The LabelHash Server

Top 150 matches

For each match you can click on the "[pdb]" link to download a PDB file with the matching chain aligned with the motif.
Download a zip file with PDB files for all the matches and the motif itself.

PDB ID		LRMSD / p-value	Matching Residues	EC	Gene Ontology annotations
PDB ID		LRMSD / p-value	Matching Residues	EC	Biological Process	Cellular Component	Molecular Function
2zpiA nitrile hydratase subunit alpha nitrile hydratase subunit beta	[pdb]	0.0811 1.9e-05	53^ASP 120^THR 127^GLN 190^PHE 193^ASP 196^GLY	4.2.1.84	nitrogen compound metabolic process nitrogen compound metabolic process photosynthesis	plastid	catalytic activity lyase activity nitrile hydratase activity metal ion binding transition metal ion binding catalytic activity lyase activity nitrile hydratase activity transition metal ion binding
3qygC co-type nitrile hydratase alpha subunit co-type nitrile hydratase beta subunit	[pdb]	0.454 8.31e-05	56^GLN 123^ARG 130^ARG 193^VAL 196^TRP 199^ASP
1v29A nitrile hydratase a chain nitrile hydratase b chain	[pdb]	0.497 0.000109	64^PRO 131^SER 138^SER 201^PHE 204^GLU 207^TRP	0.0.0.0	nitrogen compound metabolic process		catalytic activity nitrile hydratase activity transition metal ion binding
3hhtA nitrile hydratase alpha subunit nitrile hydratase beta subunit	[pdb]	0.533 0.000133	60^GLU 127^ASN 134^ARG 197^TYR 200^ARG 203^ALA	0.0.0.0	nitrogen compound metabolic process nitrogen compound metabolic process photosynthesis	plastid	catalytic activity nitrile hydratase activity transition metal ion binding catalytic activity nitrile hydratase activity transition metal ion binding
2dxcI thiocyanate hydrolase subunit beta thiocyanate hydrolase subunit alpha thiocyanate hydrolase subunit gamma	[pdb]	0.541 0.000138	61^PRO 139^LEU 146^TYR 209^VAL 212^ASP 215^ILE	3.5.5.8	nitrogen compound metabolic process photosynthesis photosynthesis	plastid plastid	catalytic activity hydrolase activity thiocyanate hydrolase activity metal ion binding transition metal ion binding catalytic activity hydrolase activity thiocyanate hydrolase activity catalytic activity hydrolase activity thiocyanate hydrolase activity
1gpmA gmp synthetase	[pdb]	1.28 0.000233	375^PRO 376^LEU 33^TYR 218^VAL 216^ASP 213^ILE	6.3.5.2	purine nucleotide biosynthetic process GMP biosynthetic process glutamine metabolic process biosynthetic process	cytosol	nucleotide binding catalytic activity GMP synthase activity GMP synthase (glutamine-hydrolyzing) activity protein binding ATP binding ligase activity
2rdsA 1-deoxypentalenic acid 11-beta hydroxylasefe(ii)/alpha-ketoglutarate dependent hydroxylase	[pdb]	1.38 0.000287	155^PRO 156^LEU 87^TYR 166^VAL 244^ASP 116^ILE	0.0.0.0
3i2vA adenylyltransferase and sulfurtransferase mocs3	[pdb]	1.4 0.000305	40^PRO 41^LEU 75^TYR 28^VAL 21^ASP 77^ILE	0.0.0.0	tRNA wobble uridine modification Mo-molybdopterin cofactor biosynthetic process tRNA processing metabolic process enzyme active site formation via L-cysteine persulfide tRNA thio-modification	cytoplasm cytosol	nucleotide binding catalytic activity thiosulfate sulfurtransferase activity binding protein binding ATP binding transferase activity nucleotidyltransferase activity sulfurtransferase activity URM1 activating enzyme activity metal ion binding
2uvbC fatty acid synthase alpha subunits	[pdb]	1.49 0.000408	794^PRO 837^LEU 829^TYR 889^VAL 895^ASP 839^ILE
3ke5B hypothetical cytosolic protein	[pdb]	1.49 0.000419	105^PRO 106^LEU 177^TYR 165^VAL 174^ASP 110^ILE	0.0.0.0	cobalamin biosynthetic process		ATP binding cob(I)yrinic acid a,c-diamide adenosyltransferase activity
2tmkB thymidylate kinase	[pdb]	1.53 0.000485	126^PRO 128^LEU 26^TYR 96^VAL 93^ASP 10^ILE	2.7.4.9	dUDP biosynthetic process dTDP biosynthetic process dTTP biosynthetic process nucleotide biosynthetic process	nucleus cytoplasm	nucleotide binding thymidylate kinase activity protein binding ATP binding uridylate kinase activity kinase activity transferase activity identical protein binding
3bv0A adenosylmethionine-8-amino-7-oxononanoate aminotransferase	[pdb]	1.53 0.000501	276^PRO 251^LEU 247^TYR 274^VAL 242^ASP 243^ILE	2.6.1.62	biotin biosynthetic process protein homotetramerization	cytoplasm	catalytic activity adenosylmethionine-8-amino-7-oxononanoate transaminase activity transaminase activity transferase activity pyridoxal phosphate binding
2ah6B bh1595, unknown conserved protein	[pdb]	1.55 0.000517	106^PRO 108^LEU 179^TYR 167^VAL 176^ASP 112^ILE	0.0.0.0	cobalamin biosynthetic process		ATP binding cob(I)yrinic acid a,c-diamide adenosyltransferase activity
2xznW rps31e rps17e rps21e rps15e rps13e rps27e 18s rrna rps30e ribosomal protein s26e containing protein rps29e rps14e ribosomal protein s8 containing protein rps18e ribosomal protein s4 containing protein rack1 rps7e ribosomal protein s10 containing protein ribosomal protein s7 containing protein 40s ribosomal protein s8 ribosomal protein s28e containing protein 40s ribosomal protein s4 ribosomal protein l7ae containing protein ribosomal protein s5 containing protein rps24e 40s ribosomal protein s12 kh domain containing protein rps25e rps16e, 40s ribosomal protein rps16e eif1 ribosomal protein s17 containing protein rps19e plectin/s10 domain containing protein rps0e 40s ribosomal protein s3a rps6e	[pdb]	1.57 0.000586	85^MG 42^MG 105^ASP 74^MG 90^MG 103^GLY	0.0.0.0	translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation	intracellular ribosome intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome small ribosomal subunit intracellular ribosome ribonucleoprotein complex intracellular ribosome small ribosomal subunit intracellular ribosome intracellular ribosome intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome intracellular ribosome intracellular cytoplasm ribosome ribonucleoprotein complex intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome intracellular ribosome	structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome RNA binding structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome RNA binding structural constituent of ribosome RNA binding structural constituent of ribosome rRNA binding structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome RNA binding structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome
1rtyB yvqk protein	[pdb]	1.59 0.000645	105^PRO 107^LEU 178^TYR 166^VAL 175^ASP 111^ILE	2.5.1.17	porphyrin biosynthetic process cobalamin biosynthetic process	cytoplasm	nucleotide binding ATP binding cob(I)yrinic acid a,c-diamide adenosyltransferase activity transferase activity
3bs8A glutamate-1-semialdehyde 2,1-aminomutase	[pdb]	1.6 0.000645	261^PRO 237^LEU 233^TYR 259^VAL 228^ASP 229^ILE	5.4.3.8	porphyrin biosynthetic process tetrapyrrole biosynthetic process	cytoplasm	catalytic activity transaminase activity isomerase activity pyridoxal phosphate binding glutamate-1-semialdehyde 2,1-aminomutase activity
1ui7B phenylethylamine oxidase	[pdb]	1.61 0.000666	136^PRO 137^LEU 144^TYR 107^VAL 180^ASP 152^ILE	1.4.3.21	amine metabolic process oxidation-reduction process		copper ion binding primary amine oxidase activity oxidoreductase activity metal ion binding quinone binding
3olmA ubiquitin e3 ubiquitin-protein ligase rsp5	[pdb]	1.63 0.000759	784^PRO 783^LEU 705^TYR 787^VAL 712^ASP 715^ILE		DNA repair response to DNA damage stimulus ribosomal large subunit export from nucleus protein polyubiquitination chromatin assembly or disassembly rRNA processing tRNA export from nucleus protein modification process ubiquitin-dependent protein catabolic process protein monoubiquitination regulation of nitrogen utilization mitochondrion organization tRNA processing positive regulation of gene-specific transcription from RNA polymerase II promoter regulation of mRNA export from nucleus regulation of dolichol biosynthetic process regulation of ubiquinone biosynthetic process regulation of multivesicular body size regulation of phosphate metabolic process regulation of ergosterol biosynthetic process late endosome to vacuole transport via multivesicular body sorting pathway regulation of protein localization regulation of actin cytoskeleton organization ribophagy cellular response to UV response to drug protein ubiquitination involved in ubiquitin-dependent protein catabolic process proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway positive regulation of fatty acid biosynthetic process positive regulation of endocytosis positive regulation of receptor-mediated endocytosis ubiquitin-dependent endocytosis	nucleus cytoplasm ubiquitin ligase complex plasma membrane enriched fraction intracellular nucleus cytoplasm mitochondrion Golgi apparatus cellular bud tip endosome membrane extrinsic to internal side of plasma membrane	ubiquitin-protein ligase activity protein binding ligase activity acid-amino acid ligase activity phosphatidylinositol binding identical protein binding ubiquitin binding
3nyyA putative glycyl-glycine endopeptidase lytm	[pdb]	1.64 0.000811	263^PRO 265^LEU 202^TYR 137^VAL 156^ASP 157^ILE	0.0.0.0	proteolysis		metalloendopeptidase activity
2nwuA upf0201 protein sso1042	[pdb]	1.65 0.000838	128^PRO 126^LEU 72^TYR 134^VAL 67^ASP 65^ILE	0.0.0.0	translation	intracellular ribosome	structural constituent of ribosome
1oriA protein arginine n-methyltransferase 1	[pdb]	1.66 0.000866	224^PRO 227^LEU 262^TYR 222^VAL 187^ASP 185^ILE	0.0.0.0	protein methylation peptidyl-arginine methylation peptidyl-arginine methylation to asymmetrical-dimethyl arginine	nucleus cytoplasm protein complex	protein binding methyltransferase activity protein methyltransferase activity histone-arginine N-methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity [cytochrome c]-arginine N-methyltransferase activity transferase activity snoRNP binding protein-arginine omega-N monomethyltransferase activity protein-arginine omega-N asymmetric methyltransferase activity
3mprC putative endonuclease/exonuclease/phosphatase familyprotein	[pdb]	1.67 0.000895	234^PRO 197^LEU 188^TYR 238^VAL 199^ASP 230^ILE	0.0.0.0			endonuclease activity exonuclease activity
2vlcB type 2 ribosome-inactivating protein cinnamominiii	[pdb]	1.67 0.000926	546^PRO 547^LEU 232^TYR 503^VAL 238^ASP 241^ILE	0.0.0.0	defense response pathogenesis negative regulation of translation		hydrolase activity rRNA N-glycosylase activity
1ofvA flavodoxin	[pdb]	1.7 0.00106	149^PRO 151^LEU 125^TYR 13^VAL 144^ASP 143^ILE	0.0.0.0	transport response to stress electron transport chain		electron carrier activity FMN binding oxidoreductase activity
2q8bA apical membrane antigen 1 1f9 heavy chain 1f9 light chain	[pdb]	1.7 0.00106	303^PRO 431^LEU 397^TYR 301^VAL 118^PRO 119^SER	0.0.0.0	pathogenesis entry into host cell pathogenesis	extracellular region plasma membrane membrane integral to membrane membrane apical complex membrane integral to membrane	antigen binding
2iujA lipoxygenase l-5	[pdb]	1.7 0.00106	254^PRO 253^LEU 270^TYR 525^VAL 548^ASP 552^ILE	0.0.0.0	fatty acid biosynthetic process lipid biosynthetic process oxylipin biosynthetic process oxidation-reduction process		iron ion binding lipoxygenase activity oxidoreductase activity oxidoreductase activity acting on single donors with incorporation of molecular oxygen
3hw2A protein sifa pleckstrin homology domain-containing family mmember 2	[pdb]	1.73 0.00118	161^PRO 160^LEU 186^TYR 176^VAL 179^ASP 181^ILE	0.0.0.0	pathogenesis Golgi organization	extracellular region membrane host cell plasma membrane host cell cytoplasm host cell membrane cytoplasm	protein binding protein binding kinesin binding
3gkqC terminal oxygenase component of carbazole 1,9a-dioxygenase	[pdb]	1.73 0.00122	46^PRO 58^LEU 100^TYR 49^VAL 70^ASP 68^ILE	0.0.0.0	oxidation-reduction process		oxidoreductase activity oxidoreductase activity acting on single donors with incorporation of molecular oxygen incorporation of two atoms of oxygen metal ion binding
2e7jB sep-trna	[pdb]	1.76 0.00142	156^PRO 163^LEU 128^TYR 182^VAL 99^ASP 130^ILE	0.0.0.0	translation		catalytic activity transferase activity pyridoxal phosphate binding Sep-tRNA:Cys-tRNA synthase activity
3hkzJ dna-directed rna polymerase, subunit f (rpof) dna-directed rna polymerase subunit p dna-directed rna polymerase, subunit e' (rpoe1) dna-directed rna polymerase subunit k dna-directed rna polymerase subunit a'' dna-directed rna polymerase subunit h dna-directed rna polymerase subunit 13 dna-directed rna polymerase subunit l dna-directed rna polymerase subunit a' dna-directed rna polymerase subunit n dna-directed rna polymerase, subunit g (rpog) dna-directed rna polymerase subunit b dna-directed rna polymerase subunit d	[pdb]	1.76 0.00142	893^PRO 891^LEU 750^TYR 905^VAL 907^ASP 908^ILE	0.0.0.0	transcription DNA-dependent coenzyme M biosynthetic process transcription DNA-dependent	RNA polymerase complex	DNA binding DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity protein dimerization activity DNA binding DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity magnesium ion binding DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity 2-phosphosulfolactate phosphatase activity DNA binding DNA-directed RNA polymerase activity zinc ion binding transferase activity nucleotidyltransferase activity metal ion binding nucleotide binding catalytic activity DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity DNA binding RNA binding DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity DNA binding DNA-directed RNA polymerase activity zinc ion binding transferase activity nucleotidyltransferase activity ribonucleoside binding DNA binding DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity metal ion binding DNA binding DNA-directed RNA polymerase activity zinc ion binding transferase activity nucleotidyltransferase activity metal ion binding DNA binding DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity DNA binding DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity DNA binding DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity protein dimerization activity
2g3nC alpha-glucosidase	[pdb]	1.77 0.00147	599^PRO 598^LEU 467^TYR 570^VAL 548^ASP 561^ILE	0.0.0.0	carbohydrate metabolic process metabolic process carbohydrate metabolic process metabolic process	cytoplasm cytoplasm	catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds alpha-glucosidase activity hydrolase activity hydrolase activity acting on glycosyl bonds carbohydrate binding catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds alpha-glucosidase activity
2ivfB ethylbenzene dehydrogenase alpha-subunit ethylbenzene dehydrogenase beta-subunit ethylbenzene dehydrogenase gamma-subunit	[pdb]	1.78 0.00153	259^PRO 260^LEU 146^GLY 251^VAL 24^ALA 23^GLY	0.0.0.0	oxidation-reduction process oxidation-reduction process	periplasmic space	heme binding binding oxidoreductase activity molybdenum ion binding metal ion binding
3d0hE spike protein s1 angiotensin-converting enzyme 2	[pdb]	1.78 0.00153	477^PRO 478^LEU 410^TYR 458^VAL 454^ASP 455^ILE	0.0.0.0	regulation of cytokine production angiotensin catabolic process in blood angiotensin-mediated drinking behavior regulation of systemic arterial blood pressure by renin-angiotensin proteolysis oxygen and reactive oxygen species metabolic process regulation of vasoconstriction receptor biosynthetic process regulation of cell proliferation regulation of vasodilation interspecies interaction between organisms entry of virus into host cell virion attachment binding of host cell surface receptor regulation of inflammatory response cellular membrane fusion pathogenesis transmission of virus interspecies interaction between organisms virion attachment	extracellular region extracellular space plasma membrane cell surface membrane integral to membrane membrane raft membrane integral to membrane virion viral envelope host cell plasma membrane host cell membrane host cell endoplasmic reticulum-Golgi intermediate compartment membrane virion membrane extracellular region plasma membrane membrane integral to membrane	viral receptor activity glycoprotein binding carboxypeptidase activity peptidase activity metallopeptidase activity peptidyl-dipeptidase activity zinc ion binding hydrolase activity metal ion binding structural molecule activity host cell surface receptor binding carboxypeptidase activity peptidase activity metallopeptidase activity peptidyl-dipeptidase activity hydrolase activity metal ion binding
1u9wA cathepsin k	[pdb]	1.78 0.00158	50^PRO 53^LEU 98^TYR 31^VAL 82^ASP 81^ILE	3.4.22.38	intramembranous ossification proteolysis bone resorption	extracellular space cytoplasm lysosome	cysteine-type endopeptidase activity protein binding peptidase activity cysteine-type peptidase activity hydrolase activity
2wb7A pt26-6p	[pdb]	1.78 0.00158	419^PRO 383^LEU 661^TYR 398^VAL 157^ASP 155^ILE	0.0.0.0
3dtyA oxidoreductase, gfo/idh/moca family	[pdb]	1.79 0.00164	116^PRO 117^LEU 360^TYR 121^VAL 364^ASP 363^ILE	0.0.0.0	metabolic process oxidation-reduction process		catalytic activity binding oxidoreductase activity
1kmhB atpase beta subunit atpase alpha subunit	[pdb]	1.79 0.00165	105^PRO 107^LEU 213^TYR 124^VAL 119^ASP 110^ILE	3.6.3.14	ATP biosynthetic process transport ion transport ATP synthesis coupled proton transport proton transport ATP metabolic process ATP biosynthetic process transport ion transport ATP synthesis coupled proton transport proton transport ATP metabolic process	chloroplast chloroplast thylakoid membrane plastid thylakoid membrane proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex catalytic domain proton-transporting ATP synthase complex catalytic core F(1) chloroplast chloroplast thylakoid membrane plastid thylakoid membrane proton-transporting two-sector ATPase complex	nucleotide binding ATP binding hydrolase activity hydrolase activity acting on acid anhydrides catalyzing transmembrane movement of substances hydrogen ion transporting ATP synthase activity rotational mechanism proton-transporting ATPase activity rotational mechanism nucleotide binding ATP binding hydrogen-exporting ATPase activity phosphorylative mechanism
2pygB poly(beta-d-mannuronate) c5 epimerase 4	[pdb]	1.79 0.00171	300^PRO 303^LEU 245^TYR 360^VAL 292^ASP 290^ILE	0.0.0.0	alginic acid biosynthetic process	extracellular region extracellular space	calcium ion binding isomerase activity
1ehxA scaffoldin protein	[pdb]	1.8 0.00171	79^PRO 81^LEU 43^TYR 74^VAL 71^ASP 35^ILE	0.0.0.0	polysaccharide catabolic process carbohydrate metabolic process	peptidoglycan-based cell wall	carbohydrate binding
2p4bC sigma-e factor regulatory protein rseb	[pdb]	1.8 0.00171	112^PRO 114^LEU 154^TYR 185^VAL 171^ASP 157^ILE	0.0.0.0		periplasmic space
2rh3A protein virc2	[pdb]	1.82 0.00191	90^PRO 112^LEU 106^TYR 95^VAL 100^ASP 98^ILE	0.0.0.0			DNA binding
1s58A b19 parvovirus capsid	[pdb]	1.82 0.00191	462^PRO 461^LEU 184^TYR 479^VAL 49^ASP 46^ILE	0.0.0.0		viral capsid	structural molecule activity
2y3aA phosphatidylinositol-4,5-bisphosphate 3-kinase catalyticsubunit beta isoform phosphatidylinositol 3-kinase regulatory subunit beta	[pdb]	1.82 0.00198	755^PRO 756^LEU 784^TYR 702^LEU 751^ASP 761^ILE		platelet activation embryonic cleavage phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling signal transduction insulin receptor signaling pathway negative regulation of anti-apoptosis regulation of phosphorylation regulation of cell-matrix adhesion cellular calcium ion homeostasis homophilic cell adhesion signal transduction	intracellular phosphatidylinositol 3-kinase complex phosphatidylinositol 3-kinase complex	kinase activity 1-phosphatidylinositol-3-kinase activity transferase activity phosphotransferase activity alcohol group as acceptor insulin receptor substrate binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein binding phosphatidylinositol 3-kinase regulator activity 1-phosphatidylinositol-3-kinase activity nucleotide binding inositol or phosphatidylinositol kinase activity binding
1n7uA adsorption protein p2	[pdb]	1.82 0.00198	155^PRO 156^LEU 303^TYR 153^VAL 306^ASP 307^ILE	0.0.0.0		virion
1fp7B formate--tetrahydrofolate ligase	[pdb]	1.83 0.00198	1434^PRO 1430^LEU 1297^TYR 1375^VAL 1326^ASP 1060^ILE	6.3.4.3	one-carbon metabolic process folic acid-containing compound biosynthetic process		nucleotide binding formate-tetrahydrofolate ligase activity ATP binding ligase activity
3bdlA staphylococcal nuclease domain-containingprotein 1	[pdb]	1.83 0.00198	543^PRO 545^LEU 672^TYR 763^VAL 740^ASP 739^ILE	0.0.0.0	RNA interference interspecies interaction between organisms	nucleus cytoplasm mitochondrion Golgi apparatus RNA-induced silencing complex melanosome	nucleic acid binding transcription cofactor activity nuclease activity protein binding hydrolase activity
3jtxA aminotransferase	[pdb]	1.84 0.00214	311^PRO 313^LEU 394^TYR 384^VAL 389^ASP 390^ILE	0.0.0.0	biosynthetic process		catalytic activity transaminase activity transferase activity transferase activity transferring nitrogenous groups
2kieA inositol polyphosphate 5-phosphatase ocrl-1	[pdb]	1.84 0.00214	9^PRO 10^LEU 44^TYR 57^VAL 59^ASP 47^ILE	3.1.3.36	lipid metabolic process signal transduction phosphatidylinositol dephosphorylation	intracellular Golgi stack Golgi-associated vesicle	inositol or phosphatidylinositol phosphatase activity phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity hydrolase activity
3bg5A pyruvate carboxylase	[pdb]	1.84 0.00222	767^PRO 738^LEU 783^TYR 557^VAL 792^ASP 793^ILE	0.0.0.0	gluconeogenesis metabolic process	cytoplasm	catalytic activity pyruvate carboxylase activity ATP binding biotin binding ligase activity
3c26A putative acetyltransferase ta0821	[pdb]	1.85 0.00222	162^PRO 160^LEU 210^TYR 205^VAL 208^ASP 214^ILE	0.0.0.0	metabolic process		N-acetyltransferase activity
3bccF ubiquinol cytochrome c oxidoreductase	[pdb]	1.85 0.00222	92^PRO 90^LEU 38^GLY 97^VAL 42^ILE 47^ASN	0.0.0.0	transport electron transport chain oxidation-reduction process proteolysis transport electron transport chain transport electron transport chain respiratory electron transport chain transport electron transport chain mitochondrial electron transport ubiquinol to cytochrome c proteolysis transport electron transport chain mitochondrial electron transport ubiquinol to cytochrome c transport electron transport chain mitochondrial electron transport ubiquinol to cytochrome c transport electron transport chain transport electron transport chain	mitochondrion mitochondrial inner membrane membrane integral to membrane respiratory chain mitochondrion mitochondrial inner membrane membrane respiratory chain membrane fraction mitochondrion mitochondrial inner membrane membrane integral to membrane respiratory chain mitochondrion mitochondrial inner membrane membrane respiratory chain mitochondrion mitochondrial inner membrane membrane respiratory chain mitochondrion mitochondrial inner membrane membrane respiratory chain mitochondrion mitochondrial envelope mitochondrial inner membrane membrane respiratory chain mitochondrion mitochondrial inner membrane membrane integral to membrane respiratory chain mitochondrion mitochondrial inner membrane membrane respiratory chain	ubiquinol-cytochrome-c reductase activity oxidoreductase activity oxidoreductase activity acting on diphenols and related substances as donors metal ion binding iron-sulfur cluster binding 2 iron 2 sulfur cluster binding catalytic activity metalloendopeptidase activity zinc ion binding metal ion binding electron carrier activity oxidoreductase activity metal ion binding ubiquinol-cytochrome-c reductase activity catalytic activity metalloendopeptidase activity protein binding zinc ion binding metal ion binding ubiquinol-cytochrome-c reductase activity ubiquinol-cytochrome-c reductase activity iron ion binding electron carrier activity heme binding
3c9fB 5'-nucleotidase	[pdb]	1.85 0.0023	471^PRO 47^LEU 308^TYR 475^VAL 486^ASP 299^ILE	0.0.0.0	nucleotide catabolic process		hydrolase activity
3fawA reticulocyte binding protein	[pdb]	1.85 0.0023	1150^PRO 1151^LEU 1038^TYR 1139^VAL 1124^ASP 1154^ILE	0.0.0.0	carbohydrate metabolic process	cell wall cell surface membrane	catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds carbohydrate binding
2x4dA phospholysine phosphohistidine inorganicpyrophosphate phosphatase	[pdb]	1.85 0.0023	83^PRO 153^LEU 172^TYR 106^VAL 125^ASP 123^ILE	3.6.1.1	metabolic process		catalytic activity inorganic diphosphatase activity hydrolase activity
2xgiA beta-amylase	[pdb]	1.86 0.0023	141^PRO 142^LEU 210^TYR 149^VAL 138^ASP 119^ILE		polysaccharide catabolic process carbohydrate metabolic process metabolic process		catalytic activity beta-amylase activity hydrolase activity hydrolase activity acting on glycosyl bonds
1jylA ctp	[pdb]	1.86 0.0023	27^PRO 30^LEU 109^TYR 58^VAL 105^ASP 39^ILE	0.0.0.0	biosynthetic process		nucleotidyltransferase activity
1tv4A monomethylamine methyltransferase mtmb1	[pdb]	1.86 0.0023	124^PRO 364^LEU 147^TYR 113^VAL 154^ASP 156^ILE	0.0.0.0	methanogenesis		methyltransferase activity transferase activity
2v9xH deoxycytidine triphosphate deaminase	[pdb]	1.86 0.00239	100^PRO 99^LEU 179^TYR 104^VAL 128^ASP 127^ILE	3.5.4.13	dUTP biosynthetic process nucleotide metabolic process dUTP metabolic process		protein binding dCTP deaminase activity hydrolase activity
2x36C lon protease homolog, mitochondrial	[pdb]	1.86 0.00239	913^PRO 912^LEU 921^TYR 892^VAL 919^ASP 895^ILE	0.0.0.0	mitochondrial genome maintenance response to hypoxia ATP catabolic process proteolysis mitochondrion organization mitochondrial DNA metabolic process cellular response to oxidative stress protein homooligomerization proteolysis involved in cellular protein catabolic process oxidation-dependent protein catabolic process	mitochondrion mitochondrial matrix mitochondrial nucleoid	nucleotide binding DNA binding single-stranded DNA binding single-stranded RNA binding ATP-dependent peptidase activity serine-type endopeptidase activity protein binding ATP binding peptidase activity serine-type peptidase activity hydrolase activity ATPase activity nucleoside-triphosphatase activity ADP binding sequence-specific DNA binding G-quadruplex DNA binding DNA polymerase binding mitochondrial light strand promoter anti-sense binding mitochondrial heavy strand promoter anti-sense binding mitochondrial light strand promoter sense binding mitochondrial heavy strand promoter sense binding
1kqgA formate dehydrogenase, nitrate-inducible, iron-sulfur subunit formate dehydrogenase, nitrate-inducible, majorsubunit formate dehydrogenase, nitrate-inducible,cytochrome b556(fdn) subunit	[pdb]	1.87 0.00248	959^HOH 960^HOH 272^LEU 891^HOH 259^PRO 275^HIS	1.2.1.2	transport electron transport chain respiratory electron transport chain cellular respiration transport electron transport chain respiratory electron transport chain cellular respiration anaerobic respiration cellular respiration oxidation-reduction process transport anaerobic respiration cytochrome complex assembly electron transport chain respiratory electron transport chain cellular respiration transport anaerobic respiration electron transport chain cellular respiration	plasma membrane formate dehydrogenase complex membrane integral to membrane plasma membrane formate dehydrogenase complex membrane integral to membrane cytoplasm formate dehydrogenase complex membrane periplasmic space plasma membrane formate dehydrogenase complex membrane integral to membrane plasma membrane formate dehydrogenase complex membrane integral to membrane	formate dehydrogenase activity electron carrier activity oxidoreductase activity metal ion binding formate dehydrogenase activity electron carrier activity oxidoreductase activity metal ion binding binding selenium binding formate dehydrogenase activity electron carrier activity oxidoreductase activity molybdenum ion binding metal ion binding iron-sulfur cluster binding 4 iron 4 sulfur cluster binding formate dehydrogenase activity electron carrier activity oxidoreductase activity metal ion binding formate dehydrogenase activity electron carrier activity metal ion binding iron-sulfur cluster binding
1olmA sec14-like protein 2	[pdb]	1.87 0.00248	195^PRO 158^LEU 260^TYR 191^VAL 154^ASP 103^ILE	0.0.0.0	transport regulation of cholesterol biosynthetic process positive regulation of cholesterol biosynthetic process positive regulation of transcription	intracellular nucleus cytoplasm cytosol	transporter activity phospholipid binding enzyme activator activity lipid binding vitamin E binding transcription activator activity
1ovtA ovotransferrin	[pdb]	1.87 0.00248	76^PRO 74^LEU 42^TYR 260^VAL 55^ASP 49^ILE	0.0.0.0	transport ion transport iron ion transport cellular iron ion homeostasis acute-phase response response to lipopolysaccharide	extracellular region extracellular space extracellular matrix	ferric iron binding metal ion binding
2ajcC dipeptidyl peptidase 4	[pdb]	1.87 0.00248	257^PRO 235^LEU 238^TYR 202^VAL 709^ASP 254^ILE	3.4.14.5	response to hypoxia proteolysis cell adhesion positive regulation of cell proliferation negative regulation of extracellular matrix disassembly T cell costimulation regulation of cell-cell adhesion mediated by integrin T cell activation endothelial cell migration	extracellular region plasma membrane cell surface membrane integral to membrane apical plasma membrane lamellipodium cell junction endocytic vesicle lamellipodium membrane cell projection membrane raft intercellular canaliculus invadopodium membrane	protease binding aminopeptidase activity serine-type endopeptidase activity receptor binding protein binding peptidase activity serine-type peptidase activity dipeptidyl-peptidase activity hydrolase activity protein homodimerization activity
1ixkA methyltransferase	[pdb]	1.87 0.00248	116^PRO 114^LEU 244^TYR 145^VAL 124^ASP 191^ILE	0.0.0.0	rRNA processing		RNA binding methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity
1iktA estradiol 17 beta-dehydrogenase 4	[pdb]	1.88 0.00257	24^PRO 19^LEU 60^TYR 30^VAL 51^ASP 50^ILE	1.1.1.35, 4.2.1.107	lipid metabolic process fatty acid metabolic process metabolic process fatty acid beta-oxidation using acyl-CoA oxidase oxidation-reduction process	peroxisome peroxisomal matrix	catalytic activity 3-hydroxyacyl-CoA dehydrogenase activity estradiol 17-beta-dehydrogenase activity binding protein binding sterol transporter activity oxidoreductase activity lyase activity isomerase activity sterol binding 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
3dwoX probable outer membrane protein	[pdb]	1.88 0.00257	410^PRO 411^LEU 331^TYR 406^VAL 375^ASP 373^ILE	0.0.0.0		cell outer membrane integral to membrane
1fnnA cell division control protein 6	[pdb]	1.88 0.00257	138^PRO 141^LEU 77^TYR 170^VAL 132^ASP 163^ILE	0.0.0.0	DNA replication cell division		nucleotide binding ATP binding nucleoside-triphosphatase activity
3n9xB phosphotransferase	[pdb]	1.88 0.00266	96^PRO 105^LEU 43^TYR 404^VAL 92^ASP 107^ILE		protein phosphorylation		nucleotide binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity ATP binding kinase activity transferase activity
3dmaA exopolyphosphatase-related protein	[pdb]	1.89 0.00276	63^PRO 66^LEU 171^TYR 30^VAL 35^ASP 37^ILE	0.0.0.0			nucleic acid binding hydrolase activity manganese ion binding
3ks7A putative putative pngase f	[pdb]	1.9 0.00286	197^PRO 198^LEU 410^TYR 83^VAL 194^ASP 192^ILE	0.0.0.0	cellular process		catalytic activity
2gbfA dipeptidyl peptidase 4	[pdb]	1.9 0.00296	255^PRO 233^LEU 236^TYR 200^VAL 710^ASP 252^ILE	3.4.14.5	response to hypoxia regulation of T cell mediated immunity proteolysis cell adhesion positive regulation of cell proliferation negative regulation of extracellular matrix disassembly T cell costimulation regulation of cell-cell adhesion mediated by integrin T cell activation endothelial cell migration establishment of localization	extracellular region membrane fraction soluble fraction endoplasmic reticulum Golgi apparatus plasma membrane cell surface membrane integral to membrane apical plasma membrane lamellipodium cell junction endocytic vesicle lamellipodium membrane cell projection membrane raft intercellular canaliculus invadopodium membrane	protease binding aminopeptidase activity serine-type endopeptidase activity receptor binding protein binding collagen binding peptidase activity serine-type peptidase activity dipeptidyl-peptidase activity hydrolase activity peptide binding protein homodimerization activity
1x6lA chitinase a	[pdb]	1.91 0.00297	180^PRO 549^LEU 479^TYR 176^VAL 542^ASP 541^ILE	3.2.1.14	polysaccharide catabolic process carbohydrate metabolic process chitin catabolic process metabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds chitinase activity hydrolase activity hydrolase activity
1xfjA conserved hypothetical protein	[pdb]	1.91 0.00307	207^PRO 206^LEU 172^TYR 225^VAL 228^ASP 167^ILE	0.0.0.0
1ngsA transketolase	[pdb]	1.91 0.00307	31^PRO 35^LEU 75^TYR 272^VAL 21^ASP 17^ILE	2.2.1.1	pentose-phosphate shunt metabolic process		catalytic activity transketolase activity protein binding transferase activity metal ion binding
3qi7B putative transcriptional regulator	[pdb]	1.91 0.00307	126^PRO 125^LEU 385^TYR 131^VAL 157^ASP 141^ILE
3bwwA protein of unknown function duf692/cog3220	[pdb]	1.92 0.00307	187^PRO 253^LEU 201^TYR 177^VAL 171^ASP 204^ILE	0.0.0.0
2e85A hydrogenase 3 maturation protease	[pdb]	1.92 0.00318	20^PRO 21^LEU 122^TYR 61^VAL 16^ASP 128^ILE	0.0.0.0			aspartic-type endopeptidase activity protein binding enzyme activator activity peptidase activity hydrolase activity metal ion binding
3hijB dihydrodipicolinate synthase	[pdb]	1.92 0.00318	195^PRO 194^LEU 186^TYR 239^VAL 189^ASP 204^ILE	0.0.0.0	metabolic process cellular amino acid biosynthetic process lysine biosynthetic process diaminopimelate biosynthetic process	cytoplasm	catalytic activity dihydrodipicolinate synthase activity lyase activity
1uj4A ribose 5-phosphate isomerase	[pdb]	1.93 0.00341	57^PRO 28^LEU 36^TYR 111^VAL 86^ASP 85^ILE	5.3.1.6	pentose-phosphate shunt		ribose-5-phosphate isomerase activity isomerase activity
3a9uA 4-coumarate--coa ligase	[pdb]	1.93 0.00341	39^PRO 41^LEU 270^TYR 248^VAL 224^ASP 226^ILE	0.0.0.0	metabolic process		catalytic activity ligase activity
3hguB ehpf	[pdb]	1.93 0.00341	337^PRO 336^LEU 262^TYR 339^VAL 286^ASP 284^ILE	0.0.0.0	metabolic process		catalytic activity
1f07A coenzyme f420-dependent n5,n10-methylenetetrahydromethanopterin reductase	[pdb]	1.94 0.00341	147^PRO 90^LEU 43^TYR 142^VAL 81^ASP 77^ILE	1.5.99.11	one-carbon metabolic process methanogenesis oxidation-reduction process	cytoplasm	oxidoreductase activity coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity
1ywmA c protein alpha-antigen	[pdb]	1.94 0.00341	141^PRO 140^LEU 107^TYR 143^VAL 150^ASP 134^ILE	0.0.0.0	pathogenesis	extracellular region cell wall cell surface membrane
2rirA dipicolinate synthase, a chain	[pdb]	1.94 0.00354	235^PRO 238^LEU 150^TYR 210^VAL 214^ASP 215^ILE	0.0.0.0	metabolic process cellular amino acid biosynthetic process lysine biosynthetic process diaminopimelate biosynthetic process sporulation resulting in formation of a cellular spore		catalytic activity binding oxidoreductase activity acting on the CH-OH group of donors
1vdwA hypothetical protein ph1897	[pdb]	1.94 0.00354	85^PRO 86^LEU 196^TYR 103^VAL 201^ASP 175^ILE	0.0.0.0			inositol or phosphatidylinositol phosphatase activity
1i9yA phosphatidylinositol phosphate phosphatase	[pdb]	1.94 0.00354	586^PRO 587^LEU 635^TYR 558^VAL 589^ASP 590^ILE	3.1.3.36	lipid metabolic process transport protein transport inositol lipid-mediated signaling	cytoplasm cytosol cell division site cell tip	inositol or phosphatidylinositol phosphatase activity phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity inositol-polyphosphate 5-phosphatase activity hydrolase activity
1iuqA glycerol-3-phosphate acyltransferase	[pdb]	1.94 0.00354	175^PRO 176^LEU 95^TYR 76^VAL 75^ASP 72^ILE	2.3.1.15	metabolic process phospholipid biosynthetic process	chloroplast plastid chloroplast stroma	glycerol-3-phosphate O-acyltransferase activity acyltransferase activity transferase activity
1gjiA il-2 cd28re dna c-rel proto-oncogene protein	[pdb]	1.95 0.0038	75^PRO 64^LEU 88^TYR 109^VAL 77^ASP 106^ILE	0.0.0.0	cytokine production DNA fragmentation involved in apoptotic nuclear change regulation of transcription DNA-dependent positive regulation of I-kappaB kinase/NF-kappaB cascade positive regulation of interleukin-12 biosynthetic process	nucleus cytoplasm	DNA binding sequence-specific DNA binding transcription factor activity protein binding protein homodimerization activity protein heterodimerization activity
3n1uA hydrolase, had superfamily, subfamily iii a	[pdb]	1.96 0.0038	124^PRO 125^LEU 89^TYR 133^VAL 25^ASP 23^ILE	0.0.0.0	lipopolysaccharide biosynthetic process		hydrolase activity 3-deoxy-manno-octulosonate-8-phosphatase activity
1yroD beta-1,4-galactosyltransferase alpha-lactalbumin	[pdb]	1.96 0.00394	139^PRO 140^LEU 264^TYR 142^VAL 260^ASP 205^ILE	2.4.1.22, 2.4.1.38, 2.4.1.90	lactose biosynthetic process epithelial cell development acute inflammatory response carbohydrate metabolic process lactose biosynthetic process galactose metabolic process protein amino acid terminal N-glycosylation cell adhesion binding of sperm to zona pellucida penetration of zona pellucida negative regulation of cell proliferation glycoprotein biosynthetic process oligosaccharide biosynthetic process extracellular matrix organization mammary gland development wound healing regulation of cell proliferation positive regulation of apoptosis development of secondary sexual characteristics branching morphogenesis of a tube leukocyte migration regulation of cellular component movement regulation of acrosome reaction positive regulation of epithelial cell proliferation involved in wound healing angiogenesis involved in wound healing positive regulation of apoptosis involved in mammary gland involution	extracellular region Golgi trans cisterna extracellular region Golgi apparatus plasma membrane external side of plasma membrane cell surface membrane integral to membrane basolateral plasma membrane desmosome glycocalyx brush border membrane Golgi cisterna membrane	lactose synthase activity calcium ion binding protein binding beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity N-acetyllactosamine synthase activity lactose synthase activity protein binding cytoskeletal protein binding galactosyltransferase activity transferase activity transferase activity transferring glycosyl groups UDP-galactosyltransferase activity protein homodimerization activity alpha-tubulin binding metal ion binding
1pv9A xaa-pro dipeptidase	[pdb]	1.96 0.00394	254^PRO 304^LEU 299^TYR 249^VAL 262^ASP 296^ILE	3.4.13.9	proteolysis cellular process	cytoplasm	aminopeptidase activity peptidase activity metalloexopeptidase activity metallopeptidase activity hydrolase activity dipeptidase activity metal ion binding
2zwsA neutral ceramidase	[pdb]	1.96 0.00394	364^PRO 367^LEU 467^TYR 362^VAL 379^ASP 376^ILE	3.5.1.23	lipid metabolic process	extracellular region	hydrolase activity ceramidase activity
3cdzA coagulation factor viii light chain coagulation factor viii heavy chain	[pdb]	1.97 0.00394	521^PRO 529^LEU 532^TYR 517^VAL 519^ASP 553^ILE		acute-phase response cell adhesion blood coagulation oxidation-reduction process	extracellular region extracellular space plasma membrane platelet alpha granule lumen	copper ion binding protein binding oxidoreductase activity metal ion binding
2vycH biodegradative arginine decarboxylase	[pdb]	1.97 0.00394	555^PRO 558^LEU 626^TYR 554^VAL 633^ASP 631^ILE	4.1.1.19	response to acid cellular amino acid metabolic process intracellular pH elevation	cytoplasm cytosol	catalytic activity arginine decarboxylase activity lyase activity carboxy-lyase activity pyridoxal phosphate binding
3fu9B laccase-1	[pdb]	1.97 0.00408	162^PRO 161^LEU 132^TYR 276^VAL 274^ASP 250^ILE	1.10.3.2	cellulose catabolic process lignin catabolic process oxidation-reduction process	extraorganismal space	copper ion binding laccase activity oxidoreductase activity metal ion binding
1ihmC capsid protein	[pdb]	1.98 0.00422	3393^PRO 3323^LEU 3343^TYR 3387^VAL 3327^ASP 3376^ILE	0.0.0.0		virion viral capsid host cell cytoplasm
3kf5B invertase	[pdb]	1.98 0.00437	358^PRO 357^LEU 489^TYR 363^VAL 392^ASP 480^ILE	3.2.1.26	carbohydrate metabolic process metabolic process		hydrolase activity hydrolyzing O-glycosyl compounds beta-fructofuranosidase activity hydrolase activity
2czvA ribonuclease p protein component 2 ribonuclease p protein component 3	[pdb]	1.99 0.00437	178^PRO 181^LEU 20^ALA 7^THR 28^ASP 10^PRO	3.1.26.5	tRNA processing tRNA 5'-leader removal tRNA processing		catalytic activity ribonuclease P activity ribonuclease activity protein binding hydrolase activity ribonuclease P activity ribonuclease activity protein binding hydrolase activity
3h7rA aldo-keto reductase	[pdb]	1.99 0.00437	17^PRO 16^LEU 107^TYR 19^VAL 43^ASP 74^ILE	0.0.0.0	response to cold response to water deprivation response to salt stress response to cadmium ion oxidation-reduction process		aldo-keto reductase activity steroid dehydrogenase activity oxidoreductase activity
3mqmA probable histone-lysine n-methyltransferase ash1l	[pdb]	1.99 0.00453	2485^PRO 2486^LEU 2499^TYR 2513^VAL 2509^ASP 2491^ILE	2.1.1.43	DNA packaging transcription from RNA polymerase II promoter cell-cell signaling chromatin modification	nucleus tight junction cell junction	DNA binding RNA polymerase II transcription factor activity protein binding methyltransferase activity zinc ion binding transferase activity histone-lysine N-methyltransferase activity metal ion binding
3efmA ferric alcaligin siderophore receptor	[pdb]	2 0.00469	157^PRO 158^LEU 652^TYR 219^VAL 180^ASP 181^ILE	0.0.0.0	transport siderophore transport	plasma membrane cell outer membrane membrane	receptor activity transporter activity iron ion binding siderophore transmembrane transporter activity
1kd0A beta-methylaspartase	[pdb]	2 0.00469	193^PRO 192^LEU 231^TYR 383^VAL 190^ASP 234^ILE	4.3.1.2			lyase activity cobalamin binding methylaspartate ammonia-lyase activity
3cxrA dehydrogenase with different specificities	[pdb]	2 0.00486	126^PRO 123^LEU 163^TYR 72^VAL 122^ASP 119^ILE	0.0.0.0	metabolic process oxidation-reduction process		catalytic activity binding oxidoreductase activity
3pmmA putative cytoplasmic protein	[pdb]	2.01 0.00486	175^PRO 174^LEU 300^TYR 246^VAL 241^ASP 239^ILE	0.0.0.0			catalytic activity
1otvB coenzyme pqq synthesis protein c	[pdb]	2.01 0.00486	58^PRO 59^LEU 128^TYR 78^VAL 61^ASP 64^ILE	1.3.3.11	pyrroloquinoline quinone biosynthetic process oxidation-reduction process		oxidoreductase activity pyrroloquinoline-quinone synthase activity
2rhyA lethal(3)malignant brain tumor-like protein	[pdb]	2.01 0.00486	292^PRO 244^LEU 255^TYR 334^VAL 289^ASP 290^ILE	0.0.0.0	regulation of transcription DNA-dependent regulation of mitosis chromatin modification hemopoiesis regulation of megakaryocyte differentiation	chromatin condensed chromosome nucleus nucleoplasm nucleolus	DNA binding chromatin binding sequence-specific DNA binding transcription factor activity protein binding zinc ion binding transcription repressor activity nucleosome binding nucleosomal histone binding SAM domain binding methylated histone residue binding histone binding identical protein binding metal ion binding
1hwgC growth hormone binding protein growth hormone	[pdb]	2.01 0.00504	234^PRO 233^LEU 178^TYR 144^VAL 152^ASP 153^ILE	0.0.0.0	activation of MAPK activity allantoin metabolic process citrate metabolic process 2-oxoglutarate metabolic process succinate metabolic process oxaloacetate metabolic process isoleucine metabolic process valine metabolic process creatine metabolic process fatty acid metabolic process endocytosis JAK-STAT cascade response to hormone stimulus hormone-mediated signaling pathway taurine metabolic process receptor internalization response to food response to estradiol stimulus cellular response to insulin stimulus cellular response to hormone stimulus response to cytokine stimulus regulation of multicellular organism growth positive regulation of multicellular organism growth positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of tyrosine phosphorylation of Stat5 protein activation of JAK2 kinase activity response to morphine response to peptide hormone stimulus neuroprotection multicellular organismal metabolic process positive regulation of cell differentiation positive regulation of JAK-STAT cascade creatinine metabolic process response to cycloheximide insulin-like growth factor receptor signaling pathway positive regulation of peptidyl-tyrosine phosphorylation response to glucocorticoid stimulus cartilage development involved in endochondral bone morphogenesis growth hormone receptor signaling pathway response to interleukin-1 JAK-STAT cascade positive regulation of activation of JAK2 kinase activity positive regulation of phosphatidylinositol 3-kinase cascade glucose transport response to estradiol stimulus positive regulation of multicellular organism growth positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of tyrosine phosphorylation of Stat5 protein positive regulation of MAP kinase activity positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of JAK-STAT cascade positive regulation of peptidyl-tyrosine phosphorylation growth hormone receptor signaling pathway positive regulation of receptor internalization	extracellular region extracellular space nucleus cytoplasm mitochondrion plasma membrane integral to plasma membrane cell surface membrane integral to membrane extrinsic to membrane neuronal cell body receptor complex growth hormone receptor complex extracellular region extracellular space	receptor activity cytokine receptor activity growth hormone receptor activity protein binding peptide hormone binding growth factor binding protein kinase binding protein phosphatase binding SH2 domain binding protein homodimerization activity proline-rich region binding growth hormone receptor binding prolactin receptor binding hormone activity protein binding growth factor activity metal ion binding
2okeB deoxyuridine 5'-triphosphate nucleotidohydrolase	[pdb]	2.01 0.00504	22^PRO 34^LEU 38^TYR 13^VAL 53^ASP 92^ILE	0.0.0.0	dUTP metabolic process		dUTP diphosphatase activity hydrolase activity
1wraA teichoic acid phosphorylcholine esterase/cholinebinding protein e (cbpe)	[pdb]	2.01 0.00504	127^PRO 123^LEU 132^TYR 100^VAL 104^ASP 106^ILE	0.0.0.0			hydrolase activity
3bh6B adp-ribosylation factor-like protein 3 protein xrp2	[pdb]	2.01 0.00504	54^PRO 53^LEU 151^TYR 57^VAL 76^ASP 74^ILE	0.0.0.0	GTP biosynthetic process UTP biosynthetic process CTP biosynthetic process protein folding visual perception response to stimulus cell cycle small GTPase mediated signal transduction cell division	plasma membrane membrane Golgi membrane intracellular nucleus cytoplasm Golgi apparatus spindle cytoskeleton membrane	nucleoside diphosphate kinase activity binding ATP binding unfolded protein binding nucleotide binding GTP binding GDP binding metal ion binding
3ge6B nitroreductase	[pdb]	2.01 0.00504	161^PRO 187^LEU 22^TYR 151^VAL 158^ASP 189^ILE	0.0.0.0			oxidoreductase activity
1y89B devb protein	[pdb]	2.02 0.00504	108^PRO 103^LEU 81^TYR 162^VAL 68^ASP 102^ILE	0.0.0.0	carbohydrate metabolic process pentose-phosphate shunt		6-phosphogluconolactonase activity
3brkX glucose-1-phosphate adenylyltransferase	[pdb]	2.02 0.00504	288^PRO 290^LEU 276^TYR 286^VAL 282^ASP 281^ILE	2.7.7.27	glycogen biosynthetic process biosynthetic process		nucleotide binding ATP binding glucose-1-phosphate adenylyltransferase activity transferase activity nucleotidyltransferase activity
3h79A thioredoxin-like protein	[pdb]	2.02 0.00504	94^PRO 39^LEU 81^TYR 49^VAL 77^ASP 76^ILE	0.0.0.0	cell redox homeostasis
1w99A pesticidial crystal protein cry4ba	[pdb]	2.02 0.00523	593^PRO 539^LEU 272^TYR 598^VAL 595^ASP 631^ILE	0.0.0.0	defense response pathogenesis sporulation resulting in formation of a cellular spore		receptor binding
1nkhB beta-1,4-galactosyltransferase alpha-lactalbumin	[pdb]	2.02 0.00523	139^PRO 140^LEU 264^TYR 142^VAL 260^ASP 205^ILE	2.4.1.22, 2.4.1.38, 2.4.1.90	epithelial cell development acute inflammatory response carbohydrate metabolic process lactose biosynthetic process galactose metabolic process protein amino acid terminal N-glycosylation cell adhesion binding of sperm to zona pellucida penetration of zona pellucida negative regulation of cell proliferation glycoprotein biosynthetic process oligosaccharide biosynthetic process extracellular matrix organization mammary gland development wound healing regulation of cell proliferation positive regulation of apoptosis development of secondary sexual characteristics branching morphogenesis of a tube leukocyte migration regulation of cellular component movement regulation of acrosome reaction positive regulation of epithelial cell proliferation involved in wound healing angiogenesis involved in wound healing positive regulation of apoptosis involved in mammary gland involution lactose biosynthetic process	Golgi trans cisterna extracellular region Golgi apparatus plasma membrane external side of plasma membrane cell surface membrane integral to membrane basolateral plasma membrane desmosome glycocalyx brush border membrane Golgi cisterna membrane extracellular region	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity N-acetyllactosamine synthase activity lactose synthase activity protein binding cytoskeletal protein binding galactosyltransferase activity transferase activity transferase activity transferring glycosyl groups UDP-galactosyltransferase activity protein homodimerization activity alpha-tubulin binding metal ion binding beta-tubulin binding lactose synthase activity calcium ion binding
1dk4A inositol monophosphatase	[pdb]	2.02 0.00523	195^PRO 234^LEU 206^TYR 193^VAL 192^ASP 236^ILE	3.1.3.25			inositol or phosphatidylinositol phosphatase activity inositol-1(or 4)-monophosphatase activity hydrolase activity metal ion binding
3imlC s-adenosylmethionine synthetase	[pdb]	2.02 0.00523	141^PRO 140^LEU 176^TYR 187^VAL 185^ASP 184^ILE	0.0.0.0	one-carbon metabolic process	cytoplasm	nucleotide binding methionine adenosyltransferase activity ATP binding transferase activity metal ion binding
2o5eA dna topoisomerase 3 5'-d(cpgpcpapapcptpt)-3'	[pdb]	2.03 0.00542	9^PRO 11^LEU 328^TYR 112^VAL 103^ASP 134^ILE	5.99.1.2	DNA metabolic process DNA topological change DNA unwinding involved in replication	chromosome	nucleotide binding nucleic acid binding DNA binding DNA topoisomerase activity DNA topoisomerase type I activity protein binding ATP binding isomerase activity
3bwbB spermidine synthase	[pdb]	2.03 0.00542	94^PRO 90^LEU 170^TYR 261^VAL 203^ASP 205^ILE	0.0.0.0			catalytic activity spermidine synthase activity transferase activity
2b9vP alpha-amino acid ester hydrolase	[pdb]	2.03 0.00542	521^PRO 518^LEU 564^TYR 524^VAL 549^ASP 612^ILE	0.0.0.0	metabolic process		dipeptidyl-peptidase activity hydrolase activity alpha-amino-acid esterase activity
13pkB 3-phosphoglycerate kinase	[pdb]	2.03 0.00542	300^PRO 301^LEU 245^TYR 347^VAL 316^ASP 317^ILE	2.7.2.3	glycolysis	peroxisome glycosome	nucleotide binding phosphoglycerate kinase activity ATP binding kinase activity transferase activity
3h1cV ribonuclease e polyribonucleotide nucleotidyltransferase	[pdb]	2.03 0.00542	98^PRO 94^LEU 63^TYR 178^VAL 127^ASP 91^ILE	2.7.7.8	RNA processing RNA processing mRNA catabolic process response to stress	cytoplasm cytoplasm mitochondrion cytosol membrane	RNA binding nuclease activity endonuclease activity ribonuclease activity protein binding hydrolase activity identical protein binding 3'-5'-exoribonuclease activity RNA binding polyribonucleotide nucleotidyltransferase activity transferase activity nucleotidyltransferase activity
3g85A transcriptional regulator (laci family)	[pdb]	2.03 0.00542	329^PRO 330^LEU 284^TYR 163^VAL 296^ASP 277^ILE	0.0.0.0	regulation of transcription	intracellular	DNA binding sequence-specific DNA binding transcription factor activity
2plrA probable thymidylate kinase	[pdb]	2.03 0.00542	60^PRO 61^LEU 116^TYR 104^VAL 102^ASP 109^ILE	2.7.4.9	dTDP biosynthetic process nucleotide biosynthetic process		nucleotide binding thymidylate kinase activity ATP binding kinase activity transferase activity
2z1qA acyl-coa dehydrogenase	[pdb]	2.04 0.00562	409^PRO 412^LEU 490^TYR 478^VAL 484^ASP 485^ILE	0.0.0.0	metabolic process oxidation-reduction process		acyl-CoA dehydrogenase activity oxidoreductase activity oxidoreductase activity acting on the CH-CH group of donors
1puiA probable gtp-binding protein engb	[pdb]	2.04 0.00562	22^PRO 21^LEU 102^TYR 12^VAL 78^ASP 65^ILE	0.0.0.0	cytokinesis barrier septum formation cell cycle cell division	intracellular	nucleotide binding GTP binding
2vpxF nrfc protein hypothetical membrane spanning protein thiosulfate reductase	[pdb]	2.04 0.00562	181^ALA 10^GLN 138^LEU 162^LEU 9^ALA 8^ASN	0.0.0.0	oxidation-reduction process		electron carrier activity metal ion binding iron-sulfur cluster binding 4 iron 4 sulfur cluster binding binding oxidoreductase activity molybdenum ion binding metal ion binding
1lrvA leucine-rich repeat variant	[pdb]	2.04 0.00562	123^PRO 122^LEU 96^TYR 142^VAL 120^ASP 116^ILE	0.0.0.0			binding
1pz0A iols protein	[pdb]	2.04 0.00583	250^PRO 248^LEU 215^TYR 257^VAL 258^ASP 259^ILE	0.0.0.0	oxidation-reduction process		oxidoreductase activity
2qjxA protein bim1	[pdb]	2.05 0.00584	117^PRO 20^LEU 36^TYR 114^VAL 41^ASP 39^ILE	0.0.0.0	microtubule depolymerization microtubule nucleation negative regulation of microtubule depolymerization cell cycle mitotic sister chromatid cohesion mitosis mitotic cell cycle spindle assembly checkpoint nuclear migration along microtubule cell division	kinetochore spindle pole spindle pole body spindle microtubule cytoplasmic microtubule spindle midzone	structural constituent of cytoskeleton protein binding microtubule binding identical protein binding
2o3iB hypothetical protein	[pdb]	2.05 0.00605	312^PRO 313^LEU 297^TYR 389^VAL 318^ASP 320^ILE	0.0.0.0
1tkkG similar to chloromuconate cycloisomerase	[pdb]	2.05 0.00605	72^PRO 74^LEU 82^TYR 69^VAL 88^ASP 89^ILE	0.0.0.0	cellular cell wall organization metabolic process		catalytic activity isomerase activity racemase and epimerase activity acting on amino acids and derivatives
3hgmB universal stress protein tead	[pdb]	2.05 0.00605	8^PRO 36^LEU 67^TYR 16^VAL 10^ASP 71^ILE	0.0.0.0	response to stress
2xihA ascorbate peroxidase	[pdb]	2.05 0.00605	219^PRO 220^LEU 235^TYR 216^VAL 153^ASP 156^ILE	0.0.0.0	response to oxidative stress oxidation-reduction process		peroxidase activity oxidoreductase activity L-ascorbate peroxidase activity heme binding metal ion binding
3ixqD ribose-5-phosphate isomerase a	[pdb]	2.05 0.00605	54^PRO 26^LEU 111^TYR 50^VAL 79^ASP 80^ILE	5.3.1.6	carbohydrate metabolic process pentose-phosphate shunt		ribose-5-phosphate isomerase activity isomerase activity
1vmeB flavoprotein	[pdb]	2.05 0.00605	176^PRO 175^LEU 16^TYR 187^VAL 180^ASP 231^ILE	0.0.0.0			electron carrier activity FMN binding oxidoreductase activity hydrolase activity metal ion binding
3c72B geranylgeranyl transferase type-2 subunit alpha geranylgeranyl transferase type-2 subunit beta	[pdb]	2.05 0.00605	288^PRO 292^LEU 241^TYR 286^VAL 280^ASP 267^ILE	2.5.1.60	protein geranylgeranylation		prenyltransferase activity Rab geranylgeranyltransferase activity protein binding zinc ion binding protein prenyltransferase activity transferase activity metal ion binding catalytic activity prenyltransferase activity Rab geranylgeranyltransferase activity transferase activity metal ion binding
1edgA endoglucanase a	[pdb]	2.06 0.00627	8^PRO 6^LEU 2^TYR 327^VAL 369^ASP 367^ILE	3.2.1.4	polysaccharide catabolic process carbohydrate metabolic process metabolic process cellulose catabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds cellulase activity hydrolase activity hydrolase activity
3fs8B qdtc	[pdb]	2.06 0.00627	70^PRO 71^LEU 56^TYR 21^VAL 37^ASP 35^ILE	0.0.0.0			transferase activity
2duoB vesicular integral-membrane protein vip36	[pdb]	2.06 0.00627	92^PRO 90^LEU 64^TYR 120^VAL 267^ASP 268^ILE	0.0.0.0	transport protein transport	Golgi membrane ER-Golgi intermediate compartment Golgi apparatus membrane integral to membrane	sugar binding
2q29B oxalyl-coa decarboxylase	[pdb]	2.06 0.00627	196^PRO 194^LEU 224^TYR 318^VAL 302^ASP 303^ILE	4.1.1.8	oxalate catabolic process		magnesium ion binding catalytic activity oxalyl-CoA decarboxylase activity lyase activity carboxy-lyase activity thiamine pyrophosphate binding metal ion binding
2zkrk rna expansion segment es15 part i e site t-rna rna expansion segment es27 rna expansion segment es9 rna expansion segment es20 60s ribosomal protein l10a rna expansion segment es3 60s ribosomal protein l10 rna helices 60s ribosomal protein l12 60s acidic ribosomal protein p0 rna expansion segment es9 part2 60s ribosomal protein l30e 60s ribosomal protein l17 60s ribosomal protein l32 60s ribosomal protein l19 rna expansion segment es31 part ii 60s ribosomal protein l31 rna expansion segment es39 part i 60s ribosomal protein l35 rna expansion segment es39 part ii 60s ribosomal protein l4 rna expansion segment es41 rna expansion segment es7 part iii rna expansion segment es24 60s ribosomal protein l11 rna expansion segment es30 60s ribosomal protein l15e 60s ribosomal protein l44e 5.8s ribosomal rna rna expansion segment es7 part ii 60s ribosomal protein l8 60s ribosomal protein l37e 60s ribosomal protein l13a 60s ribosomal protein l3 60s ribosomal protein l7 60s ribosomal protein l27a 60s ribosomal protein l5 60s ribosomal protein l23a 5s ribosomal rna rna expansion segment es4 60s ribosomal protein l39e 60s ribosomal protein l21 rna expansion segment es5 60s ribosomal protein l23 60s ribosomal protein l37a 60s ribosomal protein l24 60s ribosomal protein l26 rna expansion segment es7 part i 60s ribosomal protein l18 60s ribosomal protein l9 rna expansion segment es12 rna expansion segment es15 part ii rna expansion segment es10 60s ribosomal protein l7a rna expansion segment es39 part iii 28s ribosomal rna rna expansion segment es31 part i rna expansion segment es19	[pdb]	2.06 0.00627	21^VAL 20^LEU 88^TYR 61^GLU 59^GLU 82^GLY	0.0.0.0	translation translation translation RNA processing translation translation translation translation translation translation translation translation translation ribosomal large subunit assembly translation exit from mitosis optic nerve development retinal ganglion cell axon guidance mitotic cell cycle G1/S transition checkpoint retina development in camera-type eye ribosome biogenesis translation translation translational elongation translation translation translation	intracellular ribosome ribonucleoprotein complex intracellular ribosome large ribosomal subunit ribonucleoprotein complex intracellular ribosome intracellular ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome intracellular ribosome intracellular ribosome ribonucleoprotein complex intracellular nucleolus ribosome ribonucleoprotein complex ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome intracellular ribosome cytosolic large ribosomal subunit ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome intracellular ribosome intracellular ribosome ribonucleoprotein complex intracellular ribosome intracellular ribosome ribonucleoprotein complex	structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome RNA binding structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome protein binding 5S rRNA binding structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome nucleotide binding RNA binding structural constituent of ribosome structural constituent of ribosome protein binding structural constituent of ribosome protein binding structural constituent of ribosome structural constituent of ribosome rRNA binding structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome structural constituent of ribosome protein binding
1zjjA hypothetical protein ph1952	[pdb]	2.06 0.00627	251^PRO 250^LEU 244^TYR 11^VAL 210^ASP 227^ILE	0.0.0.0	metabolic process		catalytic activity hydrolase activity phosphatase activity
2kfsA conserved hypothetical regulatory protein	[pdb]	2.06 0.0065	82^PRO 84^LEU 146^TYR 13^VAL 90^ASP 87^ILE	0.0.0.0	peptidyl-threonine phosphorylation		DNA binding
1wghA ubiquitin-like 3	[pdb]	2.07 0.0065	62^PRO 65^LEU 47^TYR 78^VAL 41^ASP 42^ILE	0.0.0.0		intracellular plasma membrane membrane
1b5fA protein (cardosin a)	[pdb]	2.07 0.0065	135^PRO 38^LEU 56^TYR 134^VAL 100^ASP 102^ILE	0.0.0.0	proteolysis lipid metabolic process	protein storage vacuole extracellular region proteinaceous extracellular matrix cell wall vacuole endoplasmic reticulum microsome membrane	aspartic-type endopeptidase activity peptidase activity hydrolase activity
3iw2A cytochrome p450 cyp125	[pdb]	2.07 0.0065	51^PRO 46^LEU 341^TYR 329^VAL 78^ASP 73^ILE	0.0.0.0	growth of symbiont in host oxidation-reduction process		monooxygenase activity iron ion binding electron carrier activity oxidoreductase activity heme binding metal ion binding
1e3jA nadp(h)-dependent ketose reductase	[pdb]	2.07 0.00674	61^PRO 10^LEU 129^TYR 58^VAL 122^ASP 64^ILE	0.0.0.0	metabolic process oxidation-reduction process		catalytic activity binding zinc ion binding oxidoreductase activity metal ion binding
2b3yA iron-responsive element binding protein 1	[pdb]	2.07 0.00674	116^PRO 231^LEU 882^TYR 94^VAL 96^ASP 224^ILE	4.2.1.3	tricarboxylic acid cycle citrate metabolic process metabolic process response to iron(II) ion	cytoplasm endoplasmic reticulum Golgi apparatus cytosol	RNA binding aconitate hydratase activity protein binding lyase activity iron-responsive element binding metal ion binding iron-sulfur cluster binding 4 iron