The LabelHash Server

Top 150 matches

For each match you can click on the "[pdb]" link to download a PDB file with the matching chain aligned with the motif.
Download a zip file with PDB files for all the matches and the motif itself.

PDB ID		LRMSD / p-value	Matching Residues	EC	Gene Ontology annotations
PDB ID		LRMSD / p-value	Matching Residues	EC	Biological Process	Cellular Component	Molecular Function
2i9kA modification methylase hhai 5'-d(tgpaptpapgpcpgpcptpaptp*c)-3'	[pdb]	0.326 2.8e-05	80^PRO 81^CYS 85^SER 119^GLU 163^ARG 165^ARG	2.1.1.37	DNA methylation DNA restriction-modification system		DNA binding DNA (cytosine-5-)-methyltransferase activity methyltransferase activity transferase activity
1dctA dna (5'-d(tpcpapcptpgpgptpgpgp(c5m)pcptpgpcptpgpg)-3') protein (modification methylase haeiii) dna (5'-d(apcpcpapgpcpapgpgp(c49)pcpapcpcpapgptpg)-3')	[pdb]	0.461 7.3e-05	70^PRO 71^CYS 75^SER 109^GLU 153^ARG 155^ARG	2.1.1.37	DNA methylation DNA restriction-modification system		DNA binding DNA (cytosine-5-)-methyltransferase activity methyltransferase activity transferase activity
2qrvE dna (cytosine-5)-methyltransferase 3-like dna (cytosine-5)-methyltransferase 3a	[pdb]	0.604 0.000121	705^PRO 706^CYS 710^SER 752^GLU 786^ARG 788^ARG		negative regulation of transcription from RNA polymerase II promoter DNA methylation methylation-dependent chromatin silencing regulation of gene expression by genetic imprinting spermatogenesis DNA methylation on cytosine within a CG sequence chromatin modification DNA methylation involved in embryo development DNA methylation involved in gamete generation S-adenosylhomocysteine metabolic process S-adenosylmethioninamine metabolic process in utero embryonic development DNA methylation regulation of gene expression by genetic imprinting spermatogenesis	chromosome centromeric region euchromatin heterochromatin nucleus nuclear heterochromatin cytoplasm nuclear matrix condensed nuclear chromosome nucleus nuclear heterochromatin cytoplasm	DNA binding chromatin binding DNA (cytosine-5-)-methyltransferase activity protein binding methyltransferase activity zinc ion binding transferase activity unmethylated CpG binding metal ion binding DNA (cytosine-5-)-methyltransferase activity acting on CpG substrates protein binding enzyme activator activity zinc ion binding transcription repressor activity enzyme binding
2napA protein (periplasmic nitrate reductase)	[pdb]	1.1 0.000176	552^PRO 553^CYS 555^SER 549^LEU 540^ARG 542^ARG	1.7.99.4	transport electron transport chain nitrate assimilation oxidation-reduction process	periplasmic space	binding nitrate reductase activity oxidoreductase activity molybdenum ion binding metal ion binding iron-sulfur cluster binding 4 iron
1zejA 3-hydroxyacyl-coa dehydrogenase	[pdb]	1.33 0.000267	90^PRO 92^CYS 93^SER 84^GLU 106^ARG 81^ARG	0.0.0.0	fatty acid metabolic process metabolic process		catalytic activity binding oxidoreductase activity coenzyme binding
1j74A mms2	[pdb]	1.41 0.000372	78^PRO 69^CYS 44^THR 75^GLU 14^ARG 11^ARG	0.0.0.0	protein polyubiquitination DNA double-strand break processing regulation of DNA repair cell proliferation protein ubiquitination post-translational protein modification regulation of protein metabolic process	nucleus cytoplasm UBC13-MMS2 complex	protein binding small conjugating protein ligase activity
2gjxA beta-hexosaminidase beta chain beta-hexosaminidase alpha chain	[pdb]	1.43 0.000441	102^PRO 104^CYS 59^SER 107^LEU 249^ARG 247^ARG	3.2.1.52	carbohydrate metabolic process metabolic process skeletal system development carbohydrate metabolic process N-acetylglucosamine metabolic process glycosphingolipid metabolic process ganglioside catabolic process cellular calcium ion homeostasis lysosome organization single fertilization penetration of zona pellucida sensory perception of sound locomotory behavior male courtship behavior metabolic process phospholipid biosynthetic process oligosaccharide catabolic process lipid storage sexual reproduction glycosaminoglycan metabolic process regulation of cellular metabolic process myelination cellular protein metabolic process oogenesis neuromuscular process controlling balance neuromuscular process	lysosome acrosomal vesicle soluble fraction lysosome membrane	catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds beta-N-acetylhexosaminidase activity protein binding hydrolase activity hydrolase activity acting on glycosyl bonds cation binding protein heterodimerization activity catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds beta-N-acetylhexosaminidase activity sugar binding hexosaminidase activity beta-N-acetylglucosaminidase activity hydrolase activity hydrolase activity
2nxoD hypothetical protein sco4506	[pdb]	1.47 0.000553	133^PRO 132^CYS 131^THR 41^GLU 113^ARG 109^ARG	0.0.0.0
2a4dA ubiquitin-conjugating enzyme e2 variant 1	[pdb]	1.48 0.000553	154^PRO 145^CYS 120^THR 151^GLU 90^ARG 87^ARG		protein polyubiquitination regulation of DNA repair regulation of transcription DNA-dependent cell differentiation positive regulation of I-kappaB kinase/NF-kappaB cascade post-translational protein modification positive regulation of NF-kappaB transcription factor activity	nucleus cytoplasm cytosol ubiquitin conjugating enzyme complex	protein binding transcription activator activity small conjugating protein ligase activity
2hlwA ubiquitin-conjugating enzyme e2 variant 1	[pdb]	1.48 0.000579	103^PRO 94^CYS 69^THR 100^GLU 39^ARG 36^ARG		protein polyubiquitination regulation of DNA repair regulation of transcription DNA-dependent cell differentiation positive regulation of I-kappaB kinase/NF-kappaB cascade post-translational protein modification positive regulation of NF-kappaB transcription factor activity	nucleus cytoplasm cytosol ubiquitin conjugating enzyme complex	protein binding transcription activator activity small conjugating protein ligase activity
3ifrB carbohydrate kinase, fggy	[pdb]	1.5 0.000637	345^PRO 343^CYS 364^THR 380^LEU 372^ARG 377^ARG	0.0.0.0	carbohydrate metabolic process		xylulokinase activity kinase activity transferase activity phosphotransferase activity
1fp3B n-acyl-d-glucosamine 2-epimerase	[pdb]	1.51 0.000738	384^PRO 386^CYS 317^SER 357^GLU 348^ARG 351^ARG	5.1.3.8	mannose metabolic process N-acetylglucosamine metabolic process		catalytic activity mannose-6-phosphate isomerase activity isomerase activity N-acylglucosamine 2-epimerase activity
2pmzY dna-directed rna polymerase subunit p dna-directed rna polymerase subunit h dna-directed rna polymerase subunit k dna-directed rna polymerase subunit a" dna-directed rna polymerase subunit l dna-directed rna polymerase subunit n dna-directed rna polymerase subunit a dna-directed rna polymerase subunit b dna-directed rna polymerase subunit e dna-directed rna polymerase subunit d dna-directed rna polymerase subunit f	[pdb]	1.54 0.000892	4^PRO 7^GLY 9^CYS 49^LEU 42^ILE 46^LYS	2.7.7.6	transcription DNA-dependent transcription DNA-dependent	RNA polymerase complex	DNA binding DNA-directed RNA polymerase activity zinc ion binding transferase activity nucleotidyltransferase activity metal ion binding DNA binding DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity protein dimerization activity DNA binding DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity nucleotide binding catalytic activity DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity DNA binding RNA binding DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity DNA binding DNA-directed RNA polymerase activity zinc ion binding transferase activity nucleotidyltransferase activity ribonucleoside binding DNA binding DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity protein dimerization activity DNA binding DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity DNA binding DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity DNA binding DNA-directed RNA polymerase activity zinc ion binding transferase activity nucleotidyltransferase activity metal ion binding DNA binding DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity metal ion binding
2v65A l-lactate dehydrogenase a chain	[pdb]	1.54 0.000892	290^PRO 291^CYS 299^THR 274^LEU 159^ARG 157^ARG	1.1.1.27	carbohydrate metabolic process glycolysis metabolic process cellular carbohydrate metabolic process oxidation-reduction process	cytoplasm	catalytic activity L-lactate dehydrogenase activity binding oxidoreductase activity oxidoreductase activity
3g0qA 5'-d(apapgpapcp(8og)pgpgpgpapc)-3' a/g-specific adenine glycosylase 5'-d(gptpcpcpcpapgptpcptpt)-3'	[pdb]	1.54 0.000892	209^PRO 208^CYS 204^SER 154^LEU 149^ARG 153^ARG	0.0.0.0	DNA repair base-excision repair metabolic process	intracellular	DNA binding catalytic activity endonuclease activity hydrolase activity hydrolase activity acting on glycosyl bonds DNA N-glycosylase activity
2o7dE putative histidine ammonia-lyase	[pdb]	1.54 0.000892	306^PRO 304^CYS 301^SER 242^GLU 238^ARG 240^ARG	0.0.0.0	histidine metabolic process biosynthetic process		catalytic activity histidine ammonia-lyase activity lyase activity ammonia-lyase activity
2jndA corticotropin-releasing factor receptor 2 astressin	[pdb]	1.55 0.000935	83^PRO 84^CYS 69^THR 81^GLU 112^ARG 101^ARG	0.0.0.0	signal transduction cell surface receptor linked signaling pathway G-protein coupled receptor protein signaling pathway negative regulation of angiogenesis	plasma membrane membrane integral to membrane	signal transducer activity receptor activity transmembrane receptor activity G-protein coupled receptor activity hormone activity protein binding corticotrophin-releasing factor receptor activity
1ml0D m3 protein small inducible cytokine	[pdb]	1.56 0.00103	37^PRO 36^CYS 33^SER 39^GLU 29^ARG 30^ARG	0.0.0.0	response to hypoxia positive regulation of endothelial cell proliferation monocyte chemotaxis protein phosphorylation cellular calcium ion homeostasis anti-apoptosis chemotaxis inflammatory response immune response humoral immune response cell adhesion signal transduction cell surface receptor linked signaling pathway transforming growth factor beta receptor signaling pathway G-protein coupled receptor protein signaling pathway G-protein signaling coupled to cyclic nucleotide second messenger JAK-STAT cascade response to heat response to mechanical stimulus response to bacterium organ morphogenesis response to gamma radiation response to activity viral genome replication cytokine-mediated signaling pathway neutrophil chemotaxis organ regeneration response to lipopolysaccharide response to progesterone stimulus response to vitamin B3 response to drug response to amino acid stimulus response to ethanol response to antibiotic vascular endothelial growth factor receptor signaling pathway macrophage chemotaxis lymphocyte chemotaxis positive regulation of synaptic transmission response to glucocorticoid stimulus maternal process involved in parturition	extracellular region extracellular space cytoplasm neuronal cell body	protein binding G-protein-coupled receptor binding protein kinase activity signal transducer activity receptor binding cytokine activity protein binding chemokine activity heparin binding CCR2 chemokine receptor binding
1ej6A lambda1 lambda2 sigma2	[pdb]	1.56 0.00103	803^ILE 806^MET 808^PRO 1001^TYR 989^SER 992^PRO	2.7.7.50, 2.1.1.56	mRNA capping mRNA processing mRNA capping mRNA processing	intracellular virion viral nucleocapsid viral capsid virion viral nucleocapsid viral capsid virion viral nucleocapsid viral capsid virion viral nucleocapsid viral capsid	nucleotide binding helicase activity ATP binding zinc ion binding hydrolase activity metal ion binding nucleotide binding catalytic activity mRNA (guanine-N7-)-methyltransferase activity mRNA guanylyltransferase activity ATP binding GTP binding methyltransferase activity transferase activity nucleotidyltransferase activity
1v6aA l-lactate dehydrogenase a chain	[pdb]	1.57 0.00108	292^PRO 293^CYS 301^THR 276^LEU 157^ARG 155^ARG	1.1.1.27	carbohydrate metabolic process glycolysis metabolic process cellular carbohydrate metabolic process oxidation-reduction process	cytoplasm	catalytic activity L-lactate dehydrogenase activity binding oxidoreductase activity oxidoreductase activity
3flvB acyl-coa-binding domain-containing protein 5	[pdb]	1.59 0.00118	46^PRO 47^CYS 68^SER 49^LEU 60^ARG 51^ARG	0.0.0.0	transport	membrane integral to membrane	fatty-acyl-CoA binding binding lipid binding
3opeA probable histone-lysine n-methyltransferase ash1l	[pdb]	1.59 0.00118	2123^PRO 2122^CYS 2118^SER 2126^GLU 2132^ARG 2135^ARG	2.1.1.43	DNA packaging transcription from RNA polymerase II promoter cell-cell signaling chromatin modification	nucleus tight junction cell junction	DNA binding RNA polymerase II transcription factor activity protein binding methyltransferase activity zinc ion binding transferase activity histone-lysine N-methyltransferase activity metal ion binding
1pp9A ubiquinol-cytochrome c reductase complex 7.2 kdaprotein cytochrome c1, heme protein, mitochondrial ubiquinol-cytochrome c reductase complex 11 kdaprotein ubiquinol-cytochrome c reductase complex coreprotein i, mitochondrial ubiquinol-cytochrome c reductase complex coreprotein 2, mitochondrial cytochrome b ubiquinol-cytochrome c reductase complex 14 kdaprotein ubiquinol-cytochrome c reductase complexubiquinone-binding protein qp-c ubiquinol-cytochrome c reductase iron-sulfursubunit, mitochondrial	[pdb]	1.6 0.00136	233^ARG 234^LYS 161^HIS 231^LYS 92^PRO 46^ILE	0.0.0.0	proteolysis transport electron transport chain transport electron transport chain oxidation-reduction process transport electron transport chain respiratory electron transport chain mitochondrial electron transport ubiquinol to cytochrome c transport electron transport chain mitochondrial electron transport ubiquinol to cytochrome c proteolysis transport electron transport chain mitochondrial electron transport ubiquinol to cytochrome c transport electron transport chain mitochondrial electron transport ubiquinol to cytochrome c transport electron transport chain	mitochondrion mitochondrial inner membrane membrane respiratory chain mitochondrion mitochondrial inner membrane membrane integral to membrane respiratory chain mitochondrion mitochondrial inner membrane membrane integral to membrane respiratory chain mitochondrion mitochondrial inner membrane membrane respiratory chain mitochondrion mitochondrial inner membrane membrane respiratory chain mitochondrion mitochondrial inner membrane membrane respiratory chain mitochondrion mitochondrial envelope mitochondrial inner membrane membrane respiratory chain mitochondrion mitochondrial inner membrane membrane integral to membrane respiratory chain mitochondrion mitochondrial inner membrane membrane respiratory chain	catalytic activity metalloendopeptidase activity zinc ion binding metal ion binding ubiquinol-cytochrome-c reductase activity oxidoreductase activity oxidoreductase activity acting on diphenols and related substances as donors metal ion binding iron-sulfur cluster binding 2 iron 2 sulfur cluster binding electron carrier activity oxidoreductase activity metal ion binding ubiquinol-cytochrome-c reductase activity catalytic activity metalloendopeptidase activity protein binding zinc ion binding metal ion binding ubiquinol-cytochrome-c reductase activity ubiquinol-cytochrome-c reductase activity iron ion binding electron carrier activity heme binding
2hcyA alcohol dehydrogenase 1	[pdb]	1.61 0.00136	150^PRO 153^CYS 157^THR 305^LEU 298^ARG 302^ARG	1.1.1.1	amino acid catabolic process to alcohol via Ehrlich pathway NADH oxidation metabolic process ethanol biosynthetic process involved in glucose fermentation to ethanol oxidation-reduction process	plasma membrane enriched fraction cytoplasm	catalytic activity alcohol dehydrogenase (NAD) activity binding protein binding zinc ion binding oxidoreductase activity methylglyoxal reductase (NADH-dependent) activity metal ion binding
2qtzA methionine synthase reductase	[pdb]	1.61 0.00136	436^PRO 434^CYS 433^SER 385^LEU 399^ARG 400^ARG	1.16.1.8	methionine metabolic process cellular amino acid biosynthetic process methionine biosynthetic process oxidation-reduction process	cytoplasm cytosol	iron ion binding FMN binding oxidoreductase activity [methionine synthase] reductase activity flavin adenine dinucleotide binding NADP binding
1guzC malate dehydrogenase	[pdb]	1.61 0.00142	248^PRO 169^CYS 185^THR 146^LEU 207^ARG 150^ARG	1.1.1.37	carbohydrate metabolic process glycolysis tricarboxylic acid cycle malate metabolic process metabolic process cellular carbohydrate metabolic process oxidation-reduction process carbohydrate metabolic process glycolysis tricarboxylic acid cycle malate metabolic process metabolic process cellular carbohydrate metabolic process oxidation-reduction process carbohydrate metabolic process glycolysis tricarboxylic acid cycle malate metabolic process metabolic process cellular carbohydrate metabolic process oxidation-reduction process		catalytic activity binding oxidoreductase activity oxidoreductase activity acting on the CH-OH group of donors NAD or NADP as acceptor L-malate dehydrogenase activity catalytic activity binding oxidoreductase activity oxidoreductase activity acting on the CH-OH group of donors NAD or NADP as acceptor L-malate dehydrogenase activity catalytic activity
2hayA putative nad(p)h-flavin oxidoreductase	[pdb]	1.62 0.00148	165^PRO 164^CYS 17^THR 197^LEU 202^ARG 200^ARG	0.0.0.0	oxidation-reduction process		oxidoreductase activity
2jcvB 1-deoxy-d-xylulose 5-phosphate reductoisomerase	[pdb]	1.63 0.00155	365^PRO 321^CYS 323^THR 372^LEU 381^ARG 376^ARG	1.1.1.267	metabolic process isoprenoid biosynthetic process terpenoid biosynthetic process mevalonate-independent		magnesium ion binding catalytic activity binding oxidoreductase activity manganese ion binding 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity metal ion binding cobalt ion binding NADPH binding
3k71B integrin alpha-x integrin beta-2	[pdb]	1.63 0.00155	19^PRO 21^CYS 22^THR 16^GLU 426^ARG 12^ARG	0.0.0.0	apoptosis inflammatory response cell adhesion leukocyte cell-cell adhesion cell-matrix adhesion integrin-mediated signaling pathway cell-cell signaling multicellular organismal development regulation of cell shape neutrophil chemotaxis regulation of peptidyl-tyrosine phosphorylation cell adhesion integrin-mediated signaling pathway organ morphogenesis	plasma membrane integrin complex membrane integral to membrane integrin complex external side of plasma membrane membrane integral to membrane	glycoprotein binding receptor activity binding protein binding protein kinase binding receptor activity protein binding
2o6xA secreted cathepsin l 1	[pdb]	1.63 0.00162	255^PRO 302^CYS 250^SER 217^GLU 293^ARG 296^ARG	0.0.0.0	proteolysis proteolysis	extracellular region	cysteine-type endopeptidase activity peptidase activity cysteine-type peptidase activity hydrolase activity endopeptidase activity cysteine-type endopeptidase activity peptidase activity cysteine-type peptidase activity hydrolase activity
2gh0B artemin gdnf family receptor alpha-3	[pdb]	1.64 0.00169	274^PRO 340^CYS 342^THR 284^GLU 290^ARG 287^ARG	0.0.0.0	neuron migration signal transduction nervous system development axon guidance peripheral nervous system development sympathetic nervous system development neuron development signal transduction neuroblast proliferation	plasma membrane external side of plasma membrane membrane extrinsic to membrane anchored to membrane extracellular region	receptor activity receptor binding protein binding axon guidance receptor activity receptor binding growth factor activity
1v47B atp sulfurylase	[pdb]	1.66 0.00185	295^PRO 294^CYS 302^SER 335^GLU 176^ARG 169^ARG	0.0.0.0	sulfate assimilation		sulfate adenylyltransferase (ATP) activity protein binding transferase activity nucleotidyltransferase activity
3orgC cmclc	[pdb]	1.66 0.00193	658^PRO 659^CYS 662^SER 592^GLU 572^ARG 590^ARG
2o0rB rv0858c (n-succinyldiaminopimelateaminotransferase)	[pdb]	1.67 0.00193	34^PRO 375^CYS 373^THR 287^LEU 297^ARG 292^ARG	0.0.0.0	biosynthetic process		catalytic activity transaminase activity transferase activity transferase activity transferring nitrogenous groups 1-aminocyclopropane-1-carboxylate synthase activity pyridoxal phosphate binding
1yujA dna (5'-d(gptpapcptpcptpcpgpgpc)-3') gaga-factor dna (5'-d(gpcpcpgpapgpapgptpapc)-3')	[pdb]	1.67 0.00201	37^PRO 36^CYS 35^THR 53^LEU 47^ARG 51^ARG		nuclear division chromatin organization cell cycle mitosis multicellular organismal development imaginal disc-derived wing morphogenesis dosage compensation cellular process chromatin modification cell differentiation chromatin assembly syncytial blastoderm mitotic cell cycle positive regulation of transcription DNA-dependent oogenesis protein oligomerization	chromatin euchromatin intracellular nucleus polytene chromosome centromeric heterochromatin	nucleic acid binding DNA binding specific RNA polymerase II transcription factor activity protein binding zinc ion binding transcription activator activity metal ion binding protein heterodimerization activity
1f2rI caspase-activated dnase inhibitor of caspase-activated dnase	[pdb]	1.68 0.0021	20^PRO 21^CYS 83^THR 49^LEU 29^ARG 24^ARG	0.0.0.0	DNA fragmentation involved in apoptotic nuclear change apoptosis induction of apoptosis DNA fragmentation involved in apoptotic nuclear change apoptosis induction of apoptosis positive regulation of apoptosis negative regulation of apoptosis	intracellular nucleus cytoplasm intracellular nucleus cytoplasm	DNA binding nicotinate phosphoribosyltransferase activity nuclease activity deoxyribonuclease activity protein binding hydrolase activity protein binding identical protein binding
3b8iD pa4872 oxaloacetate decarboxylase	[pdb]	1.68 0.0021	84^PRO 44^CYS 25^THR 17^LEU 21^ARG 229^ARG	0.0.0.0	metabolic process		catalytic activity oxaloacetate decarboxylase activity lyase activity carboxy-lyase activity metal ion binding
2f9wA pantothenate kinase	[pdb]	1.68 0.00219	144^PRO 143^CYS 127^THR 189^LEU 197^ARG 193^ARG	2.7.1.33	coenzyme A biosynthetic process response to antibiotic	cytoplasm	nucleotide binding pantothenate kinase activity ATP binding kinase activity transcription activator activity transferase activity metal ion binding
1sxjE activator 1 40 kda subunit proliferating cell nuclear antigen activator 1 37 kda subunit activator 1 95 kda subunit activator 1 41 kda subunit	[pdb]	1.68 0.00219	37^ALA 185^PHE 183^LYS 167^ILE 156^ASP 155^SER	0.0.0.0	mitotic cell cycle DNA replication leading strand elongation DNA repair mismatch repair cell cycle cell division DNA replication leading strand elongation mismatch repair cell cycle sister chromatid cohesion meiotic mismatch repair DNA replication leading strand elongation lagging strand elongation regulation of DNA replication DNA repair base-excision repair nucleotide-excision repair mismatch repair postreplication repair chromatin silencing at telomere response to DNA damage stimulus mitotic sister chromatid cohesion chromatin silencing at silent mating-type cassette cell cycle checkpoint DNA replication leading strand elongation mismatch repair cell cycle sister chromatid cohesion DNA replication leading strand elongation mismatch repair cell cycle sister chromatid cohesion DNA replication leading strand elongation mismatch repair cell cycle sister chromatid cohesion	intracellular nucleus DNA replication factor C complex nucleus DNA replication factor C complex Rad17 RFC-like complex Ctf18 RFC-like complex Elg1 RFC-like complex nucleus replication fork PCNA complex nucleus DNA replication factor C complex Rad17 RFC-like complex Ctf18 RFC-like complex Elg1 RFC-like complex nucleus DNA replication factor C complex Rad17 RFC-like complex Ctf18 RFC-like complex Elg1 RFC-like complex nucleus DNA replication factor C complex Rad17 RFC-like complex Ctf18 RFC-like complex Elg1 RFC-like complex	nucleotide binding DNA binding DNA clamp loader activity protein binding ATP binding nucleoside-triphosphatase activity nucleotide binding DNA binding DNA clamp loader activity protein binding ATP binding nucleoside-triphosphatase activity DNA binding protein binding DNA polymerase processivity factor activity nucleotide binding DNA binding DNA clamp loader activity protein binding ATP binding nucleoside-triphosphatase activity nucleotide binding DNA binding protein binding ATP binding nucleoside-triphosphatase activity DNA clamp loader activity nucleotide binding DNA binding DNA clamp loader activity protein binding ATP binding ATPase activity nucleoside-triphosphatase activity
3kyaA putative phosphatase	[pdb]	1.69 0.00219	396^PRO 397^CYS 469^SER 421^LEU 464^ARG 466^ARG	0.0.0.0
3lo0A inorganic pyrophosphatase	[pdb]	1.69 0.00228	53^PRO 54^CYS 76^SER 107^LEU 87^ARG 89^ARG	0.0.0.0	phosphate metabolic process	cytoplasm	magnesium ion binding inorganic diphosphatase activity hydrolase activity
1si2A eukaryotic translation initiation factor 2c 1 5'-r(cpgpupgpapcpu)-d(pcp*t)-3'	[pdb]	1.69 0.00228	338^PRO 325^CYS 283^THR 323^LEU 255^ARG 253^ARG	0.0.0.0	nuclear-transcribed mRNA catabolic process regulation of translation gene silencing by RNA negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body cytoplasm ribonucleoprotein complex	nucleic acid binding RNA binding protein binding
1jofD carboxy-cis,cis-muconate cyclase	[pdb]	1.7 0.00237	318^PRO 317^CYS 315^SER 322^GLU 346^ARG 338^ARG	5.5.1.5			isomerase activity carboxy-cis,cis-muconate cyclase activity
3fmoA nuclear pore complex protein nup214 atp-dependent rna helicase ddx19b	[pdb]	1.7 0.00237	293^ASN 294^VAL 324^THR 342^LEU 20^ARG 348^ARG	0.0.0.0	protein export from nucleus transport protein transport mRNA transport transmembrane transport mRNA export from nucleus transport protein transport mRNA transport transmembrane transport	nucleus nuclear pore cytosol nucleus nuclear pore cytoplasm membrane nuclear membrane	transporter activity protein binding nucleotide binding nucleic acid binding RNA binding helicase activity protein binding ATP binding ATP-dependent helicase activity hydrolase activity
1zrtR cytochrome b ubiquinol-cytochrome c reductase iron-sulfursubunit cytochrome c1	[pdb]	1.7 0.00237	140^PRO 153^CYS 158^SER 175^LEU 94^ARG 173^ARG	1.10.2.2	transport electron transport chain oxidation-reduction process transport electron transport chain respiratory electron transport chain transport electron transport chain	plasma membrane membrane integral to membrane plasma membrane membrane integral to membrane respiratory chain plasma membrane membrane integral to membrane respiratory chain	ubiquinol-cytochrome-c reductase activity oxidoreductase activity oxidoreductase activity acting on diphenols and related substances as donors metal ion binding iron-sulfur cluster binding 2 iron 2 sulfur cluster binding electron carrier activity oxidoreductase activity metal ion binding iron ion binding electron carrier activity
1ohtA cg14704 protein	[pdb]	1.7 0.00247	54^PRO 56^CYS 59^SER 16^LEU 24^ARG 18^ARG	3.5.1.28	peptidoglycan metabolic process peptidoglycan catabolic process innate immune response defense response to Gram-positive bacterium	extracellular region	amidase activity protein binding N-acetylmuramoyl-L-alanine amidase activity hydrolase activity peptidoglycan binding metal ion binding
1tzpA penicillin-insensitive murein endopeptidase	[pdb]	1.71 0.00258	217^PRO 216^CYS 39^SER 74^LEU 175^ARG 213^ARG	0.0.0.0	peptidoglycan metabolic process proteolysis proteolysis	outer membrane-bounded periplasmic space periplasmic space outer membrane-bounded periplasmic space periplasmic space	endopeptidase activity serine-type endopeptidase activity peptidase activity metallopeptidase activity hydrolase activity metal ion binding serine-type endopeptidase activity peptidase activity metallopeptidase activity hydrolase activity metal ion binding
3nc5B cytochrome p450 cypx	[pdb]	1.71 0.00258	284^PRO 306^CYS 44^SER 53^LEU 342^ARG 50^ARG	0.0.0.0	oxidation-reduction process		monooxygenase activity iron ion binding electron carrier activity oxidoreductase activity heme binding metal ion binding
2x47A macro domain-containing protein 1	[pdb]	1.72 0.00258	265^PRO 304^CYS 155^SER 311^GLU 317^ARG 315^ARG	0.0.0.0		mitochondrion
1kogC threonyl-trna synthetase mrna threonyl-trna synthetase	[pdb]	1.72 0.00268	331^PRO 361^CYS 360^SER 365^GLU 520^ARG 375^ARG	6.1.1.3	translation regulation of translation tRNA aminoacylation for protein translation threonyl-tRNA aminoacylation tRNA aminoacylation negative regulation of translational initiation	cytoplasm	nucleotide binding translation repressor activity nucleic acid binding RNA binding aminoacyl-tRNA ligase activity threonine-tRNA ligase activity protein binding ATP binding drug binding zinc ion binding ligase activity ligase activity
3dtyA oxidoreductase, gfo/idh/moca family	[pdb]	1.72 0.00268	116^PRO 118^CYS 120^THR 368^GLU 375^ARG 371^ARG	0.0.0.0	metabolic process oxidation-reduction process		catalytic activity binding oxidoreductase activity
3dl0B adenylate kinase	[pdb]	1.72 0.00268	144^PRO 150^CYS 135^THR 139^LEU 160^ARG 127^ARG	2.7.4.3	nucleobase nucleoside	cytoplasm	nucleotide binding adenylate kinase activity ATP binding kinase activity transferase activity phosphotransferase activity phosphate group as acceptor nucleotide kinase activity nucleobase
2yyeB selenide, water dikinase	[pdb]	1.72 0.00268	139^PRO 99^CYS 98^SER 105^LEU 115^ARG 111^ARG	2.7.9.3			nucleotide binding catalytic activity selenide water dikinase activity ATP binding kinase activity
3b4wA aldehyde dehydrogenase	[pdb]	1.73 0.0028	250^PRO 251^CYS 229^THR 246^GLU 238^ARG 242^ARG	0.0.0.0	metabolic process oxidation-reduction process	plasma membrane	oxidoreductase activity
3lvtA glycosyl hydrolase, family 38	[pdb]	1.73 0.00291	853^PRO 854^CYS 821^THR 888^GLU 893^ARG 843^ARG	0.0.0.0	carbohydrate metabolic process mannose metabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds alpha-mannosidase activity zinc ion binding mannosidase activity hydrolase activity
2y0sO rna polymerase subunit 4 rna polymerase subunit 7 rna polymerase subunit 8 dna-directed rna polymerase subunit d dna-directed rna polymerase subunit a'' dna-directed rna polymerase subunit h dna-directed rna polymerase subunit k dna-directed rna polymerase subunit l dna-directed rna polymerase subunit n dna-directed rna polymerase rna polymerase subunit 12 rna polymerase subunit 13	[pdb]	1.73 0.00291	4^TYR 7^GLY 9^ILE 49^ASP 42^LEU 46^ARG		cellular metabolic process transcription DNA-dependent transcription	RNA polymerase complex	DNA binding DNA-directed RNA polymerase activity zinc ion binding transferase activity nucleotidyltransferase activity DNA binding DNA-directed RNA polymerase activity DNA binding DNA-directed RNA polymerase activity zinc ion binding transferase activity nucleotidyltransferase activity ribonucleoside binding DNA binding DNA-directed RNA polymerase activity protein dimerization activity DNA binding RNA binding DNA-directed RNA polymerase activity nucleotide binding catalytic activity DNA-directed RNA polymerase activity DNA binding DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity DNA binding DNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity DNA binding DNA-directed RNA polymerase activity protein dimerization activity DNA binding DNA-directed RNA polymerase activity zinc ion binding transferase activity nucleotidyltransferase activity metal ion binding DNA binding DNA-directed RNA polymerase activity
2zk9X protein-glutaminase	[pdb]	1.74 0.00303	31^PRO 32^CYS 22^SER 163^LEU 50^ARG 45^ARG	0.0.0.0
2oo6A putative l-alanine-dl-glutamate epimerase	[pdb]	1.74 0.00303	125^PRO 124^CYS 122^SER 150^GLU 155^ARG 153^ARG	0.0.0.0	metabolic process		catalytic activity metal ion binding
3bzgA uv endonuclease	[pdb]	1.75 0.00315	7^PRO 8^CYS 16^THR 46^LEU 40^ARG 44^ARG	0.0.0.0	nucleotide-excision repair		endonuclease activity
2f1zB ubiquitin carboxyl-terminal hydrolase 7	[pdb]	1.76 0.00327	89^PRO 90^CYS 70^THR 95^LEU 66^ARG 93^ARG	3.1.2.15	ubiquitin-dependent protein catabolic process multicellular organismal development protein deubiquitination interspecies interaction between organisms regulation of sequence-specific DNA binding transcription factor activity	nucleus cytoplasm	p53 binding cysteine-type endopeptidase activity ubiquitin thiolesterase activity ubiquitin-specific protease activity protein binding protein C-terminus binding transcription factor binding peptidase activity cysteine-type peptidase activity hydrolase activity ubiquitin protein ligase binding
2p26A integrin beta-2	[pdb]	1.77 0.00354	19^PRO 21^CYS 22^THR 16^GLU 426^ARG 12^ARG	0.0.0.0	apoptosis inflammatory response cell adhesion leukocyte cell-cell adhesion cell-matrix adhesion integrin-mediated signaling pathway cell-cell signaling multicellular organismal development regulation of cell shape neutrophil chemotaxis regulation of peptidyl-tyrosine phosphorylation	plasma membrane integrin complex membrane integral to membrane	glycoprotein binding receptor activity binding protein binding protein kinase binding
2f1yA hausp/usp7	[pdb]	1.77 0.00354	89^PRO 90^CYS 70^THR 95^LEU 66^ARG 93^ARG		ubiquitin-dependent protein catabolic process multicellular organismal development protein deubiquitination interspecies interaction between organisms regulation of sequence-specific DNA binding transcription factor activity negative regulation of transcription from RNA polymerase II promoter protein complex assembly traversing start control point of mitotic cell cycle positive regulation of cell proliferation protein ubiquitination protein catabolic process protein destabilization positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein localization to nucleus regulation of protein catabolic process protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of DNA damage response signal transduction by p53 class mediator interspecies interaction between organisms establishment of protein localization positive regulation of cell cycle positive regulation of mitotic cell cycle	nucleus cytoplasm intracellular insoluble fraction nucleus nucleoplasm nucleolus cytoplasm cytosol plasma membrane endocytic vesicle membrane protein complex nuclear body	p53 binding cysteine-type endopeptidase activity ubiquitin thiolesterase activity ubiquitin-specific protease activity protein binding protein C-terminus binding transcription factor binding peptidase activity cysteine-type peptidase activity hydrolase activity ubiquitin protein ligase binding p53 binding ubiquitin-protein ligase activity protein binding zinc ion binding ligase activity basal transcription repressor activity enzyme binding identical protein binding metal ion binding
3nqbA adenine deaminase 2	[pdb]	1.78 0.00368	152^PRO 154^CYS 157^SER 173^LEU 197^ARG 200^ARG	3.5.4.2	adenine catabolic process		adenine deaminase activity hydrolase activity hydrolase activity
3mstA putative nitrate transport protein	[pdb]	1.78 0.00368	139^PRO 141^CYS 42^SER 204^LEU 213^ARG 208^ARG
2uvaJ fatty acid synthase beta subunits	[pdb]	1.78 0.00368	272^PRO 265^CYS 264^THR 277^GLU 160^ARG 278^ARG	0.0.0.0
3bn3B intercellular adhesion molecule 5 integrin alpha-l	[pdb]	1.78 0.00368	29^PRO 28^CYS 26^THR 32^GLU 75^ARG 71^ARG	0.0.0.0	phagocytosis cell adhesion cell-cell adhesion T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell cellular component movement inflammatory response cell adhesion heterophilic cell-cell adhesion leukocyte cell-cell adhesion signal transduction integrin-mediated signaling pathway cell-cell adhesion	plasma membrane integral to plasma membrane membrane integral to membrane plasma membrane integrin complex cell surface membrane integral to membrane	protein binding receptor activity protein binding protein heterodimerization activity cell adhesion molecule binding
2azpA hypothetical protein pa1268	[pdb]	1.79 0.00397	235^PRO 236^CYS 238^THR 270^GLU 132^ARG 272^ARG	5.1.1.8			isomerase activity proline racemase activity 4-hydroxyproline epimerase activity
2knjA microplusin preprotein	[pdb]	1.79 0.00397	82^PRO 80^CYS 78^THR 22^LEU 44^ARG 21^ARG	0.0.0.0	killing of cells of other organism defense response to bacterium innate immune response defense response to Gram-positive bacterium defense response to fungus	extracellular region	iron ion binding copper chaperone activity metal ion binding metal chelating activity
3krxA beta-adrenergic receptor kinase 1 guanine nucleotide-binding protein g(i)/g(s)/g(o) subunitgamma-2 guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1	[pdb]	1.79 0.00397	390^PRO 379^CYS 376^SER 407^LEU 436^ARG 431^ARG	2.7.11.15	signal transduction G-protein coupled receptor protein signaling pathway activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger cell proliferation sensory perception of taste signal transduction G-protein coupled receptor protein signaling pathway cell proliferation regulation of the force of heart contraction desensitization of G-protein coupled receptor protein signaling pathway negative regulation of the force of heart contraction by chemical signal protein phosphorylation response to oxidative stress signal transduction G-protein coupled receptor protein signaling pathway muscarinic acetylcholine receptor signaling pathway tachykinin receptor signaling pathway heart development aging response to organic cyclic compound phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation positive regulation of catecholamine secretion response to hydrogen peroxide negative regulation of striated muscle contraction cardiac muscle contraction	photoreceptor outer segment heterotrimeric G-protein complex Golgi apparatus heterotrimeric G-protein complex plasma membrane membrane membrane fraction soluble fraction cytoplasm cytosol plasma membrane caveola membrane axon dendritic spine dendritic shaft synapse	GTPase activity signal transducer activity GTPase activity signal transducer activity nucleotide binding protein kinase activity protein serine/threonine kinase activity G-protein coupled receptor kinase activity signal transducer activity protein binding ATP binding kinase activity transferase activity alpha-2A adrenergic receptor binding Edg-2 lysophosphatidic acid receptor binding beta-adrenergic receptor kinase activity
3kaaB hepatitis a virus cellular receptor 2	[pdb]	1.79 0.00397	18^PRO 19^CYS 20^SER 106^GLU 50^ARG 93^ARG	0.0.0.0		membrane integral to membrane	receptor activity
2gtlN extracellular hemoglobin linker l3 subunit hemoglobin linker chain l1 extracellular globin 2 extracellular globin 4 extracellular hemoglobin linker l2 subunit hemoglobin chain d1 extracellular globin-3	[pdb]	1.8 0.00413	97^ASP 100^LEU 102^THR 81^PHE 138^PHE 144^LEU	0.0.0.0	transport oxygen transport transport oxygen transport transport oxygen transport transport oxygen transport	extracellular region hemoglobin complex extracellular region hemoglobin complex extracellular region hemoglobin complex extracellular region hemoglobin complex	oxygen transporter activity iron ion binding oxygen binding heme binding metal ion binding oxygen transporter activity iron ion binding oxygen binding heme binding metal ion binding oxygen transporter activity iron ion binding oxygen binding heme binding metal ion binding oxygen transporter activity iron ion binding oxygen binding heme binding
1h7wD dihydropyrimidine dehydrogenase	[pdb]	1.8 0.00413	86^PRO 140^CYS 149^SER 80^LEU 74^ARG 78^ARG	1.3.1.2	purine base catabolic process 'de novo' pyrimidine base biosynthetic process pyrimidine base catabolic process thymine catabolic process uracil catabolic process thymidine catabolic process UMP biosynthetic process metabolic process oxidation-reduction process	cytoplasm cytosol	catalytic activity dihydroorotate dehydrogenase activity dihydroorotate oxidase activity electron carrier activity FMN binding oxidoreductase activity dihydropyrimidine dehydrogenase (NADP+) activity protein homodimerization activity metal ion binding flavin adenine dinucleotide binding NADP binding iron-sulfur cluster binding 4 iron
3bt2A urokinase plasminogen activator surface receptor anti-upar antibody, heavy chain anti-upar antibody, light chain vitronectin urokinase-type plasminogen activator	[pdb]	1.8 0.00413	73^LEU 71^CYS 63^ILE 96^ILE 110^HIS 103^MET	3.4.21.73	immune response cell adhesion cell-matrix adhesion positive regulation of cell-substrate adhesion negative regulation of endopeptidase activity positive regulation of smooth muscle cell migration negative regulation of blood coagulation extracellular matrix organization positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of protein binding cell adhesion mediated by integrin positive regulation of receptor-mediated endocytosis positive regulation of peptidyl-tyrosine phosphorylation positive regulation of wound healing angiogenesis response to hypoxia proteolysis chemotaxis signal transduction embryo implantation blood coagulation regulation of receptor activity smooth muscle cell migration regulation of smooth muscle cell migration regulation of cell adhesion mediated by integrin wound healing regulation of cell proliferation fibrinolysis skeletal muscle tissue regeneration blood vessel morphogenesis regulation of wound healing cellular component movement chemotaxis signal transduction blood coagulation attachment of GPI anchor to protein regulation of proteolysis skeletal muscle tissue regeneration	extracellular region proteinaceous extracellular matrix extracellular space extracellular matrix alphav-beta3 integrin-vitronectin complex extracellular region extracellular space plasma membrane cell surface extracellular region plasma membrane cell surface membrane integral to membrane extrinsic to membrane anchored to membrane	scavenger receptor activity integrin binding protein binding heparin binding polysaccharide binding extracellular matrix binding antigen binding protein binding antigen binding catalytic activity serine-type endopeptidase activity peptidase activity serine-type peptidase activity hydrolase activity receptor activity protein binding enzyme binding U-plasminogen activator receptor activity
3cj1A ectonucleoside triphosphate diphosphohydrolase 2	[pdb]	1.8 0.00428	264^PRO 310^CYS 315^SER 253^LEU 245^ARG 251^ARG	0.0.0.0		membrane integral to membrane	nucleotide binding ATP binding hydrolase activity
2vagA dual specificity protein kinase clk1	[pdb]	1.81 0.00428	359^PRO 360^CYS 364^SER 349^GLU 343^ARG 346^ARG	2.7.12.1	protein phosphorylation cell proliferation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation peptidyl-tyrosine phosphorylation protein autophosphorylation	nucleus	nucleotide binding protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity ATP binding kinase activity transferase activity
1rmdA rag1	[pdb]	1.81 0.00428	67^PRO 61^CYS 63^SER 54^LEU 47^ARG 52^ARG	0.0.0.0	pre-B cell allelic exclusion DNA recombination histone monoubiquitination death chromatin modification B cell differentiation T cell differentiation in thymus V(D)J recombination negative regulation of caspase activity protein autoubiquitination negative regulation of thymocyte apoptosis	intracellular nucleus	nucleic acid binding DNA binding catalytic activity nuclease activity endonuclease activity ubiquitin-protein ligase activity protein binding zinc ion binding hydrolase activity ligase activity histone binding protein homodimerization activity sequence-specific DNA binding metal ion binding
3r0sA acyl-[acyl-carrier-protein]--udp-n-acetylglucosamine o-acyltransferase	[pdb]	1.81 0.00428	180^PRO 182^CYS 193^SER 218^LEU 258^ARG 220^ARG		lipid biosynthetic process lipid A biosynthetic process	cytoplasm	acyltransferase activity acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity transferase activity
2j28Z 23s ribosomal rna 50s ribosomal protein l32 50s ribosomal protein l9 50s ribosomal protein l3 50s ribosomal protein l2 50s ribosomal protein l6 50s ribosomal protein l5 50s ribosomal protein l4 50s ribosomal protein l19 50s ribosomal protein l18 50s ribosomal protein l31 50s ribosomal protein l16 50s ribosomal protein l33 50s ribosomal protein l14 50s ribosomal protein l13 50s ribosomal protein l34 50s ribosomal protein l11 50s ribosomal protein l36 4.5s signal recognition particle rna signal sequence 50s ribosomal protein l17 50s ribosomal protein l30 50s ribosomal protein l15 5s ribosomal rna 50s ribosomal protein l35 50s ribosomal protein l29 signal recognition particle 54 50s ribosomal protein l22 50s ribosomal protein l23 50s ribosomal protein l20 50s ribosomal protein l21 50s ribosomal protein l27 50s ribosomal protein l24 50s ribosomal protein l25	[pdb]	1.81 0.00444	42^PRO 37^CYS 38^SER 34^LEU 59^ARG 56^ARG	0.0.0.0	translation translation translation translation translation protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane translation translation translation translation translation translation translation translation translation ribosomal large subunit assembly translation translation translation translation translational termination stringent response translation translation response to antibiotic translation response to antibiotic translation translation translation translation translation translation transcription termination DNA-dependent translation regulation of translation response to antibiotic	intracellular ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome large ribosomal subunit ribonucleoprotein complex intracellular ribosome large ribosomal subunit ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex signal recognition particle endoplasmic reticulum targeting ribonucleoprotein complex signal recognition particle intracellular ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome large ribosomal subunit ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome large ribosomal subunit ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome cytosolic large ribosomal subunit ribonucleoprotein complex intracellular ribosome cytosolic large ribosomal subunit ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex ribosome cytosolic large ribosomal subunit ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome large ribosomal subunit ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome large ribosomal subunit ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome	RNA binding structural constituent of ribosome rRNA binding nucleotide binding RNA binding structural constituent of ribosome protein binding rRNA binding RNA binding structural constituent of ribosome protein binding zinc ion binding transferase activity rRNA binding structural constituent of ribosome structural constituent of ribosome nucleotide binding RNA binding protein binding GTP binding 7S RNA binding nucleoside-triphosphatase activity GTPase activity RNA binding structural constituent of ribosome protein binding rRNA binding tRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding metal ion binding tRNA binding RNA binding structural constituent of ribosome rRNA binding structural constituent of ribosome protein binding tRNA binding RNA binding structural constituent of ribosome RNA binding structural constituent of ribosome protein binding rRNA binding structural constituent of ribosome tRNA binding RNA binding structural constituent of ribosome rRNA binding translation repressor activity nucleic acid binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome protein binding rRNA binding structural constituent of ribosome RNA binding structural constituent of ribosome protein binding rRNA binding structural constituent of ribosome zinc ion binding RNA binding structural constituent of ribosome protein binding rRNA binding RNA binding structural constituent of ribosome protein binding rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome protein binding 5S rRNA binding rRNA binding RNA binding structural constituent of ribosome protein binding rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome protein binding rRNA binding translation repressor activity
2c6fB angiotensin-converting enzyme, somatic isoform	[pdb]	1.82 0.00445	475^PRO 474^CYS 468^THR 252^LEU 245^ARG 230^ARG	3.4.15.1	response to hypoxia kidney development blood vessel remodeling angiotensin catabolic process in blood regulation of renal output by angiotensin neutrophil mediated immunity regulation of systemic arterial blood pressure by renin-angiotensin proteolysis peptide metabolic process regulation of blood pressure regulation of smooth muscle cell migration regulation of vasoconstriction mononuclear cell proliferation regulation of vasodilation hormone catabolic process peptide catabolic process arachidonic acid secretion hemopoietic stem cell differentiation	extracellular region extracellular space membrane fraction endosome plasma membrane external side of plasma membrane membrane integral to membrane	actin binding carboxypeptidase activity protein binding drug binding peptidase activity metallopeptidase activity peptidyl-dipeptidase activity zinc ion binding hydrolase activity chloride ion binding bradykinin receptor binding peptide binding metal ion binding
3bq9B predicted rossmann fold nucleotide-bindingdomain-containing protein	[pdb]	1.82 0.00461	221^PRO 181^CYS 179^THR 212^GLU 243^ARG 237^ARG	0.0.0.0
1d2vC myeloperoxidase	[pdb]	1.82 0.00461	231^PRO 232^CYS 241^SER 373^LEU 363^ARG 370^ARG	1.11.1.7	anti-apoptosis defense response response to oxidative stress low-density lipoprotein particle remodeling hydrogen peroxide catabolic process oxidation-reduction process	extracellular space nucleus lysosome stored secretory granule	chromatin binding peroxidase activity heparin binding oxidoreductase activity heme binding metal ion binding
2wcyA complement component c7	[pdb]	1.82 0.00461	718^PRO 721^CYS 724^SER 706^GLU 836^ARG 704^ARG	0.0.0.0	cellular sodium ion homeostasis complement activation complement activation alternative pathway complement activation classical pathway	extracellular region membrane attack complex
1dj3B adenylosuccinate synthetase	[pdb]	1.82 0.00461	153^PRO 154^CYS 160^THR 124^LEU 120^ARG 165^ARG	6.3.4.4	purine nucleotide biosynthetic process	cytoplasm chloroplast plastid	nucleotide binding magnesium ion binding adenylosuccinate synthase activity GTP binding ligase activity metal ion binding
2ja4A t-cell surface glycoprotein cd5	[pdb]	1.82 0.00478	343^PRO 350^CYS 348^SER 353^LEU 277^ARG 292^ARG	0.0.0.0	cell recognition cell proliferation induction of apoptosis by extracellular signals T cell costimulation regulation of lymphocyte proliferation	plasma membrane integral to plasma membrane external side of plasma membrane membrane integral to membrane	glycoprotein binding receptor activity transmembrane receptor activity scavenger receptor activity protein binding
1ez0C aldehyde dehydrogenase	[pdb]	1.83 0.00478	168^PRO 167^CYS 161^SER 49^LEU 59^ARG 54^ARG	1.2.1.4	metabolic process oxidation-reduction process		oxidoreductase activity aldehyde dehydrogenase (NADP+) activity
1up6E 6-phospho-beta-glucosidase	[pdb]	1.83 0.00496	335^PRO 336^CYS 345^THR 332^LEU 150^ARG 318^ARG	3.2.1.86	carbohydrate metabolic process metabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds binding 6-phospho-beta-glucosidase activity hydrolase activity hydrolase activity
1vi5A 30s ribosomal protein s2p	[pdb]	1.83 0.00496	123^PRO 144^CYS 159^THR 155^LEU 56^ARG 54^ARG	0.0.0.0	translation	intracellular ribosome small ribosomal subunit ribonucleoprotein complex	structural constituent of ribosome
1tmf2 theiler's murine encephalomyelitis virus(subunit vp3) theiler's murine encephalomyelitis virus(subunit vp2) theiler's murine encephalomyelitis virus(subunit vp4) theiler's murine encephalomyelitis virus(subunit vp1)	[pdb]	1.84 0.00496	254^PRO 106^ARG 215^GLY 100^ARG 260^ARG 101^ASN	0.0.0.0	transcription RNA-dependent proteolysis RNA-protein covalent cross-linking viral genome replication evasion by virus of host immune response interspecies interaction between organisms transcription RNA-dependent proteolysis RNA-protein covalent cross-linking viral genome replication	membrane virion viral capsid icosahedral viral capsid host cell cytoplasm host cell membrane host cell cytoplasmic vesicle host cell cytoplasmic vesicle membrane membrane virion viral capsid icosahedral viral capsid host cell cytoplasm host cell membrane host cell cytoplasmic vesicle host cell cytoplasmic vesicle membrane	nucleotide binding RNA binding RNA helicase activity catalytic activity RNA-directed RNA polymerase activity cysteine-type endopeptidase activity helicase activity structural molecule activity ATP binding peptidase activity cysteine-type peptidase activity transferase activity nucleotidyltransferase activity hydrolase activity nucleoside-triphosphatase activity nucleotide binding RNA binding RNA helicase activity catalytic activity RNA-directed RNA polymerase activity cysteine-type endopeptidase activity helicase activity structural molecule activity ATP binding peptidase activity cysteine-type peptidase activity transferase activity nucleotidyltransferase activity hydrolase activity nucleoside-triphosphatase activity
1uscA putative styrene monooxygenase small component	[pdb]	1.84 0.00496	36^PRO 35^CYS 60^THR 111^LEU 69^ARG 27^ARG	0.0.0.0			FMN binding
3c4mA parathyroid hormone fusion protein of maltose-binding periplasmicprotein and parathyroid hormone/parathyroid hormone- related peptide receptor	[pdb]	1.84 0.00496	107^PRO 108^CYS 153^SER 125^HOH 146^ARG 147^ARG	0.0.0.0	skeletal system development signal transduction cell surface receptor linked signaling pathway G-protein coupled receptor protein signaling pathway G-protein signaling coupled to cyclic nucleotide second messenger skeletal system development cellular calcium ion homeostasis G-protein coupled receptor protein signaling pathway activation of adenylate cyclase activity by G-protein signaling pathway Rho protein signal transduction cell-cell signaling induction of apoptosis by hormones positive regulation of signal transduction regulation of gene expression positive regulation of gene-specific transcription from RNA polymerase II promoter positive regulation of cAMP biosynthetic process cellular macromolecule biosynthetic process bone resorption positive regulation of transcription from RNA polymerase II promoter cAMP metabolic process transport carbohydrate transport maltose transport	nucleus cytoplasm plasma membrane integral to plasma membrane membrane integral to membrane extracellular region extracellular space periplasmic space ATP-binding cassette (ABC) transporter complex ATP-binding cassette (ABC) transporter complex	signal transducer activity receptor activity transmembrane receptor activity G-protein coupled receptor activity parathyroid hormone receptor activity hormone activity parathyroid hormone receptor binding transporter activity maltose transmembrane transporter activity disaccharide binding
3glgG dna (5'-d(cptpgpgpcpcptpaptpa)-3') dna polymerase iii subunit delta dna polymerase iii subunit tau dna (5'-d(tptptptptptptptptptptpaptpapgpgpcpcpap g)-3') dna polymerase iii subunit delta'	[pdb]	1.84 0.00496	72^THR 64^GLY 66^GLN 62^CYS 117^ALA 119^LEU	2.7.7.7	DNA replication DNA replication DNA replication	DNA polymerase III complex DNA polymerase III complex DNA polymerase III complex DNA polymerase III	DNA binding DNA-directed DNA polymerase activity protein binding transferase activity nucleotidyltransferase activity DNA binding DNA-directed DNA polymerase activity protein binding 3'-5' exonuclease activity transferase activity nucleotidyltransferase activity nucleotide binding DNA binding DNA-directed DNA polymerase activity protein binding ATP binding transferase activity nucleotidyltransferase activity ATPase activity nucleoside-triphosphatase activity DNA polymerase processivity factor activity
3ptaA dna (5'-d(cpcptpgpcpgpgpapgpgpcptpcpapcpgpgpgpa)-3') dna (5'-d(tpcpcpcpgptpgpapgpcpcptpcpcpgpcpapgpg)-3') dna (cytosine-5)-methyltransferase 1	[pdb]	1.84 0.00496	1225^PRO 1226^CYS 1230^SER 1266^GLU 1310^ARG 1312^ARG	2.1.1.37, 0.0.0.0	negative regulation of transcription from RNA polymerase II promoter DNA methylation maintenance of DNA methylation regulation of gene expression positive regulation of gene expression gene silencing chromatin modification regulation of cell proliferation negative regulation of transcription DNA-dependent positive regulation of histone H3-K4 methylation	heterochromatin nucleus replication fork centromeric heterochromatin	DNA binding DNA (cytosine-5-)-methyltransferase activity protein binding transcription factor binding methyltransferase activity zinc ion binding DNA-methyltransferase activity transcription repressor activity transferase activity metal ion binding
3eofA putative oxidoreductase	[pdb]	1.84 0.00496	152^PRO 77^CYS 109^THR 148^GLU 82^ARG 81^ARG	0.0.0.0			oxidoreductase activity
1szlA f-spondin	[pdb]	1.84 0.00515	479^PRO 480^CYS 440^SER 470^LEU 466^ARG 468^ARG	0.0.0.0	cell adhesion	extracellular region proteinaceous extracellular matrix	protein binding
3pt6A dna (5'-d(cpcptpgpcpgpgpapgpgpcptpcpapcpgpgpgpa)-3') dna (5'-d(tpcpcpcpgptpgpapgpcpcptpcpcpgpcpapgpg)-3') dna (cytosine-5)-methyltransferase 1	[pdb]	1.84 0.00515	1228^PRO 1229^CYS 1233^SER 1269^GLU 1313^ARG 1315^ARG	0.0.0.0	DNA methylation maintenance of DNA methylation regulation of gene expression positive regulation of gene expression gene silencing chromatin modification regulation of cell proliferation negative regulation of transcription DNA-dependent positive regulation of histone H3-K4 methylation	heterochromatin nucleus replication fork centromeric heterochromatin cytoplasm	DNA binding DNA (cytosine-5-)-methyltransferase activity protein binding transcription factor binding methyltransferase activity zinc ion binding DNA-methyltransferase activity transcription repressor activity transferase activity metal ion binding
3gycB putative glycoside hydrolase	[pdb]	1.84 0.00515	377^PRO 375^CYS 46^THR 71^GLU 391^ARG 75^ARG	0.0.0.0	carbohydrate metabolic process		catalytic activity cation binding
2ardA tryptophan halogenase prna	[pdb]	1.85 0.00515	147^PRO 148^CYS 150^SER 141^LEU 501^ARG 503^ARG	0.0.0.0
1ixkA methyltransferase	[pdb]	1.85 0.00534	196^PRO 197^CYS 106^SER 249^LEU 295^ARG 296^ARG	0.0.0.0	rRNA processing		RNA binding methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity
1m22A peptide amidase	[pdb]	1.85 0.00534	230^PRO 200^CYS 198^SER 167^LEU 84^ARG 86^ARG	0.0.0.0			carbon-nitrogen ligase activity
1p59A 5'-d(apapgpapcpgp(5iu)pgpgpapc)-3' endonuclease iii 5'-d(tpgp(5iu)pcpcpap(3dr)pgp(5iu)pcp*t)-3'	[pdb]	1.85 0.00534	197^PRO 196^CYS 193^SER 207^GLU 144^ARG 148^ARG	0.0.0.0
3binA cell adhesion molecule 1 band 4.1-like protein 3	[pdb]	1.85 0.00534	219^PRO 220^CYS 224^THR 209^LEU 254^ARG 210^ARG	0.0.0.0	biological_process cortical actin cytoskeleton organization liver development apoptosis cell adhesion homophilic cell adhesion heterophilic cell-cell adhesion multicellular organismal development spermatogenesis cell recognition cell differentiation susceptibility to natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity positive regulation of cytokine secretion detection of stimulus T cell mediated cytotoxicity activated T cell proliferation	cytoplasm cytoskeleton plasma membrane cell-cell junction extrinsic to membrane paranode region of axon juxtaparanode region of axon plasma membrane cell-cell junction membrane integral to membrane basolateral plasma membrane synaptosome	actin binding structural molecule activity binding protein binding cytoskeletal protein binding receptor binding protein binding protein C-terminus binding PDZ domain binding protein homodimerization activity
3lxkA tyrosine-protein kinase jak3	[pdb]	1.85 0.00553	1067^PRO 1066^CYS 1022^THR 927^LEU 920^ARG 925^ARG	2.7.10.2	protein phosphorylation enzyme linked receptor protein signaling pathway intracellular protein kinase cascade peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway positive regulation of transcription from RNA polymerase II promoter	cytoskeleton endomembrane system membrane	nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding kinase activity transferase activity
1sddB coagulation factor v	[pdb]	1.85 0.00553	1677^PRO 1710^CYS 1714^THR 1707^LEU 1542^ARG 1608^ARG	0.0.0.0	cell adhesion blood coagulation blood circulation oxidation-reduction process	extracellular region extracellular space platelet alpha granule	copper ion binding oxidoreductase activity metal ion binding
1beaA bifunctional amylase/serine protease inhibitor	[pdb]	1.86 0.00553	18^PRO 20^CYS 25^THR 60^LEU 88^ARG 92^ARG	0.0.0.0		extracellular region	serine-type endopeptidase inhibitor activity peptidase inhibitor activity
3mo5B histone-lysine n-methyltransferase, h3 lysine-9 specific 5	[pdb]	1.86 0.00553	1004^PRO 1003^CYS 1000^SER 1099^LEU 1103^ARG 1101^ARG	2.1.1.43	negative regulation of transcription from RNA polymerase II promoter chromatin modification histone methylation	nucleus	methyltransferase activity zinc ion binding transferase activity histone-lysine N-methyltransferase activity metal ion binding
1ib9A trypsin inhibitor ii	[pdb]	1.86 0.00553	9^PRO 8^CYS 1^SER 12^LEU 17^ARG 28^ARG	0.0.0.0		extracellular region	endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity peptidase inhibitor activity
2oriB adenylate kinase	[pdb]	1.86 0.00574	144^PRO 150^CYS 135^THR 139^LEU 160^ARG 127^ARG	2.7.4.3	nucleobase nucleoside	cytoplasm	nucleotide binding adenylate kinase activity ATP binding kinase activity transferase activity phosphotransferase activity phosphate group as acceptor nucleotide kinase activity nucleobase
3n5nX a/g-specific adenine dna glycosylase	[pdb]	1.86 0.00574	287^PRO 286^CYS 284^SER 291^LEU 231^ARG 293^ARG		DNA repair base-excision repair mismatch repair response to DNA damage stimulus metabolic process depurination	nucleus nucleoplasm	catalytic activity endonuclease activity protein binding hydrolase activity hydrolase activity acting on glycosyl bonds DNA N-glycosylase activity MutSalpha complex binding metal ion binding iron-sulfur cluster binding 4 iron 4 sulfur cluster binding MutLalpha complex binding
1s3gA adenylate kinase	[pdb]	1.86 0.00574	144^PRO 150^CYS 135^THR 139^LEU 160^ARG 127^ARG	2.7.4.3	nucleobase nucleoside	cytoplasm	nucleotide binding adenylate kinase activity ATP binding kinase activity transferase activity phosphotransferase activity phosphate group as acceptor nucleotide kinase activity nucleobase
2xcnA ns4a ns3 protease	[pdb]	1.86 0.00574	96^PRO 97^CYS 101^SER 143^LEU 119^ARG 118^ARG	0.0.0.0	viral reproduction proteolysis transformation of host cell by virus	virion part	catalytic activity peptidase activity serine-type peptidase activity
3dkvA adenylate kinase	[pdb]	1.86 0.00574	144^PRO 150^CYS 135^THR 139^LEU 160^ARG 127^ARG	2.7.4.3	nucleobase nucleoside	cytoplasm	nucleotide binding adenylate kinase activity ATP binding kinase activity transferase activity phosphotransferase activity phosphate group as acceptor nucleotide kinase activity nucleobase
1q4kB serine/threonine-protein kinase plk phospho-peptide sequencemet.gln.ser.pthr.pro.leu	[pdb]	1.86 0.00574	545^PRO 544^CYS 529^SER 378^LEU 579^ARG 584^ARG	2.7.11.21	mitotic prometaphase protein phosphorylation cell cycle mitosis regulation of mitotic cell cycle cell proliferation G2/M transition DNA damage checkpoint positive regulation of proteasomal ubiquitin-dependent protein catabolic process polar body extrusion after meiotic divisions response to antibiotic cell division positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity	chromosome centromeric region kinetochore condensed chromosome kinetochore spindle pole condensed nuclear chromosome outer kinetochore nucleus nucleoplasm chromosome cytoplasm centrosome microtubule organizing center cytosol cytoskeleton	nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding anaphase-promoting complex binding kinase activity transferase activity protein kinase binding polo kinase kinase activity
1k78A pax5/ets binding site on the mb-1 promoter paired box protein pax5 c-ets-1 protein	[pdb]	1.87 0.00574	51^PRO 52^CYS 55^SER 44^LEU 38^ARG 40^ARG	0.0.0.0	negative regulation of transcription from RNA polymerase II promoter regulation of transcription DNA-dependent transcription from RNA polymerase II promoter humoral immune response multicellular organismal development spermatogenesis nervous system development organ morphogenesis cell differentiation negative regulation of histone H3-K9 methylation response to hypoxia regulation of transcription DNA-dependent regulation of transcription from RNA polymerase II promoter anti-apoptosis female pregnancy positive regulation of cell proliferation response to wounding response to mechanical stimulus regulation of extracellular matrix disassembly hypothalamus development pituitary gland development positive regulation of cell migration response to estradiol stimulus response to laminar fluid shear stress positive regulation of erythrocyte differentiation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter angiogenesis involved in wound healing estrous cycle phase	nucleus nucleus transcription factor complex	DNA binding sequence-specific DNA binding transcription factor activity protein binding DNA binding sequence-specific DNA binding transcription factor activity protein binding transcription activator activity sequence-specific DNA binding
3p8nB hcv serine protease ns3 hcv non-structural protein 4a	[pdb]	1.87 0.00594	96^PRO 97^CYS 101^SER 143^LEU 119^ARG 118^ARG	0.0.0.0	transcription RNA-dependent proteolysis apoptosis viral reproduction viral genome replication transformation of host cell by virus evasion by virus of host immune response	extracellular region endoplasmic reticulum membrane membrane integral to membrane virion viral capsid viral envelope host cell plasma membrane host cell cytoplasm ribonucleoprotein complex host cell membrane host cell mitochondrion host cell nucleus host cell endoplasmic reticulum host cell endoplasmic reticulum membrane host cell lipid particle host cell mitochondrial membrane host cell perinuclear region of cytoplasm virion part virion membrane	nucleotide binding nucleic acid binding RNA binding catalytic activity RNA-directed RNA polymerase activity cysteine-type endopeptidase activity serine-type endopeptidase activity helicase activity structural molecule activity ATP binding peptidase activity cysteine-type peptidase activity serine-type peptidase activity zinc ion binding transferase activity nucleotidyltransferase activity hydrolase activity nucleoside-triphosphatase activity metal ion binding
1uf2B outer capsid protein p8 structural protein p7 core protein p3	[pdb]	1.87 0.00595	246^ALA 244^THR 240^THR 206^ALA 213^ALA 211^VAL	0.0.0.0	viral envelope fusion with host membrane	virion viral nucleocapsid virion viral capsid viral envelope virion viral nucleocapsid	RNA binding structural molecule activity host cell surface receptor binding structural molecule activity
3oypA non-structural protein 4a serine protease ns3	[pdb]	1.87 0.00595	96^PRO 97^CYS 101^SER 143^LEU 119^ARG 118^ARG		transcription RNA-dependent proteolysis apoptosis viral reproduction viral genome replication transformation of host cell by virus evasion by virus of host immune response	extracellular region endoplasmic reticulum membrane membrane integral to membrane virion viral capsid viral envelope host cell plasma membrane host cell cytoplasm ribonucleoprotein complex host cell membrane host cell mitochondrion host cell nucleus host cell endoplasmic reticulum host cell endoplasmic reticulum membrane host cell lipid particle host cell mitochondrial membrane host cell perinuclear region of cytoplasm virion part virion membrane	nucleotide binding nucleic acid binding RNA binding catalytic activity RNA-directed RNA polymerase activity cysteine-type endopeptidase activity serine-type endopeptidase activity helicase activity structural molecule activity ATP binding peptidase activity cysteine-type peptidase activity serine-type peptidase activity zinc ion binding transferase activity nucleotidyltransferase activity hydrolase activity nucleoside-triphosphatase activity metal ion binding
3m5nA secttpc peptide ns3/4a	[pdb]	1.87 0.00595	1096^PRO 1097^CYS 1101^SER 1143^LEU 1119^ARG 1118^ARG		transcription RNA-dependent proteolysis apoptosis viral reproduction viral genome replication transformation of host cell by virus evasion by virus of host immune response interspecies interaction between organisms transcription RNA-dependent proteolysis apoptosis viral reproduction viral genome replication transformation of host cell by virus	extracellular region endoplasmic reticulum membrane membrane integral to membrane virion viral capsid viral envelope ribonucleoprotein complex host cell membrane virion part extracellular region endoplasmic reticulum membrane membrane integral to membrane virion viral capsid viral envelope ribonucleoprotein complex host cell membrane virion part	nucleotide binding nucleic acid binding RNA binding catalytic activity RNA-directed RNA polymerase activity cysteine-type endopeptidase activity serine-type endopeptidase activity helicase activity structural molecule activity ATP binding serine-type peptidase activity zinc ion binding transferase activity nucleotidyltransferase activity hydrolase activity nucleoside-triphosphatase activity nucleotide binding nucleic acid binding RNA binding catalytic activity RNA-directed RNA polymerase activity cysteine-type endopeptidase activity serine-type endopeptidase activity helicase activity structural molecule activity ATP binding serine-type peptidase activity zinc ion binding transferase activity nucleotidyltransferase activity hydrolase activity nucleoside-triphosphatase activity
3oxnB putative transcriptional regulator, lysr family	[pdb]	1.87 0.00595	173^PRO 171^CYS 122^THR 185^LEU 309^ARG 313^ARG	0.0.0.0	regulation of transcription		DNA binding sequence-specific DNA binding transcription factor activity
3i5dA p2x purinoceptor	[pdb]	1.87 0.00595	169^PRO 168^CYS 166^SER 163^GLU 143^ARG 148^ARG	0.0.0.0	transport ion transport	membrane integral to membrane	receptor activity ion channel activity ATP binding
2ix5D acyl-coenzyme a oxidase 4, peroxisomal	[pdb]	1.87 0.00616	43^PRO 44^CYS 46^SER 71^GLU 63^ARG 67^ARG	1.3.3.6	lipid metabolic process fatty acid metabolic process fatty acid beta-oxidation metabolic process embryo development ending in seed dormancy short-chain fatty acid metabolic process oxidation-reduction process	peroxisome glyoxysome	acyl-CoA dehydrogenase activity acyl-CoA oxidase activity oxidoreductase activity oxidoreductase activity acting on the CH-CH group of donors
2i6jA sulfolobus solfataricus protein tyrosinephosphatase	[pdb]	1.88 0.00616	36^PRO 96^CYS 12^SER 63^LEU 25^ARG 31^ARG	0.0.0.0	protein dephosphorylation dephosphorylation		protein tyrosine phosphatase activity phosphatase activity
1bnlC collagen xviii	[pdb]	1.88 0.00616	143^PRO 165^CYS 20^SER 136^GLU 24^ARG 139^ARG		angiogenesis endothelial cell morphogenesis cell adhesion visual perception positive regulation of cell proliferation negative regulation of cell proliferation organ morphogenesis extracellular matrix organization positive regulation of cell migration response to drug positive regulation of apoptosis response to hydrostatic pressure	extracellular region proteinaceous extracellular matrix collagen basement membrane extracellular space extracellular matrix	structural molecule activity extracellular matrix structural constituent binding metal ion binding
1sftA alanine racemase	[pdb]	1.88 0.00637	357^PRO 358^CYS 361^SER 11^GLU 378^ARG 366^ARG	5.1.1.1	alanine metabolic process cellular cell wall organization regulation of cell shape peptidoglycan biosynthetic process		catalytic activity alanine racemase activity isomerase activity
2ihsB 20-mer from atp-dependent rna helicase vasa cg2944-pf, isoform f	[pdb]	1.88 0.00638	215^PRO 122^CYS 143^SER 97^LEU 206^ARG 209^ARG	0.0.0.0	mRNA polyadenylation regulation of translation multicellular organismal development germarium-derived egg chamber formation germarium-derived oocyte fate determination oocyte anterior/posterior axis specification pole plasm assembly pole plasm RNA localization intracellular mRNA localization cell differentiation karyosome formation positive regulation of translation regulation of oskar mRNA translation positive regulation of oskar mRNA translation dorsal appendage formation germ-line cyst formation oogenesis oocyte anterior/posterior axis specification dorsal appendage formation	cytoplasm P granule	nucleotide binding nucleic acid binding RNA binding RNA helicase activity mRNA 3'-UTR binding ATP-dependent RNA helicase activity helicase activity protein binding ATP binding ATP-dependent helicase activity hydrolase activity
6paxA 26 nucleotide dna homeobox protein pax-6	[pdb]	1.89 0.00638	36^PRO 37^CYS 40^SER 29^LEU 23^ARG 25^ARG	0.0.0.0	eye development regulation of transcription DNA-dependent multicellular organismal development central nervous system development visual perception response to wounding organ morphogenesis cell differentiation	nucleus cytoplasm	DNA binding sequence-specific DNA binding transcription factor activity protein binding transcription regulator activity sequence-specific DNA binding
3ehtA corticoliberin fusion protein of crfr1 extracellular domain andmbp	[pdb]	1.89 0.0066	59^PRO 44^CYS 47^SER 86^GLU 66^ARG 85^ARG	0.0.0.0	immune response signal transduction cell surface receptor linked signaling pathway G-protein coupled receptor protein signaling pathway G-protein signaling coupled to cAMP nucleotide second messenger activation of adenylate cyclase activity female pregnancy parturition transport carbohydrate transport maltose transport maltodextrin transport glucocorticoid biosynthetic process response to stress inflammatory response signal transduction synaptic transmission female pregnancy parturition learning or memory long-term memory feeding behavior induction of apoptosis by hormones positive regulation of circadian sleep/wake cycle wakefulness lung development adrenal gland development negative regulation of circadian sleep/wake cycle	plasma membrane integral to plasma membrane membrane integral to membrane periplasmic space ATP-binding cassette (ABC) transporter complex ATP-binding cassette (ABC) transporter complex substrate-binding subunit-containing extracellular region	signal transducer activity receptor activity transmembrane receptor activity G-protein coupled receptor activity corticotrophin-releasing factor receptor activity transporter activity maltose transmembrane transporter activity disaccharide binding receptor binding hormone activity neuropeptide hormone activity adrenocorticotropin-releasing hormone activity corticotropin-releasing hormone receptor 1 binding corticotropin-releasing hormone receptor 2 binding
2fr1A erythromycin synthase, eryai	[pdb]	1.89 0.0066	1567^PRO 1566^CYS 1473^THR 1563^GLU 1518^ARG 1520^ARG	2.3.1.94	metabolic process biosynthetic process antibiotic biosynthetic process		acyl carrier activity catalytic activity binding acyltransferase activity transferase activity phosphopantetheine binding erythronolide synthase activity cofactor binding
1ps9A 2,4-dienoyl-coa reductase	[pdb]	1.89 0.0066	628^PRO 649^CYS 463^SER 655^LEU 666^ARG 659^ARG	1.3.1.34	metabolic process oxidation-reduction process		catalytic activity 2,4-dienoyl-CoA reductase (NADPH) activity FMN binding oxidoreductase activity metal ion binding iron-sulfur cluster binding 4 iron
2rdlA (msu)aap(alm) peptide chymase 2	[pdb]	1.89 0.0066	165^PRO 182^CYS 226^SER 163^LEU 137^ARG 161^ARG	0.0.0.0	proteolysis		catalytic activity serine-type endopeptidase activity peptidase activity serine-type peptidase activity hydrolase activity
3g0tA putative aminotransferase	[pdb]	1.9 0.00683	190^PRO 197^CYS 199^THR 161^LEU 170^ARG 165^ARG	0.0.0.0	biosynthetic process		catalytic activity transaminase activity transferase activity transferase activity transferring nitrogenous groups
2wmhA fucolectin-related protein	[pdb]	1.9 0.00683	88^PRO 97^CYS 95^THR 105^LEU 133^ARG 100^ARG	0.0.0.0	cell adhesion
3q8gA cral-trio domain-containing protein ykl091c	[pdb]	1.91 0.00707	286^PRO 164^CYS 165^SER 123^LEU 210^ARG 121^ARG			nucleus
1su6A carbon monoxide dehydrogenase 2	[pdb]	1.91 0.00707	183^PRO 215^CYS 216^SER 192^GLU 80^ARG 84^ARG	1.2.99.2	generation of precursor metabolites and energy oxidation-reduction process	cytoplasm plasma membrane membrane	catalytic activity nickel ion binding oxidoreductase activity carbon-monoxide dehydrogenase (acceptor) activity metal ion binding iron-sulfur cluster binding 4 iron
1cd3F protein (capsid protein gpf) protein (scaffolding protein gpb) protein (scaffolding protein gpd) protein (spike protein gpg)	[pdb]	1.91 0.00707	369^PRO 393^CYS 396^SER 58^HIS 50^ASN 263^ARG	0.0.0.0	virus-host interaction interspecies interaction between organisms viral capsid assembly viral capsid assembly viral procapsid maturation	virion viral capsid host cell cytoplasm host cell cytoplasm viral procapsid host cell cytoplasm virion viral capsid host cell cytoplasm	structural molecule activity
3pihA dna (32-mer) uvrabc system protein a	[pdb]	1.91 0.00707	277^PRO 279^CYS 285^THR 392^LEU 95^ARG 391^ARG	0.0.0.0	DNA repair nucleotide-excision repair response to DNA damage stimulus SOS response	cytoplasm excinuclease repair complex	nucleotide binding DNA binding catalytic activity nuclease activity ATP binding excinuclease ABC activity ATPase activity nucleoside-triphosphatase activity metal ion binding
1pw4A glycerol-3-phosphate transporter	[pdb]	1.91 0.00731	15^PRO 215^CYS 211^THR 18^GLU 25^ARG 24^ARG	0.0.0.0	glycerol metabolic process transport glycerol transport glycerol-3-phosphate transport transmembrane transport	plasma membrane membrane integral to membrane	transporter activity glycerol-3-phosphate transmembrane transporter activity organophosphate:inorganic phosphate antiporter activity glycerol-phosphate:inorganic phosphate antiporter activity
1jroD xanthine dehydrogenase, chain a xanthine dehydrogenase, chain b	[pdb]	1.91 0.00731	27^PRO 28^CYS 32^THR 23^LEU 107^ARG 256^ARG	0.0.0.0	oxidation-reduction process oxidation-reduction process		catalytic activity xanthine dehydrogenase activity xanthine oxidase activity electron carrier activity oxidoreductase activity metal ion binding flavin adenine dinucleotide binding iron-sulfur cluster binding 2 iron 2 sulfur cluster binding xanthine dehydrogenase activity xanthine oxidase activity oxidoreductase activity molybdenum ion binding
2yvwA udp-n-acetylglucosamine 1-carboxyvinyltransferase	[pdb]	1.91 0.00731	47^PRO 48^CYS 41^THR 72^GLU 60^ARG 67^ARG	2.5.1.7	cellular cell wall organization cell cycle regulation of cell shape peptidoglycan biosynthetic process UDP-N-acetylgalactosamine biosynthetic process cell division	cytoplasm	catalytic activity UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity transferase activity transferase activity
2glzA similar to formylmethanofuran dehydrogenase subunit e	[pdb]	1.92 0.00756	20^PRO 19^CYS 18^THR 109^LEU 117^ARG 119^ARG	0.0.0.0	protein polymerization	protein complex	GTPase activity GTP binding
1nouB beta-hexosaminidase beta chain	[pdb]	1.92 0.00756	89^PRO 91^CYS 135^SER 96^GLU 279^ARG 281^ARG	3.2.1.52	skeletal system development carbohydrate metabolic process N-acetylglucosamine metabolic process glycosphingolipid metabolic process ganglioside catabolic process cellular calcium ion homeostasis lysosome organization single fertilization penetration of zona pellucida sensory perception of sound locomotory behavior male courtship behavior metabolic process phospholipid biosynthetic process oligosaccharide catabolic process lipid storage sexual reproduction glycosaminoglycan metabolic process regulation of cellular metabolic process myelination cellular protein metabolic process oogenesis neuromuscular process controlling balance neuromuscular process	acrosomal vesicle soluble fraction lysosome membrane	catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds beta-N-acetylhexosaminidase activity sugar binding hexosaminidase activity beta-N-acetylglucosaminidase activity hydrolase activity hydrolase activity acting on glycosyl bonds protein homodimerization activity
2xvoD sso1725	[pdb]	1.92 0.00757	95^PRO 96^CYS 157^THR 75^LEU 188^ARG 100^ARG	0.0.0.0
2is1B 5'-d(cpgpapgpcpapcptpgpc)-3' dna helicase ii 5'-d(gpcpapgptpgpcptpcpgptptptptptptp*t)-3'	[pdb]	1.93 0.00783	317^PRO 640^CYS 291^SER 610^LEU 284^ARG 605^ARG	0.0.0.0	DNA replication DNA unwinding involved in replication DNA repair response to DNA damage stimulus SOS response	cytoplasm	nucleotide binding DNA binding ATP-dependent DNA helicase activity helicase activity protein binding ATP binding hydrolase activity
3fm8D kinesin-like protein kif13b centaurin-alpha-1	[pdb]	1.93 0.00783	186^PRO 101^CYS 99^SER 103^LEU 95^ARG 105^ARG	0.0.0.0	cell surface receptor linked signaling pathway regulation of ARF GTPase activity regulation of GTPase activity protein targeting microtubule-based movement signal transduction T cell activation	nucleus cytoplasm plasma membrane nucleolus cytoplasm cytoskeleton microtubule	GTPase activator activity protein binding ARF GTPase activator activity zinc ion binding inositol 1,3,4,5 tetrakisphosphate binding metal ion binding nucleotide binding motor activity microtubule motor activity protein binding ATP binding protein kinase binding
2gepA sulfite reductase hemoprotein	[pdb]	1.93 0.00783	441^PRO 440^CYS 436^SER 81^LEU 366^ARG 113^ARG	1.8.1.2	cellular amino acid biosynthetic process cysteine biosynthetic process oxidation-reduction process	sulfite reductase complex (NADPH)	sulfite reductase (NADPH) activity oxidoreductase activity heme binding metal ion binding NADP binding iron-sulfur cluster binding 4 iron
3fe4A carbonic anhydrase 6	[pdb]	1.93 0.00809	36^PRO 42^CYS 218^SER 32^GLU 265^ARG 264^ARG	4.2.1.1	one-carbon metabolic process	extracellular region	carbonate dehydratase activity zinc ion binding lyase activity metal ion binding
3k4wC uncharacterized protein bb4693	[pdb]	1.93 0.00809	246^PRO 245^CYS 31^THR 43^GLU 19^ARG 23^ARG	0.0.0.0	metabolic process		catalytic activity
1kptB kp4 toxin	[pdb]	1.93 0.00809	36^PRO 35^CYS 33^THR 86^LEU 23^ARG 68^ARG	0.0.0.0	pathogenesis	extracellular region
1jswA l-aspartate ammonia-lyase	[pdb]	1.93 0.00809	333^PRO 295^CYS 292^SER 387^LEU 205^ARG 171^ARG	4.3.1.1	tricarboxylic acid cycle aspartate metabolic process	cytosol membrane	catalytic activity protein binding aspartate ammonia-lyase activity lyase activity
2zetD melanophilin ras-related protein rab-27b	[pdb]	1.93 0.0081	106^PRO 104^CYS 93^SER 86^LEU 78^ARG 79^ARG	0.0.0.0	protein targeting intracellular protein transport melanocyte differentiation melanosome localization pigmentation small GTPase mediated signal transduction protein transport regulation of exocytosis	actin cytoskeleton melanosome Golgi apparatus membrane zymogen granule membrane	actin binding protein binding zinc ion binding myosin binding Rab GTPase binding myosin V binding metal ion binding microtubule plus-end binding nucleotide binding GTPase activity protein binding GTP binding
3ewnA thij/pfpi family protein	[pdb]	1.93 0.0081	121^PRO 154^CYS 173^SER 118^LEU 195^ARG 199^ARG	0.0.0.0