The LabelHash Server

Top 150 matches

For each match you can click on the "[pdb]" link to download a PDB file with the matching chain aligned with the motif.
Download a zip file with PDB files for all the matches and the motif itself.

PDB ID		LRMSD / p-value	Matching Residues	EC	Gene Ontology annotations
PDB ID		LRMSD / p-value	Matching Residues	EC	Biological Process	Cellular Component	Molecular Function
3tliA thermolysin	[pdb]	0.186 2.04e-05	120^MET 143^GLU 144^LEU 157^TYR 231^HIS	3.4.24.27	proteolysis	extracellular region	metalloendopeptidase activity peptidase activity metallopeptidase activity zinc ion binding hydrolase activity metal ion binding
1bqbA protein (aureolysin)	[pdb]	0.235 4.5e-05	122^MET 145^GLU 146^ILE 159^TYR 228^HIS	3.4.24.29	proteolysis	extracellular region	metalloendopeptidase activity peptidase activity metallopeptidase activity zinc ion binding hydrolase activity metal ion binding
2bh2B 23s ribosomal rna 1932-1968 23s rrna (uracil-5-)-methyltransferase ruma	[pdb]	0.417 9.67e-05	416^MET 424^GLU 423^LEU 117^SER 428^LEU	0.0.0.0	rRNA processing RNA processing rRNA methylation rRNA base methylation		RNA binding methyltransferase activity RNA methyltransferase activity transferase activity metal ion binding iron-sulfur cluster binding 4 iron 4 sulfur cluster binding
1u4gA elastase	[pdb]	0.458 0.000134	120^MET 141^GLU 142^VAL 155^TYR 223^HIS	3.4.24.26	proteolysis	extracellular region	metalloendopeptidase activity peptidase activity metallopeptidase activity zinc ion binding hydrolase activity metal ion binding
3bjqH phage-related protein	[pdb]	0.469 0.00014	28^LEU 119^ALA 120^LEU 266^TYR 271^HIS	0.0.0.0
2pz9A putative regulatory protein	[pdb]	0.539 0.000222	205^LEU 176^ALA 175^ILE 95^LEU 89^LEU	0.0.0.0	regulation of transcription		DNA binding sequence-specific DNA binding transcription factor activity specific transcriptional repressor activity transcription regulator activity
2nn6B 3'-5' exoribonuclease csl4 homolog polymyositis/scleroderma autoantigen 1 exosome complex exonuclease rrp4 exosome complex exonuclease rrp46 exosome complex exonuclease rrp41 exosome complex exonuclease rrp40 exosome complex exonuclease rrp43 exosome complex exonuclease rrp42 exosome component 6	[pdb]	0.545 0.00023	189^LEU 196^ILE 195^VAL 134^SER 100^ARG	0.0.0.0	rRNA processing RNA processing immune response rRNA processing RNA processing rRNA processing RNA processing rRNA processing rRNA processing rRNA processing rRNA processing RNA processing histone mRNA catabolic process rRNA processing RNA processing biological_process rRNA processing RNA processing RNA catabolic process	nuclear exosome (RNase complex) exosome (RNase complex) nucleus nucleolus cytoplasm exosome (RNase complex) nucleus nucleolus cytoplasm exosome (RNase complex) nucleus nucleolus cytoplasm exosome (RNase complex) nucleus nucleolus nuclear exosome (RNase complex) cytoplasmic exosome (RNase complex) exosome (RNase complex) nucleus nucleolus cytoplasm exosome (RNase complex) nucleus nucleolus cytoplasm exosome (RNase complex) nucleus nucleolus cytoplasm exosome (RNase complex) cellular_component nucleus nucleolus cytoplasm exosome (RNase complex) nucleus nucleolus	3'-5'-exoribonuclease activity RNA binding nuclease activity exonuclease activity protein binding hydrolase activity 3'-5'-exoribonuclease activity RNA binding nuclease activity exonuclease activity protein binding hydrolase activity 3'-5'-exoribonuclease activity RNA binding nuclease activity exonuclease activity hydrolase activity RNA binding nuclease activity exonuclease activity protein binding hydrolase activity 3'-5'-exoribonuclease activity RNA binding nuclease activity exonuclease activity protein binding hydrolase activity 3'-5'-exoribonuclease activity RNA binding nuclease activity exonuclease activity protein binding 7S RNA binding hydrolase activity 3'-5'-exoribonuclease activity RNA binding nuclease activity exonuclease activity protein binding hydrolase activity 3'-5'-exoribonuclease activity molecular_function RNA binding nuclease activity exonuclease activity protein binding hydrolase activity identical protein binding 3'-5'-exoribonuclease activity RNA binding nuclease activity exonuclease activity protein binding hydrolase activity
3nqzB secreted metalloprotease mcp02	[pdb]	0.566 0.000259	325^MET 346^GLU 347^VAL 360^TYR 428^HIS	0.0.0.0	proteolysis	extracellular region	metalloendopeptidase activity peptidase activity metallopeptidase activity zinc ion binding
1x3fA single-strand binding protein	[pdb]	0.6 0.000325	83^LEU 100^GLU 99^VAL 35^SER 13^LEU	0.0.0.0	DNA replication DNA repair response to DNA damage stimulus		DNA binding single-stranded DNA binding
2we9A moba-related protein	[pdb]	0.635 0.000443	11^LEU 13^ALA 53^LEU 26^LEU 19^LEU	0.0.0.0
1hdsD hemoglobin s (deoxy) (beta chain) hemoglobin s (deoxy) (alpha chain)	[pdb]	0.643 0.000517	80^LEU 139^ALA 136^VAL 90^LEU 145^HIS	0.0.0.0	transport oxygen transport transport oxygen transport	hemoglobin complex hemoglobin complex	oxygen transporter activity iron ion binding oxygen binding heme binding metal ion binding oxygen transporter activity iron ion binding oxygen binding heme binding metal ion binding
1zcdA na(+)/h(+) antiporter 1	[pdb]	0.649 0.000517	138^LEU 135^ALA 134^ILE 255^LEU 262^LEU	0.0.0.0	transport ion transport sodium ion transport cellular sodium ion homeostasis regulation of pH proton transport	plasma membrane membrane integral to membrane	antiporter activity cation:cation antiporter activity
1xbaA tyrosine-protein kinase syk	[pdb]	0.651 0.000562	495^LEU 497^ALA 561^LEU 507^TYR 453^LEU	2.7.10.2	activation of MAPK activity serotonin secretion protein complex assembly protein phosphorylation leukocyte cell-cell adhesion cell surface receptor linked signaling pathway enzyme linked receptor protein signaling pathway integrin-mediated signaling pathway activation of JUN kinase activity cell proliferation organ morphogenesis peptidyl-tyrosine phosphorylation leukotriene biosynthetic process neutrophil chemotaxis positive regulation of mast cell degranulation beta selection interspecies interaction between organisms positive regulation of interleukin-3 biosynthetic process positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process positive regulation of B cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of alpha-beta T cell differentiation positive regulation of alpha-beta T cell proliferation protein autophosphorylation positive regulation of peptidyl-tyrosine phosphorylation regulation of immune response positive regulation of calcium-mediated signaling B cell receptor signaling pathway	cytoplasm B cell receptor complex T cell receptor complex	nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity integrin binding protein binding ATP binding kinase activity transferase activity protein domain specific binding
2arzB hypothetical protein pa4388	[pdb]	0.652 0.000562	236^TRP 182^ALA 181^LEU 192^LEU 208^LEU	0.0.0.0			FMN binding
1m9lA outer arm dynein light chain 1	[pdb]	0.654 0.000562	108^LEU 137^ALA 136^LEU 153^TYR 146^LEU	0.0.0.0		cytoplasm cytoskeleton microtubule cilium flagellum dynein complex flagellar axoneme cell projection	motor activity protein binding
2o5vA dna replication and repair protein recf	[pdb]	0.669 0.00066	285^LEU 281^ALA 200^LEU 253^LEU 123^LEU	0.0.0.0	DNA replication DNA repair response to DNA damage stimulus SOS response	cytoplasm	nucleotide binding DNA binding single-stranded DNA binding ATP binding nucleoside-triphosphatase activity
2wawA moba relate protein	[pdb]	0.674 0.000717	11^LEU 13^ALA 53^LEU 26^LEU 19^LEU	0.0.0.0	isoprenoid biosynthetic process		catalytic activity
1s9cB peroxisomal multifunctional enzyme type 2	[pdb]	0.676 0.000717	126^MET 110^ALA 111^VAL 136^LEU 106^LEU	4.2.1.107, 1.1.1.35	lipid metabolic process fatty acid metabolic process metabolic process fatty acid beta-oxidation using acyl-CoA oxidase oxidation-reduction process	peroxisome peroxisomal matrix	catalytic activity 3-hydroxyacyl-CoA dehydrogenase activity estradiol 17-beta-dehydrogenase activity binding protein binding sterol transporter activity oxidoreductase activity lyase activity isomerase activity sterol binding 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
1dtzA apo lactoferrin	[pdb]	0.679 0.000781	308^LEU 80^GLU 81^VAL 320^LEU 63^LEU	0.0.0.0	transport ion transport iron ion transport cellular iron ion homeostasis	extracellular region	ferric iron binding peptidase activity serine-type peptidase activity hydrolase activity metal ion binding
1ue6C single-strand binding protein	[pdb]	0.681 0.000781	83^LEU 100^GLU 99^ILE 35^SER 13^LEU	0.0.0.0	DNA replication DNA repair response to DNA damage stimulus protein homotetramerization	extracellular region plasma membrane	DNA binding single-stranded DNA binding
3ohdD 30s ribosomal protein s16 30s ribosomal protein s17 30s ribosomal protein s14 30s ribosomal protein s15 30s ribosomal protein s12 30s ribosomal protein s13 30s ribosomal protein s10 30s ribosomal protein s11 30s ribosomal protein s7 30s ribosomal protein s18 30s ribosomal protein s19 30s ribosomal protein s8 30s ribosomal protein s9 16s rrna 30s ribosomal protein s4 30s ribosomal protein s5 30s ribosomal protein s6 30s ribosomal protein s20 30s ribosomal protein thx 30s ribosomal protein s2 30s ribosomal protein s3	[pdb]	0.689 0.000852	202^LEU 60^GLU 58^LYS 68^LYS 19^GLY	0.0.0.0	translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation translation	intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome small ribosomal subunit ribonucleoprotein complex ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex ribosome ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex	tRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding metal ion binding tRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding tRNA binding nucleic acid binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding tRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding metal ion binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding rRNA binding RNA binding structural constituent of ribosome rRNA binding structural constituent of ribosome RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding
1gkiG conjugal transfer protein trwb	[pdb]	0.69 0.000929	403^LEU 368^ALA 371^LEU 330^SER 202^LEU	0.0.0.0
3kreA phosphoribosylaminoimidazole-succinocarboxamidesynthase	[pdb]	0.693 0.000929	178^LEU 194^ALA 193^LEU 52^TYR 27^HIS	6.3.2.6	purine nucleotide biosynthetic process		nucleotide binding catalytic activity phosphoribosylaminoimidazolesuccinocarboxamide synthase activity ATP binding ligase activity
2y3aA phosphatidylinositol-4,5-bisphosphate 3-kinase catalyticsubunit beta isoform phosphatidylinositol 3-kinase regulatory subunit beta	[pdb]	0.696 0.00101	624^THR 628^GLU 629^MET 993^LEU 820^LEU		platelet activation embryonic cleavage phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling signal transduction insulin receptor signaling pathway negative regulation of anti-apoptosis regulation of phosphorylation regulation of cell-matrix adhesion cellular calcium ion homeostasis homophilic cell adhesion signal transduction	intracellular phosphatidylinositol 3-kinase complex phosphatidylinositol 3-kinase complex	kinase activity 1-phosphatidylinositol-3-kinase activity transferase activity phosphotransferase activity alcohol group as acceptor insulin receptor substrate binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein binding phosphatidylinositol 3-kinase regulator activity 1-phosphatidylinositol-3-kinase activity nucleotide binding inositol or phosphatidylinositol kinase activity binding
3dl8G preprotein translocase subunit secy sece protein translocase subunit seca protein-export membrane protein secg	[pdb]	0.703 0.00101	375^LEU 379^ALA 380^LEU 283^LEU 58^LEU	0.0.0.0	protein targeting transport intracellular protein transport protein transport protein import transmembrane transport transport protein transport transmembrane transport transport protein secretion protein transport transmembrane transport protein targeting intracellular protein transport protein secretion	cytoplasm plasma membrane membrane plasma membrane membrane integral to membrane plasma membrane membrane integral to membrane membrane integral to membrane	nucleotide binding protein binding ATP binding metal ion binding P-P-bond-hydrolysis-driven protein transmembrane transporter activity P-P-bond-hydrolysis-driven protein transmembrane transporter activity P-P-bond-hydrolysis-driven protein transmembrane transporter activity
3d3aA beta-galactosidase	[pdb]	0.703 0.00111	356^LEU 68^ALA 69^LEU 111^TYR 104^LEU	0.0.0.0	carbohydrate metabolic process cell adhesion		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds
1tpzA interferon-inducible gtpase	[pdb]	0.705 0.00111	62^LEU 285^GLU 284^LEU 316^TYR 309^LEU	0.0.0.0		nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatus membrane nuclear membrane Golgi cisterna membrane	nucleotide binding GTP binding hydrolase activity hydrolase activity
1i3cB response regulator rcp1	[pdb]	0.706 0.00111	71^LEU 15^GLU 14^VAL 118^LEU 127^LEU	0.0.0.0	two-component signal transduction system (phosphorelay) regulation of transcription		two-component response regulator activity protein binding
3eycC lipocalin-1	[pdb]	0.706 0.00111	39^MET 51^ALA 41^LEU 87^TYR 84^HIS	0.0.0.0	proteolysis transport response to stimulus sensory perception of taste	extracellular region	cysteine-type endopeptidase inhibitor activity transporter activity binding protein binding
1iqcA di-heme peroxidase	[pdb]	0.708 0.00111	167^LEU 171^GLU 172^LEU 233^LEU 251^LEU	1.11.1.5	transport electron transport chain oxidation-reduction process	periplasmic space	cytochrome-c peroxidase activity peroxidase activity iron ion binding electron carrier activity oxidoreductase activity heme binding metal ion binding
3busA methyltransferase	[pdb]	0.712 0.00121	139^LEU 137^GLU 136^LEU 217^SER 224^LEU	0.0.0.0	metabolic process metabolic process		methyltransferase activity transferase activity methyltransferase activity transferase activity
3i1mD 30s ribosomal protein s16 30s ribosomal protein s17 30s ribosomal protein s14 30s ribosomal protein s15 30s ribosomal protein s12 30s ribosomal protein s13 30s ribosomal protein s10 30s ribosomal protein s11 30s ribosomal protein s7 30s ribosomal protein s18 30s ribosomal protein s19 30s ribosomal protein s8 30s ribosomal protein s9 16s rrna 30s ribosomal protein s4 30s ribosomal protein s5 30s ribosomal protein s21 30s ribosomal protein s20 30s ribosomal protein s6 30s ribosomal protein s2 30s ribosomal protein s3	[pdb]	0.712 0.00121	198^G 56^U 54^C 64^G 18^C	0.0.0.0	translation translation translation translation translation response to antibiotic translation transcription termination DNA-dependent translation regulation of translation response to antibiotic translation response to antibiotic translation translation ribosomal small subunit assembly translation translation translation transcription antitermination translation Group I intron splicing translation positive regulation of RNA splicing RNA folding response to antibiotic translation translation regulation of translation regulation of mRNA stability translation translation	intracellular ribosome cytosolic small ribosomal subunit ribonucleoprotein complex ribosome cytosolic small ribosomal subunit ribonucleoprotein complex intracellular ribosome small ribosomal subunit cytosolic small ribosomal subunit ribonucleoprotein complex intracellular ribosome cytosolic small ribosomal subunit ribonucleoprotein complex intracellular ribosome cytosolic small ribosomal subunit ribonucleoprotein complex intracellular ribosome cytosolic small ribosomal subunit ribonucleoprotein complex intracellular ribosome small ribosomal subunit cytosolic small ribosomal subunit ribonucleoprotein complex intracellular ribosome small ribosomal subunit ribonucleoprotein complex intracellular ribosome cytosolic small ribosomal subunit ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome cytosolic small ribosomal subunit ribonucleoprotein complex intracellular ribosome cytosolic small ribosomal subunit ribonucleoprotein complex intracellular ribosome small ribosomal subunit cytosolic small ribosomal subunit ribonucleoprotein complex intracellular ribosome small ribosomal subunit cytosolic small ribosomal subunit ribonucleoprotein complex intracellular ribosome small ribosomal subunit cytosolic small ribosomal subunit ribonucleoprotein complex intracellular ribosome small ribosomal subunit membrane ribonucleoprotein complex intracellular ribosome cytosolic small ribosomal subunit ribonucleoprotein complex intracellular ribosome ribonucleoprotein complex intracellular ribosome small ribosomal subunit cytosolic small ribosomal subunit ribonucleoprotein complex intracellular ribosome cytosolic small ribosomal subunit ribonucleoprotein complex	structural constituent of ribosome RNA binding structural constituent of ribosome rRNA binding tRNA binding RNA binding structural constituent of ribosome rRNA binding structural constituent of ribosome RNA binding structural constituent of ribosome rRNA binding SSU rRNA binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome protein binding rRNA binding translation repressor activity RNA binding structural constituent of ribosome protein binding rRNA binding tRNA binding nucleic acid binding RNA binding structural constituent of ribosome rRNA binding RNA binding structural constituent of ribosome rRNA binding structural constituent of ribosome nuclease activity endonuclease activity endodeoxyribonuclease activity hydrolase activity structure-specific DNA binding RNA binding structural constituent of ribosome rRNA binding SSU rRNA binding tRNA binding RNA binding structural constituent of ribosome protein binding structural constituent of ribosome protein binding zinc ion binding tRNA binding RNA binding structural constituent of ribosome rRNA binding misfolded RNA binding tRNA binding RNA binding structural constituent of ribosome protein binding rRNA binding RNA binding structural constituent of ribosome rRNA binding translation repressor activity tRNA binding RNA binding structural constituent of ribosome protein binding RNA binding structural constituent of ribosome protein binding rRNA binding SSU rRNA binding RNA binding structural constituent of ribosome rRNA binding
3l72P mitochondrial ubiquinol-cytochrome c reductase7.2 kda protein cytochrome b-c1 complex subunit rieske,mitochondrial mitochondrial ubiquinol-cytochrome c reductaseubiquinone-binding protein qp-c mitochondrial ubiquinol-cytochrome c reductase 11kda protein, complex iii subunit viii cytochrome b-c1 complex subunit 5, rieskeironsulfur protein, mitochondrial cytochrome b mitochondrial ubiquinol-cytochrome-c reductasecomplex core protein 2 mitochondrial ubiquinol-cytochrome-c reductasecomplex core protein i mitochondrial cytochrome c1, heme protein mitochondrial ubiquinol-cytochrome c reductase 14kda protein	[pdb]	0.713 0.00121	282^LEU 294^ALA 293^LEU 302^LEU 364^LEU	0.0.0.0	transport electron transport chain oxidation-reduction process proteolysis mitochondrial electron transport ubiquinol to cytochrome c proteolysis mitochondrial electron transport ubiquinol to cytochrome c mitochondrial electron transport ubiquinol to cytochrome c mitochondrial electron transport	mitochondrion mitochondrial inner membrane membrane integral to membrane respiratory chain nucleus mitochondrion mitochondrial inner membrane mitochondrion mitochondrial inner membrane mitochondrion mitochondrial inner membrane mitochondrion mitochondrial inner membrane mitochondrion mitochondrial envelope mitochondrial inner membrane membrane fraction mitochondrion mitochondrial inner membrane membrane integral to membrane respiratory chain	ubiquinol-cytochrome-c reductase activity oxidoreductase activity oxidoreductase activity acting on diphenols and related substances as donors metal ion binding iron-sulfur cluster binding 2 iron 2 sulfur cluster binding catalytic activity metalloendopeptidase activity protein binding ubiquinol-cytochrome-c reductase activity zinc ion binding metal ion binding ubiquinol-cytochrome-c reductase activity catalytic activity metalloendopeptidase activity protein binding ubiquinol-cytochrome-c reductase activity zinc ion binding metal ion binding iron ion binding ubiquinol-cytochrome-c reductase activity electron carrier activity heme binding ubiquinol-cytochrome-c reductase activity ubiquinol-cytochrome-c reductase activity ubiquinol-cytochrome-c reductase activity electron carrier activity
1p9nB molybdopterin-guanine dinucleotide biosynthesisprotein b	[pdb]	0.717 0.00132	4^LEU 111^ALA 110^ILE 115^LEU 148^LEU	0.0.0.0	Mo-molybdopterin cofactor biosynthetic process		nucleotide binding protein binding GTP binding
2ch8D 33 kda early protein	[pdb]	0.718 0.00132	108^LEU 45^GLU 44^ILE 103^LEU 59^LEU	0.0.0.0
1i9yA phosphatidylinositol phosphate phosphatase	[pdb]	0.72 0.00132	648^LEU 683^ALA 682^VAL 820^TYR 732^HIS	3.1.3.36	lipid metabolic process transport protein transport inositol lipid-mediated signaling	cytoplasm cytosol cell division site cell tip	inositol or phosphatidylinositol phosphatase activity phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity inositol-polyphosphate 5-phosphatase activity hydrolase activity
2c9kA pesticidal crystal protein cry4aa	[pdb]	0.72 0.00132	326^LEU 308^ALA 309^LEU 592^TYR 630^LEU	0.0.0.0	defense response pathogenesis sporulation resulting in formation of a cellular spore		receptor binding
1i1rB viral il-6 interleukin-6 receptor beta chain	[pdb]	0.721 0.00132	109^LEU 75^ALA 74^LEU 120^LEU 124^HIS	0.0.0.0	positive regulation of acute inflammatory response positive regulation of adaptive immune response glycogen metabolic process triglyceride mobilization signal transduction JAK-STAT cascade response to nutrient positive regulation of cell proliferation regulation of Notch signaling pathway positive regulation vascular endothelial growth factor production positive regulation of cardiac muscle hypertrophy positive regulation of smooth muscle cell migration cytokine-mediated signaling pathway response to cytokine stimulus positive regulation of T cell proliferation positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of osteoblast differentiation positive regulation of anti-apoptosis positive regulation of astrocyte differentiation leukemia inhibitory factor signaling pathway reduction of cytosolic calcium ion concentration negative regulation of interleukin-6-mediated signaling pathway interleukin-27-mediated signaling pathway ciliary neurotrophic factor-mediated signaling pathway immune response	extracellular region extracellular space plasma membrane interleukin-6 receptor complex oncostatin-M receptor complex external side of plasma membrane membrane integral to membrane ciliary neurotrophic factor receptor complex extracellular region	receptor activity cytokine receptor activity ciliary neurotrophic factor receptor activity interleukin-11 receptor activity ciliary neurotrophic factor receptor binding protein binding growth factor binding interleukin-11 binding protein homodimerization activity interleukin-27 receptor activity interleukin-6 receptor activity leukemia inhibitory factor receptor activity oncostatin-M receptor activity interleukin-6 receptor binding interleukin-6 binding cytokine activity interleukin-6 receptor binding protein binding
1fnyA bark agglutinin i,polypeptide a	[pdb]	0.723 0.00143	32^LEU 24^ALA 25^LEU 44^SER 103^LEU	0.0.0.0			binding sugar binding metal ion binding
2cbzA multidrug resistance-associated protein 1	[pdb]	0.725 0.00143	816^MET 743^ALA 740^VAL 795^LEU 801^HIS		transport response to drug transmembrane transport	membrane fraction plasma membrane integral to plasma membrane membrane integral to membrane	nucleotide binding transporter activity ATP binding hydrolase activity ATPase activity nucleoside-triphosphatase activity ATPase activity
3c5cA ras-like protein 12	[pdb]	0.726 0.00143	136^LEU 162^GLU 163^VAL 109^SER 152^LEU	0.0.0.0	signal transduction small GTPase mediated signal transduction	membrane	nucleotide binding GTPase activity GTP binding
3afqC single-stranded dna-binding protein	[pdb]	0.729 0.00143	83^LEU 100^GLU 99^VAL 35^SER 13^LEU		DNA replication DNA repair response to DNA damage stimulus		DNA binding single-stranded DNA binding
2p4oA hypothetical protein	[pdb]	0.729 0.00143	84^LEU 86^ALA 76^LEU 141^LEU 112^LEU	0.0.0.0
3c65A uvrabc system protein c	[pdb]	0.734 0.00156	398^LEU 382^GLU 400^VAL 440^LEU 472^LEU	0.0.0.0	DNA repair nucleotide-excision repair response to DNA damage stimulus SOS response	intracellular cytoplasm excinuclease repair complex	DNA binding nuclease activity excinuclease ABC activity
1x1cA crtf-related protein	[pdb]	0.734 0.00156	27^MET 30^ALA 31^ILE 81^SER 46^LEU	0.0.0.0			methyltransferase activity O-methyltransferase activity transferase activity
1l7vB vitamin b12 transport atp-binding protein btud vitamin b12 transport system permease proteinbtuc	[pdb]	0.737 0.00169	216^ARG 218^GLU 219^GLU 141^VAL 133^GLN	0.0.0.0	transport transport cobalamin transport	peripheral to membrane of membrane fraction plasma membrane membrane plasma membrane membrane integral to membrane	nucleotide binding ATP binding cobalamin-transporting ATPase activity hydrolase activity ATPase activity nucleoside-triphosphatase activity transporter activity
1kt8B branched-chain amino acid aminotransferase,mitochondrial	[pdb]	0.737 0.00169	548^TRP 542^GLU 541^VAL 567^SER 562^HIS	2.6.1.42	isoleucine catabolic process lactation metabolic process cellular amino acid biosynthetic process branched chain family amino acid metabolic process branched chain family amino acid biosynthetic process branched chain family amino acid catabolic process leucine biosynthetic process	nucleus cytoplasm mitochondrion	catalytic activity branched-chain-amino-acid transaminase activity transaminase activity transferase activity
1gkzA [3-methyl-2-oxobutanoate dehydrogenase[lipoamide]] kinase	[pdb]	0.739 0.00169	143^LEU 140^ALA 139^LEU 340^LEU 334^HIS	2.7.11.4	signal transduction branched chain family amino acid catabolic process phosphorylation peptidyl-histidine phosphorylation	mitochondrion mitochondrial matrix mitochondrial alpha-ketoglutarate dehydrogenase complex	two-component sensor activity nucleotide binding protein kinase activity protein histidine kinase activity protein serine/threonine kinase activity protein binding ATP binding kinase activity transferase activity transferase activity transferring phosphorus-containing groups
1npcA neutral protease	[pdb]	0.739 0.00169	121^MET 144^GLU 145^LEU 158^TYR 232^HIS	3.4.24.28	proteolysis	extracellular region	metalloendopeptidase activity peptidase activity metallopeptidase activity zinc ion binding hydrolase activity metal ion binding
3k70F exodeoxyribonuclease v beta chain dna (46-mer) exodeoxyribonuclease v alpha chain exodeoxyribonuclease v gamma chain	[pdb]	0.74 0.00169	303^SER 301^LEU 299^ASP 247^GLN 286^LEU	3.1.11.5	DNA repair response to DNA damage stimulus DNA repair response to DNA damage stimulus DNA repair DNA recombination response to DNA damage stimulus	exodeoxyribonuclease V complex exodeoxyribonuclease V complex	nucleotide binding DNA binding ATP-dependent DNA helicase activity helicase activity nuclease activity endonuclease activity exonuclease activity ATP binding exodeoxyribonuclease V activity hydrolase activity nucleotide binding DNA binding helicase activity nuclease activity endonuclease activity exonuclease activity protein binding ATP binding exodeoxyribonuclease V activity hydrolase activity nucleotide binding helicase activity nuclease activity endonuclease activity exonuclease activity protein binding ATP binding exodeoxyribonuclease V activity hydrolase activity nucleoside-triphosphatase activity
3fg2P putative rubredoxin reductase	[pdb]	0.742 0.00169	135^LEU 131^GLU 126^LEU 59^LEU 37^HIS	0.0.0.0	cell redox homeostasis oxidation-reduction process	cytoplasm	ferredoxin-NAD+ reductase activity oxidoreductase activity flavin adenine dinucleotide binding
3mh8B lipoprotein lprg	[pdb]	0.747 0.00183	209^LEU 207^ALA 194^VAL 136^LEU 59^HIS		pathogenesis	plasma membrane membrane
1v04A serum paraoxonase/arylesterase 1	[pdb]	0.749 0.00198	281^TRP 334^ALA 333^VAL 58^LEU 90^LEU	3.1.1.2, 3.1.8.1	lipid metabolic process response to external stimulus response to toxin positive regulation of cholesterol efflux aromatic compound catabolic process positive regulation of transporter activity carboxylic acid catabolic process organophosphate catabolic process phosphatidylcholine metabolic process positive regulation of binding negative regulation of plasma lipoprotein particle oxidation	extracellular region extracellular space microsome high-density lipoprotein particle spherical high-density lipoprotein particle	aryldialkylphosphatase activity arylesterase activity calcium ion binding phospholipid binding hydrolase activity protein homodimerization activity metal ion binding
2wrcA hemagglutinin	[pdb]	0.749 0.00198	292^LEU 38^GLU 37^LEU 300^LEU 285^LEU	0.0.0.0	viral envelope fusion with host membrane	membrane integral to membrane virion viral envelope host cell plasma membrane host cell membrane virion membrane	host cell surface receptor binding
1vcfB isopentenyl-diphosphate delta-isomerase	[pdb]	0.752 0.00198	206^LEU 208^ALA 209^VAL 120^LEU 57^LEU	0.0.0.0	metabolic process isoprenoid biosynthetic process	cytoplasm	catalytic activity isopentenyl-diphosphate delta-isomerase activity FMN binding oxidoreductase activity isomerase activity
2ct9B calcium-binding protein p22	[pdb]	0.752 0.00198	62^LEU 58^ALA 59^ILE 201^LEU 38^LEU	0.0.0.0	calcium ion-dependent exocytosis calcium-mediated signaling transcytosis	cytoplasm cytosol	calcium ion binding metal ion binding
1vs3A trna pseudouridine synthase a	[pdb]	0.754 0.00198	115^LEU 128^ALA 129^LEU 110^TYR 58^LEU	5.4.99.12	pseudouridine synthesis tRNA processing RNA modification		RNA binding pseudouridine synthase activity isomerase activity
3c4nA uncharacterized protein dr_0571	[pdb]	0.757 0.00214	239^LEU 196^GLU 197^LEU 191^LEU 207^LEU	0.0.0.0			oxidoreductase activity
2plkA lysine/ornithine decarboxylase	[pdb]	0.758 0.00214	18^LEU 22^GLU 23^ILE 38^LEU 387^LEU	0.0.0.0	polyamine biosynthetic process		catalytic activity
3icjA uncharacterized metal-dependent hydrolase	[pdb]	0.758 0.00214	213^LEU 210^GLU 207^ILE 241^SER 271^LEU	0.0.0.0			endodeoxyribonuclease activity
1k0nA chloride intracellular channel protein 1	[pdb]	0.761 0.00214	88^LEU 85^GLU 84^LEU 173^LEU 99^LEU	0.0.0.0	transport ion transport chloride transport signal transduction	membrane fraction soluble fraction nucleus nuclear envelope cytoplasm plasma membrane brush border membrane integral to membrane nuclear membrane chloride channel complex	ion channel activity voltage-gated ion channel activity voltage-gated chloride channel activity chloride channel activity protein binding
1vpvA upf0230 protein tm1468	[pdb]	0.763 0.00231	95^LEU 121^ALA 120^LEU 163^TYR 236^HIS	0.0.0.0
2jwxA fk506-binding protein 8 variant	[pdb]	0.765 0.00231	23^MET 21^ALA 20^LEU 105^LEU 90^LEU	5.2.1.8	protein folding apoptosis interspecies interaction between organisms	mitochondrion membrane integral to membrane mitochondrial membrane	peptidyl-prolyl cis-trans isomerase activity binding isomerase activity
1tpyA methoxy mycolic acid synthase 2	[pdb]	0.767 0.00231	263^MET 240^ALA 243^LEU 34^SER 231^HIS	0.0.0.0	lipid biosynthetic process Actinobacterium-type cell wall biogenesis mycolic acid biosynthetic process	plasma membrane	methyltransferase activity cyclopropane-fatty-acyl-phospholipid synthase activity transferase activity
1y4sB chaperone protein htpg	[pdb]	0.768 0.00231	423^MET 456^GLU 455^ILE 482^SER 460^LEU	0.0.0.0	protein folding response to stress response to heat	cytoplasm cytosol plasma membrane membrane	nucleotide binding protein binding ATP binding ATPase activity coupled
3memA putative signal transduction protein	[pdb]	0.773 0.00249	32^LEU 111^ALA 110^VAL 11^LEU 3^LEU	0.0.0.0
1s1mB ctp synthase	[pdb]	0.776 0.00249	453^LEU 502^GLU 510^VAL 497^LEU 478^LEU	6.3.4.2	pyrimidine nucleotide biosynthetic process CTP biosynthetic process glutamine metabolic process	cytosol	nucleotide binding catalytic activity CTP synthase activity ATP binding ligase activity
1ku2A sigma factor siga	[pdb]	0.776 0.00267	109^LEU 205^ALA 202^LEU 212^SER 100^LEU	0.0.0.0	transcription initiation DNA-dependent		DNA binding sequence-specific DNA binding transcription factor activity sigma factor activity
1qpwD poricine hemoglobin (beta subunit) poricine hemoglobin (alpha subunit)	[pdb]	0.777 0.00267	81^LEU 140^ALA 137^VAL 91^LEU 146^HIS	0.0.0.0	transport oxygen transport transport oxygen transport	hemoglobin complex hemoglobin complex	oxygen transporter activity iron ion binding protein binding oxygen binding heme binding metal ion binding oxygen transporter activity iron ion binding oxygen binding heme binding metal ion binding
2vpwC nrfc protein hypothetical membrane spanning protein thiosulfate reductase	[pdb]	0.781 0.00267	16^THR 240^LEU 243^LEU 27^ALA 232^LEU	0.0.0.0	oxidation-reduction process		binding oxidoreductase activity molybdenum ion binding metal ion binding iron-sulfur cluster binding electron carrier activity metal ion binding iron-sulfur cluster binding 4 iron
2ef0A ornithine carbamoyltransferase	[pdb]	0.782 0.00267	195^LEU 172^GLU 171^LEU 130^SER 12^LEU	0.0.0.0	cellular amino acid metabolic process	cytoplasm ornithine carbamoyltransferase complex	ornithine carbamoyltransferase activity amino acid binding transferase activity carboxyl- or carbamoyltransferase activity
3c7jA transcriptional regulator, gntr family	[pdb]	0.782 0.00267	70^LEU 29^GLU 32^LEU 59^SER 22^HIS	0.0.0.0	regulation of transcription DNA-dependent	intracellular intracellular	DNA binding sequence-specific DNA binding transcription factor activity DNA binding sequence-specific DNA binding transcription factor activity
2rkbA serine dehydratase-like	[pdb]	0.785 0.00287	239^LEU 210^ALA 216^LEU 229^LEU 202^HIS	0.0.0.0	cellular amino acid metabolic process metabolic process biological adhesion	cellular_component mitochondrion	molecular_function catalytic activity L-serine ammonia-lyase activity L-threonine ammonia-lyase activity lyase activity pyridoxal phosphate binding
3kwlA uncharacterized protein	[pdb]	0.786 0.00288	415^LEU 404^ALA 406^LEU 399^SER 436^HIS
3kfuF glutamyl-trna(gln) amidotransferase subunit a glutamyl-trna(gln) amidotransferase subunit c trna-asn non-discriminating and archaeal-type aspartyl-trnasynthetase aspartyl/glutamyl-trna(asn/gln) amidotransferase subunit b	[pdb]	0.787 0.00288	12^U 146^GLU 147^LEU 74^C 77^GLU	0.0.0.0	translation tRNA aminoacylation for protein translation aspartyl-tRNA aminoacylation translation translation translation regulation of translational fidelity	cytoplasm	nucleotide binding nucleic acid binding aminoacyl-tRNA ligase activity aspartate-tRNA ligase activity ATP binding nucleotide binding ATP binding ligase activity carbon-nitrogen ligase activity with glutamine as amido-N-donor nucleotide binding ATP binding ligase activity carbon-nitrogen ligase activity with glutamine as amido-N-donor nucleotide binding
3lreB kinesin-like protein kif18a	[pdb]	0.787 0.00288	236^LEU 252^ALA 251^ILE 315^LEU 320^LEU	0.0.0.0	transport microtubule-based movement microtubule depolymerization mitotic metaphase plate congression protein transport	ruffle nucleus cytoplasm microtubule organizing center kinetochore microtubule cytoskeleton microtubule caveola microtubule cytoskeleton cell projection	nucleotide binding motor activity microtubule motor activity actin binding protein binding ATP binding microtubule binding plus-end-directed microtubule motor activity ubiquitin binding microtubule plus-end binding tubulin-dependent ATPase activity
1j3yD hemoglobin beta chain hemoglobin alpha chain	[pdb]	0.788 0.00288	81^LEU 140^ALA 137^VAL 91^LEU 146^HIS		transport oxygen transport transport regulation of blood pressure oxygen transport nitric oxide transport positive regulation of nitric oxide biosynthetic process regulation of blood vessel size	hemoglobin complex cytosolic small ribosomal subunit hemoglobin complex	oxygen transporter activity iron ion binding protein binding oxygen binding heme binding metal ion binding oxygen transporter activity iron ion binding protein binding oxygen binding heme binding hemoglobin binding metal ion binding
3ebiA m1 family aminopeptidase	[pdb]	0.79 0.00308	1064^MET 1022^ALA 1025^ILE 1045^LEU 1011^HIS	0.0.0.0	proteolysis	cytoplasm	aminopeptidase activity peptidase activity metallopeptidase activity zinc ion binding hydrolase activity metal ion binding
2htdA predicted flavin-nucleotide-binding protein from cog3576family structurally related to pyridoxine 5'-phosphate oxidase	[pdb]	0.791 0.00308	24^LEU 70^ALA 69^VAL 9^LEU 4^LEU	0.0.0.0			FMN binding
1yt3A ribonuclease d	[pdb]	0.791 0.00308	263^LEU 267^GLU 268^ILE 225^LEU 233^LEU	3.1.13.5	nucleobase nucleoside nucleotide and nucleic acid metabolic process	intracellular cytoplasm	nucleotide binding nucleic acid binding catalytic activity nuclease activity exonuclease activity ribonuclease activity protein binding 3'-5' exonuclease activity hydrolase activity ribonuclease D activity
2vl0E elic pentameric ligand gated ion channel fromerwinia chrysanthemi	[pdb]	0.792 0.00308	219^TRP 275^ALA 272^ILE 228^SER 283^HIS	0.0.0.0	transport ion transport	membrane integral to membrane	receptor activity ion channel activity extracellular ligand-gated ion channel activity
2j8mA acetyltransferase pa4866 from p. aeruginosa	[pdb]	0.792 0.00308	165^LEU 111^ALA 116^LEU 87^SER 56^LEU	0.0.0.0	metabolic process		N-acetyltransferase activity
3qi6A cystathionine gamma-synthase metb (cgs)	[pdb]	0.794 0.00308	134^LEU 164^ALA 163^ILE 203^LEU 195^LEU		cellular amino acid metabolic process		catalytic activity pyridoxal phosphate binding
1fnoA peptidase t	[pdb]	0.795 0.00308	47^LEU 60^ALA 50^ILE 34^LEU 78^HIS	3.4.11.4	proteolysis peptide metabolic process metabolic process	cytoplasm	aminopeptidase activity protein binding peptidase activity metallopeptidase activity zinc ion binding hydrolase activity tripeptide aminopeptidase activity metal ion binding
2alrA aldehyde reductase	[pdb]	0.795 0.00308	7^LEU 180^ALA 204^LEU 176^SER 146^LEU	1.1.1.2	glucose metabolic process cellular aldehyde metabolic process L-ascorbic acid biosynthetic process D-glucuronate catabolic process aldehyde catabolic process oxidation-reduction process	cytosol apical plasma membrane	aldehyde reductase activity protein binding alcohol dehydrogenase (NADP+) activity electron carrier activity oxidoreductase activity L-glucuronate reductase activity
1pjcA protein (l-alanine dehydrogenase)	[pdb]	0.799 0.00329	300^MET 136^ALA 135^ILE 239^LEU 173^LEU	0.0.0.0	metabolic process oxidation-reduction process		alanine dehydrogenase activity catalytic activity binding oxidoreductase activity
3efeF thij/pfpi family protein	[pdb]	0.799 0.00329	22^LEU 25^GLU 26^LEU 183^LEU 204^LEU	0.0.0.0
1v26A long-chain-fatty-acid-coa synthetase	[pdb]	0.799 0.00329	203^LEU 207^ALA 206^LEU 324^TYR 359^LEU		metabolic process		catalytic activity ligase activity
3ml4C muscle, skeletal receptor tyrosine-protein kinase protein dok-7	[pdb]	0.8 0.00329	89^LEU 79^ALA 87^VAL 108^LEU 112^HIS	0.0.0.0	positive regulation of protein phosphorylation neuromuscular junction development receptor clustering regulation of transcription DNA-dependent protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway neuromuscular junction development regulation of synaptic growth at neuromuscular junction	plasma membrane membrane cell junction neuromuscular junction synapse plasma membrane integral to plasma membrane membrane integral to membrane neuromuscular junction	insulin receptor binding protein binding nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor activity protein binding ATP binding kinase activity transferase activity PDZ domain binding
1v3uA leukotriene b4 12-hydroxydehydrogenase/prostaglandin 15-keto reductase	[pdb]	0.803 0.00352	44^LEU 41^ALA 42^LEU 97^SER 29^LEU	1.3.1.48, 1.3.1.74	metabolic process oxidation-reduction process	cytoplasm	catalytic activity binding zinc ion binding oxidoreductase activity 2-alkenal reductase activity 15-oxoprostaglandin 13-oxidase activity
1vdhE muconolactone isomerase-like protein	[pdb]	0.804 0.00352	114^LEU 13^GLU 12^LEU 193^LEU 83^LEU	0.0.0.0
1t60U type iv collagen	[pdb]	0.804 0.00352	7^LEU 114^ALA 113^VAL 154^SER 118^HIS	0.0.0.0	negative regulation of angiogenesis	extracellular region proteinaceous extracellular matrix collagen collagen type IV basement membrane extracellular region proteinaceous extracellular matrix collagen collagen type IV basement membrane	extracellular matrix structural constituent binding protein binding platelet-derived growth factor binding extracellular matrix structural constituent binding protein binding
3nnbA alginate lyase	[pdb]	0.804 0.00352	32^LEU 22^ALA 21^VAL 313^LEU 253^LEU	0.0.0.0	alginic acid catabolic process	periplasmic space	poly(beta-D-mannuronate) lyase activity
2fl0B bacterioferritin	[pdb]	0.805 0.00352	52^MET 18^GLU 19^LEU 91^LEU 98^LEU	0.0.0.0	iron ion transport cellular iron ion homeostasis oxidation-reduction process		ferric iron binding oxidoreductase activity metal ion binding transition metal ion binding
1vixA peptidase t	[pdb]	0.805 0.00352	47^LEU 60^ALA 50^VAL 34^LEU 78^HIS	3.4.11.4	proteolysis peptide metabolic process metabolic process	cytoplasm	aminopeptidase activity protein binding peptidase activity metallopeptidase activity zinc ion binding hydrolase activity tripeptide aminopeptidase activity metal ion binding
1l1eB mycolic acid synthase	[pdb]	0.806 0.00352	263^MET 240^ALA 243^LEU 34^SER 231^HIS	0.0.0.0	lipid biosynthetic process pathogenesis active evasion of host immune response S-adenosylmethionine metabolic process modulation by symbiont of host innate immunity mycolic acid biosynthetic process	cytoplasm	methyltransferase activity cyclopropane-fatty-acyl-phospholipid synthase activity transferase activity
1yspA transcriptional regulator kdgr	[pdb]	0.806 0.00352	159^LEU 124^ALA 123^ILE 34^TYR 27^LEU	0.0.0.0	regulation of transcription DNA-dependent		DNA binding sequence-specific DNA binding transcription factor activity specific transcriptional repressor activity
1l5jB aconitate hydratase 2	[pdb]	0.808 0.00352	196^LEU 18^ALA 17^ILE 5^TYR 48^LEU	4.2.1.3	tricarboxylic acid cycle regulation of translation metabolic process propionate catabolic process		mRNA binding mRNA 3'-UTR binding aconitate hydratase activity protein binding lyase activity metal ion binding 2-methylisocitrate dehydratase activity iron-sulfur cluster binding 4 iron
3r2nC cytidine deaminase	[pdb]	0.808 0.00352	55^LEU 57^ALA 44^VAL 66^TYR 73^LEU		cytidine metabolic process		catalytic activity cytidine deaminase activity zinc ion binding hydrolase activity
1vrmA hypothetical protein tm1553	[pdb]	0.809 0.00376	189^LEU 193^ALA 192^ILE 56^SER 76^LEU	0.0.0.0	thiamine biosynthetic process
1htyA alpha-mannosidase ii	[pdb]	0.81 0.00376	894^LEU 775^GLU 776^ILE 678^LEU 752^LEU	3.2.1.114	carbohydrate metabolic process mannose metabolic process metabolic process	Golgi membrane endoplasmic reticulum Golgi apparatus Golgi stack membrane integral to membrane	catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds alpha-mannosidase activity mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity zinc ion binding mannosidase activity hydrolase activity hydrolase activity acting on glycosyl bonds carbohydrate binding
1zsvA nadp-dependent leukotriene b4 12-hydroxydehydrogenase	[pdb]	0.81 0.00376	44^LEU 41^ALA 42^LEU 97^SER 29^LEU	1.3.1.74, 1.3.1.48	leukotriene metabolic process metabolic process response to toxin oxidation-reduction process	cytoplasm	catalytic activity alcohol dehydrogenase (NAD) activity binding zinc ion binding oxidoreductase activity 2-alkenal reductase activity 15-oxoprostaglandin 13-oxidase activity
1w98B g1/s-specific cyclin e1 cell division protein kinase 2	[pdb]	0.81 0.00376	212^LEU 215^GLU 216^LEU 187^LEU 153^LEU	0.0.0.0	G1/S transition of mitotic cell cycle antral ovarian follicle growth liver development cell cycle response to organic nitrogen response to organic cyclic compound response to purine-containing compound androgen receptor signaling pathway organ regeneration cellular response to nutrient response to estradiol stimulus response to progesterone stimulus response to vitamin E response to cytokine stimulus response to drug response to ethanol positive regulation of cell differentiation positive regulation of transcription DNA-dependent response to steroid hormone stimulus cell division response to corticosterone stimulus response to methylmercury G2/M transition of mitotic cell cycle DNA replication regulation of DNA replication protein phosphorylation potassium ion transport cell cycle mitosis traversing start control point of mitotic cell cycle Ras protein signal transduction positive regulation of cell proliferation	nucleus nucleoplasm cytoplasm centrosome cytosol nucleolus cyclin-dependent protein kinase holoenzyme complex chromosome telomeric region condensed chromosome X chromosome Y chromosome nucleus nucleoplasm transcription factor complex cytoplasm	transcription coactivator activity protein binding protein complex binding androgen receptor binding nucleotide binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein kinase activity protein binding ATP binding kinase activity transferase activity identical protein binding histone kinase activity
2g9dA succinylglutamate desuccinylase	[pdb]	0.81 0.00376	154^LEU 219^GLU 220^LEU 195^LEU 325^LEU	3.5.1.96	arginine metabolic process metabolic process arginine catabolic process to glutamate		zinc ion binding succinylglutamate desuccinylase activity hydrolase activity hydrolase activity acting on ester bonds
1t11A trigger factor	[pdb]	0.813 0.00376	278^LEU 299^GLU 300^ILE 187^LEU 294^LEU	0.0.0.0	protein folding cell cycle protein transport cell division		peptidyl-prolyl cis-trans isomerase activity isomerase activity
1r5mA sir4-interacting protein sif2	[pdb]	0.816 0.00376	151^LEU 534^ALA 535^ILE 197^TYR 200^LEU	0.0.0.0	chromatin modification histone deacetylation negative regulation of chromatin silencing at telomere positive regulation of stress-activated MAPK cascade negative regulation of meiosis	nucleus Set3 complex Rpd3L-Expanded complex	protein binding
3n9iB tryptophanyl-trna synthetase	[pdb]	0.816 0.00401	221^LEU 27^GLU 28^LEU 73^LEU 67^LEU	6.1.1.2	translation tRNA aminoacylation for protein translation tryptophanyl-tRNA aminoacylation	cytoplasm	nucleotide binding aminoacyl-tRNA ligase activity tryptophan-tRNA ligase activity ATP binding ligase activity
1ppjP ubiquinol-cytochrome c reductase complex 7.2 kdaprotein cytochrome c1, heme protein, mitochondrial ubiquinol-cytochrome c reductase complex 11 kdaprotein ubiquinol-cytochrome c reductase complex coreprotein i, mitochondrial ubiquinol-cytochrome c reductase complex coreprotein 2, mitochondrial cytochrome b ubiquinol-cytochrome c reductase complex 14 kdaprotein ubiquinol-cytochrome c reductase complexubiquinone-binding protein qp-c ubiquinol-cytochrome c reductase iron-sulfursubunit, mitochondrial	[pdb]	0.818 0.00401	281^LEU 293^ALA 292^LEU 301^LEU 363^HOH	0.0.0.0	transport electron transport chain oxidation-reduction process transport electron transport chain respiratory electron transport chain proteolysis transport electron transport chain mitochondrial electron transport ubiquinol to cytochrome c proteolysis transport electron transport chain mitochondrial electron transport ubiquinol to cytochrome c transport electron transport chain mitochondrial electron transport ubiquinol to cytochrome c transport electron transport chain transport electron transport chain mitochondrial electron transport ubiquinol to cytochrome c	mitochondrion mitochondrial inner membrane membrane integral to membrane respiratory chain mitochondrion mitochondrial inner membrane membrane integral to membrane respiratory chain mitochondrion mitochondrial inner membrane membrane respiratory chain mitochondrion mitochondrial inner membrane membrane respiratory chain mitochondrion mitochondrial inner membrane membrane respiratory chain mitochondrion mitochondrial envelope mitochondrial inner membrane membrane respiratory chain mitochondrion mitochondrial inner membrane membrane integral to membrane respiratory chain mitochondrion mitochondrial inner membrane membrane respiratory chain mitochondrion mitochondrial inner membrane membrane respiratory chain	ubiquinol-cytochrome-c reductase activity oxidoreductase activity oxidoreductase activity acting on diphenols and related substances as donors metal ion binding iron-sulfur cluster binding 2 iron 2 sulfur cluster binding electron carrier activity oxidoreductase activity metal ion binding catalytic activity metalloendopeptidase activity zinc ion binding metal ion binding catalytic activity metalloendopeptidase activity protein binding zinc ion binding metal ion binding ubiquinol-cytochrome-c reductase activity ubiquinol-cytochrome-c reductase activity iron ion binding electron carrier activity heme binding metal ion binding
1lnsA x-prolyl dipeptidyl aminopetidase	[pdb]	0.818 0.00401	144^LEU 159^ALA 158^LEU 197^SER 166^LEU	3.4.14.11	proteolysis	cytoplasm	aminopeptidase activity peptidase activity serine-type peptidase activity dipeptidyl-peptidase activity hydrolase activity
3pdeB farnesyl-diphosphate synthase	[pdb]	0.819 0.00401	53^LEU 57^ALA 56^VAL 210^LEU 275^LEU		isoprenoid biosynthetic process		geranyltranstransferase activity transferase activity
1ukpD beta-amylase	[pdb]	0.819 0.00401	339^LEU 293^ALA 294^ILE 464^SER 461^LEU	3.2.1.2	polysaccharide catabolic process carbohydrate metabolic process metabolic process		catalytic activity beta-amylase activity hydrolase activity hydrolase activity acting on glycosyl bonds
2gq0B chaperone protein htpg	[pdb]	0.819 0.00401	423^MET 456^GLU 455^ILE 482^SER 460^LEU	0.0.0.0	protein folding response to stress response to heat	cytoplasm cytosol plasma membrane membrane	nucleotide binding protein binding ATP binding ATPase activity coupled
1yycA putative late embryogenesis abundant protein	[pdb]	0.82 0.00401	127^LEU 124^ALA 125^VAL 139^TYR 167^LEU	0.0.0.0	response to desiccation	plasma membrane
3lxuX tripeptidyl-peptidase 2	[pdb]	0.82 0.00401	1254^LEU 1250^ALA 1249^ILE 1153^SER 1147^LEU	3.4.14.10	proteolysis protein homooligomerization	cytoplasm	aminopeptidase activity serine-type endopeptidase activity peptidase activity serine-type peptidase activity exopeptidase activity tripeptidyl-peptidase activity hydrolase activity
2pw9A putative formate dehydrogenase accessory protein	[pdb]	0.821 0.00401	123^LEU 210^ALA 212^ILE 196^TYR 201^LEU	0.0.0.0		cytoplasm formate dehydrogenase complex	formate dehydrogenase activity
1qyiA hypothetical protein	[pdb]	0.821 0.00401	328^LEU 359^ALA 354^LEU 369^LEU 376^LEU	0.0.0.0
2j4kA uridylate kinase	[pdb]	0.823 0.00428	202^MET 138^ALA 137^VAL 26^SER 20^LEU	2.7.4.22	pyrimidine nucleotide biosynthetic process cellular amino acid biosynthetic process	cytoplasm	nucleotide binding ATP binding uridylate kinase activity kinase activity transferase activity UMP kinase activity
2xyxB peroxisome proliferator-activated receptor delta	[pdb]	0.825 0.00428	357^LEU 354^ALA 355^ILE 183^TYR 384^HIS		negative regulation of transcription from RNA polymerase II promoter placenta development glucose metabolic process generation of precursor metabolites and energy regulation of transcription DNA-dependent regulation of transcription from RNA polymerase II promoter lipid metabolic process fatty acid beta-oxidation vitamin A metabolic process apoptosis embryo implantation cholesterol metabolic process cell proliferation positive regulation of cell proliferation axon ensheathment fatty acid catabolic process response to glucose stimulus positive regulation of phosphatidylinositol 3-kinase cascade glucose transport fatty acid transport fatty acid oxidation cell differentiation cell-substrate adhesion wound healing regulation of cell proliferation anagen keratinocyte proliferation regulation of fat cell differentiation positive regulation of fat cell differentiation decidualization negative regulation of epithelial cell proliferation keratinocyte migration	nucleus	DNA binding sequence-specific DNA binding transcription factor activity steroid hormone receptor activity receptor activity ligand-dependent nuclear receptor activity fatty acid binding protein binding drug binding zinc ion binding lipid binding transcription activator activity transcription repressor activity sequence-specific DNA binding metal ion binding NF-kappaB binding linoleic acid binding
3nowA unc-45 protein, sd10334p	[pdb]	0.826 0.00428	336^LEU 410^ALA 411^LEU 645^SER 575^LEU				binding
1cs6A axonin-1	[pdb]	0.828 0.00428	265^LEU 234^GLU 233^LEU 140^TYR 166^LEU	0.0.0.0	cell adhesion neuron cell-cell adhesion	plasma membrane membrane anchored to membrane	cell adhesion molecule binding
2gffA lsrg protein	[pdb]	0.829 0.00428	5^LEU 54^GLU 3^VAL 71^TYR 27^LEU		antibiotic biosynthetic process	cytoplasm	oxidoreductase activity
1xsvA hypothetical upf0122 protein sav1236	[pdb]	0.829 0.00457	36^LEU 32^GLU 33^LEU 65^LEU 22^LEU	0.0.0.0	transcription initiation DNA-dependent		DNA binding sequence-specific DNA binding transcription factor activity sigma factor activity
2fenD 3-carboxy-cis,cis-muconate lactonizing enzyme	[pdb]	0.829 0.00457	182^LEU 124^ALA 127^ILE 324^LEU 116^LEU	0.0.0.0	protocatechuate catabolic process		catalytic activity isomerase activity 3-carboxy-cis,cis-muconate cycloisomerase activity
1uf7A n-carbamyl-d-amino acid amidohydrolase	[pdb]	0.83 0.00457	30^MET 267^GLU 268^VAL 195^TYR 244^LEU	3.5.1.77	nitrogen compound metabolic process		hydrolase activity hydrolase activity acting on carbon-nitrogen (but not peptide) bonds
2gnpA transcriptional regulator	[pdb]	0.83 0.00457	141^LEU 264^ALA 265^ILE 190^SER 183^LEU	0.0.0.0			carbohydrate binding transcription regulator activity
3kldA receptor-type tyrosine-protein phosphatase gamma contactin 4	[pdb]	0.831 0.00457	280^GLN 246^LEU 245^SER 155^SER 179^TYR	0.0.0.0	protein dephosphorylation brain development negative regulation of neuron projection development dephosphorylation	extracellular space membrane integral to membrane	phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding hydrolase activity phosphatase activity identical protein binding
2g17A n-acetyl-gamma-glutamyl-phosphate reductase	[pdb]	0.831 0.00457	102^LEU 79^ALA 78^LEU 19^SER 49^HIS	1.2.1.38	cellular amino acid metabolic process arginine biosynthetic process metabolic process cellular amino acid biosynthetic process oxidation-reduction process	cytoplasm	catalytic activity N-acetyl-gamma-glutamyl-phosphate reductase activity binding oxidoreductase activity oxidoreductase activity acting on the aldehyde or oxo group of donors NAD or NADP as acceptor
1v6aA l-lactate dehydrogenase a chain	[pdb]	0.832 0.00457	58^LEU 79^ALA 51^VAL 40^LEU 75^HIS	1.1.1.27	carbohydrate metabolic process glycolysis metabolic process cellular carbohydrate metabolic process oxidation-reduction process	cytoplasm	catalytic activity L-lactate dehydrogenase activity binding oxidoreductase activity oxidoreductase activity
2qiaA udp-n-acetylglucosamine acyltransferase	[pdb]	0.835 0.00457	118^MET 121^ALA 96^VAL 146^SER 160^HIS	2.3.1.129	lipid biosynthetic process lipid A biosynthetic process	cytoplasm	acyltransferase activity acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity transferase activity
1iruU 20s proteasome	[pdb]	0.835 0.00457	81^HIS 78^GLY 77^LEU 211^ILE 201^GLY	3.4.25.1	ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process ubiquitin-dependent protein catabolic process response to virus proteolysis involved in cellular protein catabolic process proteolysis involved in cellular protein catabolic process ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process negative regulation of inflammatory response to antigenic stimulus proteolysis involved in cellular protein catabolic process proteolysis involved in cellular protein catabolic process proteolysis involved in cellular protein catabolic process ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process response to oxidative stress proteasomal ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process proteolysis involved in cellular protein catabolic process ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process ubiquitin-dependent protein catabolic process proteolysis involved in cellular protein catabolic process proteolysis involved in cellular protein catabolic process	proteasome complex nucleus cytoplasm proteasome core complex microtubule cytoskeleton proteasome core complex alpha-subunit complex proteasome complex nucleus cytoplasm proteasome core complex proteasome core complex alpha-subunit complex proteasome complex nucleus cytoplasm proteasome core complex proteasome complex nucleus cytoplasm proteasome core complex proteasome core complex alpha-subunit complex proteasome complex nucleus cytoplasm centrosome proteasome core complex intermediate filament cytoskeleton proteasome complex nucleus cytoplasm proteasome core complex proteasome complex nucleus cytoplasm proteasome core complex proteasome complex nucleus cytoplasm mitochondrion proteasome core complex proteasome core complex alpha-subunit complex proteasome complex nucleus cytoplasm proteasome core complex proteasome complex nucleus cytoplasm proteasome core complex proteasome complex nucleus cytoplasm proteasome core complex proteasome core complex alpha-subunit complex proteasome complex nucleus cytoplasm proteasome core complex proteasome core complex alpha-subunit complex proteasome complex nucleus cytoplasm	endopeptidase activity threonine-type endopeptidase activity protein binding peptidase activity hydrolase activity endopeptidase activity threonine-type endopeptidase activity protein binding peptidase activity hydrolase activity endopeptidase activity threonine-type endopeptidase activity peptidase activity hydrolase activity endopeptidase activity threonine-type endopeptidase activity protein binding peptidase activity hydrolase activity identical protein binding lipopolysaccharide binding endopeptidase activity threonine-type endopeptidase activity peptidase activity hydrolase activity endopeptidase activity threonine-type endopeptidase activity peptidase activity hydrolase activity endopeptidase activity threonine-type endopeptidase activity protein binding peptidase activity hydrolase activity endopeptidase activity threonine-type endopeptidase activity protein binding peptidase activity hydrolase activity endopeptidase activity threonine-type endopeptidase activity peptidase activity hydrolase activity endopeptidase activity threonine-type endopeptidase activity protein binding peptidase activity hydrolase activity endopeptidase activity threonine-type endopeptidase activity protein binding peptidase activity hydrolase activity endopeptidase activity threonine-type endopeptidase activity protein binding peptidase activity hydrolase activity identical protein binding lipopolysaccharide binding endopeptidase activity threonine-type endopeptidase activity protein binding peptidase activity hydrolase activity endopeptidase activity threonine-type endopeptidase activity peptidase activity hydrolase activity
2j0xB lysine-sensitive aspartokinase 3	[pdb]	0.835 0.00457	310^LEU 350^ALA 351^LEU 377^LEU 316^LEU	2.7.2.4	metabolic process cellular amino acid biosynthetic process biosynthetic process lysine biosynthetic process lysine biosynthetic process via diaminopimelate homoserine biosynthetic process		nucleotide binding aspartate kinase activity ATP binding kinase activity amino acid binding transferase activity
3f3pH nucleoporin seh1 nucleoporin nup85	[pdb]	0.835 0.00457	488^LEU 490^ALA 491^LEU 524^SER 531^LEU	0.0.0.0	mRNA export from nucleus rRNA export from nucleus snRNA export from nucleus tRNA export from nucleus NLS-bearing substrate import into nucleus snRNP protein import into nucleus mRNA-binding (hnRNP) protein import into nucleus ribosomal protein import into nucleus protein export from nucleus transport nuclear pore organization protein transport mRNA transport transmembrane transport mRNA export from nucleus rRNA export from nucleus snRNA export from nucleus tRNA export from nucleus NLS-bearing substrate import into nucleus snRNP protein import into nucleus mRNA-binding (hnRNP) protein import into nucleus ribosomal protein import into nucleus protein export from nucleus transport nuclear envelope organization nuclear pore organization protein transport mRNA transport transmembrane transport	nucleus nuclear pore plasma membrane membrane Nup107-160 complex nucleus nuclear pore membrane Nup107-160 complex nuclear membrane	structural molecule activity protein binding structural molecule activity protein binding
1z7lB ubiquitin-activating enzyme e1 1	[pdb]	0.837 0.00487	703^TRP 773^ALA 778^LEU 694^SER 655^LEU	0.0.0.0	protein modification process metabolic process		nucleotide binding catalytic activity binding protein binding ATP binding small protein activating enzyme activity ligase activity
2kdyA factor h binding protein variant b01_001	[pdb]	0.837 0.00487	112^LEU 114^ALA 137^ILE 47^SER 52^LEU	0.0.0.0
2vceA hydroquinone glucosyltransferase	[pdb]	0.838 0.00487	391^MET 388^GLU 183^LEU 138^TYR 19^HIS	2.4.1.218	xenobiotic metabolic process metabolic process response to toxin response to salt stress xenobiotic catabolic process		UDP-glycosyltransferase activity transferase activity transferase activity transferring glycosyl groups transferase activity transferring hexosyl groups
3nr9A dual specificity protein kinase clk2	[pdb]	0.839 0.00487	397^LEU 457^GLU 460^LEU 375^TYR 449^HIS		protein phosphorylation	nucleus	nucleotide binding protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity ATP binding kinase activity transferase activity
3peaB enoyl-coa hydratase/isomerase family protein	[pdb]	0.84 0.00487	130^LEU 112^GLU 111^LEU 27^SER 83^LEU	0.0.0.0	metabolic process		catalytic activity isomerase activity
2dbrC glyoxylate reductase	[pdb]	0.841 0.00487	158^LEU 211^ALA 212^VAL 100^LEU 107^LEU	1.1.1.26	metabolic process oxidation-reduction process	cytoplasm	catalytic activity binding oxidoreductase activity oxidoreductase activity acting on the CH-OH group of donors NAD or NADP as acceptor glyoxylate reductase activity
1l4gA nicotinate-nucleotide--dimethylbenzimidazolephosphoribosyltransferase	[pdb]	0.841 0.00487	205^LEU 78^ALA 77^VAL 266^LEU 175^LEU	2.4.2.21	nucleoside biosynthetic process cobalamin biosynthetic process		nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity transferase activity transferase activity
1kfcB tryptophan synthase beta chain tryptophan synthase alpha chain	[pdb]	0.842 0.00487	152^MET 120^ALA 117^VAL 48^LEU 96^LEU	4.2.1.20	tryptophan biosynthetic process tryptophan metabolic process metabolic process cellular amino acid biosynthetic process aromatic amino acid family biosynthetic process tryptophan biosynthetic process tryptophan metabolic process metabolic process cellular amino acid biosynthetic process aromatic amino acid family biosynthetic process		catalytic activity tryptophan synthase activity protein binding lyase activity catalytic activity tryptophan synthase activity protein binding lyase activity pyridoxal phosphate binding
2znlA polymerase acidic protein rna-directed rna polymerase catalytic subunit	[pdb]	0.844 0.00519	270^LEU 691^GLU 694^LEU 666^LEU 683^LEU	0.0.0.0	transcription RNA-dependent viral genome maturation viral genome replication	nucleoplasm cytosol endosome lumen host cell nucleus nucleoplasm cytosol endosome lumen	nucleotide binding RNA-directed RNA polymerase activity transferase activity nucleotidyltransferase activity RNA binding RNA-directed RNA polymerase activity
3hymB anaphase-promoting complex subunit cdc26 cell division cycle protein 16 homolog	[pdb]	0.845 0.00519	447^LEU 428^ALA 429^LEU 243^TYR 395^LEU	0.0.0.0	cell cycle mitosis anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process cell division negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle protein K11-linked ubiquitination cell cycle mitosis regulation of mitosis cell proliferation anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process cell division negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle protein K11-linked ubiquitination	nucleus nucleoplasm anaphase-promoting complex cytosol nucleus nucleoplasm anaphase-promoting complex cytoplasm centrosome microtubule organizing center spindle cytosol cytoskeleton spindle microtubule	binding protein binding
2q71A uroporphyrinogen decarboxylase	[pdb]	0.845 0.00519	214^LEU 211^ALA 207^VAL 14^LEU 145^LEU	4.1.1.37	porphyrin biosynthetic process heme biosynthetic process heme metabolic process uroporphyrinogen III metabolic process	cytoplasm cytosol	uroporphyrinogen decarboxylase activity lyase activity carboxy-lyase activity
1t47A 4-hydroxyphenylpyruvate dioxygenase	[pdb]	0.847 0.00519	23^MET 71^ALA 185^ILE 75^LEU 48^LEU	1.13.11.27	L-phenylalanine catabolic process tyrosine catabolic process aromatic amino acid family metabolic process oxidation-reduction process		4-hydroxyphenylpyruvate dioxygenase activity oxidoreductase activity oxidoreductase activity acting on single donors with incorporation of molecular oxygen
2b39B c3	[pdb]	0.85 0.00553	76^LEU 45^GLU 44^LEU 487^TYR 535^LEU	0.0.0.0	positive regulation of type IIa hypersensitivity positive regulation of activation of membrane attack complex inflammatory response complement activation complement activation alternative pathway complement activation classical pathway positive regulation vascular endothelial growth factor production innate immune response	extracellular region extracellular space	endopeptidase inhibitor activity protein binding
3nvqB plexin-c1 semaphorin-7a	[pdb]	0.85 0.00553	109^LEU 48^ALA 49^ILE 298^SER 295^LEU	0.0.0.0	cell adhesion signal transduction multicellular organismal development immune response multicellular organismal development nervous system development cell differentiation	intracellular plasma membrane membrane integral to membrane plasma membrane membrane anchored to membrane	receptor activity receptor binding receptor activity protein binding
2il3A epsilon-class glutathione s-transferase	[pdb]	0.851 0.00553	75^LEU 22^ALA 25^LEU 164^SER 10^HIS	0.0.0.0			transferase activity
1yewA particulate methane monooxygenase, b subunit particulate methane monooxygenase, a subunit particulate methane monooxygenase subunit c2	[pdb]	0.852 0.00553	54^ALA 66^ARG 65^VAL 89^TRP 109^GLY	0.0.0.0	oxidation-reduction process oxidation-reduction process		monooxygenase activity methane monooxygenase activity oxidoreductase activity monooxygenase activity methane monooxygenase activity oxidoreductase activity monooxygenase activity
2q3mA flavonol sulfotransferase-like	[pdb]	0.853 0.00554	231^LEU 238^GLU 237^VAL 89^LEU 246^LEU	0.0.0.0	defense response response to salt stress response to salicylic acid stimulus brassinosteroid metabolic process		sulfotransferase activity transferase activity brassinosteroid sulfotransferase activity
1r5zC v-type atp synthase subunit c	[pdb]	0.855 0.00554	219^LEU 199^GLU 196^VAL 241^LEU 258^LEU	0.0.0.0	ATP biosynthetic process transport ion transport ATP synthesis coupled proton transport proton transport	proton-transporting two-sector ATPase complex	hydrogen ion transmembrane transporter activity