The LabelHash Server

Top 150 matches

For each match you can click on the "[pdb]" link to download a PDB file with the matching chain aligned with the motif.
Download a zip file with PDB files for all the matches and the motif itself.

PDB ID		LRMSD / p-value	Matching Residues	EC	Gene Ontology annotations
PDB ID		LRMSD / p-value	Matching Residues	EC	Biological Process	Cellular Component	Molecular Function
1k3dA phosphoenolpyruvate carboxykinase	[pdb]	0.0911 1.89e-05	249^LEU 250^SER 251^GLY 253^GLY 254^LYS 255^THR	4.1.1.49	gluconeogenesis	cytoplasm	nucleotide binding phosphoenolpyruvate carboxykinase activity phosphoenolpyruvate carboxykinase (ATP) activity ATP binding lyase activity carboxy-lyase activity purine nucleotide binding
1xkvA atp-dependent phosphoenolpyruvate carboxykinase	[pdb]	0.296 7.81e-05	233^LEU 234^SER 235^GLY 237^GLY 238^LYS 239^THR	4.1.1.49	gluconeogenesis	cytoplasm	nucleotide binding phosphoenolpyruvate carboxykinase activity phosphoenolpyruvate carboxykinase (ATP) activity ATP binding lyase activity carboxy-lyase activity purine nucleotide binding metal ion binding
1x6vB bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 1	[pdb]	0.318 8.91e-05	60^LEU 61^SER 62^GLY 64^GLY 65^LYS 66^THR	2.7.7.4, 2.7.1.25	sulfate assimilation skeletal system development 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process		nucleotide binding catalytic activity adenylylsulfate kinase activity sulfate adenylyltransferase (ATP) activity ATP binding kinase activity transferase activity transferase activity transferring phosphorus-containing groups
2ax4B bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2	[pdb]	0.393 0.000136	60^LEU 61^SER 62^GLY 64^GLY 65^LYS 66^THR	2.7.1.25, 2.7.7.4	sulfate assimilation skeletal system development		nucleotide binding catalytic activity adenylylsulfate kinase activity sulfate adenylyltransferase (ATP) activity protein binding ATP binding kinase activity transferase activity transferase activity transferring phosphorus-containing groups
1ii2B phosphoenolpyruvate carboxykinase	[pdb]	0.457 0.000172	222^LEU 223^SER 224^GLY 226^GLY 227^LYS 228^THR	0.0.0.0	gluconeogenesis	peroxisome glycosome	nucleotide binding phosphoenolpyruvate carboxykinase activity phosphoenolpyruvate carboxykinase (ATP) activity ATP binding lyase activity carboxy-lyase activity purine nucleotide binding
1yggA phosphoenolpyruvate carboxykinase	[pdb]	0.487 0.000188	249^LEU 250^SER 251^GLY 253^GLY 254^LYS 255^THR	0.0.0.0	gluconeogenesis gluconeogenesis	cytoplasm cytoplasm	phosphoenolpyruvate carboxykinase activity phosphoenolpyruvate carboxykinase (ATP) activity ATP binding kinase activity lyase activity purine nucleotide binding nucleotide binding phosphoenolpyruvate carboxykinase activity phosphoenolpyruvate carboxykinase (ATP) activity ATP binding lyase activity carboxy-lyase activity purine nucleotide binding
1yvyB phosphoenolpyruvate carboxykinase [atp]	[pdb]	0.724 0.000255	1243^LEU 1244^SER 1245^GLY 1247^GLY 1248^LYS 1249^THR	4.1.1.49	gluconeogenesis	cytoplasm	nucleotide binding phosphoenolpyruvate carboxykinase activity phosphoenolpyruvate carboxykinase (ATP) activity ATP binding lyase activity carboxy-lyase activity purine nucleotide binding
2f48B diphosphate--fructose-6-phosphate 1-phosphotransferase	[pdb]	1.26 0.000331	79^LEU 80^SER 81^GLY 175^GLY 203^LYS 204^THR	0.0.0.0	glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity ATP binding transferase activity diphosphate-fructose-6-phosphate 1-phosphotransferase activity
2g04D probable fatty-acid-coa racemase far	[pdb]	1.27 0.000341	210^LEU 209^SER 208^GLY 206^GLY 205^LYS 203^THR	0.0.0.0	metabolic process	plasma membrane	catalytic activity isomerase activity
3cr8C sulfate adenylyltranferase, adenylylsulfatekinase	[pdb]	1.29 0.000351	377^LEU 378^SER 379^GLY 381^GLY 382^LYS 384^THR	0.0.0.0	sulfate assimilation		adenylylsulfate kinase activity sulfate adenylyltransferase (ATP) activity ATP binding kinase activity transferase activity transferase activity transferring phosphorus-containing groups
1f9oA endo-1,4-beta-glucanase f	[pdb]	1.38 0.000427	140^LEU 342^SER 345^GLY 264^GLY 262^LYS 261^THR	3.2.1.4	polysaccharide catabolic process carbohydrate metabolic process metabolic process cellulose catabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds cellulase activity hydrolase activity
2hxhA tubulin alpha chain tubulin beta chain kinesin-like protein kif1a	[pdb]	1.42 0.000481	152^GLU 151^CYS 148^GLU 111^GLN 112^GLU 109^GLY	0.0.0.0	neuron migration microtubule-based process microtubule-based movement protein polymerization microtubule-based movement microtubule-based process microtubule-based movement protein polymerization	microtubule protein complex microtubule microtubule protein complex	nucleotide binding GTPase activity structural molecule activity GTP binding nucleotide binding motor activity microtubule motor activity ATP binding nucleotide binding GTPase activity structural molecule activity GTP binding
2px0E flagellar biosynthesis protein flhf	[pdb]	1.5 0.000622	290^LEU 183^SER 185^GLY 187^GLY 188^LYS 189^THR	0.0.0.0	SRP-dependent cotranslational protein targeting to membrane transport protein transport flagellum organization	plasma membrane membrane	nucleotide binding GTP binding
2duoB vesicular integral-membrane protein vip36	[pdb]	1.5 0.00064	262^LEU 263^SER 130^GLY 258^GLY 97^LYS 91^THR	0.0.0.0	transport protein transport	Golgi membrane ER-Golgi intermediate compartment Golgi apparatus membrane integral to membrane	sugar binding
1r9dA glycerol dehydratase	[pdb]	1.5 0.00064	771^LEU 770^SER 335^GLY 334^GLY 331^LYS 330^THR	0.0.0.0	glucose metabolic process metabolic process	cytoplasm	catalytic activity formate C-acetyltransferase activity
3c9fB 5'-nucleotidase	[pdb]	1.51 0.00066	327^LEU 325^SER 53^GLY 321^GLY 320^LYS 318^THR	0.0.0.0	nucleotide catabolic process		hydrolase activity
1jjuA quinohemoprotein amine dehydrogenase	[pdb]	1.53 0.000724	63^ASP 64^VAL 225^ASP 68^TRP 31^GLU 32^ALA	0.0.0.0	transport electron transport chain oxidation-reduction process	periplasmic space	oxidoreductase activity oxidoreductase activity acting on the CH-NH2 group of donors iron ion binding electron carrier activity
2x12A fimbriae-associated protein fap1	[pdb]	1.53 0.000748	316^LEU 366^SER 367^GLY 278^GLY 279^LYS 277^THR	0.0.0.0		cell wall cell surface
3hzzA crotonyl coa reductase	[pdb]	1.54 0.000772	239^LEU 241^SER 237^GLY 413^GLY 414^LYS 389^THR	0.0.0.0	metabolic process oxidation-reduction process		catalytic activity binding zinc ion binding oxidoreductase activity
1iv8A maltooligosyl trehalose synthase	[pdb]	1.56 0.000822	457^LEU 455^SER 563^GLY 681^GLY 680^LYS 679^THR	0.0.0.0	carbohydrate metabolic process		catalytic activity cation binding
2dr3C upf0273 protein ph0284	[pdb]	1.56 0.000849	28^LEU 29^SER 30^GLY 35^GLY 36^LYS 37^THR	0.0.0.0	DNA repair		nucleotide binding damaged DNA binding ATP binding nucleoside-triphosphatase activity
1ls1A signal recognition particle protein	[pdb]	1.56 0.000849	218^LEU 109^SER 108^GLY 110^GLY 111^LYS 112^THR	0.0.0.0	SRP-dependent cotranslational protein targeting to membrane	signal recognition particle endoplasmic reticulum targeting ribonucleoprotein complex	nucleotide binding RNA binding protein binding GTP binding 7S RNA binding nucleoside-triphosphatase activity
2g8yB malate/l-lactate dehydrogenases	[pdb]	1.58 0.000907	115^LEU 251^SER 252^GLY 253^GLY 254^LYS 255^THR	0.0.0.0	metabolic process oxidation-reduction process	cytoplasm	oxidoreductase activity
1r87A endo-1,4-beta-xylanase	[pdb]	1.61 0.00104	325^LEU 327^SER 353^GLY 355^GLY 356^LYS 280^THR	3.2.1.8	carbohydrate metabolic process metabolic process xylan catabolic process	extracellular region	catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds hydrolase activity hydrolase activity acting on glycosyl bonds
1w36D exodeoxyribonuclease v beta chain dna hairpin exodeoxyribonuclease v alpha chain exodeoxyribonuclease v gamma chain	[pdb]	1.61 0.00104	354^LEU 170^SER 171^GLY 176^GLY 177^LYS 178^THR	3.1.11.5	DNA repair response to DNA damage stimulus DNA repair DNA recombination response to DNA damage stimulus DNA repair response to DNA damage stimulus	exodeoxyribonuclease V complex exodeoxyribonuclease V complex	nucleotide binding DNA binding helicase activity nuclease activity endonuclease activity exonuclease activity protein binding ATP binding exodeoxyribonuclease V activity hydrolase activity nucleotide binding helicase activity nuclease activity endonuclease activity exonuclease activity protein binding ATP binding exodeoxyribonuclease V activity hydrolase activity nucleoside-triphosphatase activity nucleotide binding DNA binding ATP-dependent DNA helicase activity helicase activity nuclease activity endonuclease activity exonuclease activity ATP binding exodeoxyribonuclease V activity hydrolase activity
1q3hD cystic fibrosis transmembrane conductanceregulator	[pdb]	1.61 0.00104	619^LEU 459^SER 461^GLY 463^GLY 464^LYS 465^THR	3.6.3.49	cholesterol biosynthetic process transport ion transport chloride transport water transport bicarbonate transport iodide transport cholesterol transport transepithelial chloride transport lung development cellular response to hormone stimulus response to cytokine stimulus vasodilation response to drug response to peptide hormone stimulus response to estrogen stimulus positive regulation of vasodilation transmembrane transport	cytoplasm endosome early endosome microvillus membrane integral to membrane basolateral plasma membrane apical plasma membrane cytoplasmic vesicle membrane endoplasmic reticulum Sec complex early endosome membrane chloride channel complex	nucleotide binding ion channel activity chloride channel activity channel-conductance-controlling ATPase activity protein binding ATP binding hydrolase activity ATPase activity nucleoside-triphosphatase activity enzyme binding PDZ domain binding ATPase activity
2inrA dna topoisomerase 4 subunit a	[pdb]	1.62 0.00108	482^LEU 481^SER 217^GLY 218^GLY 242^LYS 258^THR	0.0.0.0	DNA metabolic process DNA topological change regulation of transcription	chromosome	DNA binding sequence-specific DNA binding transcription factor activity DNA topoisomerase activity DNA topoisomerase (ATP-hydrolyzing) activity ATP binding isomerase activity
2kdoA ribosome maturation protein sbds	[pdb]	1.62 0.00108	236^LEU 235^SER 234^GLY 232^GLY 231^LYS 230^THR	0.0.0.0	inner cell mass cell proliferation rRNA processing learning bone mineralization leukocyte chemotaxis ribosome biogenesis mitotic spindle stabilization bone marrow development	spindle pole nucleus nucleolus cytoplasm	protein binding microtubule binding rRNA binding
1sxjB activator 1 40 kda subunit proliferating cell nuclear antigen activator 1 37 kda subunit activator 1 95 kda subunit activator 1 41 kda subunit	[pdb]	1.62 0.00108	161^MSE 48^VAL 49^SER 54^VAL 55^GLU 56^ALA	0.0.0.0	mitotic cell cycle DNA replication leading strand elongation DNA repair mismatch repair cell cycle cell division DNA replication leading strand elongation mismatch repair cell cycle sister chromatid cohesion meiotic mismatch repair DNA replication leading strand elongation lagging strand elongation regulation of DNA replication DNA repair base-excision repair nucleotide-excision repair mismatch repair postreplication repair chromatin silencing at telomere response to DNA damage stimulus mitotic sister chromatid cohesion chromatin silencing at silent mating-type cassette cell cycle checkpoint DNA replication leading strand elongation mismatch repair cell cycle sister chromatid cohesion DNA replication leading strand elongation mismatch repair cell cycle sister chromatid cohesion DNA replication leading strand elongation mismatch repair cell cycle sister chromatid cohesion	intracellular nucleus DNA replication factor C complex nucleus DNA replication factor C complex Rad17 RFC-like complex Ctf18 RFC-like complex Elg1 RFC-like complex nucleus replication fork PCNA complex nucleus DNA replication factor C complex Rad17 RFC-like complex Ctf18 RFC-like complex Elg1 RFC-like complex nucleus DNA replication factor C complex Rad17 RFC-like complex Ctf18 RFC-like complex Elg1 RFC-like complex nucleus DNA replication factor C complex Rad17 RFC-like complex Ctf18 RFC-like complex Elg1 RFC-like complex	nucleotide binding DNA binding DNA clamp loader activity protein binding ATP binding nucleoside-triphosphatase activity nucleotide binding DNA binding DNA clamp loader activity protein binding ATP binding nucleoside-triphosphatase activity DNA binding protein binding DNA polymerase processivity factor activity nucleotide binding DNA binding DNA clamp loader activity protein binding ATP binding nucleoside-triphosphatase activity nucleotide binding DNA binding protein binding ATP binding nucleoside-triphosphatase activity DNA clamp loader activity nucleotide binding DNA binding DNA clamp loader activity protein binding ATP binding ATPase activity nucleoside-triphosphatase activity
2vdcB glutamate synthase [nadph] large chain glutamate synthase [nadph] small chain	[pdb]	1.62 0.00111	1300^LEU 1301^SER 1302^GLY 1334^GLY 1335^LYS 1354^THR	1.4.1.13	glutamate biosynthetic process glutamine metabolic process nitrogen compound metabolic process metabolic process cellular amino acid biosynthetic process oxidation-reduction process glutamate biosynthetic process metabolic process cellular amino acid biosynthetic process oxidation-reduction process		catalytic activity glutamate synthase (NADPH) activity glutamate synthase activity oxidoreductase activity metal ion binding iron-sulfur cluster binding 3 iron 4 sulfur cluster binding catalytic activity glutamate synthase (NADPH) activity binding oxidoreductase activity oxidoreductase activity acting on the CH-NH2 group of donors NAD or NADP as acceptor metal ion binding
2hb6A leucine aminopeptidase 1	[pdb]	1.62 0.00111	121^LEU 122^SER 397^GLY 393^GLY 394^LYS 86^THR	3.4.11.1	proteolysis	intracellular	aminopeptidase activity protein binding peptidase activity hydrolase activity identical protein binding metal ion binding
2pg0A acyl-coa dehydrogenase	[pdb]	1.67 0.00138	189^LEU 188^SER 235^GLY 186^GLY 175^LYS 176^THR	0.0.0.0	metabolic process oxidation-reduction process		acyl-CoA dehydrogenase activity oxidoreductase activity oxidoreductase activity acting on the CH-CH group of donors
2zuyA yesx protein	[pdb]	1.68 0.00148	399^LEU 398^SER 410^GLY 454^GLY 453^LYS 451^THR	0.0.0.0	cellular cell wall organization	extracellular region	lyase activity metal ion binding
1hdcD 3-alpha, 20 beta-hydroxysteroid dehydrogenase	[pdb]	1.69 0.00154	4^LEU 5^SER 30^GLY 6^GLY 7^LYS 8^THR	1.1.1.53	lipid metabolic process metabolic process steroid metabolic process oxidation-reduction process		catalytic activity binding oxidoreductase activity androstan-3-alpha,17-beta-diol dehydrogenase activity
3d8bB fidgetin-like protein 1	[pdb]	1.69 0.00161	567^LEU 604^SER 605^GLY 446^GLY 447^LYS 448^THR	0.0.0.0	ATP metabolic process		nucleotide binding magnesium ion binding ATP binding hydrolase activity nucleoside-triphosphatase activity metal ion binding
1zl9B glutathione s-transferase 5	[pdb]	1.71 0.00167	155^LEU 154^SER 152^GLY 81^GLY 82^LYS 83^THR	2.5.1.18	apoptosis determination of adult lifespan	cellular_component	glutathione transferase activity transferase activity
1g3rA cell division inhibitor	[pdb]	1.72 0.00181	139^LEU 9^SER 12^GLY 15^GLY 16^LYS 17^THR	0.0.0.0	cell division
3czoC histidine ammonia-lyase	[pdb]	1.72 0.00181	171^LEU 164^SER 163^GLY 111^GLY 109^LYS 110^THR	0.0.0.0	histidine metabolic process biosynthetic process		catalytic activity histidine ammonia-lyase activity lyase activity ammonia-lyase activity
3m34A transketolase	[pdb]	1.72 0.00188	260^LEU 255^SER 30^GLY 34^GLY 244^LYS 241^THR	0.0.0.0	metabolic process		catalytic activity transketolase activity transferase activity
3g62A pfluding	[pdb]	1.73 0.00188	1108^LEU 1109^SER 1229^GLY 1238^GLY 1230^LYS 1236^THR	0.0.0.0
2qz4A paraplegin	[pdb]	1.73 0.00188	479^LEU 517^SER 518^GLY 354^GLY 355^LYS 356^THR	0.0.0.0	proteolysis nervous system development cell death protein catabolic process	mitochondrion membrane integral to membrane mitochondrial membrane	nucleotide binding metalloendopeptidase activity ATP binding peptidase activity metallopeptidase activity zinc ion binding hydrolase activity nucleoside-triphosphatase activity metal ion binding unfolded protein binding
3lomB geranyltranstransferase	[pdb]	1.73 0.00196	155^LEU 159^SER 160^GLY 163^GLY 195^LYS 193^THR	0.0.0.0	isoprenoid biosynthetic process		geranyltranstransferase activity transferase activity
1zkqA thioredoxin reductase 2, mitochondrial	[pdb]	1.74 0.00196	52^LEU 49^SER 50^GLY 375^GLY 373^LYS 370^THR	1.8.1.9	response to oxygen radical heart development hemopoiesis cell redox homeostasis oxidation-reduction process	cytoplasm mitochondrion	thioredoxin-disulfide reductase activity protein binding oxidoreductase activity oxidoreductase activity acting on a sulfur group of donors NAD or NADP as acceptor
1nhcF polygalacturonase i	[pdb]	1.74 0.00204	350^LEU 351^SER 352^GLY 353^GLY 354^LYS 355^THR	3.2.1.15	carbohydrate metabolic process cellular cell wall organization metabolic process	extracellular region	polygalacturonase activity hydrolase activity hydrolase activity
1w36B exodeoxyribonuclease v beta chain dna hairpin exodeoxyribonuclease v alpha chain exodeoxyribonuclease v gamma chain	[pdb]	1.75 0.00222	443^ALA 24^ALA 26^DA 28^DC 29^DA 30^DG	3.1.11.5	DNA repair response to DNA damage stimulus DNA repair DNA recombination response to DNA damage stimulus DNA repair response to DNA damage stimulus	exodeoxyribonuclease V complex exodeoxyribonuclease V complex	nucleotide binding DNA binding helicase activity nuclease activity endonuclease activity exonuclease activity protein binding ATP binding exodeoxyribonuclease V activity hydrolase activity nucleotide binding helicase activity nuclease activity endonuclease activity exonuclease activity protein binding ATP binding exodeoxyribonuclease V activity hydrolase activity nucleoside-triphosphatase activity nucleotide binding DNA binding ATP-dependent DNA helicase activity helicase activity nuclease activity endonuclease activity exonuclease activity ATP binding exodeoxyribonuclease V activity hydrolase activity
1xmiC cystic fibrosis transmembrane conductanceregulator	[pdb]	1.76 0.00222	619^LEU 459^SER 461^GLY 463^GLY 464^LYS 465^THR	3.6.3.49	cholesterol biosynthetic process transport ion transport chloride transport water transport respiratory gaseous exchange bicarbonate transport iodide transport cholesterol transport transepithelial chloride transport lung development cellular response to hormone stimulus response to cytokine stimulus vasodilation response to drug response to peptide hormone stimulus response to estrogen stimulus positive regulation of vasodilation transmembrane transport	cytoplasm endosome early endosome microvillus membrane integral to membrane basolateral plasma membrane apical plasma membrane cytoplasmic vesicle membrane early endosome membrane chloride channel complex endoplasmic reticulum Sec complex	nucleotide binding ion channel activity ATP-binding and phosphorylation-dependent chloride channel activity chloride channel activity channel-conductance-controlling ATPase activity protein binding ATP binding hydrolase activity ATPase activity nucleoside-triphosphatase activity enzyme binding PDZ domain binding ATPase activity
1zjjA hypothetical protein ph1952	[pdb]	1.76 0.00232	126^LEU 43^SER 70^GLY 93^GLY 45^LYS 46^THR	0.0.0.0	metabolic process		catalytic activity hydrolase activity phosphatase activity
3k5pA d-3-phosphoglycerate dehydrogenase	[pdb]	1.76 0.00232	174^LEU 173^SER 175^GLY 152^GLY 153^LYS 154^THR	0.0.0.0	metabolic process oxidation-reduction process		catalytic activity phosphoglycerate dehydrogenase activity binding oxidoreductase activity amino acid binding oxidoreductase activity acting on the CH-OH group of donors NAD or NADP as acceptor
1cc5A cytochrome c5	[pdb]	1.76 0.00232	57^LEU 58^SER 59^GLY 67^GLY 66^LYS 68^THR	0.0.0.0	transport electron transport chain		iron ion binding electron carrier activity heme binding metal ion binding
3porA porin	[pdb]	1.76 0.00232	63^LEU 64^SER 65^GLY 68^GLY 69^LYS 122^THR	0.0.0.0	transport ion transport	plasma membrane cell outer membrane membrane integral to membrane pore complex	transporter activity porin activity
2gblD circadian clock protein kinase kaic	[pdb]	1.77 0.00243	207^LEU 45^SER 46^GLY 51^GLY 52^LYS 53^THR	2.7.11.1	entrainment of circadian clock regulation of circadian rhythm negative regulation of circadian rhythm rhythmic process		nucleotide binding magnesium ion binding DNA binding protein serine/threonine kinase activity protein binding ATP binding kinase activity transferase activity identical protein binding metal ion binding
1y9kB iaa acetyltransferase	[pdb]	1.77 0.00243	151^LEU 94^SER 92^GLY 90^GLY 89^LYS 87^THR	0.0.0.0	metabolic process		N-acetyltransferase activity acyltransferase activity transferase activity
2pw0B prpf methylaconitate isomerase	[pdb]	1.77 0.00253	48^LEU 53^SER 52^GLY 65^GLY 73^LYS 71^THR
2vl7A xpd	[pdb]	1.77 0.00253	31^LEU 326^SER 327^GLY 38^GLY 39^LYS 40^THR	0.0.0.0	nucleobase		nucleic acid binding DNA binding ATP-dependent DNA helicase activity ATP binding ATP-dependent helicase activity hydrolase activity
3krtB crotonyl coa reductase	[pdb]	1.78 0.00253	241^LEU 243^SER 239^GLY 415^GLY 416^LYS 391^THR	0.0.0.0	metabolic process oxidation-reduction process		catalytic activity binding zinc ion binding oxidoreductase activity
2pxxA uncharacterized protein mgc2408	[pdb]	1.78 0.00253	72^LEU 70^SER 68^GLY 66^GLY 130^LYS 132^THR	3.4.24.71	proteolysis cell-cell signaling brain development heart development metabolic process cardioblast differentiation peptide hormone processing	Golgi membrane Golgi apparatus membrane integral to membrane cytoplasmic vesicle membrane	catalytic activity metalloendopeptidase activity methyltransferase activity peptidase activity metallopeptidase activity transferase activity hydrolase activity metal ion binding
1eepA inosine 5'-monophosphate dehydrogenase	[pdb]	1.78 0.00265	363^LEU 268^SER 362^GLY 361^GLY 360^LYS 357^THR	1.1.1.205	purine nucleotide biosynthetic process GMP biosynthetic process metabolic process oxidation-reduction process		catalytic activity IMP dehydrogenase activity oxidoreductase activity metal ion binding
2zudA dna repair and recombination protein rada	[pdb]	1.78 0.00265	287^LEU 118^SER 117^GLY 119^GLY 120^LYS 121^THR	0.0.0.0	DNA metabolic process DNA repair DNA recombination response to DNA damage stimulus		nucleotide binding DNA binding damaged DNA binding protein binding ATP binding DNA-dependent ATPase activity nucleoside-triphosphatase activity
2rgoA alpha-glycerophosphate oxidase	[pdb]	1.79 0.00276	348^LEU 353^SER 354^GLY 257^GLY 256^LYS 301^THR	0.0.0.0	glycerol-3-phosphate metabolic process oxidation-reduction process glycerol-3-phosphate metabolic process oxidation-reduction process	glycerol-3-phosphate dehydrogenase complex glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase activity oxidoreductase activity glycerol-3-phosphate dehydrogenase activity glycerol-3-phosphate oxidase activity oxidoreductase activity
3m1aG putative dehydrogenase	[pdb]	1.79 0.00276	143^LEU 144^SER 140^GLY 141^GLY 155^LYS 154^THR	0.0.0.0	metabolic process oxidation-reduction process		catalytic activity binding oxidoreductase activity
3enkA udp-glucose 4-epimerase	[pdb]	1.79 0.00276	146^LEU 147^SER 133^GLY 153^GLY 156^LYS 155^THR	0.0.0.0	galactose metabolic process metabolic process cellular metabolic process		catalytic activity UDP-glucose 4-epimerase activity binding isomerase activity coenzyme binding
1m7jA d-aminoacylase	[pdb]	1.79 0.00276	12^LEU 13^SER 14^GLY 56^GLY 57^LYS 16^THR	0.0.0.0			zinc ion binding hydrolase activity hydrolase activity acting on carbon-nitrogen (but not peptide) bonds hydrolase activity
2wdxC putative hexose oxidase antibiotic a40926 derivative	[pdb]	1.8 0.00288	168^LEU 169^SER 404^GLY 405^GLY 406^LYS 409^THR	0.0.0.0			catalytic activity oxidoreductase activity flavin adenine dinucleotide binding
1npcA neutral protease	[pdb]	1.8 0.00288	20^LEU 19^SER 8^GLY 10^GLY 11^LYS 17^THR	3.4.24.28	proteolysis	extracellular region	metalloendopeptidase activity peptidase activity metallopeptidase activity zinc ion binding hydrolase activity metal ion binding
3l4eA uncharacterized peptidase lmo0363	[pdb]	1.8 0.00288	55^LEU 54^SER 56^GLY 26^GLY 27^LYS 28^THR	0.0.0.0	proteolysis		peptidase activity serine-type peptidase activity hydrolase activity
1pznC dna repair and recombination protein rad51	[pdb]	1.8 0.00288	315^LEU 142^SER 141^GLY 143^GLY 144^LYS 145^THR	0.0.0.0	DNA metabolic process DNA repair DNA recombination response to DNA damage stimulus		nucleotide binding DNA binding damaged DNA binding protein binding ATP binding DNA-dependent ATPase activity nucleoside-triphosphatase activity
3etlA dna repair and recombination protein rada	[pdb]	1.8 0.00301	288^LEU 109^SER 108^GLY 110^GLY 111^LYS 112^THR	0.0.0.0	DNA metabolic process DNA repair DNA recombination response to DNA damage stimulus		nucleotide binding DNA binding damaged DNA binding protein binding ATP binding DNA-dependent ATPase activity nucleoside-triphosphatase activity
1pieA galactokinase	[pdb]	1.81 0.00301	142^LEU 141^SER 59^GLY 128^GLY 127^LYS 61^THR	2.7.1.6	carbohydrate metabolic process galactose metabolic process metabolic process phosphorylation carbohydrate phosphorylation	cytoplasm	nucleotide binding galactokinase activity ATP binding kinase activity transferase activity phosphotransferase activity
2wafA penicillin-binding protein 2b	[pdb]	1.81 0.00301	375^LEU 374^SER 360^GLY 342^GLY 362^LYS 371^THR	0.0.0.0	cellular cell wall organization regulation of cell shape peptidoglycan biosynthetic process peptidoglycan-based cell wall biogenesis response to antibiotic	plasma membrane membrane integral to membrane	penicillin binding
3nr8A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2	[pdb]	1.81 0.00301	455^LEU 706^SER 452^GLY 450^GLY 449^LYS 710^THR		glucose metabolic process endocytosis actin filament organization cell adhesion brain development negative regulation of DNA replication negative regulation of cell proliferation post-embryonic development negative regulation of gene expression negative regulation of platelet-derived growth factor receptor signaling pathway negative regulation of neuron projection development response to insulin stimulus inositol trisphosphate metabolic process response to drug negative regulation of MAP kinase activity negative regulation of insulin-like growth factor receptor signaling pathway cellular lipid metabolic process negative regulation of insulin receptor signaling pathway	cellular_component cytoplasm cytosol cytoskeleton plasma membrane membrane lamellipodium actin cortical patch	actin binding inositol or phosphatidylinositol phosphatase activity inositol-polyphosphate 5-phosphatase activity protein binding phosphatidylinositol-3,4,5-trisphosphate binding hydrolase activity phosphatase activity SH3 domain binding SH2 domain binding
3k3tA peptidoglycan hydrolase flgj	[pdb]	1.81 0.00301	171^LEU 170^SER 172^GLY 265^GLY 266^LYS 267^THR	0.0.0.0	ciliary or flagellar motility peptidoglycan catabolic process flagellum assembly	bacterial-type flagellum	motor activity amidase activity hydrolase activity hydrolase activity
1gjqA nitrite reductase	[pdb]	1.81 0.00301	305^LEU 319^SER 321^GLY 302^GLY 299^LYS 301^THR	1.7.2.1, 1.7.99.1	transport electron transport chain oxidation-reduction process	periplasmic space	iron ion binding electron carrier activity oxidoreductase activity heme binding metal ion binding hydroxylamine reductase activity nitrite reductase (NO-forming) activity
3miiB probable chaperone protein hsp33	[pdb]	1.81 0.00301	10^LEU 12^SER 53^GLY 52^GLY 89^LYS 90^THR	0.0.0.0	response to stress		peptidase activity hydrolase activity
2x7iA mevalonate kinase	[pdb]	1.81 0.00314	93^LEU 101^SER 100^GLY 11^GLY 36^LYS 10^THR	0.0.0.0	metabolic process isoprenoid biosynthetic process phosphorylation	cytoplasm	nucleotide binding mevalonate kinase activity ATP binding kinase activity transferase activity phosphotransferase activity
1gyhA arabinan endo-1,5-alpha-l-arabinosidase a	[pdb]	1.81 0.00314	278^LEU 277^SER 276^GLY 254^GLY 266^LYS 267^THR	0.0.0.0	carbohydrate metabolic process metabolic process		hydrolase activity hydrolyzing O-glycosyl compounds hydrolase activity hydrolase activity
2v7yA chaperone protein dnak	[pdb]	1.82 0.00328	366^LEU 367^SER 412^GLY 369^GLY 379^LYS 378^THR	0.0.0.0	protein folding response to stress		nucleotide binding ATP binding unfolded protein binding
3ecpA tn5 transposase dna non-transferred strand dna transferred strand	[pdb]	1.82 0.00328	356^LEU 42^SER 43^GLY 337^GLY 333^LYS 334^THR		DNA recombination transposition DNA-mediated		nucleic acid binding DNA binding nuclease activity endonuclease activity transposase activity hydrolase activity metal ion binding
1gpwA hisf protein amidotransferase hish	[pdb]	1.82 0.00328	222^LEU 201^ARG 202^GLY 203^GLY 179^PRO 178^HIS	0.0.0.0	histidine biosynthetic process metabolic process cellular amino acid biosynthetic process histidine biosynthetic process glutamine metabolic process cellular amino acid biosynthetic process	cytoplasm cytoplasm	imidazoleglycerol-phosphate synthase activity catalytic activity lyase activity catalytic activity transferase activity transferase activity
2e6kB transketolase	[pdb]	1.82 0.00328	400^LEU 373^SER 426^GLY 371^GLY 383^LYS 382^THR	0.0.0.0	metabolic process		catalytic activity transketolase activity
1uaaA protein (atp-dependent dna helicase rep.) dna (5'-d(tptptptptptptptptptptptptptptpt)-3')	[pdb]	1.82 0.00328	273^LEU 26^SER 25^GLY 27^GLY 28^LYS 29^THR	0.0.0.0	DNA replication DNA unwinding involved in replication DNA repair	cytoplasm	nucleotide binding DNA binding ATP-dependent DNA helicase activity helicase activity ATP binding hydrolase activity
3g8yA susd/ragb-associated esterase-like protein	[pdb]	1.82 0.00343	176^LEU 173^SER 155^GLY 152^GLY 150^LYS 149^THR	0.0.0.0
2pbrB thymidylate kinase	[pdb]	1.83 0.00343	129^LEU 11^SER 10^GLY 12^GLY 13^LYS 14^THR	2.7.4.9	dTDP biosynthetic process nucleotide biosynthetic process		nucleotide binding thymidylate kinase activity ATP binding kinase activity transferase activity
3fdiA uncharacterized protein	[pdb]	1.83 0.00343	121^LEU 14^SER 15^GLY 13^GLY 127^LYS 128^THR	0.0.0.0
1igrA insulin-like growth factor receptor 1	[pdb]	1.83 0.00343	384^LEU 389^SER 380^GLY 414^GLY 415^LYS 438^THR	2.7.10.1	protein phosphorylation anti-apoptosis immune response signal transduction transmembrane receptor protein tyrosine kinase signaling pathway axonogenesis brain development positive regulation of cell proliferation insulin receptor signaling pathway organ morphogenesis phosphatidylinositol 3-kinase cascade establishment of cell polarity male sex determination positive regulation of cell migration mammary gland development exocrine pancreas development neuron projection development positive regulation of cytokinesis response to vitamin E negative regulation of MAPKKK cascade positive regulation of MAPKKK cascade positive regulation of DNA replication positive regulation of anti-apoptosis protein autophosphorylation insulin-like growth factor receptor signaling pathway phosphatidylinositol-mediated signaling positive regulation of DNA metabolic process protein tetramerization protein heterooligomerization positive regulation of protein kinase B signaling cascade negative regulation of protein kinase B signaling cascade prostate gland epithelium morphogenesis	microsome plasma membrane integral to plasma membrane caveola membrane integral to membrane neuron projection	nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor activity insulin-like growth factor receptor activity insulin receptor binding protein binding insulin-like growth factor binding ATP binding kinase activity transferase activity insulin-like growth factor I binding identical protein binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding metal ion binding
3b6uB kinesin-like protein kif3b	[pdb]	1.83 0.00343	80^LEU 83^SER 87^GLY 239^GLY 240^LYS 222^THR	0.0.0.0	microtubule-based movement determination of left/right symmetry anterograde axon cargo transport	plus-end kinesin complex microtubule	nucleotide binding motor activity microtubule motor activity protein binding ATP binding plus-end-directed microtubule motor activity
3bv0A adenosylmethionine-8-amino-7-oxononanoate aminotransferase	[pdb]	1.83 0.00343	292^LEU 123^SER 124^GLY 282^GLY 283^LYS 66^THR	2.6.1.62	biotin biosynthetic process protein homotetramerization	cytoplasm	catalytic activity adenosylmethionine-8-amino-7-oxononanoate transaminase activity transaminase activity transferase activity pyridoxal phosphate binding
2a5zC hypothetical protein so2946	[pdb]	1.83 0.00359	70^LEU 69^SER 106^GLY 229^GLY 231^LYS 141^THR	0.0.0.0
2qyoB o-methyltransferase	[pdb]	1.83 0.00359	238^LEU 235^SER 234^GLY 205^GLY 209^LYS 206^THR	0.0.0.0			methyltransferase activity O-methyltransferase activity protein dimerization activity
3b85A phosphate starvation-inducible protein	[pdb]	1.84 0.00375	301^LEU 145^SER 144^GLY 146^GLY 147^LYS 148^THR	0.0.0.0			RNA binding ATP binding RNA binding ATP binding
3pfiB holliday junction atp-dependent dna helicase ruvb	[pdb]	1.85 0.00392	178^LEU 58^SER 59^GLY 64^GLY 65^LYS 66^THR		DNA repair DNA recombination response to DNA damage stimulus SOS response		nucleotide binding DNA binding helicase activity ATP binding four-way junction helicase activity hydrolase activity nucleoside-triphosphatase activity
3qauA 3-hydroxy-3-methylglutaryl-coenzyme a reductase	[pdb]	1.85 0.00392	331^LEU 328^SER 277^GLY 326^GLY 325^LYS 324^THR	0.0.0.0	coenzyme A metabolic process oxidation-reduction process		hydroxymethylglutaryl-CoA reductase (NADPH) activity oxidoreductase activity oxidoreductase activity acting on the CH-OH group of donors NAD or NADP as acceptor
1sjpB 60 kda chaperonin 2	[pdb]	1.85 0.00392	311^LEU 312^SER 295^GLY 315^GLY 316^LYS 293^THR	0.0.0.0	response to hypoxia protein folding response to heat growth cellular protein metabolic process	cell wall cytoplasm cytosol plasma membrane	nucleotide binding protein binding ATP binding protein homodimerization activity
1vquA anthranilate phosphoribosyltransferase 2	[pdb]	1.85 0.00392	261^LEU 262^SER 264^GLY 234^GLY 235^LYS 211^THR	2.4.2.18	tryptophan biosynthetic process metabolic process cellular amino acid biosynthetic process aromatic amino acid family biosynthetic process		anthranilate phosphoribosyltransferase activity transferase activity transferase activity
3ljdA zebrafish rnase1	[pdb]	1.85 0.00392	110^LEU 77^SER 68^GLY 65^GLY 61^LYS 62^THR
1nqdA class 1 collagenase	[pdb]	1.86 0.0041	923^LEU 922^SER 1000^GLY 953^GLY 995^LYS 955^THR	0.0.0.0	proteolysis	extracellular region	serine-type endopeptidase activity peptidase activity zinc ion binding
2w5qA processed glycerol phosphate lipoteichoic acidsynthase	[pdb]	1.86 0.0041	278^LEU 279^SER 281^GLY 517^GLY 511^LYS 286^THR	0.0.0.0	cellular cell wall organization metabolic process	extracellular region plasma membrane membrane integral to membrane	catalytic activity sulfuric ester hydrolase activity transferase activity metal ion binding
2v9kA uncharacterized protein flj32312	[pdb]	1.86 0.0041	504^LEU 503^SER 502^GLY 492^GLY 498^LYS 497^THR	0.0.0.0	pseudouridine synthesis tRNA processing RNA modification		RNA binding pseudouridine synthase activity isomerase activity
3glgG dna (5'-d(cptpgpgpcpcptpaptpa)-3') dna polymerase iii subunit delta dna polymerase iii subunit tau dna (5'-d(tptptptptptptptptptptpaptpapgpgpcpcpap g)-3') dna polymerase iii subunit delta'	[pdb]	1.86 0.0041	175^TRP 44^LEU 45^SER 50^CYS 51^GLN 52^GLN	2.7.7.7	DNA replication DNA replication DNA replication	DNA polymerase III complex DNA polymerase III complex DNA polymerase III complex DNA polymerase III	DNA binding DNA-directed DNA polymerase activity protein binding transferase activity nucleotidyltransferase activity DNA binding DNA-directed DNA polymerase activity protein binding 3'-5' exonuclease activity transferase activity nucleotidyltransferase activity nucleotide binding DNA binding DNA-directed DNA polymerase activity protein binding ATP binding transferase activity nucleotidyltransferase activity ATPase activity nucleoside-triphosphatase activity DNA polymerase processivity factor activity
1kc3A dtdp-glucose oxidoreductase	[pdb]	1.86 0.00428	29^LEU 33^SER 38^GLY 7^GLY 8^LYS 9^THR	1.1.1.133	metabolic process lipopolysaccharide biosynthetic process extracellular polysaccharide biosynthetic process oxidation-reduction process		catalytic activity binding dTDP-4-dehydrorhamnose reductase activity oxidoreductase activity metal ion binding
2hr7A insulin receptor	[pdb]	1.87 0.00428	393^LEU 399^SER 390^GLY 424^GLY 425^LYS 448^THR	2.7.10.1	activation of MAPK activity negative regulation of protein phosphorylation positive regulation of protein phosphorylation heart morphogenesis carbohydrate metabolic process protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation insulin receptor signaling pathway response to hormone stimulus response to glucose stimulus organ morphogenesis response to manganese ion regulation of hydrogen peroxide metabolic process positive regulation of glycoprotein biosynthetic process negative regulation of gene expression response to activity peptidyl-tyrosine phosphorylation transformation of host cell by virus male sex determination positive regulation of cell migration exocrine pancreas development response to nutrient levels activation of protein kinase activity activation of protein kinase B activity response to estradiol stimulus negative regulation of transporter activity regulation of gene-specific transcription response to insulin stimulus cellular response to insulin stimulus response to vitamin D response to testosterone stimulus response to tumor necrosis factor positive regulation of phosphorylation glucose homeostasis positive regulation of MAPKKK cascade response to peptide hormone stimulus positive regulation of nitric oxide biosynthetic process fat cell differentiation response to ethanol positive regulation of glycogen biosynthetic process positive regulation of DNA replication positive regulation of glycolysis positive regulation of mitosis regulation of embryonic development positive regulation of glucose import protein autophosphorylation positive regulation of developmental growth protein heterotetramerization response to glucocorticoid stimulus response to protein stimulus positive regulation of protein kinase B signaling cascade positive regulation of respiratory burst	soluble fraction nucleus endosome microsome cytosol plasma membrane integral to plasma membrane insulin receptor complex caveola endosome membrane membrane integral to membrane synapse	nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity receptor activity insulin receptor activity insulin-like growth factor receptor binding protein binding ATP binding GTP binding kinase activity transferase activity protein kinase binding protein phosphatase binding protein domain specific binding lipoic acid binding insulin-like growth factor I binding insulin-like growth factor II binding protein complex binding SH2 domain binding 3-phosphoinositide-dependent protein kinase binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding metal ion binding PTB domain binding
3p7zB neurofibromin	[pdb]	1.87 0.00428	1685^LEU 1682^SER 1681^GLY 1753^GLY 1680^LYS 1677^THR	0.0.0.0	MAPKKK cascade osteoblast differentiation metanephros development response to hypoxia liver development negative regulation of endothelial cell proliferation regulation of cell-matrix adhesion negative regulation of protein kinase activity cell communication signal transduction Ras protein signal transduction negative regulation of neuroblast proliferation brain development peripheral nervous system development heart development visual learning Schwann cell development phosphatidylinositol 3-kinase cascade spinal cord development forebrain astrocyte development cerebral cortex development myelination in peripheral nervous system actin cytoskeleton organization extracellular matrix organization collagen fibril organization adrenal gland development negative regulation of cell migration regulation of Ras GTPase activity positive regulation of Ras GTPase activity wound healing negative regulation of transcription factor import into nucleus positive regulation of apoptosis negative regulation of MAP kinase activity negative regulation of MAPKKK cascade pigmentation positive regulation of neuron apoptosis regulation of blood vessel endothelial cell migration regulation of bone resorption regulation of glial cell differentiation positive regulation of adenylate cyclase activity regulation of angiogenesis sympathetic nervous system development camera-type eye morphogenesis negative regulation of oligodendrocyte differentiation smooth muscle tissue development artery morphogenesis forebrain morphogenesis cognition regulation of small GTPase mediated signal transduction	intracellular nucleus cytoplasm axon dendrite	GTPase activator activity Ras GTPase activator activity binding protein binding
2wadC penicillin-binding protein 2b	[pdb]	1.87 0.00428	375^LEU 374^SER 360^GLY 342^GLY 362^LYS 371^THR	0.0.0.0	cellular cell wall organization regulation of cell shape peptidoglycan biosynthetic process peptidoglycan-based cell wall biogenesis response to antibiotic	plasma membrane membrane integral to membrane	penicillin binding
2ccgB thymidylate kinase	[pdb]	1.87 0.00446	131^LEU 13^SER 12^GLY 14^GLY 15^LYS 16^THR	2.7.4.9	dTDP biosynthetic process nucleotide biosynthetic process		nucleotide binding thymidylate kinase activity ATP binding kinase activity transferase activity
2h58A kinesin-like protein kifc3 variant	[pdb]	1.87 0.00446	512^LEU 515^SER 519^GLY 668^GLY 669^LYS 654^THR	0.0.0.0	microtubule-based process microtubule-based movement Golgi organization visual perception zonula adherens maintenance epithelial cell-cell adhesion	cytoplasm Golgi apparatus centrosome microtubule organizing center cytoskeleton kinesin complex microtubule adherens junction zonula adherens membrane cell junction cytoplasmic vesicle membrane cytoplasmic vesicle	nucleotide binding motor activity microtubule motor activity ATP binding
1k7hB alkaline phosphatase	[pdb]	1.87 0.00446	41^LEU 40^SER 358^GLY 434^GLY 75^LYS 76^THR	0.0.0.0	metabolic process		catalytic activity alkaline phosphatase activity hydrolase activity phosphatase activity
1pyyA penicillin-binding protein 2x	[pdb]	1.87 0.00446	689^LEU 690^SER 664^GLY 666^GLY 668^LYS 667^THR	0.0.0.0	cellular cell wall organization cell cycle regulation of cell shape peptidoglycan biosynthetic process peptidoglycan-based cell wall biogenesis response to antibiotic cell division	plasma membrane membrane integral to membrane	penicillin binding
1kb0A quinohemoprotein alcohol dehydrogenase	[pdb]	1.87 0.00446	164^LEU 163^SER 183^GLY 115^GLY 114^LYS 438^THR	0.0.0.0	oxidation-reduction process	membrane outer membrane-bounded periplasmic space periplasmic space	iron ion binding calcium ion binding electron carrier activity oxidoreductase activity oxidoreductase activity acting on CH-OH group of donors heme binding
1eizA ftsj	[pdb]	1.87 0.00446	48^LEU 160^SER 159^GLY 206^GLY 184^LYS 183^THR	0.0.0.0	enzyme-directed rRNA 2'-O-methylation rRNA processing response to stress rRNA methylation methylation rRNA processing rRNA methylation methylation rRNA processing rRNA methylation methylation rRNA processing rRNA methylation methylation	cytoplasm cytoplasm cytoplasm cytoplasm	nucleic acid binding methyltransferase activity RNA methyltransferase activity rRNA (uridine-2'-O-)-methyltransferase activity rRNA (uridine) methyltransferase activity transferase activity nucleic acid binding methyltransferase activity RNA methyltransferase activity rRNA (uridine) methyltransferase activity transferase activity nucleic acid binding methyltransferase activity RNA methyltransferase activity rRNA (uridine) methyltransferase activity transferase activity nucleic acid binding methyltransferase activity RNA methyltransferase activity rRNA (uridine) methyltransferase activity transferase activity
2icsA adenine deaminase	[pdb]	1.87 0.00446	323^LEU 53^SER 55^GLY 321^GLY 309^LYS 308^THR	0.0.0.0			hydrolase activity hydrolase activity
3obyB protein pelota homolog	[pdb]	1.88 0.00486	331^LEU 330^SER 333^GLY 325^GLY 326^LYS 320^THR		translation	cytoplasm	nuclease activity endonuclease activity hydrolase activity metal ion binding
1wndB putative betaine aldehyde dehydrogenase	[pdb]	1.88 0.00486	449^LEU 450^SER 248^GLY 249^GLY 250^LYS 281^THR	1.2.1.19	metabolic process putrescine catabolic process oxidation-reduction process		oxidoreductase activity aminobutyraldehyde dehydrogenase activity NAD binding
1vyhS platelet-activating factor acetylhydrolase ibalpha subunit platelet-activating factor acetylhydrolase ibbeta subunit	[pdb]	1.89 0.00486	345^LEU 355^SER 343^GLY 314^GLY 321^LYS 319^THR	0.0.0.0	lipid metabolic process spermatogenesis lipid catabolic process establishment of mitotic spindle orientation microtubule cytoskeleton organization acrosome assembly neuron migration transport microtubule-based process cell cycle mitosis synaptic transmission multicellular organismal development nervous system development neuroblast proliferation learning or memory retrograde axon cargo transport adult locomotory behavior lipid catabolic process cell migration stem cell division transmission of nerve impulse corpus callosum morphogenesis hippocampus development layer formation in cerebral cortex cerebral cortex development actin cytoskeleton organization cell differentiation microtubule organizing center organization regulation of Rho GTPase activity vesicle transport along microtubule brain morphogenesis neuromuscular process controlling balance nuclear envelope disassembly cell division lipid metabolic process spermatogenesis lipid catabolic process	cytoplasm astral microtubule kinetochore soluble fraction insoluble fraction nucleus nuclear envelope cytoplasm centrosome microtubule organizing center spindle cytoskeleton microtubule microtubule associated complex cell cortex microtubule cytoskeleton membrane growth cone motile primary cilium nuclear membrane vesicular fraction neuronal cell body perinuclear region of cytoplasm nonmotile primary cilium cell leading edge cytoplasm	1-alkyl-2-acetylglycerophosphocholine esterase activity protein binding hydrolase activity hydrolase activity acting on ester bonds protein binding microtubule binding protein homodimerization activity dynein binding dynein intermediate chain binding phosphoprotein binding 1-alkyl-2-acetylglycerophosphocholine esterase activity protein binding hydrolase activity
2gk6B regulator of nonsense transcripts 1	[pdb]	1.89 0.00486	659^LEU 638^SER 661^GLY 492^GLY 498^LYS 499^THR	0.0.0.0	nuclear-transcribed mRNA catabolic process nonsense-mediated decay DNA replication DNA repair mRNA export from nucleus regulation of translational termination cell cycle	chromatin cytoplasmic mRNA processing body cytoplasm	nucleotide binding DNA binding chromatin binding RNA binding ATP-dependent RNA helicase activity helicase activity protein binding ATP binding zinc ion binding hydrolase activity metal ion binding
2w8oA succinic semialdehyde dehydrogenasemitochondrial	[pdb]	1.89 0.00486	307^LEU 285^SER 284^GLY 289^GLY 290^LYS 287^THR	1.2.1.24	glucose metabolic process acetate metabolic process succinate metabolic process glutamate metabolic process glutamine metabolic process glycerophospholipid metabolic process galactosylceramide metabolic process glutathione metabolic process central nervous system development metabolic process gamma-aminobutyric acid catabolic process respiratory electron transport chain neurotransmitter catabolic process short-chain fatty acid metabolic process protein homotetramerization oxidation-reduction process	soluble fraction mitochondrion	succinate-semialdehyde dehydrogenase activity oxidoreductase activity oxidoreductase activity acting on the aldehyde or oxo group of donors
3q1oA geranyltranstransferase (ispa)	[pdb]	1.89 0.00486	150^LEU 151^SER 155^GLY 158^GLY 189^LYS 187^THR	0.0.0.0	isoprenoid biosynthetic process		transferase activity
1w1wC sister chromatid cohesion protein 1 structural maintenance of chromosome 1	[pdb]	1.89 0.00507	1129^LEU 1130^SER 1131^GLY 1132^GLY 1134^LYS 1135^THR	0.0.0.0	double-strand break repair protein acetylation apoptosis response to DNA damage stimulus cell cycle chromosome segregation mitosis mitotic chromosome condensation establishment of mitotic sister chromatid cohesion cell division mitotic sister chromatid segregation double-strand break repair cell cycle mitotic sister chromatid cohesion mitosis chromosome organization cell division	nuclear chromosome chromosome centromeric region condensed nuclear chromosome nucleus chromosome mitochondrion nuclear mitotic cohesin complex nucleus chromosome	chromatin binding protein binding nucleotide binding DNA secondary structure binding AT DNA binding double-stranded DNA binding protein binding ATP binding
2yvuA probable adenylyl-sulfate kinase	[pdb]	1.9 0.00507	21^LEU 24^SER 23^GLY 25^GLY 26^LYS 27^THR	2.7.1.25	sulfate assimilation		nucleotide binding adenylylsulfate kinase activity ATP binding kinase activity transferase activity transferase activity
1zmxH deoxynucleoside kinase	[pdb]	1.9 0.00529	153^LEU 31^SER 30^GLY 32^GLY 33^LYS 34^THR	2.7.1.145	nucleobase nucleoside nucleotide and nucleic acid metabolic process nucleoside diphosphate phosphorylation	cellular_component	nucleotide binding protein binding ATP binding kinase activity transferase activity phosphotransferase activity alcohol group as acceptor
3dwkD penicillin-binding protein 2	[pdb]	1.9 0.00529	400^LEU 398^SER 397^GLY 585^GLY 583^LYS 584^THR	0.0.0.0	cellular cell wall organization regulation of cell shape peptidoglycan biosynthetic process peptidoglycan-based cell wall biogenesis	peptidoglycan-based cell wall	catalytic activity penicillin binding
3n8eB stress-70 protein, mitochondrial	[pdb]	1.9 0.00529	443^LEU 444^SER 489^GLY 446^GLY 456^LYS 455^THR	0.0.0.0	protein folding protein export from nucleus anti-apoptosis	cytoplasm mitochondrion cell surface mitochondrial nucleoid	nucleotide binding protein binding ATP binding enzyme binding unfolded protein binding
1czfB polygalacturonase ii	[pdb]	1.9 0.00529	66^LEU 93^SER 94^GLY 69^GLY 71^LYS 98^THR	3.2.1.15	carbohydrate metabolic process cellular cell wall organization metabolic process	extracellular region	polygalacturonase activity hydrolase activity hydrolase activity
3jruB probable cytosol aminopeptidase	[pdb]	1.9 0.00529	349^LEU 229^SER 228^GLY 335^GLY 336^LYS 337^THR	3.4.11.1	proteolysis protein metabolic process	intracellular cytoplasm	aminopeptidase activity peptidase activity metalloexopeptidase activity hydrolase activity manganese ion binding metal ion binding
1tnyD guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-2subunit geranylgeranyltransferase type i alpha subunit geranylgeranyl transferase type i beta subunit	[pdb]	1.9 0.00529	331^LEU 330^SER 328^GLY 277^GLY 281^LYS 279^THR	2.5.1.59	positive regulation of cell proliferation response to cytokine stimulus positive regulation of cell cycle negative regulation of nitric-oxide synthase 2 biosynthetic process response to protein stimulus positive regulation of cell proliferation response to inorganic substance response to organic cyclic compound response to cytokine stimulus negative regulation of apoptosis neurotransmitter receptor metabolic process positive regulation of cell cycle positive regulation of nitric-oxide synthase 2 biosynthetic process negative regulation of nitric-oxide synthase 2 biosynthetic process response to protein stimulus positive regulation of tubulin deacetylation positive regulation of deacetylase activity	CAAX-protein geranylgeranyltransferase complex cytoplasm microtubule associated complex CAAX-protein geranylgeranyltransferase complex	catalytic activity prenyltransferase activity CAAX-protein geranylgeranyltransferase activity protein binding transferase activity metal ion binding drug binding zinc ion binding isoprenoid binding peptide binding prenyltransferase activity protein farnesyltransferase activity CAAX-protein geranylgeranyltransferase activity protein binding microtubule binding protein prenyltransferase activity transferase activity acetylcholine receptor regulator activity alpha-tubulin binding drug binding zinc ion binding isoprenoid binding peptide binding
3cf1A transitional endoplasmic reticulum atpase	[pdb]	1.9 0.00552	647^LEU 683^SER 684^GLY 523^GLY 524^LYS 525^THR	0.0.0.0	double-strand break repair ubiquitin-dependent protein catabolic process transport ER to Golgi vesicle-mediated transport activation of caspase activity response to DNA damage stimulus retrograde protein transport ER to cytosol positive regulation of proteasomal ubiquitin-dependent protein catabolic process proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process protein homooligomerization	proteasome complex nucleus cytoplasm endoplasmic reticulum microsome cytosol protein complex	nucleotide binding binding protein binding ATP binding lipid binding hydrolase activity ATPase activity nucleoside-triphosphatase activity protein phosphatase binding protein domain specific binding polyubiquitin binding identical protein binding
3mleE dethiobiotin synthetase	[pdb]	1.91 0.00552	144^LEU 5^SER 119^GLY 12^GLY 13^LYS 14^THR	6.3.3.3	biotin biosynthetic process		nucleotide binding magnesium ion binding dethiobiotin synthase activity ATP binding ligase activity
2j9aA microginin fr1 cytosol aminopeptidase	[pdb]	1.91 0.00552	337^LEU 215^SER 214^GLY 323^GLY 324^LYS 325^THR	3.4.11.1, 3.4.11.5	proteolysis protein metabolic process	intracellular cytoplasm mitochondrion	aminopeptidase activity peptidase activity metalloexopeptidase activity hydrolase activity manganese ion binding metal ion binding
2w6rA imidazole glycerol phosphate synthase subunithisf	[pdb]	1.91 0.00552	227^LEU 206^SER 207^GLY 208^GLY 184^LYS 183^THR	0.0.0.0	histidine biosynthetic process metabolic process cellular amino acid biosynthetic process	cytoplasm	imidazoleglycerol-phosphate synthase activity catalytic activity lyase activity
2ql6H nicotinamide riboside kinase 1	[pdb]	1.91 0.00552	118^LEU 9^SER 10^GLY 15^GLY 16^LYS 17^THR	2.7.1.22	pyridine nucleotide biosynthetic process		nucleotide binding ATP binding kinase activity transferase activity phosphotransferase activity alcohol group as acceptor metal ion binding
3mvdL regulator of chromosome condensation histone h2b 1.1 histone h4 histone h3.2 histone h2a dna (146-mer)	[pdb]	1.91 0.00552	162^LEU 152^SER 151^GLY 104^GLY 168^LYS 170^THR	0.0.0.0	nucleosome assembly cell cycle mitosis regulation of mitotic cell cycle central nervous system development regulation of nucleocytoplasmic transport regulation of neurogenesis cell division nucleosome assembly nucleosome assembly nucleosome assembly	nucleosome nucleus chromosome nucleus cytoplasm nucleosome nucleus chromosome nucleosome nucleus chromosome nucleosome nucleus chromosome	DNA binding chromatin binding guanyl-nucleotide exchange factor activity protein binding DNA binding DNA binding DNA binding
3bc1E ras-related protein rab-27a synaptotagmin-like protein 2	[pdb]	1.91 0.00552	78^HOH 18^VAL 19^LEU 21^ARG 22^ASP 23^ALA		protein targeting exocytosis small GTPase mediated signal transduction blood coagulation protein transport vesicle-mediated transport melanocyte differentiation melanosome localization melanosome transport cytotoxic T cell degranulation natural killer cell degranulation pigmentation pigment granule localization pigment granule transport intracellular protein transport exocytosis vesicle docking involved in exocytosis vesicle-mediated transport positive regulation of mucus secretion	photoreceptor outer segment lysosome endosome late endosome Golgi apparatus membrane apical plasma membrane stored secretory granule dendrite secretory granule membrane melanosome exocytic vesicle membrane fraction cytoplasm plasma membrane membrane extrinsic to plasma membrane melanosome exocytic vesicle	nucleotide binding GTPase activity protein binding GTP binding myosin V binding phosphatidylserine binding protein binding phosphatidylinositol-4,5-bisphosphate binding zinc ion binding Rab GTPase binding neurexin binding
2is1B 5'-d(cpgpapgpcpapcptpgpc)-3' dna helicase ii 5'-d(gpcpapgptpgpcptpcpgptptptptptptp*t)-3'	[pdb]	1.91 0.00576	279^LEU 33^SER 32^GLY 34^GLY 35^LYS 36^THR	0.0.0.0	DNA replication DNA unwinding involved in replication DNA repair response to DNA damage stimulus SOS response	cytoplasm	nucleotide binding DNA binding ATP-dependent DNA helicase activity helicase activity protein binding ATP binding hydrolase activity
1dqdL fab hgr-2 f6	[pdb]	1.91 0.00576	124^LYS 126^THR 127^PRO 128^PRO 182^ASP 181^SER
2uyyB n-pac protein	[pdb]	1.91 0.00576	393^LEU 394^SER 397^GLY 421^GLY 422^LYS 423^THR		pentose-phosphate shunt metabolic process oxidation-reduction process	nucleus	DNA binding catalytic activity phosphogluconate dehydrogenase (decarboxylating) activity binding oxidoreductase activity coenzyme binding
1yhvA serine/threonine-protein kinase pak 1	[pdb]	1.91 0.00576	352^LEU 351^SER 350^GLY 349^GLY 538^LYS 541^THR	2.7.11.1	protein phosphorylation apoptosis ER-nucleus signaling pathway cytoskeleton organization positive regulation of JUN kinase activity protein autophosphorylation MAPKKK cascade	cytoplasm Golgi apparatus cytosol plasma membrane focal adhesion cell junction	nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding collagen binding ATP binding kinase activity transferase activity
3b6vB kinesin-like protein kif3c	[pdb]	1.91 0.00576	81^LEU 84^SER 88^GLY 240^GLY 241^LYS 223^THR		microtubule-based movement	kinesin complex microtubule	nucleotide binding motor activity microtubule motor activity ATP binding
1p9bA adenylosuccinate synthetase	[pdb]	1.92 0.00601	36^LEU 37^SER 71^GLY 30^GLY 31^LYS 55^THR	0.0.0.0	purine nucleotide biosynthetic process	cytoplasm	nucleotide binding magnesium ion binding adenylosuccinate synthase activity GTP binding ligase activity metal ion binding
3ldhA lactate dehydrogenase	[pdb]	1.92 0.00601	137^LEU 163^SER 164^GLY 142^GLY 145^LYS 143^THR	1.1.1.27	carbohydrate metabolic process glycolysis metabolic process cellular carbohydrate metabolic process oxidation-reduction process	cytoplasm	catalytic activity L-lactate dehydrogenase activity binding oxidoreductase activity oxidoreductase activity
1ofiC atp-dependent protease hslv atp-dependent hsl protease atp-binding subunithslu	[pdb]	1.92 0.00601	54^PHE 308^SER 309^GLY 57^PHE 63^LYS 64^LEU	0.0.0.0	proteolysis proteolysis involved in cellular protein catabolic process	cytoplasm HslUV protease complex cytoplasm proteasome core complex HslUV protease complex	nucleotide binding protein binding ATP binding ATPase activity nucleoside-triphosphatase activity peptidase activity acting on L-amino acid peptides threonine-type endopeptidase activity peptidase activity hydrolase activity
1cf2Q protein (glyceraldehyde-3-phosphatedehydrogenase)	[pdb]	1.92 0.00601	50^LEU 32^SER 8^GLY 13^GLY 14^LYS 11^THR	1.2.1.59	glycolysis metabolic process oxidation-reduction process	cytoplasm	catalytic activity binding glyceraldehyde-3-phosphate dehydrogenase activity oxidoreductase activity glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity NADP binding NAD binding
1aifA anti-idiotypic fab 409.5.3 (igg2a) fab (lightchain) anti-idiotypic fab 409.5.3 (igg2a) fab (heavychain)	[pdb]	1.92 0.00601	126^PRO 128^SER 129^VAL 130^TYR 184^THR 183^TYR	0.0.0.0			antigen binding protein binding
1djqA trimethylamine dehydrogenase	[pdb]	1.92 0.00601	195^LEU 194^SER 193^GLY 192^GLY 190^LYS 188^THR	1.5.8.2	metabolic process oxidation-reduction process		catalytic activity FMN binding oxidoreductase activity metal ion binding trimethylamine dehydrogenase activity iron-sulfur cluster binding 4 iron
2o3eA neurolysin	[pdb]	1.92 0.00601	653^LEU 652^SER 651^GLY 650^GLY 648^LYS 487^THR	3.4.24.16	proteolysis	cytoplasm mitochondrion mitochondrial intermembrane space	metalloendopeptidase activity peptidase activity metallopeptidase activity hydrolase activity metal ion binding
1bpwA protein (aldehyde dehydrogenase)	[pdb]	1.92 0.00601	264^LEU 242^SER 241^GLY 246^GLY 247^LYS 245^THR	1.2.1.8, 1.2.1.3	metabolic process oxidation-reduction process	cytoplasm	aldehyde dehydrogenase (NAD) activity betaine-aldehyde dehydrogenase activity oxidoreductase activity
1rrhA seed lipoxygenase-3	[pdb]	1.92 0.00601	310^LEU 312^SER 313^GLY 314^GLY 344^LYS 337^THR	1.13.11.12	fatty acid biosynthetic process lipid biosynthetic process oxylipin biosynthetic process oxidation-reduction process	cytoplasm	iron ion binding lipoxygenase activity oxidoreductase activity oxidoreductase activity acting on single donors with incorporation of molecular oxygen
2j37W ribosomal rna signal sequence signal recognition particle 54 kda protein(srp54) 60s ribosomal protein l23 srp rna signal recognition particle 19 kda protein(srp19) ribosomal protein l31 ribosomal protein l35	[pdb]	1.93 0.00627	109^G 112^A 111^U 113^G 114^C 115^C	0.0.0.0	SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane translocation SRP-dependent cotranslational protein targeting to membrane signal sequence recognition response to drug protein targeting to ER G-protein coupled receptor protein signaling pathway phototransduction cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane	nucleus cytoplasm signal recognition particle endoplasmic reticulum targeting ribonucleoprotein complex signal recognition particle integral to membrane nucleolus cytoplasm signal recognition particle endoplasmic reticulum targeting ribonucleoprotein complex signal recognition particle intracellular	nucleotide binding RNA binding GTPase activity protein binding GTP binding drug binding 7S RNA binding nucleoside-triphosphatase activity GDP binding endoplasmic reticulum signal peptide binding ribonucleoprotein binding RNA binding 7S RNA binding structural constituent of ribosome
2h57B adp-ribosylation factor-like protein 6	[pdb]	1.93 0.00627	23^LEU 71^SER 72^GLY 29^GLY 30^LYS 31^THR	0.0.0.0	small GTPase mediated signal transduction determination of left/right symmetry melanosome transport cilium assembly	intracellular cytoplasm membrane	nucleotide binding GTP binding metal ion binding
2vdxA corticosteroid-binding globulin	[pdb]	1.93 0.00627	101^LEU 100^SER 237^GLY 183^GLY 182^LYS 184^THR	0.0.0.0	transport glucocorticoid metabolic process	extracellular region extracellular space	serine-type endopeptidase inhibitor activity steroid binding lipid binding
1um8A atp-dependent clp protease atp-binding subunitclpx	[pdb]	1.93 0.00627	340^LEU 153^SER 152^GLY 154^GLY 155^LYS 156^THR	0.0.0.0	protein folding protein metabolic process		nucleotide binding ATP binding zinc ion binding ATPase activity nucleoside-triphosphatase activity metal ion binding protein dimerization activity unfolded protein binding
3f9iA 3-oxoacyl-[acyl-carrier-protein] reductase	[pdb]	1.94 0.00654	4^LEU 31^SER 30^GLY 6^GLY 7^LYS 8^THR	1.1.1.100	fatty acid biosynthetic process metabolic process lipid biosynthetic process oxidation-reduction process		catalytic activity 3-oxoacyl-[acyl-carrier-protein] reductase activity binding oxidoreductase activity NAD binding
3dqgC heat shock 70 kda protein f	[pdb]	1.94 0.00654	422^LEU 423^SER 468^GLY 425^GLY 435^LYS 434^THR		reproduction nematode larval development protein folding response to stress determination of adult lifespan embryo development embryo development ending in birth or egg hatching growth	mitochondrion	nucleotide binding ATP binding unfolded protein binding