The LabelHash Server
1dwwA motif
Motif residues: CYS194 VAL346 TRP366 TYR367 GLU371 ASP376
Table of Top 100 matches
Click here for a compact table with the top 100 matches.The images below show the motif residues and the match residues superimposed. The carbon atoms are white in the motif and green in the match. Other atoms in the motif and match are colored by element. The C-alphas are shown as spheres, while the remaining motif and match atoms are shown in stick representation. The rest of the matching protein is shown in ribbon representation.
Downloads
- A zip file with PDB files for the top 100 matches and the motif itself.
- An XML file with all matches. You can open this file in Chimera with our ViewMatch plugin.
Top 20 matches
For each match you can click on the "[pdb]" link to download a PDB file with the matching chain aligned with the motif.1. 1zviA [pdb]
LRMSD: 0.186666071415p-value: 0.000111301342258
Matching residues: CYS415 VAL567 TRP587 TYR588 GLU592 ASP597
EC class: 1.14.13.39
GO terms:
Molecular function: enzyme binding, protein homodimerization activity, protein binding, metal ion binding, oxidoreductase activity, calmodulin binding, iron ion binding, nitric-oxide synthase activity, NADP or NADPH binding, FAD binding, heme binding, FMN binding, electron carrier activity, cadmium ion binding, amino acid binding
Biological process: aging, regulation of heart contraction, response to heat, response to organic nitrogen, response to organic cyclic substance, response to vitamin E, response to estrogen stimulus, response to ethanol, negative regulation of blood pressure, negative regulation of heart contraction, positive regulation of vasodilation, negative regulation of insulin secretion, regulation of sensory perception of pain, oxidation reduction, nitric oxide biosynthetic process, arginine catabolic process, response to hypoxia
Cellular component: nucleus, cytoplasm, mitochondrial outer membrane, cytosol, dendrite, nuclear membrane, azurophil granule, dendritic spine, synapse, cell projection, membrane, plasma membrane, mitochondrion, sarcolemma, perinuclear region of cytoplasm, photoreceptor inner segment
2. 3e6nA [pdb]
LRMSD: 0.201589077711p-value: 0.000129252774059
Matching residues: CYS194 VAL346 TRP366 TYR367 GLU371 ASP376
EC class: 1.14.13.39
GO terms:
Molecular function: protein binding, calmodulin binding, metal ion binding, oxidoreductase activity, zinc ion binding, iron ion binding, nitric-oxide synthase activity, protein homodimerization activity, NADP or NADPH binding, FAD binding, heme binding, FMN binding, electron carrier activity, cAMP-dependent protein kinase regulator activity, tetrahydrobiopterin binding, arginine binding
Biological process: defense response to bacterium, superoxide metabolic process, inflammatory response, oxidation reduction, regulation of cell proliferation, nitric oxide biosynthetic process, response to hypoxia, ovulation from ovarian follicle, defense response to Gram-negative bacterium, retinoic acid receptor signaling pathway, regulation of blood pressure, regulation of heart contraction, protein kinase cascade, G-protein signaling, coupled to cGMP nucleotide second messenger, signal transduction, blood vessel remodeling, endothelial cell proliferation, arginine catabolic process
Cellular component: cytosol, perinuclear region of cytoplasm, cortical cytoskeleton, cytoplasm, peroxisome, nucleus
3. 1d1xB [pdb]
LRMSD: 0.235729977489p-value: 0.000177125941264
Matching residues: CYS186 VAL338 TRP358 TYR359 GLU363 ASN368
EC class: 1.14.13.39
GO terms:
Molecular function: metal ion binding, oxidoreductase activity, zinc ion binding, calmodulin binding, calcium ion binding, iron ion binding, nitric-oxide synthase activity, NADP or NADPH binding, FAD binding, heme binding, FMN binding, electron carrier activity
Biological process: mitochondrion organization, arginine catabolic process, oxidation reduction, blood coagulation, nitric oxide biosynthetic process, positive regulation of guanylate cyclase activity, anti-apoptosis, angiogenesis, ovulation from ovarian follicle, blood vessel remodeling, regulation of sodium ion transport, negative regulation of muscle hyperplasia, smooth muscle hyperplasia, lung development, lipopolysaccharide-mediated signaling pathway, negative regulation of potassium ion transport, positive regulation of angiogenesis, regulation of blood vessel size, negative regulation of hydrolase activity, negative regulation of calcium ion transport
Cellular component: Golgi apparatus, membrane, plasma membrane, cytoskeleton, cytoplasm, caveola
4. 3ej8A [pdb]
LRMSD: 0.264227926731p-value: 0.000216297223233
Matching residues: CYS200 VAL352 TRP372 TYR373 GLU377 ASP382
EC class: 1.14.13.39
GO terms:
Molecular function: protein binding, metal ion binding, oxidoreductase activity, zinc ion binding, calmodulin binding, calcium ion binding, iron ion binding, nitric-oxide synthase activity, NADP or NADPH binding, FAD binding, heme binding, FMN binding, electron carrier activity, tetrahydrobiopterin binding, protein homodimerization activity, arginine binding, cAMP-dependent protein kinase regulator activity
Biological process: defense response to bacterium, superoxide metabolic process, oxidation reduction, nitric oxide biosynthetic process, regulation of insulin secretion, arginine catabolic process, defense response to Gram-negative bacterium, innate immune response in mucosa, positive regulation of killing of cells of another organism, regulation of cellular respiration, positive regulation of leukocyte mediated cytotoxicity, response to hypoxia, endothelial cell proliferation, blood vessel remodeling, signal transduction, G-protein signaling, coupled to cGMP nucleotide second messenger, protein kinase cascade, regulation of heart contraction, regulation of blood pressure, regulation of cell proliferation, retinoic acid receptor signaling pathway
Cellular component: nucleus, cytoplasm, cytosol, intracellular, peroxisome, cortical cytoskeleton, perinuclear region of cytoplasm
5. 1m9jB [pdb]
LRMSD: 0.265418678522p-value: 0.000216308559175
Matching residues: CYS184 VAL336 TRP356 TYR357 GLU361 ASN366
EC class: 1.14.13.39
GO terms:
Molecular function: protein binding, metal ion binding, oxidoreductase activity, zinc ion binding, calmodulin binding, iron ion binding, nitric-oxide synthase activity, NADP or NADPH binding, FAD binding, heme binding, FMN binding, electron carrier activity, actin monomer binding, cadmium ion binding, tetrahydrobiopterin binding, arginine binding, calcium ion binding
Biological process: oxidation reduction, nitric oxide biosynthetic process, negative regulation of calcium ion transport, negative regulation of hydrolase activity, negative regulation of smooth muscle cell proliferation, negative regulation of potassium ion transport, lung development, learning, signal transduction, regulation of sodium ion transport, ovulation from ovarian follicle, angiogenesis, mitochondrion organization, positive regulation of guanylate cyclase activity, anti-apoptosis, positive regulation of angiogenesis, arginine catabolic process, endothelial cell migration, regulation of systemic arterial blood pressure by endothelin, response to fluid shear stress, regulation of blood vessel size, smooth muscle hyperplasia, negative regulation of muscle hyperplasia, negative regulation of cell proliferation, blood vessel remodeling, negative regulation of platelet activation, regulation of blood pressure, response to heat, positive regulation of vasodilation, lipopolysaccharide-mediated signaling pathway
Cellular component: Golgi apparatus, membrane, plasma membrane, cytoskeleton, cytoplasm, cytosol, Golgi membrane, apical part of cell, nucleus, caveola, soluble fraction
6. 1zsoA [pdb]
LRMSD: 1.26310062408p-value: 0.000437108043116
Matching residues: GLU11 ASN91 VAL117 TRP135 CYS145 TYR149
EC class: 0.0.0.0
GO terms:
7. 2yxmA [pdb]
LRMSD: 1.283031106p-value: 0.00044602676644
Matching residues: VAL29 TRP41 TYR42 ASP75 GLU77 CYS87
EC class: GO terms:
Molecular function: protein binding, actin binding, structural constituent of muscle, titin binding
Biological process: cell adhesion, striated muscle contraction
Cellular component: striated muscle thick filament, myofibril
8. 1m80B [pdb]
LRMSD: 1.49812078476p-value: 0.000663964543492
Matching residues: TRP104 CYS127 VAL242 TYR336 GLU341 ASP344
EC class: 2.7.3.3
GO terms:
Molecular function: arginine kinase activity, transferase activity, kinase activity, ATP binding, nucleotide binding, transferase activity, transferring phosphorus-containing groups, catalytic activity
Biological process: phosphorylation
Cellular component: cytoplasm
9. 1bdgA [pdb]
LRMSD: 1.51149344444p-value: 0.000693902198691
Matching residues: TRP261 PHE264 GLU269 ASP271 VAL297 CYS392
EC class: 2.7.1.1
GO terms:
Molecular function: transferase activity, kinase activity, ATP binding, nucleotide binding, hexokinase activity, phosphotransferase activity, alcohol group as acceptor
Biological process: glycolysis, carbohydrate metabolic process
10. 1yb0A [pdb]
LRMSD: 1.53459084034p-value: 0.000745540019125
Matching residues: GLU105 ASN107 VAL126 CYS137 TRP147 PHE150
EC class: 0.0.0.0
GO terms:
Molecular function: N-acetylmuramoyl-L-alanine amidase activity
Biological process: peptidoglycan catabolic process
11. 1gv4B [pdb]
LRMSD: 1.58040809631p-value: 0.000896951940376
Matching residues: GLU425 CYS440 VAL458 ASN467 TYR475 TRP476
EC class: 0.0.0.0
GO terms:
Molecular function: electron carrier activity, oxidoreductase activity, DNA binding, electron-transferring-flavoprotein dehydrogenase activity, FAD binding
Biological process: apoptotic chromosome condensation, neuron apoptosis, oxidation reduction, apoptosis, apoptotic mitochondrial changes, DNA fragmentation involved in apoptosis, cell redox homeostasis
Cellular component: mitochondrial intermembrane space, nucleus, mitochondrion, cytosol, microsome, mitochondrial outer membrane, cytoplasm, soluble fraction
12. 1m6iA [pdb]
LRMSD: 1.58202183247p-value: 0.000896994257346
Matching residues: GLU426 CYS441 VAL459 ASN468 TYR476 TRP477
EC class: 0.0.0.0
GO terms:
Molecular function: oxidoreductase activity, DNA binding, electron carrier activity, FAD binding, protein binding
Biological process: oxidation reduction, apoptosis, DNA fragmentation involved in apoptosis, DNA damage response, signal transduction resulting in induction of apoptosis, cell redox homeostasis, apoptotic chromosome condensation
Cellular component: mitochondrial intermembrane space, nucleus, mitochondrion, cytoplasm, microsome, soluble fraction
13. 1qf9A [pdb]
LRMSD: 1.6217110157p-value: 0.00103761814535
Matching residues: VAL9 CYS23 PHE30 TRP32 GLU186 ASN187
EC class: 2.7.4.14
GO terms:
Molecular function: transferase activity, kinase activity, ATP binding, nucleotide binding, cytidylate kinase activity, nucleobase, nucleoside, nucleotide kinase activity, nucleotide kinase activity, phosphotransferase activity, phosphate group as acceptor
Biological process: pyrimidine nucleotide biosynthetic process, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
14. 1arcA [pdb]
LRMSD: 1.62797546387p-value: 0.0010689785704
Matching residues: ASP9 VAL25 CYS36 TRP73 TYR75 GLU154
EC class: 3.4.21.50
GO terms:
Molecular function: hydrolase activity, serine-type peptidase activity, peptidase activity, serine-type endopeptidase activity, catalytic activity
Biological process: proteolysis
Cellular component: extracellular region
15. 1j0tA [pdb]
LRMSD: 1.63252341747p-value: 0.00110167346429
Matching residues: VAL20 CYS27 TRP49 PHE50 GLU60 ASP61
EC class: GO terms:
Molecular function: hormone activity, neuropeptide hormone activity
Biological process: neuropeptide signaling pathway
Cellular component: extracellular region
16. 2bo6B [pdb]
LRMSD: 1.63921666145p-value: 0.00113589165267
Matching residues: CYS233 VAL324 ASP335 GLU337 PHE341 TRP344
EC class: 0.0.0.0
GO terms:
17. 1yvjA [pdb]
LRMSD: 1.66418170929p-value: 0.0012481934391
Matching residues: VAL946 TRP993 TYR994 GLU997 ASP1001 CYS1077
EC class: 2.7.10.2
GO terms:
Molecular function: transferase activity, kinase activity, ATP binding, protein tyrosine kinase activity, nucleotide binding, non-membrane spanning protein tyrosine kinase activity, protein binding, Janus kinase activity, protein kinase activity
Biological process: enzyme linked receptor protein signaling pathway, protein kinase cascade, peptidyl-tyrosine phosphorylation, cytokine-mediated signaling pathway, positive regulation of transcription from RNA polymerase II promoter, protein amino acid phosphorylation
Cellular component: endomembrane system, membrane, cytoskeleton
18. 1ia6A [pdb]
LRMSD: 1.70064163208p-value: 0.00146452814806
Matching residues: TRP76 TYR79 GLU83 ASP86 CYS321 VAL422
EC class: 0.0.0.0
GO terms:
Molecular function: hydrolase activity, hydrolyzing O-glycosyl compounds, catalytic activity
Biological process: carbohydrate metabolic process, polysaccharide catabolic process
19. 2iqfA [pdb]
LRMSD: 1.70243024826p-value: 0.00151295843534
Matching residues: GLU89 TYR117 TRP124 ASN300 VAL356 CYS361
EC class: 1.11.1.6
GO terms:
Molecular function: oxidoreductase activity, peroxidase activity, catalase activity, heme binding, iron ion binding, metal ion binding, oxidoreductase activity, iron ion binding, peroxidase activity, catalase activity, heme binding, metal ion binding
Biological process: oxidation reduction, response to oxidative stress, oxidation reduction, hydrogen peroxide catabolic process, response to oxidative stress, hydrogen peroxide catabolic process
Cellular component: cytoplasm
20. 1bbpD [pdb]
LRMSD: 1.71368670464p-value: 0.00156408082694
Matching residues: VAL30 ASN35 GLU38 TRP45 TYR60 CYS175
EC class: 0.0.0.0
GO terms:
Molecular function: pigment binding, binding, transporter activity
Biological process: protein-chromophore linkage, transport
Cellular component: extracellular region
