	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan	extracellular region proteinaceous extracellular matrix	protein binding glycosaminoglycan binding extracellular matrix binding
3kgdA rna 3'-terminal phosphate cyclase	[pdb]	1.29 0.00277	126^ASP 236^THR 98^SER 195^GLU 227^LEU 152^GLN	0.0.0.0	RNA processing	nucleoplasm cytoplasm	nucleotide binding catalytic activity RNA-3'-phosphate cyclase activity ATP binding ligase activity ligase activity
3iayA 5'-d(aptpcpcptpcpcpcpcptpap(doc))-3' 5'-d(tpapapgpgptpapgpgpgpgpapgpgpapt)-3' dna polymerase delta catalytic subunit	[pdb]	1.29 0.00292	802^GLU 822^THR 765^SER 828^ASP 775^LEU 815^ARG	2.7.7.7	nucleobase nucleoside nucleotide and nucleic acid metabolic process DNA replication leading strand elongation lagging strand elongation RNA-dependent DNA replication base-excision repair nucleotide-excision repair mismatch repair postreplication repair	nucleus replication fork delta DNA polymerase complex	nucleotide binding nucleic acid binding DNA binding DNA-directed DNA polymerase activity nuclease activity exonuclease activity protein binding single-stranded DNA specific 3'-5' exodeoxyribonuclease activity transferase activity nucleotidyltransferase activity hydrolase activity metal ion binding
3pn1A dna ligase	[pdb]	1.29 0.00292	56^ASP 54^THR 151^ARG 51^GLU 42^LEU 65^LYS	0.0.0.0	DNA replication DNA repair response to DNA damage stimulus	intracellular	DNA binding DNA ligase (NAD+) activity ligase activity metal ion binding
3ldoB 78 kda glucose-regulated protein	[pdb]	1.29 0.00292	231^ASP 229^THR 233^SER 257^ASP 39^TYR 376^LYS	0.0.0.0	anti-apoptosis ER overload response activation of signaling protein activity involved in unfolded protein response cerebellum structural organization cerebellar Purkinje cell layer development ER-associated protein catabolic process negative regulation of transforming growth factor beta receptor signaling pathway endoplasmic reticulum unfolded protein response positive regulation of protein ubiquitination cellular response to glucose starvation negative regulation of apoptosis negative regulation of caspase activity proteolysis involved in cellular protein catabolic process regulation of protein folding in endoplasmic reticulum	nucleus endoplasmic reticulum endoplasmic reticulum lumen ER-Golgi intermediate compartment cell surface integral to endoplasmic reticulum membrane melanosome perinuclear region of cytoplasm caspase complex	nucleotide binding calcium ion binding protein binding ATP binding protein binding bridging ubiquitin protein ligase binding ribosome binding caspase inhibitor activity unfolded protein binding chaperone binding
1gfsA gdp-fucose synthetase	[pdb]	1.3 0.00292	255^GLU 259^THR 204^SER 302^GLU 185^LEU 283^LYS	1.1.1.271	metabolic process lipopolysaccharide biosynthetic process cellular metabolic process oxidation-reduction process	cytoplasm	catalytic activity binding oxidoreductase activity isomerase activity GDP-L-fucose synthase activity coenzyme binding
3ij3A cytosol aminopeptidase	[pdb]	1.3 0.00308	425^ASP 335^THR 375^ARG 249^ASP 315^LEU 447^ARG	0.0.0.0	proteolysis protein metabolic process	intracellular cytoplasm	aminopeptidase activity peptidase activity metalloexopeptidase activity hydrolase activity manganese ion binding metal ion binding
2wy3B uncharacterized protein ul16 mhc class i polypeptide-related sequence b	[pdb]	1.3 0.00308	89^ASP 80^THR 100^ARG 85^GLU 154^LEU 39^ARG	0.0.0.0	immune response-activating cell surface receptor signaling pathway immune response response to oxidative stress response to heat cytolysis antigen processing and presentation response to retinoic acid interspecies interaction between organisms gamma-delta T cell activation negative regulation of defense response to virus by host	plasma membrane integral to plasma membrane membrane integral to membrane MHC class I protein complex	natural killer cell lectin-like receptor binding
3ou5A serine hydroxymethyltransferase, mitochondrial	[pdb]	1.3 0.00308	56^GLU 390^THR 418^ARG 381^GLU 469^LEU 343^ARG	2.1.2.1	glycine metabolic process L-serine metabolic process one-carbon metabolic process	mitochondrion mitochondrial matrix mitochondrial nucleoid	catalytic activity glycine hydroxymethyltransferase activity protein binding methyltransferase activity transferase activity pyridoxal phosphate binding
2j04C hypothetical protein ypl007c ydr362cp	[pdb]	1.3 0.00308	26^ASP 584^ARG 339^SER 586^LEU 580^THR 53^LYS	0.0.0.0	transcription initiation from RNA polymerase III promoter transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex nucleus transcription factor TFIIIC complex nucleus	DNA binding RNA polymerase III transcription factor activity DNA binding RNA polymerase III transcription factor activity
3gdqA heat shock 70 kda protein 1-like	[pdb]	1.31 0.00325	208^ASP 206^THR 210^SER 234^ASP 17^TYR 353^GLN	0.0.0.0	response to unfolded protein		nucleotide binding ATP binding
2e5sA otthump00000018578	[pdb]	1.31 0.00325	21^GLU 55^THR 39^ARG 50^ASP 74^TYR 30^ASN	0.0.0.0	mRNA processing RNA splicing regulation of RNA splicing	nucleus cytoplasm	nucleic acid binding RNA binding zinc ion binding metal ion binding
1vkhB putative serine hydrolase	[pdb]	1.31 0.00343	72^GLU 46^THR 90^SER 44^GLU 247^TYR 81^ASN	3.5.1.9	tryptophan catabolic process NAD biosynthetic process		arylformamidase activity hydrolase activity
3equB penicillin-binding protein 2	[pdb]	1.31 0.00343	441^ASP 466^THR 271^ARG 322^ASP 473^LEU 430^GLN		cellular cell wall organization cell cycle regulation of cell shape peptidoglycan biosynthetic process peptidoglycan-based cell wall biogenesis response to antibiotic cell division	plasma membrane membrane	catalytic activity penicillin binding
1hn0A chondroitin abc lyase i	[pdb]	1.31 0.00343	874^GLU 830^THR 757^SER 817^ASP 899^LEU 671^GLN	4.2.2.20	carbohydrate metabolic process	extracellular region	catalytic activity lyase activity carbon-oxygen lyase activity acting on polysaccharides carbohydrate binding chondroitin-sulfate-ABC endolyase activity
2am1A udp-n-acetylmuramoylalanine-d-glutamyl-lysine-d-alanyl-d-alanine ligase, murf protein	[pdb]	1.31 0.00343	23^ASP 4^THR 19^SER 27^GLU 90^LEU 74^ASN	0.0.0.0	cellular cell wall organization cell cycle regulation of cell shape biosynthetic process peptidoglycan biosynthetic process peptidoglycan-based cell wall biogenesis cell division	cytoplasm	nucleotide binding ATP binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ligase activity UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
2azkA geranylgeranyl pyrophosphate synthetase	[pdb]	1.31 0.00343	134^GLU 131^THR 140^SER 126^ASP 171^LEU 110^ASN	0.0.0.0	isoprenoid biosynthetic process		dimethylallyltranstransferase activity farnesyltranstransferase activity geranyltranstransferase activity transferase activity
2czcB glyceraldehyde-3-phosphate dehydrogenase	[pdb]	1.31 0.00343	275^GLU 242^THR 300^SER 239^GLU 150^LEU 258^GLN	1.2.1.59	glucose metabolic process glycolysis metabolic process oxidation-reduction process	cytoplasm	catalytic activity glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity binding glyceraldehyde-3-phosphate dehydrogenase activity oxidoreductase activity glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity NADP binding NAD binding
3c3wA two component transcriptional regulatory proteindevr	[pdb]	1.32 0.00343	54^ASP 82^THR 35^SER 195^GLU 101^TYR 167^ASN	0.0.0.0	two-component signal transduction system (phosphorelay) response to hypoxia regulation of transcription DNA-dependent pathogenesis	intracellular cytoplasm cytosol plasma membrane host cell cytoplasmic vesicle	two-component response regulator activity DNA binding sequence-specific DNA binding transcription factor activity binding sequence-specific DNA binding
1v82A galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1	[pdb]	1.32 0.00343	121^GLU 90^THR 125^ARG 195^ASP 174^LEU 150^ARG	2.4.1.135	carbohydrate metabolic process	Golgi membrane Golgi apparatus membrane integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity transferase activity metal ion binding
3qm3G fructose-bisphosphate aldolase	[pdb]	1.32 0.00363	153^GLU 151^THR 208^SER 143^GLU 111^LEU 256^ASN		glycolysis metabolic process		catalytic activity fructose-bisphosphate aldolase activity zinc ion binding lyase activity metal ion binding
1rcqA catabolic alanine racemase dadx	[pdb]	1.32 0.00363	163^ASP 217^THR 160^SER 227^ASP 213^LEU 201^LYS	5.1.1.1	alanine metabolic process		catalytic activity alanine racemase activity isomerase activity
3lvtA glycosyl hydrolase, family 38	[pdb]	1.32 0.00363	642^GLU 644^THR 639^ARG 659^GLU 557^LEU 766^GLN	0.0.0.0	carbohydrate metabolic process mannose metabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds alpha-mannosidase activity zinc ion binding mannosidase activity hydrolase activity
1sv2B peptide deformylase	[pdb]	1.32 0.00363	45^GLU 40^THR 70^ARG 36^ASP 6^LEU 137^LYS	3.5.1.88	translation		iron ion binding hydrolase activity peptide deformylase activity metal ion binding
2z63A toll-like receptor 4, variable lymphocyte receptor b	[pdb]	1.32 0.00363	294^ASP 319^THR 264^ARG 321^GLU 337^LEU 241^ASN		activation of MAPK activity response to hypoxia activation of innate immune response toll-like receptor signaling pathway microglial cell activation involved in immune response nitric oxide production involved in inflammatory response innate immune response-activating signal transduction inflammatory response immune response response to oxidative stress signal transduction I-kappaB kinase/NF-kappaB cascade I-kappaB phosphorylation response to bacterium response to toxin positive regulation of gene-specific transcription from RNA polymerase II promoter positive regulation of platelet activation detection of fungus immunoglobulin mediated immune response positive regulation of B cell proliferation response to lipopolysaccharide detection of lipopolysaccharide response to progesterone stimulus interferon-gamma production negative regulation of interferon-gamma production negative regulation of interleukin-17 production negative regulation of interleukin-23 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production positive regulation of chemokine production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-gamma production positive regulation of interleukin-1 production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production response to insulin stimulus positive regulation of stress-activated MAPK cascade T-helper 1 type immune response macrophage activation positive regulation of NF-kappaB import into nucleus positive regulation of tumor necrosis factor biosynthetic process defense response to bacterium positive regulation of apoptosis positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of DNA binding positive regulation of interleukin-12 biosynthetic process innate immune response positive regulation of MHC class II biosynthetic process positive regulation of interferon-beta biosynthetic process positive regulation of interleukin-8 biosynthetic process positive regulation of nitric oxide biosynthetic process response to ethanol negative regulation of osteoclast differentiation positive regulation of JNK cascade positive regulation of lymphocyte proliferation positive regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-negative bacterium positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of nitric-oxide synthase biosynthetic process pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity intestinal epithelial structure maintenance positive regulation of macrophage cytokine production negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway response to fatty acid cellular response to lipopolysaccharide cellular response to lipoteichoic acid	cytoplasm plasma membrane integral to plasma membrane external side of plasma membrane cell surface membrane integral to membrane intrinsic to membrane membrane raft lipopolysaccharide receptor complex perinuclear region of cytoplasm	receptor activity protein binding lipopolysaccharide binding lipopolysaccharide receptor activity receptor activity transmembrane receptor activity protein binding phosphatidylinositol 3-kinase binding
2a85A l(+)-mandelate dehydrogenase	[pdb]	1.32 0.00363	324^GLU 327^THR 317^ARG 332^ASP 75^LEU 13^LYS	1.1.3.15	metabolic process photorespiration oxidative photosynthetic carbon pathway oxidation-reduction process metabolic process mandelate metabolic process aromatic compound catabolic process oxidation-reduction process	peroxisome membrane	catalytic activity (S)-2-hydroxy-acid oxidase activity FMN binding oxidoreductase activity catalytic activity FMN binding oxidoreductase activity (S)-mandelate dehydrogenase activity
3buuB uncharacterized lola superfamily protein ne2245	[pdb]	1.32 0.00383	162^GLU 164^THR 149^ARG 142^ASP 192^TYR 185^ARG	0.0.0.0
3ipsA nuclear receptor coactivator 1 oxysterols receptor lxr-alpha	[pdb]	1.33 0.00383	387^GLU 384^THR 394^SER 379^GLU 275^LEU 406^ARG	0.0.0.0	regulation of transcription DNA-dependent positive regulation of gene-specific transcription from RNA polymerase II promoter negative regulation of macrophage derived foam cell differentiation positive regulation of triglyceride biosynthetic process positive regulation of cholesterol efflux negative regulation of cholesterol storage positive regulation of cellular protein metabolic process negative regulation of lipid transport positive regulation of cholesterol transport response to progesterone stimulus positive regulation of gene-specific transcription apoptotic cell clearance positive regulation of fatty acid biosynthetic process negative regulation of pinocytosis	nucleus	DNA binding sequence-specific DNA binding transcription factor activity steroid hormone receptor activity transcription coactivator activity receptor activity ligand-dependent nuclear receptor activity thyroid hormone receptor activity protein binding zinc ion binding sterol response element binding sequence-specific DNA binding metal ion binding
2p3pB hypothetical protein	[pdb]	1.33 0.00383	134^GLU 153^THR 130^SER 165^ASP 216^LEU 89^ARG	0.0.0.0
1wppB probable manganese-dependent inorganicpyrophosphatase	[pdb]	1.33 0.00383	15^ASP 47^THR 123^SER 45^GLU 53^TYR 156^LYS	3.6.1.1		cytoplasm	inorganic diphosphatase activity pyrophosphatase activity hydrolase activity manganese ion binding metal ion binding
2xexB elongation factor g	[pdb]	1.33 0.00383	484^GLU 485^THR 481^SER 597^ASP 589^LEU 689^LYS	0.0.0.0	translation translational elongation	intracellular cytoplasm	nucleotide binding translation elongation factor activity GTPase activity GTP binding
2x9pA pimd protein	[pdb]	1.33 0.00383	244^ASP 146^THR 279^ARG 144^GLU 363^LEU 378^GLN	0.0.0.0	oxidation-reduction process		monooxygenase activity iron ion binding electron carrier activity oxidoreductase activity heme binding metal ion binding
2ipcD preprotein translocase seca subunit	[pdb]	1.33 0.00405	821^ASP 818^THR 935^ARG 813^GLU 826^LEU 278^GLN	0.0.0.0	protein targeting transport intracellular protein transport protein transport protein import transmembrane transport	cytoplasm plasma membrane membrane	nucleotide binding protein binding ATP binding
2yz2A putative abc transporter atp-binding proteintm_0222	[pdb]	1.34 0.00405	158^ASP 190^THR 78^ARG 34^GLU 193^LEU 70^ARG	0.0.0.0	transport	plasma membrane membrane	nucleotide binding ATP binding hydrolase activity ATPase activity nucleoside-triphosphatase activity
1iwpL glycerol dehydratase beta subunit glycerol dehydratase gamma subunit glycerol dehydratase alpha subunit	[pdb]	1.34 0.00405	359^ASP 138^ARG 333^SER 521^ASP 509^LEU 289^LYS	0.0.0.0	metabolic process		lyase activity glycerol dehydratase activity catalytic activity lyase activity hydro-lyase activity cobalamin binding glycerol dehydratase activity lyase activity glycerol dehydratase activity
3ojaB leucine-rich immune molecule 1 anopheles plasmodium-responsive leucine-rich repeat protein1	[pdb]	1.34 0.00405	341^GLU 362^THR 320^SER 385^GLU 377^LEU 304^GLN	0.0.0.0			protein binding
3piuA 1-aminocyclopropane-1-carboxylate synthase	[pdb]	1.34 0.00427	97^ASP 108^THR 318^SER 248^GLU 286^TYR 330^ASN	0.0.0.0	biosynthetic process ethylene biosynthetic process ripening		catalytic activity transferase activity transferring nitrogenous groups lyase activity 1-aminocyclopropane-1-carboxylate synthase activity pyridoxal phosphate binding
1oyjC glutathione s-transferase	[pdb]	1.34 0.00427	145^GLU 143^THR 151^ARG 139^GLU 110^TYR 199^ARG	2.5.1.18			glutathione transferase activity transferase activity glutathione transferase activity transferase activity
2a2gD protein (alpha-2u-globulin)	[pdb]	1.34 0.00427	79^GLU 89^THR 5^SER 83^GLU 116^LEU 16^ASN	0.0.0.0	transport	extracellular region cytoplasm cytosol	transporter activity binding pheromone binding
1jymE peptide deformylase	[pdb]	1.34 0.00427	80^GLU 82^THR 77^ARG 85^ASP 174^TYR 66^LYS	0.0.0.0	translation	apicoplast	iron ion binding formylmethionine deformylase activity hydrolase activity peptide deformylase activity
1u79A fkbp-type peptidyl-prolyl cis-trans isomerase 3	[pdb]	1.34 0.00427	122^ASP 90^THR 49^SER 18^ASP 14^LEU 34^LYS	5.2.1.8	protein folding	chloroplast plastid chloroplast thylakoid lumen thylakoid thylakoid lumen	peptidyl-prolyl cis-trans isomerase activity protein binding isomerase activity
1nktB preprotein translocase seca 1 subunit	[pdb]	1.35 0.00451	493^ASP 492^THR 573^ARG 468^GLU 503^LEU 431^GLN	0.0.0.0	protein targeting transport intracellular protein transport protein transport protein import growth protein transport by the Sec complex transmembrane transport	extracellular region cytoplasm cytosol plasma membrane membrane cell envelope Sec protein transport complex	nucleotide binding protein binding ATP binding ATPase activity protein homodimerization activity
1jvaA vma1-derived homing endonuclease x10sss	[pdb]	1.35 0.00451	363^GLU 441^THR 284^SER 439^GLU 459^TYR 318^ARG	0.0.0.0	intron homing transport ion transport vacuolar acidification ATP synthesis coupled proton transport proton transport intein-mediated protein splicing cellular protein metabolic process ATP metabolic process	vacuolar proton-transporting V-type ATPase V1 domain fungal-type vacuole membrane vacuole vacuolar membrane endomembrane system membrane proton-transporting two-sector ATPase complex	nucleotide binding DNA binding nuclease activity endonuclease activity endodeoxyribonuclease activity protein binding ATP binding hydrolase activity hydrolase activity acting on acid anhydrides catalyzing transmembrane movement of substances
1ud9A dna polymerase sliding clamp a	[pdb]	1.35 0.00451	90^ASP 100^THR 93^SER 86^GLU 77^LEU 30^LYS	0.0.0.0	DNA replication regulation of DNA replication	PCNA complex	DNA binding DNA polymerase processivity factor activity
3gq8A preneck appendage protein	[pdb]	1.35 0.00451	299^ASP 275^THR 395^ARG 273^GLU 239^LEU 358^ARG	0.0.0.0
1ka9F imidazole glycerol phosphtate synthase	[pdb]	1.35 0.00451	131^ASP 172^THR 105^SER 184^ASP 223^LEU 160^LYS	0.0.0.0	histidine biosynthetic process glutamine metabolic process cellular amino acid biosynthetic process histidine biosynthetic process metabolic process cellular amino acid biosynthetic process	cytoplasm cytoplasm	catalytic activity protein binding transferase activity transferase activity transferring pentosyl groups imidazoleglycerol-phosphate synthase activity catalytic activity protein binding
1mppA pepsin	[pdb]	1.35 0.00451	87^ASP 100^THR 61^SER 37^ASP 69^TYR 54^ARG	3.4.23.23	proteolysis		aspartic-type endopeptidase activity peptidase activity hydrolase activity
3hi8C proliferating cell nuclear antigen pcna	[pdb]	1.35 0.00451	112^ASP 94^THR 115^SER 91^ASP 108^LEU 37^ARG	0.0.0.0	DNA replication regulation of DNA replication	PCNA complex	DNA binding DNA polymerase processivity factor activity
1vgvC udp-n-acetylglucosamine 2-epimerase	[pdb]	1.35 0.00451	117^GLU 172^THR 135^ARG 358^ASP 366^LEU 154^GLN	5.1.3.14	UDP-N-acetylglucosamine metabolic process lipopolysaccharide biosynthetic process detection of virus entry of virus into host cell	cytoplasm	UDP-N-acetylglucosamine 2-epimerase activity isomerase activity
1arzD dihydrodipicolinate reductase	[pdb]	1.35 0.00451	219^GLU 221^THR 238^SER 154^GLU 137^LEU 163^LYS	1.3.1.26	metabolic process cellular amino acid biosynthetic process lysine biosynthetic process lysine biosynthetic process via diaminopimelate diaminopimelate biosynthetic process oxidation-reduction process	cytoplasm cytosol	catalytic activity binding dihydrodipicolinate reductase activity oxidoreductase activity
1md9A 2,3-dihydroxybenzoate-amp ligase	[pdb]	1.35 0.00451	334^GLU 388^THR 190^SER 361^ASP 209^TYR 309^LYS	0.0.0.0	metabolic process siderophore biosynthetic process	cytoplasm	nucleotide binding catalytic activity ATP binding (2,3-dihydroxybenzoyl)adenylate synthase activity ligase activity
3f4lC putative oxidoreductase yhhx	[pdb]	1.35 0.00475	196^ASP 209^THR 339^SER 154^ASP 173^TYR 220^LYS	0.0.0.0	metabolic process oxidation-reduction process		catalytic activity binding protein binding oxidoreductase activity
3aisA beta-glucosidase	[pdb]	1.35 0.00475	147^ASP 57^THR 103^SER 154^ASP 200^TYR 169^LYS		carbohydrate metabolic process metabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds beta-glucosidase activity hydrolase activity hydrolase activity
1x6lA chitinase a	[pdb]	1.36 0.00475	313^ASP 360^THR 278^SER 358^GLU 187^LEU 225^LYS	3.2.1.14	polysaccharide catabolic process carbohydrate metabolic process chitin catabolic process metabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds chitinase activity hydrolase activity hydrolase activity
3oyvA imelysin	[pdb]	1.36 0.00475	303^GLU 300^THR 154^SER 296^ASP 370^LEU 199^GLN	0.0.0.0
2w4mA n-acylneuraminate-9-phosphatase	[pdb]	1.36 0.00475	19^ASP 16^THR 104^ARG 189^ASP 130^LEU 53^GLN	3.1.3.29	carbohydrate metabolic process metabolic process N-acetylneuraminate biosynthetic process	cellular_component	catalytic activity phosphoglycolate phosphatase activity hydrolase activity N-acylneuraminate-9-phosphatase activity
3cetA conserved archaeal protein	[pdb]	1.36 0.00475	133^ASP 139^THR 310^SER 163^GLU 264^LEU 124^ASN				hydrolase activity
1ia6A cellulase cel9m	[pdb]	1.36 0.00475	258^ASP 253^THR 208^SER 313^GLU 265^LEU 67^GLN	0.0.0.0	polysaccharide catabolic process carbohydrate metabolic process		catalytic activity hydrolase activity
1bjnA phosphoserine aminotransferase	[pdb]	1.36 0.00475	160^ASP 162^THR 296^SER 164^ASP 189^TYR 122^LYS	2.6.1.52	L-serine metabolic process L-serine biosynthetic process metabolic process pyridoxine biosynthetic process cellular amino acid biosynthetic process pyridoxal phosphate biosynthetic process	cytoplasm	catalytic activity O-phospho-L-serine:2-oxoglutarate aminotransferase activity protein binding transaminase activity transferase activity pyridoxal phosphate binding
1pm2B ribonucleoside-diphosphate reductase 1 betachain	[pdb]	1.36 0.00501	109^GLU 106^THR 89^ARG 103^GLU 44^LEU 201^ASN	1.17.4.1	DNA replication deoxyribonucleoside diphosphate metabolic process deoxyribonucleotide biosynthetic process nucleobase nucleoside and nucleotide interconversion	cytoplasm cytosol ribonucleoside-diphosphate reductase complex	ribonucleoside-diphosphate reductase activity iron ion binding protein binding oxidoreductase activity metal ion binding transition metal ion binding
3mcmA 2-amino-4-hydroxy-6-hydroxymethyldihydropteridinepyrophosphokinase/dihydropteroate synthase	[pdb]	1.36 0.00501	255^ASP 256^THR 418^ARG 228^GLU 266^LEU 197^ASN		folic acid-containing compound biosynthetic process pteridine-containing compound metabolic process cellular metabolic process		2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity dihydropteroate synthase activity kinase activity
1c7sA beta-n-acetylhexosaminidase	[pdb]	1.36 0.00501	760^GLU 220^THR 754^ARG 334^ASP 318^LEU 371^LYS	3.2.1.52	polysaccharide catabolic process carbohydrate metabolic process chitin catabolic process metabolic process	periplasmic space	catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds beta-N-acetylhexosaminidase activity hydrolase activity hydrolase activity acting on glycosyl bonds carbohydrate binding
1kccA endopolygalacturonase	[pdb]	1.37 0.00501	174^ASP 152^THR 198^SER 140^ASP 101^LEU 216^ASN	0.0.0.0	carbohydrate metabolic process cellular cell wall organization metabolic process		polygalacturonase activity hydrolase activity hydrolase activity
2nn6C 3'-5' exoribonuclease csl4 homolog polymyositis/scleroderma autoantigen 1 exosome complex exonuclease rrp4 exosome complex exonuclease rrp46 exosome complex exonuclease rrp41 exosome complex exonuclease rrp40 exosome complex exonuclease rrp43 exosome complex exonuclease rrp42 exosome component 6	[pdb]	1.37 0.00528	145^THR 211^HIS 90^VAL 209^PRO 217^ILE 103^ILE	0.0.0.0	rRNA processing RNA processing immune response rRNA processing RNA processing rRNA processing RNA processing rRNA processing rRNA processing rRNA processing rRNA processing RNA processing histone mRNA catabolic process rRNA processing RNA processing biological_process rRNA processing RNA processing RNA catabolic process	nuclear exosome (RNase complex) exosome (RNase complex) nucleus nucleolus cytoplasm exosome (RNase complex) nucleus nucleolus cytoplasm exosome (RNase complex) nucleus nucleolus cytoplasm exosome (RNase complex) nucleus nucleolus nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) exosome (RNase complex) nucleus nucleolus cytoplasm exosome (RNase complex) nucleus nucleolus cytoplasm exosome (RNase complex) nucleus nucleolus cytoplasm exosome (RNase complex) cellular_component nucleus nucleolus cytoplasm exosome (RNase complex) nucleus nucleolus	3'-5'-exoribonuclease activity RNA binding nuclease activity exonuclease activity protein binding hydrolase activity 3'-5'-exoribonuclease activity RNA binding nuclease activity exonuclease activity protein binding hydrolase activity 3'-5'-exoribonuclease activity RNA binding nuclease activity exonuclease activity hydrolase activity RNA binding nuclease activity exonuclease activity protein binding hydrolase activity 3'-5'-exoribonuclease activity RNA binding nuclease activity exonuclease activity protein binding hydrolase activity 3'-5'-exoribonuclease activity RNA binding nuclease activity exonuclease activity protein binding 7S RNA binding hydrolase activity 3'-5'-exoribonuclease activity RNA binding nuclease activity exonuclease activity protein binding hydrolase activity 3'-5'-exoribonuclease activity molecular_function RNA binding nuclease activity exonuclease activity protein binding hydrolase activity identical protein binding 3'-5'-exoribonuclease activity RNA binding nuclease activity exonuclease activity protein binding hydrolase activity
1vqvB thiamine monophosphate kinase	[pdb]	1.37 0.00528	281^GLU 280^THR 284^ARG 278^ASP 157^LEU 203^ASN	0.0.0.0	thiamine biosynthetic process		catalytic activity thiamine-phosphate kinase activity kinase activity
1cx8D transferrin receptor protein	[pdb]	1.37 0.00528	612^GLU 657^THR 616^SER 659^ASP 607^LEU 743^GLN	0.0.0.0	response to hypoxia proteolysis cellular iron ion homeostasis endocytosis acute-phase response aging response to nutrient response to organic substance response to inorganic substance response to iron ion response to manganese ion response to retinoic acid interspecies interaction between organisms response to copper ion	extracellular region mitochondrion endosome plasma membrane integral to plasma membrane coated pit membrane integral to membrane cytoplasmic membrane-bounded vesicle melanosome perinuclear region of cytoplasm extracellular vesicular exosome	receptor activity transferrin receptor activity peptidase activity
2y5sB dihydropteroate synthase	[pdb]	1.37 0.00528	101^ASP 102^THR 268^ARG 80^GLU 112^LEU 49^ARG	0.0.0.0	folic acid-containing compound biosynthetic process pteridine-containing compound metabolic process cellular metabolic process		dihydropteroate synthase activity transferase activity
1rwhA chondroitin ac lyase	[pdb]	1.37 0.00528	659^GLU 665^THR 650^ARG 482^GLU 698^LEU 502^LYS	0.0.0.0	carbohydrate metabolic process	extracellular region	catalytic activity lyase activity carbon-oxygen lyase activity acting on polysaccharides
1aodA phosphatidylinositol-specific phospholipase c	[pdb]	1.37 0.00556	82^ASP 47^THR 176^SER 278^ASP 74^LEU 200^GLN	4.6.1.13	lipid metabolic process pathogenesis lipid catabolic process	extracellular region cytoplasm	phosphatidylinositol diacylglycerol-lyase activity phospholipase C activity phosphoric diester hydrolase activity lyase activity
1ui7B phenylethylamine oxidase	[pdb]	1.37 0.00556	444^ASP 447^THR 269^ARG 578^ASP 546^TYR 612^ARG	1.4.3.21	amine metabolic process oxidation-reduction process		copper ion binding primary amine oxidase activity oxidoreductase activity metal ion binding quinone binding
3om1B glutamate receptor gluk5 (ka2)	[pdb]	1.38 0.00556	198^ASP 226^THR 172^ARG 229^ASP 246^LEU 178^ARG
1xkoA chemotaxis protein chex	[pdb]	1.38 0.00556	91^GLU 96^THR 87^SER 15^GLU 56^LEU 67^LYS	0.0.0.0	chemotaxis		hydrolase activity
3qqcA dna-directed rna polymerase subunit b, dna-directed rnapolymerase subunit a', dna-directed rna polymerase subunit a'' transcription antitermination protein nusg dna-directed rna polymerase, subunit e''	[pdb]	1.38 0.00556	130^GLU 3^GLU 127^ARG 39^VAL 46^LYS 23^SER		translation positive regulation of transcription elongation from RNA polymerase II promoter	intracellular ribosome	transcription elongation regulator activity structural constituent of ribosome DNA binding DNA-directed RNA polymerase activity zinc ion binding electron carrier activity transferase activity nucleotidyltransferase activity ribonucleoside binding metal ion binding DNA binding DNA-directed RNA polymerase activity zinc ion binding transferase activity nucleotidyltransferase activity DNA binding DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity DNA-directed RNA polymerase activity
3n3nA catalase-peroxidase	[pdb]	1.38 0.00556	128^GLU 194^THR 113^SER 60^ASP 68^TYR 150^ARG	0.0.0.0	response to oxidative stress hydrogen peroxide catabolic process oxidation-reduction process		catalase activity peroxidase activity oxidoreductase activity heme binding metal ion binding
1a9nC spliceosomal u2b'' u2a' rna (5'-r(cpcpupgpgpupapupupgpcpapgpupapcpcpupcp cpapgp* gp*u)-3')	[pdb]	1.38 0.00556	48^THR 68^ALA 27^LYS 92^ASP 63^GLY 75^PHE	0.0.0.0	nuclear mRNA splicing via spliceosome mRNA processing RNA splicing nuclear mRNA splicing via spliceosome	nucleus spliceosomal complex U2 snRNP ribonucleoprotein complex nucleus spliceosomal complex U2 snRNP ribonucleoprotein complex small nuclear ribonucleoprotein complex	nucleotide binding nucleic acid binding RNA binding protein binding RNA binding protein binding
3d2qC muscleblind-like protein 1	[pdb]	1.38 0.00556	183^GLU 217^THR 201^ARG 212^ASP 236^TYR 192^ASN	0.0.0.0	regulation of alternative nuclear mRNA splicing via spliceosome in utero embryonic development mRNA splice site selection mRNA processing nervous system development muscle organ development skeletal muscle tissue development RNA splicing embryonic limb morphogenesis regulation of RNA splicing	nucleus cytoplasm stress granule	nucleic acid binding RNA binding double-stranded RNA binding protein binding zinc ion binding metal ion binding
2g29A nitrate transport protein nrta	[pdb]	1.38 0.00556	419^GLU 426^THR 415^SER 423^ASP 436^LEU 269^LYS	0.0.0.0	transport nitrate assimilation	plasma membrane membrane
3i4mB dna-directed rna polymerase ii subunit rpb11 dna-directed rna polymerases i, ii, and iiisubunit rpabc4 rna (5'-r(upgpcpapupcupupcpcpapgpgpcpcpu)-3') dna-directed rna polymerases i, ii, and iiisubunit rpabc5 dna (5'-d(apgptpapcptptpgpapgpcpt)-3') dna-directed rna polymerases i, ii, and iiisubunit rpabc1 dna-directed rna polymerases i, ii, and iiisubunit rpabc2 dna-directed rna polymerase ii subunit rpb4 dna-directed rna polymerase ii subunit rpb7 dna-directed rna polymerase ii subunit rpb1 dna-directed rna polymerase ii subunit rpb3 dna-directed rna polymerase ii subunit rpb2 dna (5'-d(apgcptpcpapapgptpapcptptpap(8og) pgpcpcp(bru)pgpgptpcpaptpt)-3') dna-directed rna polymerases i, ii, and iiisubunit rpabc3 dna-directed rna polymerase ii subunit rpb9	[pdb]	1.38 0.00556	61^THR 58^LYS 67^PHE 56^LEU 413^LEU 164^LYS	2.7.7.6	transcription DNA-dependent transcription from RNA polymerase I promoter transcription from RNA polymerase II promoter transcription from RNA polymerase III promoter nuclear-transcribed mRNA catabolic process deadenylation-dependent decay DNA repair transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter mRNA processing response to DNA damage stimulus mRNA export from nucleus in response to heat stress recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex cellular metabolic process DNA repair transcription-coupled nucleotide-excision repair transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter response to DNA damage stimulus transcription DNA-dependent transcription from RNA polymerase II promoter transcription from RNA polymerase III promoter tRNA transcription from RNA polymerase III promoter transcription from RNA polymerase II promoter termination of RNA polymerase II transcription transcription from RNA polymerase I promoter transcription from RNA polymerase II promoter transcription from RNA polymerase III promoter transcription from RNA polymerase I promoter transcription from RNA polymerase II promoter transcription from RNA polymerase III promoter tRNA transcription from RNA polymerase III promoter transcription from RNA polymerase I promoter transcription from RNA polymerase II promoter transcription from RNA polymerase III promoter tRNA transcription from RNA polymerase III promoter transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter nuclear-transcribed mRNA catabolic process exonucleolytic transcription from RNA polymerase II promoter	nucleus nucleoplasm DNA-directed RNA polymerase II core complex DNA-directed RNA polymerase III complex nucleolus DNA-directed RNA polymerase I complex cytoplasmic mRNA processing body nucleus DNA-directed RNA polymerase II core complex cytoplasm nucleus DNA-directed RNA polymerase II core complex nucleus nucleoplasm DNA-directed RNA polymerase II core complex DNA-directed RNA polymerase III complex DNA-directed RNA polymerase I complex cytoplasm RNA polymerase complex nucleus DNA-directed RNA polymerase II core complex nucleus nucleoplasm DNA-directed RNA polymerase II core complex DNA-directed RNA polymerase III complex nucleolus DNA-directed RNA polymerase I complex nucleus nucleoplasm DNA-directed RNA polymerase II core complex DNA-directed RNA polymerase III complex DNA-directed RNA polymerase I complex nucleus nucleoplasm DNA-directed RNA polymerase II core complex DNA-directed RNA polymerase III complex DNA-directed RNA polymerase I complex nucleus DNA-directed RNA polymerase II core complex mitochondrion nucleus	DNA binding DNA-directed RNA polymerase activity protein binding zinc ion binding metal ion binding nucleotide binding catalytic activity DNA-directed RNA polymerase activity protein binding single-stranded DNA binding single-stranded RNA binding nucleic acid binding DNA binding DNA-directed RNA polymerase activity protein binding zinc ion binding transcription regulator activity metal ion binding DNA binding DNA-directed RNA polymerase activity protein binding DNA binding DNA-directed RNA polymerase activity protein binding protein dimerization activity DNA binding DNA-directed RNA polymerase activity metal ion binding DNA-directed RNA polymerase activity protein binding DNA binding DNA-directed RNA polymerase activity protein binding DNA binding DNA-directed RNA polymerase activity protein binding transferase activity nucleotidyltransferase activity metal ion binding DNA binding DNA-directed RNA polymerase activity protein binding transferase activity nucleotidyltransferase activity ribonucleoside binding metal ion binding single-stranded DNA binding RNA binding single-stranded RNA binding DNA-directed RNA polymerase activity DNA binding DNA-directed RNA polymerase activity protein binding metal ion binding protein dimerization activity
2enxA manganese-dependent inorganic pyrophosphatase	[pdb]	1.38 0.00556	15^ASP 47^THR 123^SER 45^GLU 53^TYR 156^LYS	3.6.1.1		cytoplasm cytoplasm	inorganic diphosphatase activity pyrophosphatase activity hydrolase activity manganese ion binding metal ion binding inorganic diphosphatase activity pyrophosphatase activity hydrolase activity manganese ion binding metal ion binding
3d43B sphericase	[pdb]	1.38 0.00556	34^ASP 35^THR 137^SER 107^ASP 239^TYR 169^ASN	0.0.0.0	proteolysis		serine-type endopeptidase activity peptidase activity serine-type peptidase activity hydrolase activity
3qm2B phosphoserine aminotransferase	[pdb]	1.38 0.00586	160^ASP 162^THR 296^SER 164^ASP 189^TYR 122^LYS		L-serine biosynthetic process metabolic process pyridoxine biosynthetic process cellular amino acid biosynthetic process	cytoplasm	catalytic activity O-phospho-L-serine:2-oxoglutarate aminotransferase activity transaminase activity transferase activity pyridoxal phosphate binding