The LabelHash Server

Top 150 matches

For each match you can click on the "[pdb]" link to download a PDB file with the matching chain aligned with the motif.
Download a zip file with PDB files for all the matches and the motif itself.

PDB ID		LRMSD / p-value	Matching Residues	EC	Gene Ontology annotations
PDB ID		LRMSD / p-value	Matching Residues	EC	Biological Process	Cellular Component	Molecular Function
1a53A indole-3-glycerolphosphate synthase	[pdb]	0.11 2.59e-05	51^GLU 56^SER 57^PRO 89^PHE 91^GLY 112^PHE 159^GLU 180^ASN 211^SER 233^GLY	4.1.1.48	tryptophan biosynthetic process tryptophan metabolic process metabolic process cellular amino acid biosynthetic process aromatic amino acid family biosynthetic process		catalytic activity indole-3-glycerol-phosphate synthase activity lyase activity carboxy-lyase activity
1vc4B indole-3-glycerol phosphate synthase	[pdb]	0.246 7.21e-05	51^GLU 56^SER 57^PRO 91^PHE 93^GLY 114^PHE 160^GLU 181^ASN 215^SER 236^GLY	0.0.0.0	tryptophan biosynthetic process metabolic process cellular amino acid biosynthetic process aromatic amino acid family biosynthetic process		catalytic activity indole-3-glycerol-phosphate synthase activity lyase activity
1jcmP indole-3-glycerol-phosphate synthase	[pdb]	0.297 9.11e-05	53^GLU 58^SER 59^PRO 93^PHE 95^GLY 116^PHE 163^GLU 184^ASN 215^SER 236^GLY	4.1.1.48, 5.3.1.24	tryptophan biosynthetic process tryptophan metabolic process metabolic process cellular amino acid biosynthetic process aromatic amino acid family biosynthetic process		catalytic activity indole-3-glycerol-phosphate synthase activity phosphoribosylanthranilate isomerase activity lyase activity carboxy-lyase activity isomerase activity
1i4nA indole-3-glycerol phosphate synthase	[pdb]	0.544 0.000165	47^GLU 52^SER 53^PRO 87^PHE 89^GLY 110^PHE 157^GLU 179^ASN 210^SER 231^GLY	4.1.1.48	tryptophan biosynthetic process tryptophan metabolic process metabolic process cellular amino acid biosynthetic process aromatic amino acid family biosynthetic process		catalytic activity indole-3-glycerol-phosphate synthase activity lyase activity carboxy-lyase activity
1j5tA indole-3-glycerol phosphate synthase	[pdb]	0.579 0.000177	25^GLU 30^SER 31^PRO 65^PHE 67^GLY 88^PHE 135^GLU 157^ASN 188^SER 209^GLY	4.1.1.48	tryptophan biosynthetic process tryptophan metabolic process metabolic process cellular amino acid biosynthetic process aromatic amino acid family biosynthetic process		catalytic activity indole-3-glycerol-phosphate synthase activity lyase activity carboxy-lyase activity
2gqfA hypothetical protein hi0933	[pdb]	2.62 0.000247	336^GLU 240^SER 242^PRO 234^PHE 238^GLY 330^PHE 255^GLU 249^ASN 195^SER 337^GLY	0.0.0.0
1uc4A diol dehydrase beta subunit diol dehydrase alpha subunit diol dehydrase gamma subunit	[pdb]	2.77 0.000344	170^LYS 139^ILE 138^ALA 166^ARG 161^THR 384^PHE 379^GLU 334^ASN 333^SER 363^GLY	0.0.0.0	metabolic process		catalytic activity lyase activity hydro-lyase activity cobalamin binding propanediol dehydratase activity lyase activity propanediol dehydratase activity lyase activity propanediol dehydratase activity
2vtzB acetyl-coa acetyltransferase	[pdb]	2.79 0.000369	217^GLU 118^SER 26^PRO 22^PHE 20^GLY 202^PHE 198^GLU 359^ASN 353^SER 347^GLY	2.3.1.9	metabolic process poly-hydroxybutyrate biosynthetic process	cytoplasm	catalytic activity acetyl-CoA C-acetyltransferase activity acyltransferase activity transferase activity transferase activity
3h0lV glutamyl-trna(gln) amidotransferase subunit a aspartyl/glutamyl-trna(asn/gln) amidotransferasesubunit b glutamyl-trna(gln) amidotransferase subunit c	[pdb]	2.84 0.000448	347^LEU 125^HIS 144^LEU 404^SER 405^GLN 132^LYS 90^ARG 74^ALA 147^ALA 123^ARG	0.0.0.0	translation translation translation regulation of translational fidelity		nucleotide binding ATP binding ligase activity carbon-nitrogen ligase activity with glutamine as amido-N-donor nucleotide binding ATP binding ligase activity carbon-nitrogen ligase activity with glutamine as amido-N-donor nucleotide binding
3nqhA glycosyl hydrolase	[pdb]	2.86 0.000488	254^GLU 308^SER 299^PRO 251^PHE 249^GLY 222^PHE 229^GLU 260^ASN 256^SER 255^GLY	0.0.0.0	carbohydrate metabolic process		hydrolase activity hydrolyzing O-glycosyl compounds
2qm0B bes	[pdb]	2.87 0.000503	248^GLU 180^SER 182^PRO 178^PHE 265^GLY 244^PHE 232^GLU 228^ASN 217^SER 216^GLY	0.0.0.0
1jfrB lipase	[pdb]	2.89 0.000551	6^GLU 79^SER 75^PRO 82^PHE 55^GLY 230^PHE 238^GLU 13^ASN 15^SER 8^GLY	0.0.0.0			hydrolase activity
3nssA neuraminidase	[pdb]	2.9 0.000568	119^GLU 404^SER 459^PRO 374^PHE 351^GLY 446^PHE 165^GLU 104^ASN 105^SER 441^GLY	0.0.0.0	carbohydrate metabolic process metabolic process	membrane integral to membrane virion host cell plasma membrane host cell membrane	exo-alpha-sialidase activity hydrolase activity hydrolase activity
3b7eA neuraminidase	[pdb]	2.91 0.000585	119^GLU 404^SER 459^PRO 374^PHE 363^GLY 446^PHE 165^GLU 104^ASN 442^SER 441^GLY	3.2.1.18	carbohydrate metabolic process metabolic process	membrane integral to membrane virion host cell plasma membrane host cell membrane virion membrane	exo-alpha-sialidase activity hydrolase activity hydrolase activity acting on glycosyl bonds
3fkjB putative phosphosugar isomerases	[pdb]	2.93 0.00064	159^GLU 168^SER 132^PRO 293^PHE 290^GLY 42^PHE 146^GLU 7^ASN 2^SER 165^GLY	0.0.0.0	carbohydrate metabolic process		sugar binding isomerase activity
2ivfA ethylbenzene dehydrogenase alpha-subunit ethylbenzene dehydrogenase beta-subunit ethylbenzene dehydrogenase gamma-subunit	[pdb]	2.95 0.000699	660^GLU 91^ASP 664^PRO 670^PHE 766^GLY 753^PHE 742^GLU 487^ASN 197^ARG 196^GLU	0.0.0.0	oxidation-reduction process oxidation-reduction process	periplasmic space	heme binding binding oxidoreductase activity molybdenum ion binding metal ion binding
3kfuH glutamyl-trna(gln) amidotransferase subunit a glutamyl-trna(gln) amidotransferase subunit c trna-asn non-discriminating and archaeal-type aspartyl-trnasynthetase aspartyl/glutamyl-trna(asn/gln) amidotransferase subunit b	[pdb]	2.97 0.000764	337^ASN 119^LEU 138^ASN 394^PHE 395^GLY 126^SER 84^ARG 68^G 141^GLY 117^LEU		translation tRNA aminoacylation for protein translation aspartyl-tRNA aminoacylation translation translation translation regulation of translational fidelity	cytoplasm	nucleotide binding nucleic acid binding aminoacyl-tRNA ligase activity aspartate-tRNA ligase activity ATP binding nucleotide binding ATP binding ligase activity carbon-nitrogen ligase activity with glutamine as amido-N-donor nucleotide binding ATP binding ligase activity carbon-nitrogen ligase activity with glutamine as amido-N-donor nucleotide binding
1e04I antithrombin-iii	[pdb]	2.98 0.000787	326^GLU 79^SER 80^PRO 422^PHE 424^GLY 221^PHE 195^GLU 192^ASN 191^SER 328^GLY		response to nutrient blood coagulation negative regulation of inflammatory response	extracellular region extracellular space plasma membrane	protease binding serine-type endopeptidase inhibitor activity protein binding heparin binding peptidase inhibitor activity
2as0B hypothetical protein ph1915	[pdb]	2.99 0.000811	105^GLU 127^SER 35^PRO 53^PHE 52^GLY 133^PHE 153^GLU 155^ASN 159^SER 111^GLY	0.0.0.0			RNA binding
2xa7M ap-2 complex subunit beta adaptor-related protein complex 2, alpha 2 subunit ap-2 complex subunit mu, tgn38 cargo peptide ap-2 complex subunit sigma	[pdb]	2.99 0.000834	402^GLU 408^SER 407^PRO 322^PHE 371^GLY 298^PHE 443^GLU 182^ASN 180^SER 437^GLY	0.0.0.0	transport intracellular protein transport protein transport vesicle-mediated transport transport intracellular protein transport protein transport vesicle-mediated transport regulation of defense response to virus by virus transport intracellular protein transport protein transport vesicle-mediated transport intracellular protein transport protein transport vesicle-mediated transport	plasma membrane coated pit membrane membrane coat AP-2 adaptor complex cytosol plasma membrane coated pit membrane membrane coat clathrin adaptor complex endocytic vesicle membrane mitochondrion plasma membrane coated pit membrane clathrin vesicle coat clathrin adaptor complex clathrin coat of coated pit transport vesicle membrane membrane coat clathrin adaptor complex	protein binding protein transporter activity binding protein binding protein transporter activity clathrin binding protein binding lipid binding binding protein binding protein transporter activity
2e3tB xanthine dehydrogenase/oxidase	[pdb]	3 0.000858	871^GLU 865^SER 841^PRO 864^PHE 898^GLY 914^PHE 802^GLU 908^ASN 907^SER 868^GLY	1.17.1.4, 1.17.3.2	xanthine catabolic process response to aluminum ion bone resorption oxidation-reduction process	extracellular region cytoplasm peroxisome cytosol	catalytic activity xanthine dehydrogenase activity xanthine oxidase activity binding iron ion binding electron carrier activity oxidoreductase activity molybdenum ion binding molybdopterin cofactor binding metal ion binding flavin adenine dinucleotide binding iron-sulfur cluster binding 2 iron
1sb7A trna pseudouridine synthase d	[pdb]	3.03 0.000963	336^GLU 328^SER 325^PRO 329^PHE 161^GLY 27^PHE 319^GLU 311^ASN 309^SER 155^GLY	0.0.0.0	pseudouridine synthesis tRNA processing RNA modification		RNA binding protein binding pseudouridine synthase activity isomerase activity
2z2oC virginiamycin b lyase	[pdb]	3.06 0.00108	200^GLU 144^SER 101^PRO 145^PHE 187^GLY 156^PHE 175^GLU 138^ASN 141^SER 184^GLY	0.0.0.0	antibiotic catabolic process response to antibiotic		magnesium ion binding lyase activity carbon-oxygen lyase activity metal ion binding
3ml6D chimeric complex between protein dishevlled2 homolog dvl-2and clathrin adaptor ap-2 complex subunit mu	[pdb]	3.08 0.00118	1391^GLU 1397^SER 1396^PRO 1311^PHE 1360^GLY 1287^PHE 1432^GLU 1182^ASN 1180^SER 1426^GLY	0.0.0.0	transport intracellular protein transport protein transport vesicle-mediated transport neural tube closure heart morphogenesis transcription from RNA polymerase II promoter multicellular organismal development segment specification heart development Wnt receptor signaling pathway convergent extension involved in neural plate elongation segmentation positive regulation of JUN kinase activity convergent extension involved in organogenesis canonical Wnt receptor signaling pathway Wnt receptor signaling pathway planar cell polarity pathway cochlea morphogenesis	mitochondrion plasma membrane coated pit membrane clathrin vesicle coat clathrin adaptor complex clathrin coat of coated pit transport vesicle intracellular soluble fraction nucleus cytoplasm cytoskeleton plasma membrane clathrin-coated vesicle apical part of cell	protein binding lipid binding signal transducer activity protein binding protein domain specific binding identical protein binding
3hoaA thermostable carboxypeptidase 1	[pdb]	3.09 0.00125	324^GLU 341^SER 206^PRO 345^PHE 338^GLY 267^PHE 313^GLU 314^ASN 319^SER 321^GLY	0.0.0.0	proteolysis		carboxypeptidase activity metallocarboxypeptidase activity hydrolase activity
1iwpL glycerol dehydratase beta subunit glycerol dehydratase gamma subunit glycerol dehydratase alpha subunit	[pdb]	3.1 0.00128	171^HOH 140^GLY 139^LYS 167^HOH 163^HOH 385^PHE 383^GLU 379^ASN 378^SER 364^GLY	0.0.0.0	metabolic process		lyase activity glycerol dehydratase activity catalytic activity lyase activity hydro-lyase activity cobalamin binding glycerol dehydratase activity lyase activity glycerol dehydratase activity
3hhdD fatty acid synthase	[pdb]	3.1 0.00128	304^GLU 162^SER 334^PRO 395^PHE 396^GLY 200^PHE 209^GLU 328^ASN 324^SER 294^GLY	2.3.1.39, 1.3.1.10, 2.3.1.85, 4.2.1.61, 2.3.1.41, 1.1.1.100, 3.1.2.14, 2.3.1.38	fatty acid metabolic process fatty acid biosynthetic process metabolic process lipid biosynthetic process biosynthetic process oxidation-reduction process	cytoplasm mitochondrion Golgi apparatus cytosol melanosome glycogen granule	acyl carrier activity catalytic activity fatty acid synthase activity [acyl-carrier-protein] S-acetyltransferase activity [acyl-carrier-protein] S-malonyltransferase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity 3-oxoacyl-[acyl-carrier-protein] reductase activity 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity enoyl-[acyl-carrier-protein] reductase (NADPH B-specific) activity oleoyl-[acyl-carrier-protein] hydrolase activity binding protein binding zinc ion binding oxidoreductase activity transferase activity hydrolase activity hydrolase activity acting on ester bonds lyase activity 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
1tvnA cellulase	[pdb]	3.1 0.00132	286^GLU 25^SER 24^PRO 21^PHE 293^GLY 246^PHE 238^GLU 235^ASN 280^SER 281^GLY	0.0.0.0	carbohydrate metabolic process cell adhesion metabolic process	extracellular region	catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds calcium ion binding cellulase activity hydrolase activity hydrolase activity acting on glycosyl bonds
2jf7A strictosidine-o-beta-d-glucosidase	[pdb]	3.11 0.00132	416^GLU 113^SER 155^PRO 49^PHE 461^GLY 339^PHE 207^GLU 206^ASN 54^SER 52^GLY	0.0.0.0	carbohydrate metabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds
3h5cA vitamin k-dependent protein z protein z-dependent protease inhibitor	[pdb]	3.11 0.00132	129^ASP 85^ALA 81^ASN 82^CYS 142^ALA 217^ALA 136^LEU 274^LEU 408^SER 126^VAL	0.0.0.0	proteolysis blood coagulation tissue regeneration	extracellular region extracellular region	catalytic activity serine-type endopeptidase activity calcium ion binding serine-type endopeptidase inhibitor activity peptidase inhibitor activity
3o84B peptide arylation enzyme	[pdb]	3.12 0.0014	341^GLU 247^SER 248^PRO 243^PHE 198^GLY 193^PHE 190^GLU 212^ASN 217^SER 342^GLY	0.0.0.0	metabolic process siderophore biosynthetic process		catalytic activity (2,3-dihydroxybenzoyl)adenylate synthase activity
2j5nA 1-pyrroline-5-carboxylate dehydrogenase	[pdb]	3.13 0.00144	369^GLU 350^SER 358^PRO 317^PHE 319^GLY 185^PHE 123^GLU 57^ASN 59^SER 396^GLY	0.0.0.0	proline biosynthetic process metabolic process oxidation-reduction process		1-pyrroline-5-carboxylate dehydrogenase activity oxidoreductase activity
3pqsA transferrin-binding protein	[pdb]	3.13 0.00148	46^GLU 137^SER 261^PRO 109^PHE 133^GLY 281^PHE 225^GLU 227^ASN 229^SER 315^GLY			membrane
2hu0D neuramindase	[pdb]	3.14 0.00148	119^GLU 404^SER 459^PRO 374^PHE 363^GLY 446^PHE 165^GLU 104^ASN 440^SER 441^GLY	0.0.0.0	carbohydrate metabolic process metabolic process	membrane integral to membrane virion host cell plasma membrane host cell membrane	exo-alpha-sialidase activity hydrolase activity hydrolase activity
2qh5B mannose-6-phosphate isomerase	[pdb]	3.16 0.00162	166^GLU 186^SER 109^PRO 139^PHE 140^GLY 135^PHE 199^GLU 90^ASN 243^SER 151^GLY	0.0.0.0	polysaccharide metabolic process biosynthetic process lipopolysaccharide biosynthetic process		nucleotidyltransferase activity isomerase activity
3advB peroxisome proliferator-activated receptor gamma	[pdb]	3.17 0.00171	343^GLU 245^SER 246^PRO 247^PHE 258^GLY 352^PHE 365^GLU 335^ASN 332^SER 344^GLY	0.0.0.0	negative regulation of transcription from RNA polymerase II promoter negative regulation of cytokine production placenta development negative regulation of acute inflammatory response regulation of transcription DNA-dependent regulation of transcription from RNA polymerase II promoter lipid metabolic process induction of apoptosis activation of caspase activity signal transduction response to nutrient regulation of blood pressure negative regulation of cell proliferation response to cold response to organic substance positive regulation of gene-specific transcription from RNA polymerase II promoter negative regulation of gene-specific transcription from RNA polymerase II promoter negative regulation of macrophage derived foam cell differentiation negative regulation of receptor biosynthetic process negative regulation of cholesterol storage negative regulation of sequestering of triglyceride response to organic cyclic compound long-chain fatty acid transport regulation of lipid metabolic process fatty acid oxidation monocyte differentiation negative regulation of cell growth epithelial cell differentiation response to caffeine organ regeneration cellular response to insulin stimulus response to vitamin A response to lipid response to drug glucose homeostasis lipoprotein transport response to estrogen stimulus innate immune response cell fate commitment fat cell differentiation regulation of fat cell differentiation positive regulation of fat cell differentiation low-density lipoprotein particle receptor biosynthetic process negative regulation of transcription DNA-dependent positive regulation of transcription from RNA polymerase II promoter positive regulation of fatty acid oxidation cell maturation positive regulation of oligodendrocyte differentiation white fat cell differentiation brown fat cell differentiation positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of telomerase activity lipid homeostasis	nucleus cytosol	DNA binding chromatin binding sequence-specific DNA binding transcription factor activity steroid hormone receptor activity receptor activity ligand-dependent nuclear receptor activity prostaglandin receptor activity protein binding drug binding zinc ion binding promoter binding transcription activator activity transcription repressor activity specific transcriptional repressor activity activating transcription factor binding sequence-specific DNA binding metal ion binding retinoid X receptor binding arachidonic acid binding
1kv9A type ii quinohemoprotein alcohol dehydrogenase	[pdb]	3.18 0.00177	173^GLU 376^SER 375^PRO 378^PHE 524^GLY 425^PHE 409^GLU 255^ASN 293^SER 249^GLY	0.0.0.0	oxidation-reduction process	membrane outer membrane-bounded periplasmic space	iron ion binding calcium ion binding electron carrier activity oxidoreductase activity acting on CH-OH group of donors
1h6eA clathrin coat assembly protein ap50 cytotoxic t-lymphocyte protein 4	[pdb]	3.19 0.00187	391^GLU 397^SER 396^PRO 311^PHE 360^GLY 287^PHE 432^GLU 182^ASN 180^SER 426^GLY	0.0.0.0	immune response negative regulation of T cell proliferation negative regulation of regulatory T cell differentiation negative regulation of immune response transport intracellular protein transport protein transport vesicle-mediated transport regulation of defense response to virus by virus transport intracellular protein transport protein transport vesicle-mediated transport transport intracellular protein transport protein transport vesicle-mediated transport	Golgi apparatus integral to plasma membrane external side of plasma membrane membrane integral to membrane clathrin-coated endocytic vesicle perinuclear region of cytoplasm peroxisomal membrane cytosol plasma membrane coated pit membrane clathrin adaptor complex clathrin coat of coated pit endocytic vesicle membrane mitochondrion plasma membrane coated pit membrane clathrin adaptor complex clathrin coat of coated pit stored secretory granule mitochondrion plasma membrane coated pit membrane clathrin vesicle coat clathrin adaptor complex clathrin coat of coated pit transport vesicle	protein binding transporter activity protein binding lipid binding protein binding lipid binding protein binding lipid binding
3ahyA beta-glucosidase	[pdb]	3.19 0.00187	367^GLU 71^SER 113^PRO 114^PHE 294^GLY 118^PHE 424^GLU 422^ASN 418^SER 369^GLY	0.0.0.0	carbohydrate metabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds
3dzuD dna (5'-d(dcpdtpdgpdapdcpdcpdtpdtpdtpdgpdapdcpdcpdtpdapdgpdt pdtpdtpdg)-3') retinoic acid receptor rxr-alpha ncoa2 peptide dna (5'-d(dcpdapdapdapdcpdtpdapdgpdgpdtpdcpdapdapdapdgpdgpdt pdcpdapdg)-3') peroxisome proliferator-activated receptor gamma	[pdb]	3.19 0.00187	343^GLU 245^SER 246^PRO 247^PHE 258^GLY 352^PHE 365^GLU 335^ASN 332^SER 344^GLY		negative regulation of transcription from RNA polymerase II promoter negative regulation of cytokine production placenta development negative regulation of acute inflammatory response regulation of transcription DNA-dependent regulation of transcription from RNA polymerase II promoter lipid metabolic process induction of apoptosis activation of caspase activity signal transduction response to nutrient regulation of blood pressure negative regulation of cell proliferation response to cold response to organic substance positive regulation of gene-specific transcription from RNA polymerase II promoter negative regulation of gene-specific transcription from RNA polymerase II promoter negative regulation of macrophage derived foam cell differentiation negative regulation of receptor biosynthetic process negative regulation of cholesterol storage negative regulation of sequestering of triglyceride response to organic cyclic compound long-chain fatty acid transport regulation of lipid metabolic process fatty acid oxidation monocyte differentiation negative regulation of cell growth epithelial cell differentiation response to caffeine organ regeneration cellular response to insulin stimulus response to vitamin A response to lipid response to drug glucose homeostasis lipoprotein transport response to estrogen stimulus innate immune response cell fate commitment fat cell differentiation regulation of fat cell differentiation positive regulation of fat cell differentiation low-density lipoprotein particle receptor biosynthetic process negative regulation of transcription DNA-dependent positive regulation of transcription from RNA polymerase II promoter positive regulation of fatty acid oxidation cell maturation positive regulation of oligodendrocyte differentiation white fat cell differentiation brown fat cell differentiation positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of telomerase activity lipid homeostasis response to low-density lipoprotein particle stimulus regulation of cholesterol transporter activity liver development placenta development regulation of transcription DNA-dependent regulation of transcription from RNA polymerase II promoter vitamin metabolic process inflammatory response midgut development heart development female pregnancy aging response to nutrient cholesterol metabolic process negative regulation of cell proliferation response to selenium ion positive regulation of gene-specific transcription from RNA polymerase II promoter negative regulation of gene-specific transcription from RNA polymerase II promoter response to organic cyclic compound axon regeneration response to retinoic acid cellular response to insulin stimulus response to vitamin A response to vitamin D positive regulation of apoptosis interspecies interaction between organisms positive regulation of transcription from RNA polymerase II promoter retinoic acid receptor signaling pathway response to glucocorticoid stimulus ventricular cardiac muscle tissue morphogenesis ventricular cardiac muscle cell differentiation cardiac muscle cell proliferation secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development regulation of branching involved in prostate gland morphogenesis	nucleus cytosol nucleus axon nucleus	DNA binding chromatin binding sequence-specific DNA binding transcription factor activity steroid hormone receptor activity receptor activity ligand-dependent nuclear receptor activity prostaglandin receptor activity protein binding drug binding zinc ion binding promoter binding transcription activator activity transcription repressor activity specific transcriptional repressor activity activating transcription factor binding sequence-specific DNA binding metal ion binding retinoid X receptor binding arachidonic acid binding DNA binding double-stranded DNA binding sequence-specific DNA binding transcription factor activity ligand-regulated transcription factor activity steroid hormone receptor activity retinoic acid receptor activity transcription coactivator activity receptor activity ligand-dependent nuclear receptor activity retinoid-X receptor activity protein binding zinc ion binding promoter binding transcription regulator activity vitamin D receptor binding sequence-specific DNA binding metal ion binding protein heterodimerization activity vitamin D response element binding transcription coactivator activity histone acetyltransferase activity signal transducer activity protein binding ligand-dependent nuclear receptor binding transcription regulator activity nuclear hormone receptor binding
2dvkA upf0130 protein ape0816	[pdb]	3.19 0.00187	108^GLU 135^SER 91^PRO 115^PHE 114^GLY 177^PHE 182^GLU 29^ASN 36^SER 119^GLY	0.0.0.0
1wpxA carboxypeptidase y carboxypeptidase y inhibitor	[pdb]	3.19 0.00187	296^GLU 69^SER 68^PRO 63^PHE 72^GLY 401^PHE 145^GLU 51^ASN 58^SER 100^GLY	3.4.16.5	regulation of proteolysis regulation of Ras protein signal transduction proteolysis vacuolar protein catabolic process phytochelatin biosynthetic process	fungal-type vacuole lumen fungal-type vacuole membrane cytoplasm fungal-type vacuole fungal-type vacuole lumen cytoplasm vacuole endoplasmic reticulum	serine-type endopeptidase inhibitor activity phospholipid binding peptidase inhibitor activity carboxypeptidase activity serine-type carboxypeptidase activity protein binding peptidase activity hydrolase activity
3pdwA uncharacterized hydrolase yutf	[pdb]	3.19 0.00187	96^GLU 146^SER 178^PRO 144^PHE 134^GLY 117^PHE 104^GLU 106^ASN 75^SER 121^GLY		metabolic process		catalytic activity hydrolase activity
3kzsC glycosyl hydrolase family 5	[pdb]	3.21 0.00204	284^GLU 319^SER 279^PRO 320^PHE 321^GLY 316^PHE 262^GLU 264^ASN 240^SER 283^GLY	0.0.0.0	carbohydrate metabolic process		catalytic activity cation binding
1ebdA dihydrolipoamide acetyltransferase dihydrolipoamide dehydrogenase	[pdb]	3.21 0.00204	190^GLU 178^SER 176^PRO 198^PHE 199^GLY 85^PHE 90^GLU 171^ASN 166^PHE 192^GLY	1.8.1.4	glycolysis cell redox homeostasis oxidation-reduction process glycolysis metabolic process	cytoplasm	dihydrolipoyl dehydrogenase activity oxidoreductase activity flavin adenine dinucleotide binding dihydrolipoyllysine-residue acetyltransferase activity protein binding acyltransferase activity transferase activity
1h0gA argadin chitinase b	[pdb]	3.22 0.0021	144^GLU 50^SER 14^PRO 12^PHE 9^GLY 136^PHE 59^GLU 55^ASN 106^SER 96^GLY	3.2.1.14	polysaccharide catabolic process carbohydrate metabolic process chitin catabolic process metabolic process	extracellular region	catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds chitinase activity hydrolase activity hydrolase activity acting on glycosyl bonds
1rf8A eukaryotic translation initiation factor 4e eukaryotic initiation factor 4f subunit p150	[pdb]	3.23 0.00217	170^GLU 210^SER 209^PRO 196^PHE 179^GLY 163^PHE 103^GLU 203^ASN 201^SER 112^GLY	0.0.0.0	translation translational initiation regulation of translation RNA metabolic process stress granule assembly ribosomal large subunit biogenesis nuclear-transcribed mRNA catabolic process nonsense-mediated decay translation translational initiation regulation of translation	cytoplasm mitochondrion ribosome stress granule eukaryotic translation initiation factor 4F complex nucleus cytoplasm ribosome stress granule eukaryotic translation initiation factor 4F complex	RNA binding translation initiation factor activity binding protein binding RNA binding translation initiation factor activity protein binding phosphatidylinositol-3-phosphate binding
3agrB nucleoside triphosphate hydrolase	[pdb]	3.23 0.00217	253^GLU 297^SER 264^PRO 263^PHE 250^GLY 454^PHE 448^GLU 439^ASN 444^SER 213^GLY
1nf0A triosephosphate isomerase	[pdb]	3.24 0.00223	239^GLU 211^SER 178^PRO 229^PHE 232^GLY 6^PHE 34^GLU 248^ASN 246^SER 214^GLY	5.3.1.1	gluconeogenesis glycolysis pentose-phosphate shunt fatty acid biosynthetic process metabolic process lipid biosynthetic process	plasma membrane enriched fraction cytoplasm mitochondrion	catalytic activity triose-phosphate isomerase activity isomerase activity
2d1gA acid phosphatase	[pdb]	3.24 0.0023	43^GLU 46^SER 413^PRO 168^PHE 169^GLY 172^PHE 107^GLU 105^ASN 103^SER 349^GLY	0.0.0.0			hydrolase activity acting on ester bonds
1tvcA methane monooxygenase component c	[pdb]	3.25 0.00237	46^GLU 65^SER 66^PRO 50^PHE 106^GLY 12^PHE 73^GLU 71^ASN 135^SER 48^GLY	1.14.13.25	one-carbon metabolic process transport electron transport chain oxidation-reduction process		monooxygenase activity electron carrier activity methane monooxygenase activity oxidoreductase activity metal ion binding iron-sulfur cluster binding 2 iron
3ei4E dna damage-binding protein 2 dna damage-binding protein 1	[pdb]	3.25 0.00237	958^GLU 929^SER 951^PRO 975^PHE 996^GLY 998^PHE 1002^GLU 970^ASN 955^SER 924^GLY	0.0.0.0	cell cycle checkpoint nucleotide-excision repair DNA damage removal DNA repair nucleotide-excision repair response to DNA damage stimulus protein ubiquitination involved in ubiquitin-dependent protein catabolic process proteasomal ubiquitin-dependent protein catabolic process interspecies interaction between organisms protein polyubiquitination nucleotide-excision repair DNA damage removal DNA repair nucleotide-excision repair pyrimidine dimer repair response to DNA damage stimulus	nucleus nucleoplasm cytoplasm Cul4A-RING ubiquitin ligase complex Cul4B-RING ubiquitin ligase complex nucleus nucleoplasm protein complex	nucleic acid binding DNA binding damaged DNA binding protein binding DNA binding damaged DNA binding protein binding ubiquitin-protein ligase activity
2w61A glycolipid-anchored surface protein 2	[pdb]	3.25 0.00237	435^GLU 440^SER 385^PRO 439^PHE 437^GLY 415^PHE 143^GLU 141^ASN 187^SER 434^GLY	0.0.0.0	carbohydrate metabolic process cellular cell wall organization ascospore wall assembly	cytoplasm plasma membrane membrane anchored to membrane	catalytic activity transferase activity 1,3-beta-glucanosyltransferase activity cation binding
1z33A purine nucleoside phosphorylase	[pdb]	3.25 0.00237	179^GLU 108^SER 126^PRO 106^PHE 151^GLY 173^PHE 165^GLU 112^ASN 113^SER 65^GLY	0.0.0.0
1djhA phosphoinositide-specific phospholipase c,isozyme delta1	[pdb]	3.26 0.00244	534^GLU 509^SER 611^PRO 507^PHE 506^GLY 523^PHE 566^GLU 569^ASN 617^SER 536^GLY	3.1.4.11	lipid metabolic process signal transduction G-protein coupled receptor protein signaling pathway response to aluminum ion response to organic nitrogen positive regulation of norepinephrine secretion lipid catabolic process positive regulation of inositol trisphosphate biosynthetic process response to prostaglandin F stimulus response to peptide hormone stimulus elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger response to calcium ion response to hyperoxia	membrane fraction nucleus cytosol mitochondrial membrane membrane raft	phosphatidylinositol phospholipase C activity phospholipase C activity signal transducer activity calcium ion binding protein binding phospholipid binding phosphatidylinositol-4,5-bisphosphate binding phosphoric diester hydrolase activity hydrolase activity metal ion binding
2a2mA hypothetical protein bt3146	[pdb]	3.26 0.00244	165^GLU 112^SER 17^PRO 14^PHE 86^GLY 106^PHE 207^GLU 204^ASN 30^SER 198^GLY	0.0.0.0
2c0hA mannan endo-1,4-beta-mannosidase	[pdb]	3.27 0.00259	308^GLU 332^SER 303^PRO 34^PHE 333^GLY 291^PHE 288^GLU 241^ASN 239^SER 307^GLY	3.2.1.78	carbohydrate metabolic process metabolic process mannan catabolic process	cellular_component	catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds hydrolase activity hydrolase activity acting on glycosyl bonds
1nphA gelsolin	[pdb]	3.28 0.00267	607^GLU 558^SER 556^PRO 614^PHE 613^GLY 567^PHE 587^GLU 564^ASN 563^SER 608^GLY	0.0.0.0	apoptosis aging actin polymerization or depolymerization oligodendrocyte development vesicle-mediated transport actin filament polymerization regulation of cell adhesion wound healing tissue regeneration response to ethanol response to cadmium ion phosphatidylinositol-mediated signaling actin filament severing response to folic acid actin filament capping	extracellular region extracellular space cytoplasm cytosol cytoskeleton lamellipodium protein complex perinuclear region of cytoplasm	actin binding protein binding
3bs8A glutamate-1-semialdehyde 2,1-aminomutase	[pdb]	3.29 0.00283	54^GLU 7^SER 36^PRO 38^PHE 42^GLY 393^PHE 390^GLU 389^ASN 3^SER 52^GLY	5.4.3.8	porphyrin biosynthetic process tetrapyrrole biosynthetic process	cytoplasm	catalytic activity transaminase activity isomerase activity pyridoxal phosphate binding glutamate-1-semialdehyde 2,1-aminomutase activity
1xuaA phenazine biosynthesis protein phzf	[pdb]	3.3 0.00292	263^GLU 213^SER 75^PRO 71^PHE 99^GLY 103^PHE 106^GLU 267^ASN 265^SER 216^GLY	0.0.0.0	biosynthetic process pathogenesis antibiotic biosynthetic process		catalytic activity isomerase activity
2wabA endoglucanase e	[pdb]	3.3 0.00292	96^GLU 68^SER 66^PRO 67^PHE 51^GLY 147^PHE 307^GLU 138^ASN 154^SER 31^GLY	3.2.1.4	polysaccharide catabolic process carbohydrate metabolic process lipid metabolic process metabolic process cellulose catabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds cellulase activity hydrolase activity hydrolase activity acting on ester bonds
1np2B beta-glycosidase	[pdb]	3.3 0.00292	177^GLU 31^SER 123^PRO 36^PHE 46^GLY 391^PHE 338^GLU 163^ASN 168^SER 172^GLY	0.0.0.0	carbohydrate metabolic process metabolic process cellulose catabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds beta-glucosidase activity hydrolase activity hydrolase activity
1flgA protein (quinoprotein ethanol dehydrogenase)	[pdb]	3.31 0.00301	179^GLU 291^SER 311^PRO 317^PHE 410^GLY 455^PHE 440^GLU 271^ASN 239^SER 244^GLY	0.0.0.0	oxidation-reduction process	membrane outer membrane-bounded periplasmic space periplasmic space	calcium ion binding oxidoreductase activity oxidoreductase activity acting on CH-OH group of donors
1k3dA phosphoenolpyruvate carboxykinase	[pdb]	3.31 0.00301	282^GLU 230^SER 224^PRO 216^PHE 214^GLY 167^PHE 159^GLU 128^ASN 349^SER 267^GLY	4.1.1.49	gluconeogenesis	cytoplasm	nucleotide binding phosphoenolpyruvate carboxykinase activity phosphoenolpyruvate carboxykinase (ATP) activity ATP binding lyase activity carboxy-lyase activity purine nucleotide binding
3odmC phosphoenolpyruvate carboxylase	[pdb]	3.31 0.0031	280^GLU 271^SER 12^PRO 269^PHE 31^GLY 267^PHE 256^GLU 253^ASN 250^SER 278^GLY		tricarboxylic acid cycle carbon fixation		catalytic activity phosphoenolpyruvate carboxylase activity lyase activity
1d8wC l-rhamnose isomerase	[pdb]	3.31 0.0031	243^GLU 156^SER 208^PRO 153^PHE 152^GLY 144^PHE 234^GLU 250^ASN 249^SER 197^GLY		rhamnose metabolic process rhamnose catabolic process L-lyxose metabolic process	cytoplasm	L-rhamnose isomerase activity isomerase activity manganese ion binding metal ion binding
1iyxB enolase	[pdb]	3.32 0.0031	163^GLU 200^SER 209^PRO 207^PHE 205^GLY 185^PHE 219^GLU 214^ASN 158^SER 151^GLY	4.2.1.11	glycolysis	phosphopyruvate hydratase complex extracellular region cytoplasm cell surface	magnesium ion binding phosphopyruvate hydratase activity lyase activity metal ion binding
1qo9A acetylcholinesterase	[pdb]	3.32 0.0032	237^GLU 272^SER 331^PRO 439^PHE 436^GLY 371^PHE 81^GLU 84^ASN 156^SER 240^GLY	3.1.1.7	acetylcholine catabolic process in synaptic cleft acetylcholine catabolic process synaptic transmission neurotransmitter catabolic process phototaxis choline catabolic process	cytoplasm plasma membrane membrane cell junction anchored to membrane synapse	acetylcholinesterase activity carboxylesterase activity cholinesterase activity hydrolase activity protein homodimerization activity
1a7jA phosphoribulokinase	[pdb]	3.32 0.0032	81^GLU 200^SER 197^PRO 199^PHE 153^GLY 70^PHE 73^GLU 139^ASN 140^SER 146^GLY	2.7.1.19	carbohydrate metabolic process metabolic process photosynthesis reductive pentose-phosphate cycle		nucleotide binding ATP binding phosphoribulokinase activity kinase activity transferase activity
3ib3A coce/nond family hydrolase	[pdb]	3.32 0.0032	201^GLU 269^SER 442^PRO 444^PHE 212^GLY 426^PHE 495^GLU 408^ASN 499^SER 277^GLY	0.0.0.0	metabolic process		dipeptidyl-peptidase activity hydrolase activity
2w8oA succinic semialdehyde dehydrogenasemitochondrial	[pdb]	3.33 0.0033	375^GLU 146^SER 207^PRO 206^PHE 155^GLY 333^PHE 421^GLU 418^ASN 83^SER 373^GLY	1.2.1.24	glucose metabolic process acetate metabolic process succinate metabolic process glutamate metabolic process glutamine metabolic process glycerophospholipid metabolic process galactosylceramide metabolic process glutathione metabolic process central nervous system development metabolic process gamma-aminobutyric acid catabolic process respiratory electron transport chain neurotransmitter catabolic process short-chain fatty acid metabolic process protein homotetramerization oxidation-reduction process	soluble fraction mitochondrion	succinate-semialdehyde dehydrogenase activity oxidoreductase activity oxidoreductase activity acting on the aldehyde or oxo group of donors
1a0cA xylose isomerase	[pdb]	3.34 0.00351	182^GLU 44^SER 95^PRO 97^PHE 180^GLY 99^PHE 231^GLU 265^ASN 293^SER 333^GLY	5.3.1.5	carbohydrate metabolic process pentose-phosphate shunt D-xylose metabolic process	cytoplasm	xylose isomerase activity isomerase activity metal ion binding
2gmhA electron transfer flavoprotein-ubiquinoneoxidoreductase	[pdb]	3.35 0.00351	379^GLU 355^SER 356^PRO 211^PHE 180^GLY 346^PHE 401^GLU 405^ASN 373^SER 374^GLY	1.5.5.1	transport response to oxidative stress electron transport chain fatty acid beta-oxidation using acyl-CoA dehydrogenase oxidation-reduction process	mitochondrion mitochondrial inner membrane membrane integral to mitochondrial inner membrane mitochondrial membrane mitochondrial part	electron-transferring-flavoprotein dehydrogenase activity electron carrier activity oxidoreductase activity oxidoreductase activity oxidizing metal ions with flavin as acceptor metal ion binding quinone binding ubiquinone binding flavin adenine dinucleotide binding iron-sulfur cluster binding
1a0dC xylose isomerase	[pdb]	3.35 0.00362	38^GLU 359^SER 309^PRO 360^PHE 363^GLY 22^PHE 88^GLU 91^ASN 43^SER 332^GLY	5.3.1.5	carbohydrate metabolic process pentose-phosphate shunt D-xylose metabolic process	cytoplasm	xylose isomerase activity isomerase activity metal ion binding
2piaA phthalate dioxygenase reductase	[pdb]	3.35 0.00362	104^GLU 224^SER 201^PRO 225^PHE 275^GLY 86^PHE 27^GLU 61^ASN 128^SER 42^GLY	0.0.0.0	transport electron transport chain oxidation-reduction process		electron carrier activity oxidoreductase activity metal ion binding iron-sulfur cluster binding 2 iron
3lulA 4-amino-4-deoxychorismate lyase	[pdb]	3.36 0.00373	26^GLU 105^SER 2^PRO 16^PHE 17^GLY 109^PHE 30^GLU 51^ASN 52^SER 91^GLY	0.0.0.0	metabolic process		catalytic activity lyase activity
1tqyA actinorhodin polyketide putative beta-ketoacylsynthase 2 beta-ketoacyl synthase/acyl transferase	[pdb]	3.36 0.00374	355^ALA 74^LEU 149^GLY 76^LEU 19^ALA 85^ASP 247^ARG 178^GLY 175^ILE 172^ARG	0.0.0.0	metabolic process biosynthetic process antibiotic biosynthetic process metabolic process biosynthetic process antibiotic biosynthetic process		catalytic activity acyltransferase activity transferase activity catalytic activity acyltransferase activity transferase activity
3nb0A glycogen [starch] synthase isoform 2	[pdb]	3.36 0.00385	509^GLU 525^SER 524^PRO 504^PHE 319^GLY 331^PHE 563^GLU 529^ASN 535^SER 532^GLY	0.0.0.0	glycogen biosynthetic process	cytoplasm	glycogen (starch) synthase activity protein binding transferase activity transferase activity transferring glycosyl groups
3og2A beta-galactosidase	[pdb]	3.37 0.00398	103^GLU 116^SER 69^PRO 115^PHE 113^GLY 946^PHE 862^GLU 352^ASN 144^SER 104^GLY		carbohydrate metabolic process metabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds beta-galactosidase activity hydrolase activity hydrolase activity
3q4dC mandelate racemase/muconate lactonizing enzyme familypossible chloromuconate cycloisomerase	[pdb]	3.37 0.00398	47^GLU 297^SER 322^PRO 319^PHE 292^GLY 294^PHE 57^GLU 30^ASN 11^SER 46^GLY		metabolic process		catalytic activity isomerase activity chloromuconate cycloisomerase activity metal ion binding
2iyaA oleandomycin glycosyltransferase	[pdb]	3.37 0.00398	336^GLU 137^SER 138^PRO 234^PHE 236^GLY 221^PHE 358^GLU 356^ASN 333^SER 332^GLY	0.0.0.0	metabolic process antibiotic metabolic process		transferase activity transferase activity transferring glycosyl groups
2dq3B seryl-trna synthetase	[pdb]	3.37 0.00398	233^GLU 330^SER 106^PRO 359^PHE 207^GLY 378^PHE 298^GLU 355^ASN 354^SER 384^GLY	6.1.1.11	translation tRNA aminoacylation for protein translation seryl-tRNA aminoacylation	cytoplasm	nucleotide binding aminoacyl-tRNA ligase activity serine-tRNA ligase activity ATP binding ligase activity
1xcrB hypothetical protein ptd012	[pdb]	3.38 0.00398	110^GLU 271^SER 246^PRO 270^PHE 127^GLY 161^PHE 265^GLU 183^ASN 216^SER 277^GLY	0.0.0.0		nucleus	protein binding zinc ion binding hydrolase activity hydrolase activity acting on ester bonds
1iipA cyclophilin 40	[pdb]	3.38 0.00411	101^GLU 88^SER 65^PRO 87^PHE 92^GLY 132^PHE 46^GLU 47^ASN 97^SER 100^GLY	5.2.1.8	protein folding	cytoplasm	peptidyl-prolyl cis-trans isomerase activity binding protein binding isomerase activity heat shock protein binding peptide binding
2z1sA beta-glucosidase b	[pdb]	3.38 0.00411	180^GLU 35^SER 126^PRO 40^PHE 50^GLY 408^PHE 356^GLU 166^ASN 172^SER 175^GLY	3.2.1.21	polysaccharide catabolic process carbohydrate metabolic process metabolic process cellulose catabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds beta-glucosidase activity hydrolase activity hydrolase activity
2uveB exopolygalacturonase	[pdb]	3.38 0.00411	239^GLU 331^SER 352^PRO 354^PHE 327^GLY 385^PHE 361^GLU 246^ASN 243^SER 229^GLY	0.0.0.0
3cewD uncharacterized cupin protein	[pdb]	3.38 0.00411	66^GLU 87^SER 40^PRO 60^PHE 59^GLY 96^PHE 50^GLU 48^ASN 44^SER 65^GLY	0.0.0.0
1yqtA rnase l inhibitor	[pdb]	3.38 0.00411	267^GLU 294^SER 296^PRO 293^PHE 291^GLY 318^PHE 322^GLU 304^ASN 277^SER 103^GLY	0.0.0.0			nucleotide binding ATP binding electron carrier activity ATPase activity nucleoside-triphosphatase activity iron-sulfur cluster binding
1u4gA elastase	[pdb]	3.39 0.00424	172^GLU 143^SER 95^PRO 84^PHE 81^GLY 91^PHE 249^GLU 255^ASN 167^SER 171^GLY	3.4.24.26	proteolysis	extracellular region	metalloendopeptidase activity peptidase activity metallopeptidase activity zinc ion binding hydrolase activity metal ion binding
2x58A peroxisomal bifunctional enzyme	[pdb]	3.39 0.00424	636^GLU 447^SER 446^PRO 478^PHE 477^GLY 433^PHE 274^GLU 278^ASN 281^SER 637^GLY	4.2.1.17, 5.3.3.8, 1.1.1.35	lipid metabolic process fatty acid metabolic process metabolic process oxidation-reduction process	mitochondrion peroxisome	catalytic activity 3-hydroxyacyl-CoA dehydrogenase activity dodecenoyl-CoA delta-isomerase activity enoyl-CoA hydratase activity binding oxidoreductase activity lyase activity isomerase activity coenzyme binding
3bk7A abc transporter atp-binding protein	[pdb]	3.39 0.00438	271^GLU 298^SER 300^PRO 297^PHE 295^GLY 322^PHE 309^GLU 305^ASN 281^SER 107^GLY	0.0.0.0			nucleotide binding ATP binding electron carrier activity ATPase activity nucleoside-triphosphatase activity iron-sulfur cluster binding
2qfeA calpain-7	[pdb]	3.39 0.00438	775^GLU 779^SER 778^PRO 757^PHE 756^GLY 741^PHE 730^GLU 802^ASN 803^SER 725^GLY	0.0.0.0	proteolysis	intracellular nucleus	calcium-dependent cysteine-type endopeptidase activity peptidase activity cysteine-type peptidase activity hydrolase activity
2vhdA cytochrome c551 peroxidase	[pdb]	3.4 0.00438	103^GLU 80^SER 81^PRO 93^PHE 96^GLY 88^PHE 160^GLU 52^ASN 50^SER 107^GLY	1.11.1.5	transport electron transport chain oxidation-reduction process	periplasmic space	cytochrome-c peroxidase activity peroxidase activity iron ion binding electron carrier activity oxidoreductase activity heme binding metal ion binding
3k9eA putative ribokinase ii	[pdb]	3.4 0.00452	9^GLU 35^SER 294^PRO 63^PHE 90^GLY 106^PHE 171^GLU 167^ASN 137^SER 8^GLY	0.0.0.0
3of7A regulator of chromosome condensation	[pdb]	3.4 0.00452	58^GLU 107^SER 150^PRO 89^PHE 455^GLY 49^PHE 69^GLU 67^ASN 148^SER 109^GLY		ribosomal subunit export from nucleus rRNA export from nucleus cell cycle mitosis response to pheromone cell division	nuclear chromatin nucleus	signal transducer activity guanyl-nucleotide exchange factor activity protein binding
2dq6A aminopeptidase n	[pdb]	3.41 0.00466	810^GLU 792^SER 794^PRO 789^PHE 787^GLY 750^PHE 763^GLU 760^ASN 803^SER 804^GLY	3.4.11.2	proteolysis peptide catabolic process	plasma membrane membrane	aminopeptidase activity peptidase activity metallopeptidase activity zinc ion binding hydrolase activity metal ion binding
3ce9C glycerol dehydrogenase	[pdb]	3.41 0.00466	42^GLU 116^SER 147^PRO 126^PHE 97^GLY 74^PHE 76^GLU 80^ASN 37^SER 41^GLY	0.0.0.0	aromatic amino acid family biosynthetic process oxidation-reduction process		3-dehydroquinate synthase activity oxidoreductase activity acting on CH-OH group of donors
1tkjA aminopeptidase	[pdb]	3.41 0.00466	198^GLU 164^SER 165^PRO 242^PHE 168^GLY 186^PHE 179^GLU 158^ASN 203^SER 199^GLY	3.4.11.24	proteolysis	extracellular region	aminopeptidase activity peptidase activity hydrolase activity metal ion binding
1sqjA oligoxyloglucan reducing-end-specificcellobiohydrolase	[pdb]	3.41 0.00481	124^GLU 109^SER 110^PRO 94^PHE 84^GLY 104^PHE 98^GLU 134^ASN 148^SER 139^GLY	0.0.0.0	polysaccharide catabolic process carbohydrate metabolic process metabolic process cellulose catabolic process		hydrolase activity hydrolase activity acting on glycosyl bonds
2vquB beta-mannosidase	[pdb]	3.41 0.00481	630^GLU 544^SER 541^PRO 542^PHE 624^GLY 558^PHE 555^GLU 532^ASN 530^SER 628^GLY	0.0.0.0	carbohydrate metabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds
2jbjA glutamate carboxypeptidase 2	[pdb]	3.41 0.00481	425^GLU 554^SER 159^PRO 383^PHE 384^GLY 90^PHE 351^GLU 350^ASN 162^SER 256^GLY	3.4.17.21	proteolysis	membrane fraction cytoplasm plasma membrane integral to plasma membrane membrane integral to membrane	catalytic activity carboxypeptidase activity peptidase activity metallopeptidase activity hydrolase activity dipeptidase activity metal ion binding
1ukcB esta	[pdb]	3.41 0.00481	237^GLU 239^SER 242^PRO 400^PHE 396^GLY 342^PHE 131^GLU 132^ASN 215^SER 208^GLY	0.0.0.0			hydrolase activity
2pxxA uncharacterized protein mgc2408	[pdb]	3.42 0.00481	129^GLU 70^SER 38^PRO 42^PHE 43^GLY 45^PHE 59^GLU 83^ASN 86^SER 66^GLY	3.4.24.71	proteolysis cell-cell signaling brain development heart development metabolic process cardioblast differentiation peptide hormone processing	Golgi membrane Golgi apparatus membrane integral to membrane cytoplasmic vesicle membrane	catalytic activity metalloendopeptidase activity methyltransferase activity peptidase activity metallopeptidase activity transferase activity hydrolase activity metal ion binding
1yj5B 5' polynucleotide kinase-3' phosphatasecatalytic domain 5' polynucleotide kinase-3' phosphatase fhadomain	[pdb]	3.42 0.00481	147^GLU 158^SER 245^PRO 155^PHE 233^GLY 215^PHE 270^GLU 273^ASN 142^SER 145^HOH	3.1.3.32, 2.7.1.78	DNA repair response to DNA damage stimulus response to oxidative stress dephosphorylation DNA damage response detection of DNA damage	nucleus nucleolus	nucleotide binding catalytic activity protein binding ATP binding kinase activity transferase activity hydrolase activity nucleotide kinase activity polynucleotide 3'-phosphatase activity ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
3loqA universal stress protein	[pdb]	3.42 0.00481	28^GLU 101^SER 132^PRO -4^PHE 25^GLY 146^PHE 16^GLU 10^ASN 11^SER 30^GLY	0.0.0.0	response to stress
1bq6A chalcone synthase	[pdb]	3.42 0.00496	363^GLU 386^SER 235^PRO 237^PHE 368^GLY 344^PHE 348^GLU 356^ASN 353^SER 364^GLY	2.3.1.74	metabolic process biosynthetic process flavonoid biosynthetic process		catalytic activity acyltransferase activity naringenin-chalcone synthase activity transferase activity transferase activity
1n70A copper-containing nitrite reductase precursor	[pdb]	3.42 0.00496	298^GLU 278^SER 100^PRO 163^PHE 161^GLY 275^PHE 311^GLU 337^ASN 284^SER 317^GLY	1.7.2.1	nitrogen compound metabolic process nitrate assimilation oxidation-reduction process	periplasmic space	copper ion binding oxidoreductase activity metal ion binding nitrite reductase (NO-forming) activity
1kqgA formate dehydrogenase, nitrate-inducible, iron-sulfur subunit formate dehydrogenase, nitrate-inducible, majorsubunit formate dehydrogenase, nitrate-inducible,cytochrome b556(fdn) subunit	[pdb]	3.42 0.00497	696^GLU 735^SER 465^PRO 512^PHE 514^GLY 180^ILE 172^MET 171^TYR 742^SER 699^GLY	1.2.1.2	transport electron transport chain respiratory electron transport chain cellular respiration transport electron transport chain respiratory electron transport chain cellular respiration anaerobic respiration cellular respiration oxidation-reduction process transport anaerobic respiration cytochrome complex assembly electron transport chain respiratory electron transport chain cellular respiration transport anaerobic respiration electron transport chain cellular respiration	plasma membrane formate dehydrogenase complex membrane integral to membrane plasma membrane formate dehydrogenase complex membrane integral to membrane cytoplasm formate dehydrogenase complex membrane periplasmic space plasma membrane formate dehydrogenase complex membrane integral to membrane plasma membrane formate dehydrogenase complex membrane integral to membrane	formate dehydrogenase activity electron carrier activity oxidoreductase activity metal ion binding formate dehydrogenase activity electron carrier activity oxidoreductase activity metal ion binding binding selenium binding formate dehydrogenase activity electron carrier activity oxidoreductase activity molybdenum ion binding metal ion binding iron-sulfur cluster binding 4 iron 4 sulfur cluster binding formate dehydrogenase activity electron carrier activity oxidoreductase activity metal ion binding formate dehydrogenase activity electron carrier activity metal ion binding iron-sulfur cluster binding
1o1zA glycerophosphodiester phosphodiesterase	[pdb]	3.42 0.00497	97^GLU 162^SER 160^PRO 190^PHE 209^GLY 170^PHE 142^GLU 144^ASN 121^SER 137^GLY	0.0.0.0	glycerol metabolic process lipid metabolic process		phospholipase C activity phosphoric diester hydrolase activity glycerophosphodiester phosphodiesterase activity
2qc5A streptogramin b lactonase	[pdb]	3.43 0.00529	133^GLU 141^SER 143^PRO 156^PHE 165^GLY 145^PHE 74^GLU 78^ASN 99^SER 119^GLY	0.0.0.0	antibiotic catabolic process response to antibiotic		magnesium ion binding carbon-oxygen lyase activity
2vr0E napc/nirt cytochrome c family protein cytochrome c nitrite reductase, catalyticsubunit nfra	[pdb]	3.43 0.00529	75^LEU 79^LEU 81^PHE 82^LYS 94^THR 111^VAL 428^GLU 429^ASN 339^SER 78^LYS	0.0.0.0	nitrogen compound metabolic process oxidation-reduction process
2hpgD abc transporter, periplasmic substrate-bindingprotein	[pdb]	3.43 0.00529	311^GLU 187^SER 179^PRO 240^PHE 238^GLY 107^PHE 323^GLU 319^ASN 190^SER 192^GLY	0.0.0.0	transport	outer membrane-bounded periplasmic space
3ombA extracellular solute-binding protein, family 1	[pdb]	3.44 0.00547	347^GLU 224^SER 225^PRO 238^PHE 241^GLY 454^PHE 448^GLU 444^ASN 311^SER 163^GLY	0.0.0.0	transport		transporter activity
1xipA nucleoporin nup159	[pdb]	3.44 0.00547	371^GLU 55^SER 87^PRO 91^PHE 338^GLY 275^PHE 32^GLU 31^ASN 29^SER 372^GLY	0.0.0.0	ribosomal subunit export from nucleus mRNA export from nucleus rRNA export from nucleus transport nuclear pore organization protein transport mRNA transport transmembrane transport	nucleus nuclear pore membrane nuclear membrane Nup82 complex	structural molecule activity protein binding
2b39B c3	[pdb]	3.44 0.00547	845^GLU 1411^SER 1412^PRO 1410^PHE 1381^GLY 1490^PHE 933^GLU 1438^ASN 837^SER 1409^GLY	0.0.0.0	positive regulation of type IIa hypersensitivity positive regulation of activation of membrane attack complex inflammatory response complement activation complement activation alternative pathway complement activation classical pathway positive regulation vascular endothelial growth factor production innate immune response	extracellular region extracellular space	endopeptidase inhibitor activity protein binding
2w92A endo-beta-n-acetylglucosaminidase d	[pdb]	3.45 0.00547	742^GLU 532^SER 563^PRO 533^PHE 696^GLY 582^PHE 246^GLU 554^ASN 557^SER 756^GLY	0.0.0.0	pathogenesis	cell wall cytoplasm cell surface membrane	protein binding hydrolase activity mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity
2o1xD 1-deoxy-d-xylulose-5-phosphate synthase	[pdb]	3.45 0.00547	351^GLU 359^SER 363^PRO 358^PHE 329^GLY 343^PHE 373^GLU 190^ASN 188^SER 352^GLY	2.2.1.7	metabolic process isoprenoid biosynthetic process thiamine biosynthetic process terpenoid biosynthetic process		catalytic activity 1-deoxy-D-xylulose-5-phosphate synthase activity transferase activity
1nmlA di-haem cytochrome c peroxidase	[pdb]	3.45 0.00565	114^GLU 80^SER 81^PRO 93^PHE 107^GLY 88^PHE 160^GLU 52^ASN 50^SER 70^GLY	0.0.0.0	oxidation-reduction process		peroxidase activity iron ion binding electron carrier activity oxidoreductase activity heme binding
1eagA aspartic proteinase (sap2 gene product)	[pdb]	3.45 0.00565	202^GLU 273^SER 275^PRO 264^PHE 199^GLY 298^PHE 253^GLU 257^ASN 259^SER 205^GLY	3.4.23.24	proteolysis	extracellular region	aspartic-type endopeptidase activity peptidase activity hydrolase activity
2wjsA laminin subunit alpha-2	[pdb]	3.45 0.00565	2619^GLU 2526^SER 2530^PRO 2527^PHE 2704^GLY 2657^PHE 2592^GLU 2587^ASN 2556^SER 2617^GLY	0.0.0.0	cell adhesion regulation of cell adhesion regulation of cell migration positive regulation of synaptic transmission cholinergic	extracellular region proteinaceous extracellular matrix basement membrane basal lamina laminin-1 complex extracellular matrix sarcolemma	receptor binding
2yzgA d-alanine--d-alanine ligase	[pdb]	3.46 0.00583	300^GLU 293^SER 287^PRO 289^PHE 23^GLY 78^PHE 315^GLU 205^ASN 211^SER 302^GLY	6.3.2.4	cellular cell wall organization regulation of cell shape peptidoglycan biosynthetic process	cell wall cytoplasm	nucleotide binding catalytic activity ATP binding D-alanine-D-alanine ligase activity ligase activity metal ion binding
1t3tA phosphoribosylformylglycinamidine synthase	[pdb]	3.46 0.00583	379^GLU 1195^SER 1259^PRO 1165^PHE 1197^GLY 1157^PHE 1104^GLU 1136^ASN 1052^SER 381^GLY	6.3.5.3	purine nucleotide biosynthetic process 'de novo' IMP biosynthetic process glutamine metabolic process	cytoplasm	nucleotide binding catalytic activity phosphoribosylformylglycinamidine synthase activity ATP binding ligase activity
3nniB hla-b associated transcript 8 bat8 isoform a variant	[pdb]	3.46 0.00602	1149^GLU 1141^SER 1121^PRO 1139^PHE 1061^GLY 1063^PHE 931^GLU 1106^ASN 1108^SER 1151^GLY	0.0.0.0	negative regulation of transcription from RNA polymerase II promoter pachytene regulation of transcription from RNA polymerase II promoter synaptonemal complex assembly germ cell development spermatid development fertilization chromatin modification organ growth histone H3-K9 methylation	nucleus	methyltransferase activity zinc ion binding transferase activity histone-lysine N-methyltransferase activity
3fdhA susd homolog	[pdb]	3.46 0.00602	451^GLU 59^SER 271^PRO 272^PHE 281^GLY 343^PHE 390^GLU 388^ASN 355^SER 450^GLY	0.0.0.0
3m8sA dna polymerase i, thermostable dna (5'-d(apapapapgpgpcpgpcpcpgptpgpgptpc)-3') dna (5'-d(gpapcpcpapcpgpgpcpgpcp(doc))-3')	[pdb]	3.47 0.00621	347^GLU 409^SER 373^PRO 306^PHE 308^GLY 309^PHE 315^GLU 565^ASN 438^SER 370^GLY	2.7.7.7	DNA replication DNA repair response to DNA damage stimulus		nucleoside binding nucleic acid binding DNA binding catalytic activity DNA-directed DNA polymerase activity 5'-3' exonuclease activity transferase activity nucleotidyltransferase activity
3nedA pamcherry1 protein	[pdb]	3.47 0.00621	32^GLU 112^SER 88^PRO 118^PHE 116^GLY 11^PHE 39^GLU 217^ASN 69^SER 33^GLY		generation of precursor metabolites and energy bioluminescence protein-chromophore linkage
3p40A neurofascin	[pdb]	3.47 0.00621	267^GLU 271^SER 244^PRO 246^PHE 251^GLY 315^PHE 295^GLU 296^ASN 190^SER 192^GLY		cell adhesion axon guidance peripheral nervous system development myelination synapse organization	plasma membrane membrane integral to membrane axon node of Ranvier	protein binding
3abzC beta-glucosidase i	[pdb]	3.47 0.00621	116^GLU 669^SER 671^PRO 714^PHE 699^GLY 680^PHE 595^GLU 596^ASN 623^SER 624^GLY		carbohydrate metabolic process metabolic process		hydrolase activity hydrolyzing O-glycosyl compounds beta-glucosidase activity hydrolase activity
1hcuA alpha-1,2-mannosidase	[pdb]	3.47 0.00621	353^GLU 305^SER 303^PRO 355^PHE 354^GLY 340^PHE 396^GLU 315^ASN 241^SER 242^GLY	0.0.0.0		membrane	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity calcium ion binding
1cc1L hydrogenase (small subunit) hydrogenase (large subunit)	[pdb]	3.48 0.00641	285^GLU 290^SER 311^PRO 319^PHE 44^GLY 47^PHE 51^GLU 308^ASN 295^SER 299^GLY	1.12.99.6	oxidation-reduction process oxidation-reduction process	periplasmic space ferredoxin hydrogenase complex periplasmic space	ferredoxin hydrogenase activity nickel ion binding oxidoreductase activity hydrogenase (acceptor) activity metal ion binding NADH dehydrogenase (ubiquinone) activity ferredoxin hydrogenase activity oxidoreductase activity hydrogenase (acceptor) activity metal ion binding quinone binding iron-sulfur cluster binding 4 iron
1s4oB glycolipid 2-alpha-mannosyltransferase	[pdb]	3.48 0.00641	424^GLU 366^SER 363^PRO 324^PHE 272^GLY 372^PHE 304^GLU 315^ASN 312^SER 422^GLY	2.4.1.131	cell wall mannoprotein biosynthetic process protein glycosylation N-glycan processing protein O-linked glycosylation	Golgi membrane Golgi apparatus membrane integral to membrane	alpha-1,2-mannosyltransferase activity glycolipid 2-alpha-mannosyltransferase activity transferase activity transferase activity
1xjjA ribonucleotide reductase, b12-dependent	[pdb]	3.48 0.00641	169^GLU 244^SER 296^PRO 225^PHE 186^GLY 194^PHE 152^GLU 320^ASN 318^SER 246^GLY	0.0.0.0	DNA replication oxidation-reduction process	ribonucleoside-diphosphate reductase complex	nucleotide binding ribonucleoside-diphosphate reductase activity protein binding ATP binding oxidoreductase activity cobalamin binding
1wkyA endo-beta-1,4-mannanase	[pdb]	3.48 0.00641	253^GLU 201^SER 199^PRO 198^PHE 194^GLY 160^PHE 117^GLU 154^ASN 221^SER 252^GLY	0.0.0.0	carbohydrate metabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds
3ebiA m1 family aminopeptidase	[pdb]	3.48 0.00641	596^GLU 737^SER 739^PRO 733^PHE 694^GLY 762^PHE 531^GLU 527^ASN 584^SER 595^GLY	0.0.0.0	proteolysis	cytoplasm	aminopeptidase activity peptidase activity metallopeptidase activity zinc ion binding hydrolase activity metal ion binding
3l4xA maltase-glucoamylase, intestinal	[pdb]	3.48 0.00641	276^GLU 230^SER 173^PRO 220^PHE 179^GLY 262^PHE 90^GLU 95^ASN 94^SER 267^GLY	3.2.1.3, 3.2.1.20	carbohydrate metabolic process starch catabolic process metabolic process	plasma membrane membrane integral to membrane apical plasma membrane	catalytic activity glucan 1,4-alpha-glucosidase activity hydrolase activity hydrolyzing O-glycosyl compounds alpha-glucosidase activity hydrolase activity hydrolase activity
3psqA hypothetical exported protein	[pdb]	3.48 0.00641	90^GLU 105^SER 81^PRO 107^PHE 85^GLY 180^PHE 222^GLU 131^ASN 103^SER 104^GLY	0.0.0.0
1k45A xylanase	[pdb]	3.48 0.00662	131^GLU 102^SER 144^PRO 103^PHE 161^GLY 76^PHE 138^GLU 107^ASN 135^SER 114^GLY	0.0.0.0	carbohydrate metabolic process xylan catabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds
1rb7A cytosine deaminase	[pdb]	3.48 0.00662	20^GLU 89^SER 90^PRO 114^PHE 109^GLY 144^PHE 28^GLU 51^ASN 66^SER 35^GLY	3.5.4.1	pyrimidine-containing compound salvage cytosine metabolic process cytidine metabolic process	nucleus cytoplasm	catalytic activity cytosine deaminase activity protein binding zinc ion binding hydrolase activity identical protein binding metal ion binding
2x5sA mannose-1-phosphate guanylyltransferase	[pdb]	3.48 0.00662	170^GLU 190^SER 107^PRO 138^PHE 139^GLY 136^PHE 208^GLU 85^ASN 237^SER 150^GLY	0.0.0.0	biosynthetic process		transferase activity nucleotidyltransferase activity
3f1rB fibroblast growth factor 20	[pdb]	3.49 0.00662	1099^GLU 1115^SER 1081^PRO 1095^PHE 1096^GLY 1075^PHE 1126^GLU 1122^ASN 1130^SER 1112^GLY	0.0.0.0	signal transduction cell-cell signaling positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway cell differentiation inner ear receptor cell differentiation	extracellular region soluble fraction	fibroblast growth factor receptor binding growth factor activity
3mo5B histone-lysine n-methyltransferase, h3 lysine-9 specific 5	[pdb]	3.49 0.00662	1205^GLU 1197^SER 1178^PRO 1196^PHE 1118^GLY 1120^PHE 988^GLU 1163^ASN 1165^SER 1208^GLY	2.1.1.43	negative regulation of transcription from RNA polymerase II promoter chromatin modification histone methylation	nucleus	methyltransferase activity zinc ion binding transferase activity histone-lysine N-methyltransferase activity metal ion binding
1h83B polyamine oxidase	[pdb]	3.49 0.00662	62^GLU 190^SER 185^PRO 189^PHE 193^GLY 167^PHE 173^GLU 405^ASN 404^SER 442^GLY	0.0.0.0	oxidation-reduction process		oxidoreductase activity
2evvA hypothetical protein hp0218	[pdb]	3.49 0.00683	55^GLU 38^SER 39^PRO 20^PHE 126^GLY 175^PHE 5^GLU 80^ASN 42^SER 75^GLY	0.0.0.0
3ou8B adenosine deaminase	[pdb]	3.49 0.00683	20^GLU 247^SER 245^PRO 282^PHE 283^GLY 53^PHE 58^GLU 55^ASN 169^SER 21^GLY	3.5.4.4	nucleotide metabolic process purine ribonucleoside monophosphate biosynthetic process		adenosine deaminase activity hydrolase activity deaminase activity
2obgA maltose binding periplasmic protein and monobodymbp-74 fusion protein	[pdb]	3.49 0.00683	78^GLU 73^SER 48^PRO 67^PHE 68^GLY 61^PHE 278^GLU 272^ASN 270^SER 74^GLY	0.0.0.0	transport carbohydrate transport maltose transport maltodextrin transport	periplasmic space ATP-binding cassette (ABC) transporter complex ATP-binding cassette (ABC) transporter complex	transporter activity maltose transmembrane transporter activity disaccharide binding
2ckjC xanthine oxidoreductase	[pdb]	3.5 0.00683	1262^GLU 1009^SER 1150^PRO 1006^PHE 917^GLY 915^PHE 803^GLU 769^ASN 1083^SER 1261^GLY	1.17.3.2, 1.17.1.4	lactation xanthine catabolic process regulation of epithelial cell differentiation oxidation-reduction process	extracellular region cytoplasm peroxisome	catalytic activity xanthine dehydrogenase activity xanthine oxidase activity binding iron ion binding electron carrier activity oxidoreductase activity molybdenum ion binding protein homodimerization activity molybdopterin cofactor binding metal ion binding flavin adenine dinucleotide binding iron-sulfur cluster binding 2 iron
3c2uA xylosidase/arabinosidase	[pdb]	3.5 0.00705	186^GLU 129^SER 75^PRO 126^PHE 125^GLY 31^PHE 291^GLU 12^ASN 250^SER 187^GLY	0.0.0.0	carbohydrate metabolic process		hydrolase activity
1nrfA regulatory protein blar1	[pdb]	3.5 0.00705	584^GLU 402^SER 400^PRO 554^PHE 538^GLY 566^PHE 361^GLU 390^ASN 373^SER 579^GLY	0.0.0.0	peptidoglycan-based cell wall biogenesis	plasma membrane membrane integral to membrane	penicillin binding
3l44B glutamate-1-semialdehyde 2,1-aminomutase 1	[pdb]	3.5 0.00705	381^GLU 29^SER 26^PRO 30^PHE 35^GLY 5^PHE 393^GLU 396^ASN 400^SER 380^GLY	5.4.3.8	porphyrin biosynthetic process tetrapyrrole biosynthetic process	cytoplasm	catalytic activity transaminase activity isomerase activity pyridoxal phosphate binding glutamate-1-semialdehyde 2,1-aminomutase activity
1t77D lipopolysaccharide-responsive and beige-likeanchor protein	[pdb]	3.5 0.00727	2154^GLU 2201^SER 2202^PRO 2142^PHE 2184^GLY 2189^PHE 2224^GLU 2230^ASN 2236^SER 2234^GLY	0.0.0.0	biological_process	cellular_component lysosome endoplasmic reticulum Golgi apparatus plasma membrane membrane integral to membrane	molecular_function binding protein binding