The LabelHash Server

Top 150 matches

For each match you can click on the "[pdb]" link to download a PDB file with the matching chain aligned with the motif.
Download a zip file with PDB files for all the matches and the motif itself.

PDB ID		LRMSD / p-value	Matching Residues	EC	Gene Ontology annotations
PDB ID		LRMSD / p-value	Matching Residues	EC	Biological Process	Cellular Component	Molecular Function
1xylA xylose isomerase	[pdb]	0.167 0.000118	25^PHE 53^HIS 56^ASP 93^PHE 136^TRP 182^LYS	5.3.1.5	carbohydrate metabolic process pentose-phosphate shunt D-xylose metabolic process	cytoplasm	xylose isomerase activity isomerase activity metal ion binding
1clkA xylose isomerase	[pdb]	0.189 0.000139	25^PHE 53^HIS 56^ASP 93^PHE 136^TRP 182^LYS	5.3.1.5	carbohydrate metabolic process pentose-phosphate shunt D-xylose metabolic process	cytoplasm	xylose isomerase activity isomerase activity metal ion binding
5ximD d-xylose isomerase	[pdb]	0.192 0.000146	26^PHE 54^HIS 57^ASP 94^PHE 137^TRP 183^LYS	5.3.1.5	carbohydrate metabolic process pentose-phosphate shunt D-xylose metabolic process	cytoplasm	xylose isomerase activity isomerase activity metal ion binding
1mnzA xylose isomerase	[pdb]	0.203 0.000153	26^PHE 54^HIS 57^ASP 94^PHE 137^TRP 183^LYS	5.3.1.5	carbohydrate metabolic process pentose-phosphate shunt D-xylose metabolic process	cytoplasm	xylose isomerase activity isomerase activity metal ion binding
1xlbA d-xylose isomerase	[pdb]	0.207 0.00016	25^PHE 53^HIS 56^ASP 93^PHE 136^TRP 182^LYS	5.3.1.5	carbohydrate metabolic process pentose-phosphate shunt D-xylose metabolic process	cytoplasm	xylose isomerase activity isomerase activity metal ion binding
1bxbC xylose isomerase	[pdb]	0.302 0.000249	25^PHE 53^HIS 56^ASP 93^PHE 136^TRP 182^LYS	5.3.1.5	carbohydrate metabolic process pentose-phosphate shunt D-xylose metabolic process	cytoplasm	xylose isomerase activity isomerase activity metal ion binding
1bxcD xylose isomerase	[pdb]	0.309 0.000256	25^PHE 53^HIS 56^ASP 93^PHE 136^TRP 182^LYS	5.3.1.5	carbohydrate metabolic process pentose-phosphate shunt D-xylose metabolic process	cytoplasm	xylose isomerase activity isomerase activity metal ion binding
1a0cA xylose isomerase	[pdb]	0.548 0.000405	59^PHE 100^HIS 103^ASP 144^PHE 187^TRP 233^LYS	5.3.1.5	carbohydrate metabolic process pentose-phosphate shunt D-xylose metabolic process	cytoplasm	xylose isomerase activity isomerase activity metal ion binding
1a0eA xylose isomerase	[pdb]	0.645 0.000449	59^PHE 100^HIS 103^ASP 144^PHE 187^TRP 233^LYS	5.3.1.5	carbohydrate metabolic process pentose-phosphate shunt D-xylose metabolic process	cytoplasm	xylose isomerase activity isomerase activity metal ion binding
1a0dC xylose isomerase	[pdb]	0.678 0.000465	58^PHE 98^HIS 101^ASP 142^PHE 185^TRP 231^LYS	5.3.1.5	carbohydrate metabolic process pentose-phosphate shunt D-xylose metabolic process	cytoplasm	xylose isomerase activity isomerase activity metal ion binding
3m0yC l-rhamnose isomerase	[pdb]	1.34 0.000555	66^PHE 101^HIS 105^ASP 131^PHE 179^TRP 221^LYS	0.0.0.0			isomerase activity
2gthA replicase polyprotein 1ab	[pdb]	1.54 0.000627	43^PHE 66^HIS 155^ASP 94^PHE 81^TRP 100^LYS	0.0.0.0	transcription RNA-dependent proteolysis viral genome replication viral protein processing evasion by virus of host immune response interspecies interaction between organisms transcription RNA-dependent viral genome replication proteolysis viral genome replication viral protein processing	membrane integral to membrane viral replication complex host cell cytoplasm host cell membrane host cell endoplasmic reticulum-Golgi intermediate compartment host cell perinuclear region of cytoplasm perinuclear region of cytoplasm membrane host cell membrane membrane integral to membrane viral replication complex host cell cytoplasm host cell membrane host cell perinuclear region of cytoplasm perinuclear region of cytoplasm	nucleotide binding RNA binding catalytic activity RNA-directed RNA polymerase activity cysteine-type endopeptidase activity helicase activity nuclease activity endonuclease activity exonuclease activity ATP binding methyltransferase activity peptidase activity cysteine-type peptidase activity zinc ion binding transferase activity nucleotidyltransferase activity hydrolase activity exoribonuclease activity producing 5'-phosphomonoesters metal ion binding nucleotide binding RNA binding RNA-directed RNA polymerase activity cysteine-type endopeptidase activity helicase activity ATP binding methyltransferase activity transferase activity nucleotidyltransferase activity hydrolase activity exoribonuclease activity producing 5'-phosphomonoesters RNA binding catalytic activity RNA-directed RNA polymerase activity peptidase activity cysteine-type peptidase activity zinc ion binding
1olpA alpha-toxin	[pdb]	1.62 0.000695	175^PHE 136^HIS 71^ASP 128^PHE 1^TRP 159^LYS	0.0.0.0			phospholipase C activity zinc ion binding hydrolase activity
3b6rB creatine kinase b-type	[pdb]	1.69 0.000792	334^PHE 234^HIS 233^ASP 194^PHE 218^TRP 223^LYS	2.7.3.2	creatine metabolic process brain development cellular chloride ion homeostasis	cytoplasm mitochondrion cytosol	nucleotide binding catalytic activity creatine kinase activity protein binding ATP binding kinase activity transferase activity transferase activity
1khoA alpha-toxin	[pdb]	1.78 0.00102	175^PHE 136^HIS 71^ASP 128^PHE 1^TRP 159^LYS	3.1.4.3	pathogenesis cytolysis hemolysis in other organism	extracellular region	phospholipase C activity zinc ion binding hydrolase activity hydrolase activity acting on ester bonds phosphatidylcholine phospholipase C activity
2bkqD sentrin-specific protease 8	[pdb]	1.79 0.00107	116^PHE 30^HIS 29^ASP 36^PHE 202^TRP 198^LYS	0.0.0.0	proteolysis		protein binding peptidase activity cysteine-type peptidase activity hydrolase activity
1i0eB creatine kinase,m chain	[pdb]	1.8 0.0011	334^PHE 234^HIS 233^ASP 194^PHE 218^TRP 223^LYS	2.7.3.2	creatine metabolic process phosphocreatine biosynthetic process	cytoplasm cytosol	nucleotide binding catalytic activity creatine kinase activity ATP binding kinase activity transferase activity transferase activity
3f83A fusion of the minor pilin cfae and major pilincfab	[pdb]	1.81 0.00113	239^PHE 39^HIS 40^ASP 167^PHE 171^TRP 107^LYS	0.0.0.0		pilus pilus
1lxmA hyaluronate lyase	[pdb]	1.81 0.00116	843^PHE 649^HIS 631^ASP 752^PHE 755^TRP 703^LYS	4.2.2.1	carbohydrate metabolic process	extracellular region	catalytic activity lyase activity carbon-oxygen lyase activity acting on polysaccharides carbohydrate binding
3k60B heat shock protein 86	[pdb]	1.82 0.00116	104^PHE 133^HIS 132^ASP 156^PHE 148^TRP 86^LYS	0.0.0.0	protein folding response to stress	cytoplasm	ATP binding unfolded protein binding
2fjuB 1-phosphatidylinositol-4,5-bisphosphatephosphodiesterase beta 2 ras-related c3 botulinum toxin substrate 1	[pdb]	1.84 0.00129	89^PHE 113^HIS 28^ASP 23^PHE 126^TRP 124^LYS	3.1.4.11	detection of chemical stimulus involved in sensory perception of bitter taste lipid metabolic process phospholipid metabolic process signal transduction activation of phospholipase C activity lipid catabolic process sensory perception of bitter taste apoptosis cellular component movement inflammatory response cell adhesion cell-matrix adhesion small GTPase mediated signal transduction induction of apoptosis by extracellular signals response to wounding anatomical structure morphogenesis regulation of hydrogen peroxide metabolic process positive regulation of lamellipodium assembly lamellipodium assembly actin filament polymerization ruffle organization positive regulation of Rho protein signal transduction negative regulation of receptor-mediated endocytosis localization within membrane regulation of respiratory burst	Golgi apparatus cytosol plasma membrane intracellular cytosol plasma membrane membrane melanosome	phosphatidylinositol phospholipase C activity phospholipase C activity signal transducer activity calcium ion binding protein binding phospholipid binding phosphoric diester hydrolase activity hydrolase activity metal ion binding nucleotide binding GTPase activity protein binding GTP binding enzyme binding GTP-dependent protein binding thioesterase binding
1qh4C creatine kinase	[pdb]	1.85 0.00132	334^PHE 234^HIS 233^ASP 194^PHE 218^TRP 223^LYS	2.7.3.2		cytoplasm	nucleotide binding catalytic activity creatine kinase activity ATP binding kinase activity transferase activity transferase activity
3pt1A upf0364 protein ymr027w	[pdb]	1.86 0.00136	298^PHE 370^HIS 372^ASP 347^PHE 355^TRP 389^LYS			nucleus cytoplasm
2bjqA mfp2a	[pdb]	1.87 0.0014	192^PHE 224^HIS 51^ASP 229^PHE 246^TRP 327^LYS	0.0.0.0
3bc9A alpha amylase, catalytic region	[pdb]	1.87 0.0014	275^PHE 354^HIS 350^ASP 359^PHE 304^TRP 302^LYS		carbohydrate metabolic process metabolic process		catalytic activity hydrolase activity hydrolase activity acting on glycosyl bonds glucan 1,4-alpha-maltohexaosidase activity
1ofmA chondroitinase b	[pdb]	1.88 0.00144	83^PHE 202^HIS 201^ASP 204^PHE 467^TRP 476^LYS	4.2.2.19			lyase activity chondroitin B lyase activity
1tl2A protein (tachylectin-2)	[pdb]	1.88 0.00148	43^PHE 152^HIS 182^ASP 141^PHE 134^TRP 108^LYS	0.0.0.0	innate immune response	extracellular region	sugar binding
1qk1B creatine kinase, ubiquitous mitochondrial	[pdb]	1.88 0.00148	329^PHE 229^HIS 228^ASP 189^PHE 213^TRP 218^LYS	2.7.3.2	creatine metabolic process	mitochondrion mitochondrial inner membrane membrane	nucleotide binding catalytic activity creatine kinase activity ATP binding kinase activity transferase activity transferase activity
2h84B steely1	[pdb]	1.89 0.00157	3138^PHE 3116^HIS 3115^ASP 3068^PHE 3096^TRP 3075^LYS	0.0.0.0	metabolic process biosynthetic process flavonoid biosynthetic process resorcinol metabolic process polyketide biosynthetic process	intracellular	acyl carrier activity catalytic activity binding acyltransferase activity naringenin-chalcone synthase activity oxidoreductase activity transferase activity cofactor binding
2innA phenol hydroxylase component pho phenol hydroxylase component phn phenol hydroxylase component phm phenol hydroxylase component phl	[pdb]	1.91 0.00166	339^HOH 85^ILE 219^ASN 156^THR 495^TRP 493^LYS	0.0.0.0	cellular aromatic compound metabolic process cellular aromatic compound metabolic process oxidation-reduction process cellular aromatic compound metabolic process oxidation-reduction process		monooxygenase activity oxidoreductase activity transition metal ion binding oxidoreductase activity oxidoreductase activity acting on paired donors
1dekA deoxynucleoside monophosphate kinase	[pdb]	1.92 0.00171	20^PHE 180^HIS 183^ASP 156^PHE 152^TRP 37^LYS	2.7.4.13			nucleotide binding ATP binding kinase activity transferase activity (deoxy)nucleoside-phosphate kinase activity
2xzmR rps31e rps17e rps21e rps15e rps13e rps27e 18s rrna rps16e 40s ribosomal protein rps7e ribosomal protein s26e containing protein rps29e rps14e ribosomal protein s8 containing protein rps18e rps25e, ribosomal protein s4 containing protein rack1 ribosomal protein s10 containing protein ribosomal protein s7 containing protein 40s ribosomal protein s8 ribosomal protein s28e containing protein 40s ribosomal protein s4 ribosomal protein l7ae containing protein ribosomal protein s5 containing protein rps24e 40s ribosomal protein s12 kh domain containing protein eif1 rps30e ribosomal protein s17 containing protein rps19e plectin/s10 domain containing protein rps0e 40s ribosomal protein s3a rps6e	[pdb]	1.92 0.00171	325^PHE 212^TYR 234^VAL 252^GLU 240^LEU 226^LYS	0.0.0.0	translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation	intracellular ribosome intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome small ribosomal subunit intracellular ribosome ribonucleoprotein complex intracellular ribosome intracellular ribosome small ribosomal subunit intracellular ribosome intracellular ribosome intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome intracellular ribosome intracellular cytoplasm ribosome ribonucleoprotein complex intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome	structural constituent of ribosome structural constituent of ribosome RNA binding structural constituent of ribosome rRNA binding structural constituent of ribosome RNA binding structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome RNA binding structural constituent of ribosome RNA binding structural constituent of ribosome rRNA binding structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome RNA binding structural constituent of ribosome structural constituent of ribosome
2gjrA alpha-amylase	[pdb]	1.94 0.00181	155^PHE 240^HIS 236^ASP 245^PHE 189^TRP 185^LYS	3.2.1.98	carbohydrate metabolic process metabolic process	extracellular region	catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds calcium ion binding hydrolase activity hydrolase activity acting on glycosyl bonds glucan 1,4-alpha-maltohexaosidase activity
1pn0B phenol 2-monooxygenase	[pdb]	1.95 0.00192	640^PHE 499^HIS 502^ASP 515^PHE 606^TRP 476^LYS	1.14.13.7	metabolic process aromatic compound catabolic process oxidation-reduction process	cytoplasm	monooxygenase activity oxidoreductase activity phenol 2-monooxygenase activity
2ov3A periplasmic binding protein component of an abctype zinc uptake transporter	[pdb]	1.97 0.00209	61^PHE 83^HIS 81^ASP 108^PHE 112^TRP 117^LYS	0.0.0.0	metal ion transport		metal ion binding
1ndlC nucleoside diphosphate kinase	[pdb]	1.97 0.00209	109^PHE 52^HIS 55^ASP 9^PHE 134^TRP 40^LYS	2.7.4.6	nucleoside diphosphate phosphorylation GTP biosynthetic process UTP biosynthetic process CTP biosynthetic process protein phosphorylation microtubule-based process mitosis open tracheal system development epithelial cell migration open tracheal system nucleotide metabolic process establishment or maintenance of polarity of follicular epithelium peptidyl-serine phosphorylation adherens junction organization	cytoplasm cytoskeleton microtubule microtubule associated complex nuclear microtubule	nucleotide binding magnesium ion binding nucleoside diphosphate kinase activity ATP binding GTP binding microtubule binding kinase activity transferase activity metal ion binding
3pw3B aminopeptidase c	[pdb]	1.98 0.00215	83^PHE 390^HIS 215^ASP 111^PHE 268^TRP 360^LYS	0.0.0.0	proteolysis		aminopeptidase activity cysteine-type endopeptidase activity
3bh4B alpha-amylase	[pdb]	1.98 0.00221	152^PHE 236^HIS 232^ASP 241^PHE 185^TRP 181^LYS	3.2.1.1	carbohydrate metabolic process metabolic process	extracellular region	catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds alpha-amylase activity calcium ion binding hydrolase activity hydrolase activity acting on glycosyl bonds
1j99A alcohol sulfotransferase	[pdb]	1.99 0.00221	13^PHE 257^HIS 125^ASP 150^PHE 146^TRP 144^LYS	2.8.2.14	lipid metabolic process digestion steroid metabolic process bile acid catabolic process sulfation	cytoplasm cytosol	sulfotransferase activity transferase activity bile-salt sulfotransferase activity
1zmwB map/microtubule affinity regulating kinase 2	[pdb]	2 0.00234	170^PHE 308^HIS 311^ASP 156^PHE 303^TRP 282^LYS	2.7.11.1	protein phosphorylation intracellular protein kinase cascade multicellular organismal development cell differentiation establishment or maintenance of epithelial cell apical/basal polarity	plasma membrane membrane	nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity ATP binding kinase activity transferase activity metal ion binding
2y5eA limit dextrinase	[pdb]	2.01 0.0024	572^PHE 750^HIS 661^ASP 744^PHE 718^TRP 693^LYS	0.0.0.0	carbohydrate metabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds cation binding
1pq4A periplasmic binding protein component of an abctype zinc uptake transporter	[pdb]	2.01 0.0024	61^PHE 83^HIS 81^ASP 108^PHE 112^TRP 117^LYS	0.0.0.0	metal ion transport		metal ion binding
3lk3A f-actin-capping protein subunit alpha-1 f-actin-capping protein subunit beta isoforms 1and 2 leucine-rich repeat-containing protein 16a	[pdb]	2.02 0.00247	20^GLN 79^HOH 81^PRO 62^CYS 177^LEU 210^ILE	0.0.0.0	cell projection organization lamellipodium assembly actin cytoskeleton organization actin filament capping actin cytoskeleton organization actin filament capping	cytoplasm cytoplasm cytoskeleton F-actin capping protein complex membrane lamellipodium cortical cytoskeleton cytoplasm F-actin capping protein complex Z disc WASH complex	actin binding actin binding
1e3zA alpha-amylase	[pdb]	2.02 0.00254	151^PHE 235^HIS 231^ASP 240^PHE 184^TRP 180^LYS	3.2.1.1	carbohydrate metabolic process metabolic process carbohydrate metabolic process metabolic process	extracellular region	catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds alpha-amylase activity calcium ion binding hydrolase activity hydrolase activity acting on glycosyl bonds cation binding metal ion binding catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds alpha-amylase activity calcium ion binding hydrolase activity
2d3lA glucan 1,4-alpha-maltohexaosidase	[pdb]	2.02 0.00254	155^PHE 240^HIS 236^ASP 245^PHE 189^TRP 185^LYS	3.2.1.98	carbohydrate metabolic process metabolic process	extracellular region	catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds calcium ion binding hydrolase activity hydrolase activity acting on glycosyl bonds glucan 1,4-alpha-maltohexaosidase activity
1t2aC gdp-mannose 4,6 dehydratase	[pdb]	2.03 0.00261	118^PHE 251^HIS 35^ASP 207^PHE 249^TRP 246^LYS	4.2.1.47	carbohydrate metabolic process leukocyte cell-cell adhesion metabolic process GDP-mannose metabolic process 'de novo' GDP-L-fucose biosynthetic process cellular metabolic process	intracellular cytoplasm	catalytic activity binding GDP-mannose 4,6-dehydratase activity lyase activity coenzyme binding
1wb4B endo-1,4-beta-xylanase y	[pdb]	2.04 0.00276	1074^PHE 1058^HIS 1018^ASP 953^PHE 1060^TRP 879^LYS	3.2.1.8	polysaccharide catabolic process carbohydrate metabolic process metabolic process xylan catabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds protein binding hydrolase activity hydrolase activity acting on glycosyl bonds
2ushB 5'-nucleotidase	[pdb]	2.04 0.00276	158^PHE 43^HIS 84^ASP 101^PHE 47^TRP 60^LYS	3.6.1.45, 3.1.3.5	nucleotide catabolic process	periplasmic space	nucleotide binding 5'-nucleotidase activity UDP-sugar diphosphatase activity hydrolase activity hydrolase activity acting on ester bonds
1hvxA alpha-amylase	[pdb]	2.05 0.00283	154^PHE 238^HIS 234^ASP 243^PHE 187^TRP 183^LYS	3.2.1.1	carbohydrate metabolic process metabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds alpha-amylase activity calcium ion binding hydrolase activity hydrolase activity acting on glycosyl bonds
2bm0A elongation factor g	[pdb]	2.05 0.00283	73^PHE 20^HIS 22^ASP 135^PHE 122^TRP 129^LYS	0.0.0.0	translation translational elongation	intracellular cytoplasm	nucleotide binding translation elongation factor activity GTPase activity GTP binding
1k8kC arp2/3 complex 41 kda subunit arp2/3 complex 21 kda subunit arp2/3 complex 34 kda subunit actin-like protein 2 actin-like protein 3 arp2/3 complex 20 kda subunit arp2/3 complex 16 kda subunit	[pdb]	2.05 0.00283	164^HOH 151^VAL 149^LYS 169^HOH 185^HOH 234^HOH	0.0.0.0	regulation of actin filament polymerization regulation of actin filament polymerization actin filament polymerization regulation of actin filament polymerization regulation of actin filament polymerization regulation of actin filament polymerization	cytoplasm cytoskeleton cell projection cytoplasm cytoskeleton cytoplasm cytoskeleton cell projection cytoplasm cytoskeleton cell projection cytoplasm cytoskeleton cell projection cytoplasm cytoskeleton lamellipodium cell projection cytoplasm cytoskeleton lamellipodium cell projection	actin binding actin binding actin binding nucleotide binding actin binding protein binding ATP binding actin binding actin binding protein binding nucleotide binding actin binding protein binding ATP binding
3ecqA endo-alpha-n-acetylgalactosaminidase	[pdb]	2.06 0.00291	864^PHE 835^HIS 608^ASP 807^PHE 840^TRP 822^LYS	0.0.0.0	cell adhesion	cell wall cell surface membrane
1nouB beta-hexosaminidase beta chain	[pdb]	2.06 0.00291	370^PHE 294^HIS 354^ASP 319^PHE 298^TRP 303^LYS	3.2.1.52	skeletal system development carbohydrate metabolic process N-acetylglucosamine metabolic process glycosphingolipid metabolic process ganglioside catabolic process cellular calcium ion homeostasis lysosome organization single fertilization penetration of zona pellucida sensory perception of sound locomotory behavior male courtship behavior metabolic process phospholipid biosynthetic process oligosaccharide catabolic process lipid storage sexual reproduction glycosaminoglycan metabolic process regulation of cellular metabolic process myelination cellular protein metabolic process oogenesis neuromuscular process controlling balance neuromuscular process	acrosomal vesicle soluble fraction lysosome membrane	catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds beta-N-acetylhexosaminidase activity sugar binding hexosaminidase activity beta-N-acetylglucosaminidase activity hydrolase activity hydrolase activity acting on glycosyl bonds protein homodimerization activity
3jzhA histone peptide polycomb protein eed	[pdb]	2.07 0.00299	356^PHE 235^HIS 257^ASP 299^PHE 263^TRP 250^LYS	0.0.0.0	chromatin modification	nucleus chromosome ESC/E(Z) complex	protein binding transcription repressor activity histone methyltransferase activity identical protein binding
3mmgA nuclear inclusion protein b fragment nuclear inclusion protein a	[pdb]	2.07 0.00299	37^PHE 130^HIS 107^ASP 179^PHE 143^TRP 147^LYS	0.0.0.0	proteolysis		catalytic activity cysteine-type peptidase activity
1u7vB mothers against decapentaplegic homolog 2 mothers against decapentaplegic homolog 4	[pdb]	2.07 0.00299	339^PHE 405^HIS 404^ASP 408^PHE 509^TRP 519^LYS	0.0.0.0	branching involved in ureteric bud morphogenesis response to hypoxia in utero embryonic development gastrulation with mouth forming second kidney development regulation of transcription DNA-dependent regulation of transcription from RNA polymerase II promoter transforming growth factor beta receptor signaling pathway SMAD protein complex assembly gastrulation endoderm development mesoderm development cell proliferation negative regulation of cell proliferation anterior/posterior pattern formation positive regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation regulation of transforming growth factor beta receptor signaling pathway negative regulation of cell growth BMP signaling pathway positive regulation of transforming growth factor beta receptor signaling pathway somite rostral/caudal axis specification regulation of transforming growth factor-beta2 production regulation of cell proliferation negative regulation of protein catabolic process negative regulation of transcription DNA-dependent positive regulation of transcription DNA-dependent positive regulation of transcription from RNA polymerase II promoter developmental growth neuron fate commitment tissue morphogenesis formation of anatomical boundary regulation of binding palate development positive regulation of SMAD protein import into nucleus SMAD protein signal transduction negative regulation of cell death ureteric bud development in utero embryonic development mesoderm formation regulation of transcription DNA-dependent protein phosphorylation transforming growth factor beta receptor signaling pathway common-partner SMAD protein phosphorylation SMAD protein complex assembly zygotic specification of dorsal/ventral axis gastrulation pattern specification process endoderm development heart development negative regulation of cell proliferation response to glucose stimulus post-embryonic development embryonic pattern specification anterior/posterior pattern formation positive regulation of epithelial to mesenchymal transition regulation of transforming growth factor beta receptor signaling pathway insulin secretion lung development pancreas development primary microRNA processing organ growth positive regulation of gene-specific transcription cell fate commitment negative regulation of transcription DNA-dependent positive regulation of transcription DNA-dependent positive regulation of transcription from RNA polymerase II promoter paraxial mesoderm morphogenesis developmental growth	intracellular nucleus nucleoplasm transcription factor complex cytoplasm cytosol activin responsive factor complex protein complex nucleolus intracellular nucleus nucleoplasm transcription factor complex cytoplasm cytosol activin responsive factor complex protein complex	DNA binding chromatin binding sequence-specific DNA binding transcription factor activity protein binding collagen binding promoter binding transcription activator activity transforming growth factor beta receptor common-partner cytoplasmic mediator activity identical protein binding protein homodimerization activity SMAD binding I-SMAD binding R-SMAD binding sequence-specific DNA binding chromatin binding double-stranded DNA binding sequence-specific DNA binding transcription factor activity transforming growth factor beta receptor binding protein binding transcription factor binding promoter binding transcription activator activity transforming growth factor beta receptor pathway-specific cytoplasmic mediator activity ubiquitin protein ligase binding type I transforming growth factor beta receptor binding co-SMAD binding I-SMAD binding
2fgtA two-component system yycf/yycg regulatoryprotein yych	[pdb]	2.07 0.00307	155^PHE 317^HIS 336^ASP 331^PHE 314^TRP 306^LYS	0.0.0.0		plasma membrane membrane integral to membrane	metal ion binding
3ly9A transcriptional activator cadc	[pdb]	2.07 0.00307	234^PHE 349^HIS 345^ASP 477^PHE 488^TRP 458^LYS		two-component signal transduction system (phosphorelay) regulation of transcription	intracellular plasma membrane membrane integral to membrane	two-component response regulator activity DNA binding binding transcription activator activity
1bhnE nucleoside diphosphate transferase	[pdb]	2.07 0.00307	108^PHE 51^HIS 54^ASP 8^PHE 133^TRP 39^LYS	2.7.4.6	GTP biosynthetic process UTP biosynthetic process CTP biosynthetic process endocytosis nervous system development nucleotide metabolic process cell differentiation	nucleus cytoplasm plasma membrane membrane	nucleotide binding nucleoside diphosphate kinase activity ATP binding kinase activity transferase activity metal ion binding
2ggzB guanylyl cyclase-activating protein 3	[pdb]	2.08 0.00315	25^PHE 55^HIS 57^ASP 63^PHE 94^TRP 91^LYS	0.0.0.0	signal transduction visual perception		calcium ion binding calcium sensitive guanylate cyclase activator activity
2f1zB ubiquitin carboxyl-terminal hydrolase 7	[pdb]	2.09 0.00315	158^PHE 210^HIS 206^ASP 480^PHE 477^TRP 490^LYS	3.1.2.15	ubiquitin-dependent protein catabolic process multicellular organismal development protein deubiquitination interspecies interaction between organisms regulation of sequence-specific DNA binding transcription factor activity	nucleus cytoplasm	p53 binding cysteine-type endopeptidase activity ubiquitin thiolesterase activity ubiquitin-specific protease activity protein binding protein C-terminus binding transcription factor binding peptidase activity cysteine-type peptidase activity hydrolase activity ubiquitin protein ligase binding
3cihA putative alpha-rhamnosidase	[pdb]	2.09 0.00324	561^PHE 673^HIS 671^ASP 304^PHE 660^TRP 659^LYS	0.0.0.0			catalytic activity
3hhsB phenoloxidase subunit 1 phenoloxidase subunit 2	[pdb]	2.1 0.00332	261^PHE 383^HIS 378^ASP 387^PHE 285^TRP 275^LYS	1.14.18.1	melanin biosynthetic process from tyrosine transport defense response metabolic process positive regulation of melanization defense response melanin biosynthetic process oxidation-reduction process melanin biosynthetic process from tyrosine transport defense response metabolic process positive regulation of melanization defense response melanin biosynthetic process oxidation-reduction process	extracellular region extracellular region	monooxygenase activity monophenol monooxygenase activity oxygen transporter activity copper ion binding oxidoreductase activity chloride ion binding metal ion binding monooxygenase activity monophenol monooxygenase activity oxygen transporter activity copper ion binding oxidoreductase activity chloride ion binding metal ion binding
3lgdA adenosine deaminase cecr1	[pdb]	2.1 0.00332	209^PHE 267^HIS 266^ASP 185^PHE 178^TRP 390^LYS	0.0.0.0	adenosine catabolic process multicellular organismal development purine ribonucleoside monophosphate biosynthetic process	extracellular region extracellular space	adenosine deaminase activity growth factor activity zinc ion binding hydrolase activity deaminase activity adenosine receptor binding protein homodimerization activity proteoglycan binding
2ilyA poliovirus polymerase	[pdb]	2.11 0.00341	198^PHE 389^HIS 215^ASP 373^PHE 368^TRP 228^LYS	2.7.7.48, 3.6.1.15, 3.4.22.29, 3.4.22.28	transcription RNA-dependent proteolysis viral reproduction RNA-protein covalent cross-linking viral genome replication evasion by virus of host immune response	membrane virion viral capsid host cell cytoplasm host cell membrane host cell cytoplasmic vesicle host cell cytoplasmic vesicle membrane	nucleotide binding RNA binding RNA helicase activity catalytic activity RNA-directed RNA polymerase activity cysteine-type endopeptidase activity helicase activity structural molecule activity ATP binding peptidase activity cysteine-type peptidase activity transferase activity nucleotidyltransferase activity hydrolase activity nucleoside-triphosphatase activity
3ai7E xylulose-5-phosphate/fructose-6-phosphate phosphoketolase	[pdb]	2.12 0.0035	296^PHE 85^HIS 84^ASP 175^PHE 10^TRP 278^LYS	0.0.0.0	carbohydrate metabolic process metabolic process		catalytic activity lyase activity aldehyde-lyase activity fructose-6-phosphate phosphoketolase activity
2g62A protein phosphatase 2a, regulatory subunit b' (pr53)	[pdb]	2.13 0.00369	215^PHE 237^HIS 240^ASP 253^PHE 284^TRP 286^LYS		negative regulation of phosphoprotein phosphatase activity positive regulation of phosphoprotein phosphatase activity positive regulation of protein dephosphorylation negative regulation of protein dephosphorylation positive regulation of apoptosis regulation of phosphoprotein phosphatase activity	protein phosphatase type 2A complex soluble fraction nucleus cytoplasm calcium channel complex	nucleotide binding peptidyl-prolyl cis-trans isomerase activity receptor binding ATP binding protein tyrosine phosphatase activator activity protein phosphatase type 2A regulator activity isomerase activity phosphatase activator activity protein homodimerization activity protein heterodimerization activity protein phosphatase 2A binding ATPase activity
1ii7B mre11 nuclease	[pdb]	2.13 0.00369	3^PHE 52^HIS 86^ASP 25^PHE 229^TRP 209^LYS	0.0.0.0	DNA metabolic process DNA repair response to DNA damage stimulus		nuclease activity endonuclease activity exonuclease activity hydrolase activity identical protein binding metal ion binding
1k3dA phosphoenolpyruvate carboxykinase	[pdb]	2.13 0.00378	163^PHE 232^HIS 269^ASP 279^PHE 273^TRP 226^LYS	4.1.1.49	gluconeogenesis	cytoplasm	nucleotide binding phosphoenolpyruvate carboxykinase activity phosphoenolpyruvate carboxykinase (ATP) activity ATP binding lyase activity carboxy-lyase activity purine nucleotide binding
2z95B gdp-d-mannose dehydratase	[pdb]	2.13 0.00378	92^PHE 181^HIS 15^ASP 179^PHE 221^TRP 218^LYS	0.0.0.0	metabolic process GDP-mannose metabolic process cellular metabolic process	intracellular	catalytic activity binding GDP-mannose 4,6-dehydratase activity coenzyme binding
1u8wE nucleoside diphosphate kinase i	[pdb]	2.14 0.00388	105^PHE 48^HIS 51^ASP 5^PHE 130^TRP 36^LYS	2.7.4.6	GTP biosynthetic process UTP biosynthetic process CTP biosynthetic process nucleotide metabolic process response to salt stress response to cadmium ion	vacuole peroxisome plasma membrane chloroplast apoplast	nucleotide binding nucleoside diphosphate kinase activity ATP binding kinase activity transferase activity metal ion binding
2p0aB synapsin-3	[pdb]	2.16 0.00408	230^PHE 355^HIS 361^ASP 286^PHE 314^TRP 315^LYS	0.0.0.0	neurotransmitter secretion	synaptic vesicle membrane cell junction synaptic vesicle membrane cytoplasmic vesicle synapse	nucleotide binding catalytic activity protein binding ATP binding
1bliA alpha-amylase	[pdb]	2.16 0.00408	153^PHE 235^HIS 231^ASP 240^PHE 182^TRP 180^LYS	3.2.1.1	carbohydrate metabolic process metabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds alpha-amylase activity calcium ion binding hydrolase activity hydrolase activity acting on glycosyl bonds
3ma3A proto-oncogene serine/threonine-protein kinase pim-1 pimtide	[pdb]	2.16 0.00418	100^PHE 219^HIS 195^ASP 281^PHE 226^TRP 169^LYS	2.7.11.1	protein phosphorylation cell cycle multicellular organismal development cell proliferation positive regulation of cyclin-dependent protein kinase activity involved in G1/S negative regulation of apoptosis negative regulation of sequence-specific DNA binding transcription factor activity protein autophosphorylation	nucleus cytoplasm plasma membrane membrane	nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding transcription factor binding kinase activity transferase activity manganese ion binding metal ion binding
1tvnA cellulase	[pdb]	2.17 0.00418	51^PHE 100^HIS 98^ASP 38^PHE 33^TRP 261^LYS	0.0.0.0	carbohydrate metabolic process cell adhesion metabolic process	extracellular region	catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds calcium ion binding cellulase activity hydrolase activity hydrolase activity acting on glycosyl bonds
1olmA sec14-like protein 2	[pdb]	2.17 0.00429	174^PHE 231^HIS 92^ASP 190^PHE 224^TRP 193^LYS	0.0.0.0	transport regulation of cholesterol biosynthetic process positive regulation of cholesterol biosynthetic process positive regulation of transcription	intracellular nucleus cytoplasm cytosol	transporter activity phospholipid binding enzyme activator activity lipid binding vitamin E binding transcription activator activity
2fhxB spm-1	[pdb]	2.18 0.00439	180^PHE 263^HIS 120^ASP 53^PHE 266^TRP 257^LYS	0.0.0.0	antibiotic catabolic process		zinc ion binding beta-lactamase activity hydrolase activity
1yggA phosphoenolpyruvate carboxykinase	[pdb]	2.18 0.00439	163^PHE 232^HIS 269^ASP 279^PHE 273^TRP 226^LYS	0.0.0.0	gluconeogenesis gluconeogenesis	cytoplasm cytoplasm	phosphoenolpyruvate carboxykinase activity phosphoenolpyruvate carboxykinase (ATP) activity ATP binding kinase activity lyase activity purine nucleotide binding nucleotide binding phosphoenolpyruvate carboxykinase activity phosphoenolpyruvate carboxykinase (ATP) activity ATP binding lyase activity carboxy-lyase activity purine nucleotide binding
3ahjA xylulose 5-phosphate/fructose 6-phosphate phosphoketolase	[pdb]	2.18 0.00439	296^PHE 85^HIS 84^ASP 175^PHE 10^TRP 278^LYS	0.0.0.0	carbohydrate metabolic process metabolic process		catalytic activity lyase activity aldehyde-lyase activity phosphoketolase activity
1yrzB xylan beta-1,4-xylosidase	[pdb]	2.19 0.0045	2100^PHE 2014^HIS 2016^ASP 2497^PHE 2035^TRP 2066^LYS	0.0.0.0	carbohydrate metabolic process metabolic process		hydrolase activity hydrolyzing O-glycosyl compounds xylan 1,4-beta-xylosidase activity hydrolase activity
1i5pA pesticidial crystal protein cry2aa	[pdb]	2.19 0.00451	177^PHE 239^HIS 240^ASP 231^PHE 293^TRP 515^LYS	0.0.0.0	defense response pathogenesis sporulation resulting in formation of a cellular spore		receptor binding
1uokA oligo-1,6-glucosidase	[pdb]	2.19 0.00451	203^PHE 283^HIS 285^ASP 279^PHE 311^TRP 265^LYS	3.2.1.10	carbohydrate metabolic process metabolic process	cytoplasm	catalytic activity oligo-1,6-glucosidase activity hydrolase activity hydrolase activity acting on glycosyl bonds
2pvcB histone h3 peptide dna (cytosine-5)-methyltransferase 3-like	[pdb]	2.19 0.00451	301^PHE 250^HIS 253^ASP 196^PHE 359^TRP 362^LYS	0.0.0.0	in utero embryonic development DNA methylation regulation of gene expression by genetic imprinting spermatogenesis	condensed nuclear chromosome nucleus nuclear heterochromatin cytoplasm cytosol	protein binding enzyme activator activity zinc ion binding transcription repressor activity enzyme binding metal ion binding
2rf7B cytochrome c-552	[pdb]	2.19 0.00462	196^PHE 144^HIS 140^ASP 218^PHE 123^TRP 126^LYS	1.7.2.2	nitrogen compound metabolic process transport electron transport chain oxidation-reduction process	periplasmic space	calcium ion binding oxidoreductase activity heme binding nitrite reductase (cytochrome ammonia-forming) activity
3d3aA beta-galactosidase	[pdb]	2.2 0.00462	186^PHE 267^HIS 266^ASP 316^PHE 428^TRP 481^LYS	0.0.0.0	carbohydrate metabolic process cell adhesion		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds
2cwnB transaldolase	[pdb]	2.2 0.00462	227^PHE 298^HIS 301^ASP 294^PHE 147^TRP 154^LYS	2.2.1.2	carbohydrate metabolic process fructose 6-phosphate metabolic process pentose-phosphate shunt metabolic process pentose-phosphate shunt non-oxidative branch	soluble fraction cytoplasm microsome cytosol	catalytic activity sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity protein binding sugar binding transferase activity monosaccharide binding
3hvmA agmatine deiminase	[pdb]	2.2 0.00473	18^PHE 202^HIS 204^ASP 103^PHE 106^TRP 109^LYS	0.0.0.0
1efhB hydroxysteroid sulfotransferase	[pdb]	2.2 0.00473	13^PHE 257^HIS 125^ASP 150^PHE 146^TRP 144^LYS	2.8.2.14	lipid metabolic process digestion steroid metabolic process bile acid catabolic process sulfation	cytoplasm cytosol	sulfotransferase activity transferase activity bile-salt sulfotransferase activity
2vduB trna (guanine-n(7)-)-methyltransferase-associated wd repeat protein trm82 trna (guanine-n(7)-)-methyltransferase	[pdb]	2.2 0.00473	278^THR 221^VAL 219^THR 238^PHE 236^PRO 270^LYS	0.0.0.0	tRNA processing tRNA methylation tRNA modification tRNA processing tRNA methylation	nucleus nucleus	protein binding tRNA (guanine-N7-)-methyltransferase activity tRNA binding RNA binding protein binding methyltransferase activity tRNA (guanine-N7-)-methyltransferase activity transferase activity
3bbcD nucleoside diphosphate kinase b	[pdb]	2.21 0.00485	108^PHE 51^HIS 54^ASP 8^PHE 133^TRP 39^LYS	2.7.4.6	GTP biosynthetic process UTP biosynthetic process CTP biosynthetic process regulation of transcription DNA-dependent cell adhesion nucleotide metabolic process nucleoside triphosphate biosynthetic process negative regulation of apoptosis positive regulation of keratinocyte differentiation regulation of epidermis development	ruffle nucleus cytoplasm lamellipodium	nucleotide binding DNA binding sequence-specific DNA binding transcription factor activity nucleoside diphosphate kinase activity protein binding ATP binding kinase activity transferase activity metal ion binding
2inyA hexon protein	[pdb]	2.21 0.00485	687^PHE 889^HIS 695^ASP 865^PHE 641^TRP 619^LYS	0.0.0.0		virion viral capsid	structural molecule activity
2hv7D protein phosphatase 2a, regulatory subunit b	[pdb]	2.22 0.00496	215^PHE 237^HIS 240^ASP 253^PHE 284^TRP 286^LYS		negative regulation of phosphoprotein phosphatase activity positive regulation of phosphoprotein phosphatase activity positive regulation of protein dephosphorylation negative regulation of protein dephosphorylation positive regulation of apoptosis regulation of phosphoprotein phosphatase activity	protein phosphatase type 2A complex soluble fraction nucleus cytoplasm calcium channel complex	nucleotide binding peptidyl-prolyl cis-trans isomerase activity receptor binding ATP binding protein tyrosine phosphatase activator activity protein phosphatase type 2A regulator activity isomerase activity phosphatase activator activity protein homodimerization activity protein heterodimerization activity protein phosphatase 2A binding ATPase activity
1hjxD chitinase-3 like protein 1	[pdb]	2.22 0.00497	287^PHE 219^HIS 207^ASP 265^PHE 325^TRP 321^LYS	0.0.0.0	carbohydrate metabolic process chitin catabolic process	extracellular region proteinaceous extracellular matrix extracellular space	catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds chitinase activity extracellular matrix structural constituent sugar binding
1gyhA arabinan endo-1,5-alpha-l-arabinosidase a	[pdb]	2.22 0.00497	183^PHE 291^HIS 38^ASP 235^PHE 238^TRP 203^LYS	0.0.0.0	carbohydrate metabolic process metabolic process		hydrolase activity hydrolyzing O-glycosyl compounds hydrolase activity hydrolase activity
2i3sA cell cycle arrest protein checkpoint serine/threonine-protein kinase	[pdb]	2.22 0.00509	40^PHE 241^HIS 272^ASP 289^PHE 278^TRP 264^LYS	0.0.0.0	cell cycle checkpoint protein phosphorylation cell cycle mitotic cell cycle spindle assembly checkpoint sister chromatid biorientation protein localization to kinetochore cell cycle mitotic cell cycle spindle assembly checkpoint mitotic cell cycle G2/M transition decatenation checkpoint	kinetochore condensed nuclear chromosome kinetochore condensed nuclear chromosome centromeric region nucleus condensed nuclear chromosome kinetochore nucleus	nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding kinase activity transferase activity protein binding
2qz7B uncharacterized protein sco6318	[pdb]	2.23 0.00509	156^PHE 112^HIS 176^ASP 120^PHE 30^TRP 29^LYS	0.0.0.0	response to stress
1wubA conserved hypothetical protein tt1927b	[pdb]	2.23 0.00521	82^PHE 65^HIS 63^ASP 71^PHE 146^TRP 140^LYS	0.0.0.0
2g3hA globin	[pdb]	2.23 0.00521	32^PHE 137^HIS 136^ASP 143^PHE 89^TRP 91^LYS	0.0.0.0	transport oxygen transport		oxygen transporter activity iron ion binding protein binding oxygen binding heme binding
2qruA uncharacterized protein	[pdb]	2.23 0.00521	124^PHE 74^HIS 73^ASP 83^PHE 163^TRP 41^LYS	0.0.0.0
1f05B transaldolase	[pdb]	2.25 0.00547	227^PHE 298^HIS 301^ASP 294^PHE 147^TRP 154^LYS	2.2.1.2	carbohydrate metabolic process fructose 6-phosphate metabolic process pentose-phosphate shunt metabolic process pentose-phosphate shunt non-oxidative branch	soluble fraction cytoplasm microsome cytosol	catalytic activity sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity protein binding sugar binding transferase activity monosaccharide binding
3b8cB atpase 2, plasma membrane-type	[pdb]	2.25 0.00547	96^PHE 751^HIS 748^ASP 671^PHE 667^TRP 269^LYS	3.6.3.6	ATP biosynthetic process transport ion transport cation transport metabolic process ATP hydrolysis coupled proton transport proton transport	plasma membrane membrane integral to membrane	nucleotide binding magnesium ion binding catalytic activity protein binding ATP binding hydrogen-exporting ATPase activity phosphorylative mechanism ATPase activity coupled to transmembrane movement of ions phosphorylative mechanism hydrolase activity
2xznF rps31e rps17e rps21e rps15e rps13e rps27e 18s rrna rps30e ribosomal protein s26e containing protein rps29e rps14e ribosomal protein s8 containing protein rps18e ribosomal protein s4 containing protein rack1 rps7e ribosomal protein s10 containing protein ribosomal protein s7 containing protein 40s ribosomal protein s8 ribosomal protein s28e containing protein 40s ribosomal protein s4 ribosomal protein l7ae containing protein ribosomal protein s5 containing protein rps24e 40s ribosomal protein s12 kh domain containing protein rps25e rps16e, 40s ribosomal protein rps16e eif1 ribosomal protein s17 containing protein rps19e plectin/s10 domain containing protein rps0e 40s ribosomal protein s3a rps6e	[pdb]	2.26 0.0056	15^MG 77^MG 76^MG 84^MG 51^MG 46^MG		translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation	intracellular ribosome intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome small ribosomal subunit intracellular ribosome ribonucleoprotein complex intracellular ribosome small ribosomal subunit intracellular ribosome intracellular ribosome intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome intracellular ribosome intracellular cytoplasm ribosome ribonucleoprotein complex intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome intracellular ribosome	structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome RNA binding structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome RNA binding structural constituent of ribosome RNA binding structural constituent of ribosome rRNA binding structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome RNA binding structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome
2j47A glucosaminidase	[pdb]	2.26 0.0056	465^PHE 349^HIS 427^ASP 421^PHE 498^TRP 503^LYS	3.2.1.52	carbohydrate metabolic process metabolic process		beta-N-acetylhexosaminidase activity hydrolase activity hydrolase activity
2fyoA carnitine o-palmitoyltransferase ii,mitochondrial	[pdb]	2.26 0.00574	388^PHE 496^HIS 213^ASP 218^PHE 374^TRP 354^LYS	2.3.1.21	lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation transport long-chain fatty acid transport	mitochondrion mitochondrial inner membrane membrane	carnitine O-palmitoyltransferase activity acyltransferase activity transferase activity
3k9yB 1,25-dihydroxyvitamin d(3) 24-hydroxylase,mitochondrial	[pdb]	2.26 0.00574	162^PHE 140^HIS 139^ASP 279^PHE 275^TRP 243^LYS	0.0.0.0	osteoblast differentiation response to vitamin D vitamin D metabolic process vitamin D catabolic process oxidation-reduction process	mitochondrion	monooxygenase activity iron ion binding 25-hydroxycholecalciferol-24-hydroxylase activity electron carrier activity oxidoreductase activity oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen NADH or NADPH as one donor
3mguA pkhd-type hydroxylase tpa1	[pdb]	2.27 0.00587	599^PHE 155^HIS 86^ASP 505^PHE 617^TRP 620^LYS	0.0.0.0	nuclear-transcribed mRNA catabolic process deadenylation-dependent decay translational termination	nucleus	iron ion binding protein binding poly(A) RNA binding oxidoreductase activity oxidoreductase activity acting on single donors with incorporation of molecular oxygen incorporation of two atoms of oxygen oxidoreductase activity acting on paired donors
3ij6C uncharacterized metal-dependent hydrolase	[pdb]	2.27 0.00587	213^PHE 10^HIS 262^ASP 130^PHE 158^TRP 200^LYS	0.0.0.0	metabolic process		catalytic activity
2vfiB triosephosphate isomerase	[pdb]	2.27 0.00601	69^PHE 50^HIS 49^ASP 42^PHE 11^TRP 12^LYS	5.3.1.1	gluconeogenesis glycolysis pentose-phosphate shunt fatty acid biosynthetic process metabolic process lipid biosynthetic process		catalytic activity triose-phosphate isomerase activity isomerase activity
2veuA tyrosine-protein phosphatase non-receptor type 1	[pdb]	2.27 0.00601	256^PHE 60^HIS 65^ASP 95^PHE 100^TRP 103^LYS	3.1.3.48	protein dephosphorylation signal transduction insulin receptor signaling pathway dephosphorylation regulation of insulin receptor signaling pathway negative regulation of insulin receptor signaling pathway	insoluble fraction endoplasmic reticulum endoplasmic reticulum membrane cytosol membrane cytoplasmic vesicle	phosphoprotein phosphatase activity protein tyrosine phosphatase activity insulin receptor binding protein binding zinc ion binding hydrolase activity phosphatase activity
3e58A putative beta-phosphoglucomutase	[pdb]	2.28 0.00601	14^PHE 37^HIS 36^ASP 42^PHE 52^TRP 49^LYS	0.0.0.0	metabolic process		catalytic activity phosphoglycolate phosphatase activity hydrolase activity
1xx1D sphingomyelinase i	[pdb]	2.29 0.00616	145^PHE 12^HIS 34^ASP 88^PHE 8^TRP 226^LYS	3.1.4.41	lipid metabolic process pathogenesis cytolysis hemolysis in other organism	extracellular region	phosphoric diester hydrolase activity hydrolase activity metal ion binding sphingomyelin phosphodiesterase D activity
1c3bB cephalosporinase	[pdb]	2.29 0.00616	328^PHE 13^HIS 10^ASP 41^PHE 43^TRP 342^LYS	3.5.2.6	antibiotic catabolic process response to drug response to antibiotic	outer membrane-bounded periplasmic space periplasmic space	protein binding beta-lactamase activity hydrolase activity
3o47B adp-ribosylation factor gtpase-activating protein 1, adp-ribosylation factor 1	[pdb]	2.29 0.00631	28^PHE 210^HIS 94^ASP 181^PHE 196^TRP 160^LYS	0.0.0.0	transport retrograde vesicle-mediated transport Golgi to ER post-Golgi vesicle-mediated transport small GTPase mediated signal transduction protein transport cellular membrane organization vesicle-mediated transport COPI coating of Golgi vesicle transport retrograde vesicle-mediated transport Golgi to ER protein transport cellular membrane organization vesicle-mediated transport	Golgi membrane intracellular cytoplasm Golgi apparatus cytosol plasma membrane endomembrane system sarcomere perinuclear region of cytoplasm Golgi membrane cytoplasm Golgi apparatus	nucleotide binding GTPase activity receptor signaling protein activity protein binding GTP binding GTPase activator activity ARF GTPase activator activity zinc ion binding metal ion binding
3cweA tyrosine-protein phosphatase non-receptor type 1	[pdb]	2.3 0.00662	756^PHE 560^HIS 565^ASP 595^PHE 600^TRP 603^LYS	3.1.3.48	protein dephosphorylation signal transduction insulin receptor signaling pathway dephosphorylation regulation of insulin receptor signaling pathway negative regulation of insulin receptor signaling pathway	insoluble fraction endoplasmic reticulum endoplasmic reticulum membrane cytosol membrane cytoplasmic vesicle	phosphoprotein phosphatase activity protein tyrosine phosphatase activity insulin receptor binding protein binding zinc ion binding hydrolase activity phosphatase activity
2qgmA succinoglycan biosynthesis protein	[pdb]	2.31 0.00662	434^PHE 289^HIS 288^ASP 109^PHE 115^TRP 137^LYS	0.0.0.0	response to antibiotic
1xkvA atp-dependent phosphoenolpyruvate carboxykinase	[pdb]	2.31 0.00662	510^PHE 255^HIS 253^ASP 213^PHE 257^TRP 416^LYS	4.1.1.49	gluconeogenesis	cytoplasm	nucleotide binding phosphoenolpyruvate carboxykinase activity phosphoenolpyruvate carboxykinase (ATP) activity ATP binding lyase activity carboxy-lyase activity purine nucleotide binding metal ion binding
3osdA putative glycosyl hydrolase	[pdb]	2.31 0.00662	118^PHE 275^HIS 274^ASP 281^PHE 127^TRP 208^LYS	0.0.0.0			hydrolase activity
1g1aB dtdp-d-glucose 4,6-dehydratase	[pdb]	2.31 0.00662	54^PHE 176^HIS 175^ASP 128^PHE 181^TRP 113^LYS	4.2.1.46	metabolic process lipopolysaccharide biosynthetic process nucleotide-sugar metabolic process cellular metabolic process extracellular polysaccharide biosynthetic process metabolic process nucleotide-sugar metabolic process cellular metabolic process		catalytic activity binding dTDP-glucose 4,6-dehydratase activity lyase activity coenzyme binding NADH binding catalytic activity binding dTDP-glucose 4,6-dehydratase activity lyase activity coenzyme binding
2p9wA mal s 1 allergenic protein	[pdb]	2.31 0.00662	176^PHE 217^HIS 215^ASP 233^PHE 288^TRP 246^LYS	0.0.0.0		extracellular region cell wall
1lwhA 4-alpha-glucanotransferase	[pdb]	2.31 0.00678	334^PHE 241^HIS 238^ASP 285^PHE 248^TRP 293^LYS	2.4.1.25	carbohydrate metabolic process	cytoplasm	catalytic activity 4-alpha-glucanotransferase activity transferase activity transferase activity transferring glycosyl groups cation binding
2vr0E napc/nirt cytochrome c family protein cytochrome c nitrite reductase, catalyticsubunit nfra	[pdb]	2.31 0.00678	238^PHE 130^MET 127^VAL 174^PHE 513^TRP 140^HIS	0.0.0.0	nitrogen compound metabolic process oxidation-reduction process
1wukL periplasmic [nife] hydrogenase small subunit periplasmic [nife] hydrogenase large subunit	[pdb]	2.31 0.00678	268^PHE 541^HIS 544^ASP 136^PHE 287^TRP 285^LYS	1.12.2.1	oxidation-reduction process oxidation-reduction process	periplasmic space ferredoxin hydrogenase complex periplasmic space	ferredoxin hydrogenase activity nickel ion binding oxidoreductase activity metal ion binding cytochrome-c3 hydrogenase activity NADH dehydrogenase (ubiquinone) activity ferredoxin hydrogenase activity oxidoreductase activity metal ion binding cytochrome-c3 hydrogenase activity quinone binding iron-sulfur cluster binding 3 iron 4 sulfur cluster binding
2rmcA cyclosporin a cyclophilin c	[pdb]	2.32 0.00678	117^PHE 126^HIS 157^ASP 147^PHE 131^TRP 39^LYS	5.2.1.8	protein folding	cytoplasm	peptidyl-prolyl cis-trans isomerase activity isomerase activity peptide binding
1llnA antiviral protein 3	[pdb]	2.32 0.00694	4^PHE 256^HIS 27^ASP 176^PHE 206^TRP 204^LYS	3.2.2.22	defense response pathogenesis response to virus negative regulation of translation		hydrolase activity rRNA N-glycosylase activity
3kyaA putative phosphatase	[pdb]	2.32 0.00694	215^PHE 354^HIS 419^ASP 348^PHE 333^TRP 290^LYS	0.0.0.0
3kb4A alr8543 protein	[pdb]	2.32 0.00694	61^PHE 124^HIS 121^ASP 153^PHE 183^TRP 187^LYS		ubiquinone biosynthetic process
1cynA cyclophilin b [d-(cholinyl)ala]8-cyclosporin	[pdb]	2.32 0.00694	54^PHE 134^HIS 114^ASP 121^PHE 105^TRP 139^HOH	5.2.1.8	protein folding	endoplasmic reticulum endoplasmic reticulum lumen melanosome	peptidyl-prolyl cis-trans isomerase activity protein binding isomerase activity peptide binding unfolded protein binding
3okwA semaphorin-6a	[pdb]	2.32 0.00694	503^PHE 118^HIS 115^ASP 120^PHE 97^TRP 94^LYS	0.0.0.0	apoptosis cell surface receptor linked signaling pathway multicellular organismal development nervous system development axon guidance cell differentiation centrosome localization	membrane integral to membrane axon	receptor activity protein binding semaphorin receptor binding
2z73B rhodopsin	[pdb]	2.33 0.0071	83^PHE 20^HIS 189^ASP 105^PHE 12^TRP 99^LYS	0.0.0.0	signal transduction G-protein coupled receptor protein signaling pathway visual perception phototransduction protein-chromophore linkage response to stimulus	membrane integral to membrane	signal transducer activity receptor activity G-protein coupled receptor activity photoreceptor activity
1thtB thioesterase	[pdb]	2.34 0.00727	253^PHE 21^HIS 69^ASP 66^PHE 23^TRP 6^LYS	0.0.0.0	fatty acid metabolic process bioluminescence		acyltransferase activity transferase activity
3cu9A intracellular arabinanase	[pdb]	2.34 0.00727	7^PHE 26^HIS 27^ASP 40^PHE 24^TRP 20^LYS	0.0.0.0	carbohydrate metabolic process		hydrolase activity
1vrbB putative asparaginyl hydroxylase	[pdb]	2.34 0.00727	100^PHE 224^HIS 147^ASP 142^PHE 162^TRP 160^LYS	0.0.0.0			metal ion binding
2eslA cyclosporin a peptidyl-prolyl cis-trans isomerase c	[pdb]	2.34 0.00727	117^PHE 126^HIS 157^ASP 147^PHE 131^TRP 39^LYS	5.2.1.8	protein folding signal transduction	cytoplasm	peptidyl-prolyl cis-trans isomerase activity cyclosporin A binding isomerase activity peptide binding unfolded protein binding
3bb0A vanadium chloroperoxidase	[pdb]	2.34 0.00745	492^PHE 185^HIS 195^ASP 358^PHE 354^TRP 351^LYS	1.11.1.10	oxidation-reduction process	extracellular region membrane	catalytic activity peroxidase activity oxidoreductase activity chloride peroxidase activity metal ion binding
3qz4A endo-1,4-beta-xylanase d	[pdb]	2.34 0.00745	167^PHE 37^HIS 58^ASP 71^PHE 79^TRP 77^LYS
3eddA cyclomaltodextrinase	[pdb]	2.34 0.00745	77^PHE 188^HIS 187^ASP 13^PHE 298^TRP 21^LYS	0.0.0.0	carbohydrate metabolic process metabolic process		catalytic activity hydrolase activity hydrolase activity acting on glycosyl bonds cation binding
1iqcA di-heme peroxidase	[pdb]	2.34 0.00745	278^PHE 43^HIS 51^ASP 243^PHE 82^TRP 229^LYS	1.11.1.5	transport electron transport chain oxidation-reduction process	periplasmic space	cytochrome-c peroxidase activity peroxidase activity iron ion binding electron carrier activity oxidoreductase activity heme binding metal ion binding
2vncA glycogen operon protein glgx	[pdb]	2.35 0.00745	249^PHE 470^HIS 471^ASP 557^PHE 565^TRP 186^LYS	0.0.0.0	carbohydrate metabolic process glycogen catabolic process metabolic process		catalytic activity glycogen debranching enzyme activity hydrolase activity hydrolyzing O-glycosyl compounds hydrolase activity hydrolase activity
2iqfA catalase	[pdb]	2.35 0.00763	337^PHE 276^HIS 422^ASP 134^PHE 284^TRP 214^LYS	1.11.1.6	response to oxidative stress hydrogen peroxide catabolic process oxidation-reduction process	cytoplasm	catalase activity peroxidase activity iron ion binding oxidoreductase activity heme binding metal ion binding
2g3nC alpha-glucosidase	[pdb]	2.35 0.00763	387^PHE 214^HIS 212^ASP 222^PHE 224^TRP 233^LYS	0.0.0.0	carbohydrate metabolic process metabolic process carbohydrate metabolic process metabolic process	cytoplasm cytoplasm	catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds alpha-glucosidase activity hydrolase activity hydrolase activity acting on glycosyl bonds carbohydrate binding catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds alpha-glucosidase activity
1iu4A microbial transglutaminase	[pdb]	2.35 0.00763	85^PHE 274^HIS 255^ASP 259^PHE 272^TRP 269^LYS	2.3.2.13			protein-glutamine gamma-glutamyltransferase activity acyltransferase activity transferase activity
1ivsB valyl-trna synthetase trna (val)	[pdb]	2.35 0.00763	506^PHE 518^HIS 56^ASP 381^PHE 386^TRP 388^LYS	6.1.1.9	translation tRNA aminoacylation for protein translation valyl-tRNA aminoacylation	cytoplasm	nucleotide binding aminoacyl-tRNA ligase activity valine-tRNA ligase activity ATP binding ligase activity metal ion binding
1jofD carboxy-cis,cis-muconate cyclase	[pdb]	2.36 0.00781	287^PHE 227^HIS 223^ASP 152^PHE 170^TRP 168^LYS	5.5.1.5			isomerase activity carboxy-cis,cis-muconate cyclase activity
3nmbA putative sugar hydrolase	[pdb]	2.36 0.00781	116^PHE 273^HIS 272^ASP 279^PHE 125^TRP 206^LYS	0.0.0.0
3ck5B putative racemase	[pdb]	2.37 0.008	257^PHE 348^HIS 303^ASP 127^PHE 112^TRP 82^LYS	0.0.0.0	metabolic process cellular amino acid catabolic process		catalytic activity
3bnbA seed lipoxygenase-1	[pdb]	2.37 0.008	212^PHE 517^HIS 185^ASP 510^PHE 649^TRP 668^LYS	1.13.11.12	fatty acid biosynthetic process lipid biosynthetic process oxylipin biosynthetic process oxidation-reduction process	cytoplasm	iron ion binding lipoxygenase activity oxidoreductase activity oxidoreductase activity acting on single donors with incorporation of molecular oxygen
1hcyB arthropodan hemocyanin	[pdb]	2.37 0.00819	268^PHE 285^HIS 281^ASP 277^PHE 248^TRP 385^LYS		transport metabolic process oxygen transport	extracellular region extracellular space	oxygen transporter activity oxidoreductase activity metal ion binding
3a9gA putative uncharacterized protein	[pdb]	2.38 0.00819	328^PHE 285^HIS 339^ASP 283^PHE 295^TRP 319^LYS	0.0.0.0			catalytic activity
1dypA kappa-carrageenase	[pdb]	2.38 0.00819	282^PHE 180^HIS 179^ASP 143^PHE 144^TRP 116^LYS	3.2.1.83	carbohydrate metabolic process metabolic process	periplasmic space	hydrolase activity hydrolyzing O-glycosyl compounds hydrolase activity hydrolase activity
3m16A transaldolase	[pdb]	2.38 0.00839	219^PHE 299^HIS 295^ASP 288^PHE 144^TRP 151^LYS