The LabelHash Server

Top 150 matches

For each match you can click on the "[pdb]" link to download a PDB file with the matching chain aligned with the motif.
Download a zip file with PDB files for all the matches and the motif itself.

PDB ID		LRMSD / p-value	Matching Residues	EC	Gene Ontology annotations
PDB ID		LRMSD / p-value	Matching Residues	EC	Biological Process	Cellular Component	Molecular Function
3e6nA nitric oxide synthase, inducible	[pdb]	0.203 7.27e-05	194^CYS 363^PHE 366^TRP 371^GLU 346^VAL 367^TYR 376^ASP	1.14.13.39	response to hypoxia endothelial cell proliferation blood vessel remodeling arginine catabolic process superoxide metabolic process nitric oxide biosynthetic process inflammatory response signal transduction G-protein signaling coupled to cGMP nucleotide second messenger intracellular protein kinase cascade aging regulation of heart contraction regulation of blood pressure cGMP-mediated signaling regulation of cell proliferation defense response to bacterium retinoic acid receptor signaling pathway defense response to Gram-negative bacterium oxidation-reduction process	nucleus cytoplasm peroxisome cytosol cortical cytoskeleton perinuclear region of cytoplasm	nitric-oxide synthase activity iron ion binding protein binding calmodulin binding cAMP-dependent protein kinase regulator activity FMN binding oxidoreductase activity heme binding tetrahydrobiopterin binding arginine binding protein homodimerization activity metal ion binding flavin adenine dinucleotide binding NADP binding
1rs7B nitric-oxide synthase, brain	[pdb]	0.265 0.000135	415^CYS 584^PHE 587^TRP 592^GLU 567^VAL 588^TYR 597^ASP	1.14.13.39	response to hypoxia arginine catabolic process nitric oxide biosynthetic process aging regulation of heart contraction response to heat response to organic nitrogen response to organic cyclic compound response to vitamin E response to estrogen stimulus response to ethanol negative regulation of blood pressure negative regulation of heart contraction positive regulation of vasodilation negative regulation of insulin secretion regulation of sensory perception of pain oxidation-reduction process	photoreceptor inner segment nucleus cytoplasm mitochondrion mitochondrial outer membrane cytosol plasma membrane membrane dendrite nuclear membrane sarcolemma azurophil granule cell projection dendritic spine synapse perinuclear region of cytoplasm	nitric-oxide synthase activity iron ion binding protein binding calmodulin binding FMN binding oxidoreductase activity amino acid binding enzyme binding heme binding protein homodimerization activity cadmium ion binding metal ion binding flavin adenine dinucleotide binding NADP binding
1m9kB endothelial nitric-oxide synthase	[pdb]	0.268 0.000142	184^CYS 353^PHE 356^TRP 361^GLU 336^VAL 357^TYR 366^ASN	1.14.13.39	angiogenesis ovulation from ovarian follicle response to hypoxia blood vessel remodeling regulation of sodium ion transport regulation of systemic arterial blood pressure by endothelin arginine catabolic process nitric oxide biosynthetic process anti-apoptosis mitochondrion organization signal transduction aging regulation of blood pressure negative regulation of cell proliferation response to heat response to lead ion negative regulation of platelet activation response to organic cyclic compound negative regulation of muscle hyperplasia smooth muscle hyperplasia lung development positive regulation of guanylate cyclase activity lipopolysaccharide-mediated signaling pathway response to estradiol stimulus response to lipopolysaccharide response to cytokine stimulus response to fluid shear stress response to drug response to amino acid stimulus negative regulation of potassium ion transport response to peptide hormone stimulus endothelial cell migration response to ethanol positive regulation of angiogenesis positive regulation of vasodilation negative regulation of smooth muscle cell proliferation regulation of blood vessel size negative regulation of hydrolase activity negative regulation of calcium ion transport response to hyperoxia response to lipoprotein stimulus oxidation-reduction process	Golgi membrane soluble fraction nucleus nucleolus cytoplasm Golgi apparatus cytosol cytoskeleton plasma membrane caveola membrane apical part of cell	actin monomer binding nitric-oxide synthase activity iron ion binding protein binding calmodulin binding FMN binding oxidoreductase activity heme binding tetrahydrobiopterin binding arginine binding cadmium ion binding metal ion binding flavin adenine dinucleotide binding NADP binding
1d1xB bovine endothelial nitric oxide synthase heme domain	[pdb]	0.275 0.00015	186^CYS 355^PHE 358^TRP 363^GLU 338^VAL 359^TYR 368^ASN	1.14.13.39	angiogenesis ovulation from ovarian follicle blood vessel remodeling regulation of sodium ion transport regulation of systemic arterial blood pressure by endothelin arginine catabolic process nitric oxide biosynthetic process anti-apoptosis mitochondrion organization blood coagulation negative regulation of cell proliferation negative regulation of muscle hyperplasia smooth muscle hyperplasia lung development positive regulation of guanylate cyclase activity lipopolysaccharide-mediated signaling pathway response to fluid shear stress negative regulation of potassium ion transport endothelial cell migration positive regulation of angiogenesis regulation of blood vessel size negative regulation of hydrolase activity negative regulation of calcium ion transport oxidation-reduction process	cytoplasm Golgi apparatus cytoskeleton plasma membrane caveola membrane	actin monomer binding nitric-oxide synthase activity iron ion binding protein binding calmodulin binding FMN binding oxidoreductase activity heme binding tetrahydrobiopterin binding arginine binding metal ion binding flavin adenine dinucleotide binding NADP binding
3e7gA nitric oxide synthase, inducible	[pdb]	0.32 0.000194	200^CYS 369^PHE 372^TRP 377^GLU 352^VAL 373^TYR 382^ASP	1.14.13.39	positive regulation of leukocyte mediated cytotoxicity innate immune response in mucosa arginine catabolic process superoxide metabolic process nitric oxide biosynthetic process defense response to bacterium regulation of cellular respiration regulation of insulin secretion defense response to Gram-negative bacterium positive regulation of killing of cells of other organism oxidation-reduction process	intracellular nucleus cytoplasm cytosol	nitric-oxide synthase activity iron ion binding protein binding calmodulin binding FMN binding oxidoreductase activity heme binding tetrahydrobiopterin binding arginine binding protein homodimerization activity metal ion binding flavin adenine dinucleotide binding NADP binding
1ukeA uridylmonophosphate/cytidylmonophosphate kinase	[pdb]	1.86 0.00037	23^CYS 32^TRP 86^PHE 186^GLU 9^VAL 30^PHE 187^ASN	2.7.4.14	nucleobase nucleoside nucleotide and nucleic acid metabolic process pyrimidine nucleotide biosynthetic process UDP biosynthetic process pyrimidine base salvage		nucleotide binding magnesium ion binding cytidylate kinase activity uridine kinase activity ATP binding kinase activity transferase activity phosphotransferase activity phosphate group as acceptor nucleotide kinase activity
2rlcA choloylglycine hydrolase	[pdb]	1.93 0.000476	78^CYS 108^TRP 164^ASN 113^PHE 157^GLU 119^VAL 105^PHE	3.5.1.24			hydrolase activity choloylglycine hydrolase activity
2hjnA maintenance of ploidy protein mob1	[pdb]	1.95 0.000522	197^TRP 215^GLU 256^PHE 221^CYS 258^VAL 213^TYR 103^ASN	0.0.0.0	protein phosphorylation cell cycle regulation of exit from mitosis cell division	chromosome centromeric region nucleus chromosome cytoplasm spindle pole body cytoskeleton	protein binding kinase regulator activity metal ion binding
2r5kB major capsid protein l1	[pdb]	1.96 0.000558	99^CYS 244^PHE 309^TRP 103^GLU 156^VAL 308^TYR 305^ASN	0.0.0.0		virion viral capsid	structural molecule activity
1f97A junction adhesion molecule	[pdb]	1.97 0.000578	49^CYS 63^PHE 88^PHE 61^TRP 105^GLU 86^VAL 103^ASN	0.0.0.0	cell adhesion epithelial cell differentiation interspecies interaction between organisms	plasma membrane tight junction membrane integral to membrane cell junction
2fh7A receptor-type tyrosine-protein phosphatase s	[pdb]	2.01 0.000687	1790^CYS 1794^TRP 1839^PHE 1762^GLU 1776^VAL 1793^TYR 1763^ASP	3.1.3.48	protein dephosphorylation cell adhesion dephosphorylation	integral to plasma membrane membrane integral to membrane	phosphoprotein phosphatase activity protein tyrosine phosphatase activity receptor activity transmembrane receptor protein tyrosine phosphatase activity protein binding hydrolase activity phosphatase activity
3oh1A udp-sugar pyrophosphorylase	[pdb]	2.05 0.000883	113^CYS 258^TRP 264^GLU 165^PHE 118^VAL 263^TYR 293^ASP		metabolic process		nucleotidyltransferase activity
2ivfA ethylbenzene dehydrogenase alpha-subunit ethylbenzene dehydrogenase beta-subunit ethylbenzene dehydrogenase gamma-subunit	[pdb]	2.07 0.000946	79^LYS 106^VAL 673^PHE 92^GLY 674^VAL 95^ALA 134^GLY	0.0.0.0	oxidation-reduction process oxidation-reduction process	periplasmic space	heme binding binding oxidoreductase activity molybdenum ion binding metal ion binding
2qjkO cytochrome b ubiquinol-cytochrome c reductase iron-sulfursubunit cytochrome c1	[pdb]	2.07 0.000946	134^CYS 147^TRP 169^GLU 73^PHE 124^VAL 156^TYR 97^ASN	1.10.2.2	transport electron transport chain transport electron transport chain oxidation-reduction process transport electron transport chain respiratory electron transport chain	plasma membrane membrane integral to membrane respiratory chain plasma membrane membrane integral to membrane plasma membrane membrane integral to membrane respiratory chain	iron ion binding electron carrier activity heme binding metal ion binding iron ion binding electron carrier activity heme binding ubiquinol-cytochrome-c reductase activity oxidoreductase activity oxidoreductase activity acting on diphenols and related substances as donors metal ion binding iron-sulfur cluster binding 2 iron 2 sulfur cluster binding electron carrier activity
1tuoA putative phosphomannomutase	[pdb]	2.07 0.000979	291^PHE 317^TRP 327^CYS 345^GLU 293^VAL 315^PHE 253^ASP	0.0.0.0	carbohydrate metabolic process		intramolecular transferase activity
1p15B protein-tyrosine phosphatase alpha	[pdb]	2.08 0.000979	635^CYS 639^TRP 684^PHE 607^GLU 622^VAL 638^TYR 608^ASP	3.1.3.48	protein phosphorylation protein dephosphorylation insulin receptor signaling pathway dephosphorylation	membrane integral to membrane	phosphoprotein phosphatase activity protein tyrosine phosphatase activity hydrolase activity phosphatase activity
2r6hD nadhf subunit	[pdb]	2.08 0.00101	313^TRP 359^PHE 383^CYS 379^GLU 392^VAL 283^TYR 377^ASP	0.0.0.0	transport ion transport sodium ion transport oxidation-reduction process	plasma membrane Gram-negative-bacterium-type cell wall membrane integral to membrane	electron carrier activity oxidoreductase activity oxidoreductase activity acting on NADH or NADPH quinone or similar compound as acceptor metal ion binding
1ukcB esta	[pdb]	2.09 0.00105	338^GLU 400^PHE 526^CYS 241^TRP 320^PHE 407^VAL 335^ASP	0.0.0.0			hydrolase activity
1zzhA cytochrome c peroxidase	[pdb]	2.09 0.00108	97^TRP 203^CYS 263^PHE 245^GLU 219^VAL 248^PHE 243^ASP
1mo8A sodium/potassium-transporting atpase alpha-1	[pdb]	2.1 0.00112	418^TRP 555^PHE 584^CYS 500^GLU 506^VAL 419^PHE 495^ASN	3.6.3.9	ATP catabolic process ATP biosynthetic process transport ion transport cation transport potassium ion transport sodium ion transport metabolic process potassium ion import monovalent inorganic cation transport energy coupled proton transport	membrane fraction endosome sodium:potassium-exchanging ATPase complex caveola membrane integral to membrane melanosome	nucleotide binding catalytic activity sodium:potassium-exchanging ATPase activity protein binding ATP binding monovalent inorganic cation transmembrane transporter activity ATPase activity coupled to transmembrane movement of ions phosphorylative mechanism hydrolase activity hydrolase activity acting on acid anhydrides catalyzing transmembrane movement of substances protein domain specific binding potassium ion binding
2fsxA cog0607	[pdb]	2.11 0.00116	29^CYS 53^TRP 67^GLU 85^PHE 25^VAL 64^PHE 70^ASP	0.0.0.0
1mhyD methane monooxygenase hydroxylase	[pdb]	2.13 0.00123	199^HOH 211^HOH 276^HOH 282^HOH 187^HOH 275^HOH 196^HOH	1.14.13.25	cellular aromatic compound metabolic process one-carbon metabolic process oxidation-reduction process cellular aromatic compound metabolic process one-carbon metabolic process oxidation-reduction process one-carbon metabolic process methane metabolic process oxidation-reduction process		monooxygenase activity methane monooxygenase activity oxidoreductase activity metal ion binding transition metal ion binding monooxygenase activity methane monooxygenase activity oxidoreductase activity oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen NADH or NADPH as one donor and incorporation of one atom of oxygen
1pv1B hypothetical 33.9 kda esterase in smc3-mrpl8intergenic region	[pdb]	2.13 0.00127	10^CYS 67^GLU 71^TRP 80^PHE 83^VAL 70^PHE 64^ASN	3.1.2.12	formaldehyde catabolic process	cytoplasm cytosol cytoplasmic membrane-bounded vesicle	carboxylesterase activity protein binding hydrolase activity S-formylglutathione hydrolase activity identical protein binding
1arcA achromobacter protease i	[pdb]	2.14 0.00135	36^CYS 73^TRP 154^GLU 52^PHE 25^VAL 75^TYR 9^ASP	3.4.21.50	proteolysis	extracellular region	catalytic activity serine-type endopeptidase activity peptidase activity serine-type peptidase activity hydrolase activity
3alpB poliovirus receptor-related protein 1	[pdb]	2.15 0.00139	269^CYS 282^TRP 301^PHE 330^GLU 265^VAL 314^TYR 332^ASN		lens morphogenesis in camera-type eye immune response cell adhesion homophilic cell adhesion heterophilic cell-cell adhesion axon guidance cell-cell adhesion interspecies interaction between organisms entry of virus into host cell camera-type eye morphogenesis regulation of synaptogenesis retina development in camera-type eye	plasma membrane enriched fraction extracellular region microsome plasma membrane adherens junction cell-cell adherens junction membrane integral to membrane catenin complex synaptosome axon growth cone membrane synapse	receptor activity protein binding coreceptor activity carbohydrate binding protein homodimerization activity virion binding protein heterodimerization activity cell adhesion molecule binding
1fz5B methane monooxygenase component a, beta chain methane monooxygenase component a, alpha chain methane monooxygenase component a, gamma chain	[pdb]	2.15 0.00139	199^HOH 211^HOH 276^LEU 282^ASN 187^HOH 275^ASN 196^HOH	1.14.13.25	cellular aromatic compound metabolic process one-carbon metabolic process oxidation-reduction process one-carbon metabolic process methane metabolic process oxidation-reduction process cellular aromatic compound metabolic process one-carbon metabolic process oxidation-reduction process		monooxygenase activity methane monooxygenase activity oxidoreductase activity oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen NADH or NADPH as one donor and incorporation of one atom of oxygen transition metal ion binding monooxygenase activity methane monooxygenase activity oxidoreductase activity monooxygenase activity
1t5jA hypothetical protein mj1187	[pdb]	2.16 0.00147	13^PHE 45^GLU 278^TRP 247^CYS 16^VAL 43^TYR 55^ASN	0.0.0.0			hydrolase activity
1hy3A estrogen sulfotransferase	[pdb]	2.17 0.00147	27^TRP 33^PHE 83^CYS 86^GLU 92^VAL 26^TYR 87^ASN	2.8.2.4	female pregnancy steroid metabolic process estrogen metabolic process sulfation	cytoplasm cytosol	estrone sulfotransferase activity steroid binding sulfotransferase activity lipid binding transferase activity flavonol 3-sulfotransferase activity steroid sulfotransferase activity
1larA protein (lar)	[pdb]	2.18 0.00151	1723^CYS 1727^TRP 1772^PHE 1695^GLU 1710^VAL 1726^TYR 1696^ASP	3.1.3.48	negative regulation of cytokine-mediated signaling pathway protein dephosphorylation cell adhesion homophilic cell adhesion transmembrane receptor protein tyrosine phosphatase signaling pathway nervous system development negative regulation of cell proliferation dephosphorylation negative regulation of cell projection organization negative regulation of epidermal growth factor receptor signaling pathway positive regulation of apoptosis positive regulation of neuron apoptosis negative regulation of insulin receptor signaling pathway positive regulation of dendrite morphogenesis regulation of synapse structure and activity negative regulation of nerve growth factor receptor signaling pathway	membrane fraction insoluble fraction endosome microsome plasma membrane integral to plasma membrane membrane integral to membrane growth cone neuron projection neuronal cell body excitatory synapse	phosphoprotein phosphatase activity protein tyrosine phosphatase activity receptor activity transmembrane receptor protein tyrosine phosphatase activity insulin receptor binding hydrolase activity phosphatase activity receptor tyrosine kinase binding phosphate binding
2gz6B n-acetyl-d-glucosamine 2-epimerase	[pdb]	2.19 0.00164	36^PHE 347^GLU 370^CYS 24^TRP 45^VAL 23^PHE 342^ASP	0.0.0.0	mannose metabolic process		catalytic activity mannose-6-phosphate isomerase activity
3agnA ribonuclease u2	[pdb]	2.22 0.00178	54^CYS 60^TRP 110^PHE 94^GLU 99^VAL 88^TYR 20^ASN	3.1.27.4			RNA binding nuclease activity endonuclease activity endoribonuclease activity ribonuclease activity hydrolase activity ribonuclease U2 activity
3e7wA d-alanine--poly(phosphoribitol) ligase subunit 1	[pdb]	2.24 0.00198	244^PHE 268^CYS 306^GLU 238^TRP 245^VAL 265^PHE 309^ASN	6.1.1.13	metabolic process teichoic acid biosynthetic process	cytoplasm	nucleotide binding catalytic activity ATP binding AMP binding ligase activity D-alanine-poly(phosphoribitol) ligase activity
2fvzA inositol monophosphatase 2	[pdb]	2.25 0.00204	78^PHE 130^PHE 229^CYS 98^TRP 62^GLU 132^VAL 63^ASP	3.1.3.25	phosphate metabolic process signal transduction inositol phosphate dephosphorylation	cytoplasm	inositol or phosphatidylinositol phosphatase activity inositol-1(or 4)-monophosphatase activity hydrolase activity protein homodimerization activity metal ion binding
1zsoB hypothetical protein	[pdb]	2.27 0.00215	76^PHE 83^CYS 109^PHE 26^TRP 154^GLU 77^VAL 156^ASN	0.0.0.0
3dcdA galactose mutarotase related enzyme	[pdb]	2.27 0.00221	114^ASN 230^TRP 236^PHE 251^CYS 124^GLU 140^VAL 287^PHE	0.0.0.0	carbohydrate metabolic process		catalytic activity isomerase activity carbohydrate binding
3gg4B glycerol kinase	[pdb]	2.3 0.0024	78^PHE 82^CYS 171^TRP 49^GLU 8^VAL 168^PHE 50^ASN		carbohydrate metabolic process		kinase activity phosphotransferase activity
3ct9B acetylornithine deacetylase	[pdb]	2.31 0.00254	206^TRP 244^PHE 269^CYS 262^GLU 245^VAL 207^PHE 258^ASP	0.0.0.0	proteolysis metabolic process		protein binding metallopeptidase activity hydrolase activity
2jjdC receptor-type tyrosine-protein phosphataseepsilon	[pdb]	2.31 0.00261	536^CYS 540^TRP 590^PHE 508^GLU 523^VAL 539^TYR 509^ASP		protein phosphorylation protein dephosphorylation transmembrane receptor protein tyrosine phosphatase signaling pathway dephosphorylation regulation of mast cell activation negative regulation of insulin receptor signaling pathway	nucleus cytoplasm plasma membrane membrane integral to membrane	phosphoprotein phosphatase activity protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity protein binding hydrolase activity phosphatase activity protein homodimerization activity
3lflB glutathione s-transferase omega-1	[pdb]	2.32 0.00261	32^CYS 177^TRP 184^GLU 120^PHE 123^VAL 180^PHE 189^ASN		biological_process metabolic process L-ascorbic acid biosynthetic process	cytoplasm	glutathione transferase activity monodehydroascorbate reductase (NADH) activity transferase activity
2vrqC alpha-l-arabinofuranosidase	[pdb]	2.32 0.00261	74^CYS 302^TRP 313^PHE 298^GLU 351^VAL 344^ASN 242^TYR	0.0.0.0	metabolic process L-arabinose metabolic process		hydrolase activity hydrolase activity acting on glycosyl bonds
3okxA yaeb-like protein rpa0152	[pdb]	2.32 0.00261	51^CYS 55^VAL 77^TRP 56^PHE 73^GLU 75^PHE 145^ASP	0.0.0.0
2p14A heterodimeric restriction endonuclease r.bspd6ismall subunit	[pdb]	2.33 0.00269	9^GLU 23^TRP 74^CYS 29^PHE 28^VAL 20^TYR 6^ASP	0.0.0.0			endonuclease activity
2vtcA cel61b	[pdb]	2.33 0.00285	7^PHE 37^TRP 40^GLU 59^CYS 4^VAL 38^TYR 43^ASP	3.2.1.4	polysaccharide catabolic process carbohydrate metabolic process metabolic process cellulose catabolic process	extracellular region	cellulase activity hydrolase activity hydrolase activity acting on glycosyl bonds
3d46H putative galactonate dehydratase	[pdb]	2.34 0.00285	16^TRP 24^GLU 397^CYS 83^PHE 85^VAL 17^PHE 65^ASN	4.2.1.90	metabolic process cellular amino acid catabolic process		catalytic activity lyase activity metal ion binding L-rhamnonate dehydratase activity
1vfqA coactosin-like protein	[pdb]	2.34 0.00293	26^TRP 52^CYS 113^VAL 59^PHE 122^GLU 45^TYR 123^ASP	0.0.0.0	biological_process defense response to fungus	cellular_component intracellular cytoplasm cytoskeleton	actin binding protein binding enzyme binding
2fk9A protein kinase c, eta type	[pdb]	2.34 0.00293	101^CYS 118^PHE 121^TRP 18^GLU 133^VAL 131^PHE 69^ASN	2.7.11.13	protein phosphorylation signal transduction	cytoplasm plasma membrane	nucleotide binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity ATP binding kinase activity transferase activity enzyme binding metal ion binding
1hdfA spherulin 3a	[pdb]	2.35 0.00302	3^CYS 14^GLU 28^TRP 37^PHE 34^VAL 16^PHE 55^ASN	0.0.0.0		cytoplasm
2e4zA metabotropic glutamate receptor 7	[pdb]	2.36 0.00311	67^CYS 363^TRP 370^GLU 55^PHE 57^VAL 364^PHE 371^ASN	0.0.0.0	signal transduction G-protein coupled receptor protein signaling pathway inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway sensory perception of smell learning or memory negative regulation of glutamate secretion response to stimulus	membrane fraction rough endoplasmic reticulum Golgi apparatus plasma membrane cell surface membrane integral to membrane axon dendrite asymmetric synapse presynaptic membrane neuronal cell body terminal button dendritic shaft protein complex axon terminus synapse postsynaptic membrane presynaptic active zone	adenylate cyclase inhibiting metabotropic glutamate receptor activity group III metabotropic glutamate receptor activity signal transducer activity receptor activity G-protein coupled receptor activity calmodulin binding glutamate binding PDZ domain binding
2a2mA hypothetical protein bt3146	[pdb]	2.37 0.00331	40^TRP 158^CYS 219^VAL 222^PHE 207^GLU 39^PHE 211^ASP	0.0.0.0
1qrkB protein (coagulation factor xiii)	[pdb]	2.37 0.00331	344^ASN 370^TRP 559^PHE 314^CYS 434^GLU 563^VAL 339^PHE	2.3.2.13	blood coagulation peptide cross-linking wound healing	extracellular region cytoplasm	protein-glutamine gamma-glutamyltransferase activity acyltransferase activity transferase activity metal ion binding
3ljpA choline oxidase	[pdb]	2.38 0.00331	106^TRP 160^VAL 196^PHE 102^CYS 137^GLU 105^PHE 151^ASP	0.0.0.0	alcohol metabolic process oxidation-reduction process		oxidoreductase activity oxidoreductase activity acting on CH-OH group of donors choline:oxygen 1-oxidoreductase activity
3hbmA udp-sugar hydrolase	[pdb]	2.38 0.00341	102^GLU 247^PHE 262^TRP 251^CYS 237^VAL 117^TYR 113^ASN	0.0.0.0
2ivfC ethylbenzene dehydrogenase alpha-subunit ethylbenzene dehydrogenase beta-subunit ethylbenzene dehydrogenase gamma-subunit	[pdb]	2.38 0.00341	118^TRP 126^GLU 187^PHE 165^CYS 93^VAL 119^TYR 123^ASN	0.0.0.0	oxidation-reduction process oxidation-reduction process	periplasmic space	heme binding binding oxidoreductase activity molybdenum ion binding metal ion binding
3gnnA nicotinate-nucleotide pyrophosphorylase unknown peptide	[pdb]	2.38 0.00341	6^VAL 10^PHE 70^TRP 66^CYS 102^GLU 71^PHE 85^ASP	0.0.0.0	metabolic process NAD biosynthetic process pyridine nucleotide biosynthetic process		catalytic activity nicotinate-nucleotide diphosphorylase (carboxylating) activity transferase activity transferase activity
2wa2A non-structural protein 5	[pdb]	2.38 0.00341	88^TRP 101^VAL 127^PHE 146^CYS 73^GLU 91^TYR 97^ASN	0.0.0.0	transcription RNA-dependent viral reproduction RNA metabolic process viral genome replication	membrane integral to membrane virion viral capsid viral envelope host cell membrane virion part	nucleotide binding nucleic acid binding RNA binding RNA helicase activity double-stranded RNA binding catalytic activity RNA-directed RNA polymerase activity serine-type endopeptidase activity helicase activity structural molecule activity ATP binding methyltransferase activity hydrolase activity
3cmmA ubiquitin-activating enzyme e1 1 ubiquitin	[pdb]	2.38 0.00352	525^GLU 533^TRP 538^PHE 556^CYS 539^VAL 518^ASP 532^PHE		protein modification process metabolic process protein ubiquitination ribosomal small subunit assembly maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA LSU-rRNA,5S) DNA repair translation response to DNA damage stimulus ribosome biogenesis DNA repair translation response to DNA damage stimulus DNA repair translation response to DNA damage stimulus DNA repair	nucleus cytoplasm intracellular nucleus cytoplasm ribosome cytosolic small ribosomal subunit ribonucleoprotein complex intracellular nucleus cytoplasm ribosome ribonucleoprotein complex intracellular nucleus cytoplasm ribosome ribonucleoprotein complex nucleus cytoplasm	nucleotide binding catalytic activity ubiquitin activating enzyme activity binding protein binding ATP binding small protein activating enzyme activity ligase activity structural constituent of ribosome protein tag metal ion binding structural constituent of ribosome structural constituent of ribosome
2v62B serine/threonine-protein kinase vrk2	[pdb]	2.39 0.00352	138^PHE 243^TRP 285^CYS 234^GLU 143^VAL 238^TYR 232^ASP	2.7.11.1	protein phosphorylation protein autophosphorylation	membrane fraction endoplasmic reticulum membrane integral to membrane	nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding kinase activity transferase activity
2dirA thump domain-containing protein 1	[pdb]	2.39 0.00363	25^TRP 34^PHE 60^CYS 19^GLU 77^VAL 13^ASP 21^PHE	0.0.0.0
1h6yA endo-1,4-beta-xylanase y	[pdb]	2.4 0.00363	89^CYS 116^TRP 150^GLU 146^PHE 13^ASP 38^TYR 46^VAL	3.2.1.8	polysaccharide catabolic process carbohydrate metabolic process metabolic process xylan catabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds protein binding hydrolase activity hydrolase activity acting on glycosyl bonds
3pieD 5'->3' exoribonuclease (xrn1)	[pdb]	2.4 0.00374	292^PHE 552^CYS 557^TRP 579^GLU 544^VAL 577^ASN 580^PHE		nucleobase	intracellular	nucleic acid binding exonuclease activity 5'-3' exonuclease activity
2nv5B ptprd, phosphatase	[pdb]	2.4 0.00374	1305^GLU 1336^CYS 1340^TRP 1385^PHE 1322^VAL 1339^TYR 1309^ASP	3.1.3.48	protein dephosphorylation dephosphorylation protein dephosphorylation cell adhesion dephosphorylation	membrane integral to membrane	phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding hydrolase activity phosphatase activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity receptor activity hydrolase activity phosphatase activity
3h13A casp8 and fadd-like apoptosis regulator	[pdb]	2.4 0.00374	426^CYS 461^GLU 466^TRP 356^PHE 313^VAL 464^TYR 409^ASP		proteolysis apoptosis anti-apoptosis induction of apoptosis by extracellular signals regulation of apoptosis positive regulation of I-kappaB kinase/NF-kappaB cascade interspecies interaction between organisms		cysteine-type endopeptidase activity protein binding cysteine-type peptidase activity
3kg5A b-cell antigen receptor complex-associated protein betachain	[pdb]	2.4 0.00374	47^TRP 121^PHE 126^CYS 102^GLU 74^VAL 66^TYR 101^ASN	0.0.0.0	immune response signal transduction cell surface receptor linked signaling pathway	plasma membrane integral to plasma membrane membrane integral to membrane	transmembrane receptor activity
3hazA proline dehydrogenase	[pdb]	2.41 0.00386	611^GLU 657^TRP 792^CYS 731^PHE 730^VAL 659^PHE 614^ASP	0.0.0.0	glutamate biosynthetic process proline biosynthetic process proline catabolic process metabolic process oxidation-reduction process		1-pyrroline-5-carboxylate dehydrogenase activity proline dehydrogenase activity oxidoreductase activity
3n3kA ubiquitin carboxyl-terminal hydrolase 8 ubiquitin	[pdb]	2.41 0.00398	796^CYS 1054^PHE 1080^TRP 1087^GLU 1056^VAL 1081^PHE 1084^ASP	3.1.2.15	translation translational elongation translation translational elongation protein modification process ubiquitin-dependent protein catabolic process endosome organization cell cycle Ras protein signal transduction cell proliferation protein K63-linked deubiquitination protein K48-linked deubiquitination	nucleus cytoplasm intracellular nucleus cytoplasm cytosol ribosome small ribosomal subunit cytosolic small ribosomal subunit ribonucleoprotein complex intracellular nucleus cytoplasm cytosol ribosome cytosolic small ribosomal subunit ribonucleoprotein complex intracellular nucleus cytoplasm endosome early endosome cytosol plasma membrane endosome membrane membrane extrinsic to plasma membrane nucleus cytoplasm	structural constituent of ribosome metal ion binding structural constituent of ribosome protein binding cysteine-type endopeptidase activity ubiquitin thiolesterase activity ubiquitin-specific protease activity protein binding peptidase activity cysteine-type peptidase activity hydrolase activity SH3 domain binding
1udmA coactosin-like protein	[pdb]	2.42 0.0041	33^TRP 59^CYS 120^VAL 66^PHE 128^GLU 52^TYR 130^ASP	0.0.0.0	defense response to fungus	cellular_component intracellular cytoplasm cytoskeleton	actin binding protein binding enzyme binding
2frgP trem-like transcript-1	[pdb]	2.42 0.00411	38^CYS 51^TRP 101^GLU 78^PHE 92^VAL 102^TYR 121^ASN	0.0.0.0	calcium-mediated signaling platelet activation innate immune response	cytoplasm plasma membrane cell surface membrane integral to membrane platelet alpha granule	receptor activity protein binding
1bolA protein (ribonuclease rh)	[pdb]	2.43 0.00423	23^GLU 49^TRP 53^CYS 194^PHE 196^VAL 24^TYR 17^ASP	3.1.27.1			RNA binding nuclease activity endonuclease activity hydrolase activity ribonuclease T2 activity
3dc8B dihydropyrimidinase	[pdb]	2.43 0.00424	73^GLU 106^TRP 119^PHE 315^CYS 88^VAL 72^PHE 114^ASN	0.0.0.0			hydrolase activity hydrolase activity
2b1hL fab 2219, heavy chain fab 2219, light chain ug29 peptide of exterior membrane glycoproteingp120	[pdb]	2.43 0.00424	23^GLN 29^PHE 98^ASP 35^GLY 97^GLY 34^ILE 30^SER	0.0.0.0
3dxaI ebv decapeptide epitope beta-2-microglobulin hla class i histocompatibility complex hla-b*4402 dm1 t cell receptor beta chain dm1 t cell receptor alpha chain	[pdb]	2.43 0.00424	23^CYS 40^TYR 115^GLU 41^TRP 32^GLU 113^TYR 31^ARG	0.0.0.0	immune response cellular defense response antigen processing and presentation of peptide antigen via MHC class I immune response antigen processing and presentation interspecies interaction between organisms positive regulation of T cell mediated cytotoxicity response to molecule of bacterial origin antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of exogenous protein antigen via MHC class Ib TAP-dependent immune response response to drug response to cadmium ion viral reproduction	plasma membrane membrane integral to membrane plasma membrane integral to plasma membrane membrane integral to membrane membrane integral to membrane MHC class I protein complex Golgi membrane extracellular region extracellular space plasma membrane external side of plasma membrane early endosome membrane MHC class I protein complex host cell nucleus host cell nuclear matrix	receptor activity protein binding receptor activity protein binding MHC protein binding peptide antigen binding protein binding
2pvcB histone h3 peptide dna (cytosine-5)-methyltransferase 3-like	[pdb]	2.43 0.00424	282^TRP 367^CYS 375^PHE 197^GLU 190^VAL 242^TYR 198^ASP	0.0.0.0	in utero embryonic development DNA methylation regulation of gene expression by genetic imprinting spermatogenesis	condensed nuclear chromosome nucleus nuclear heterochromatin cytoplasm cytosol	protein binding enzyme activator activity zinc ion binding transcription repressor activity enzyme binding metal ion binding
3f5dA protein ydea	[pdb]	2.43 0.00437	8^PHE 17^TRP 100^CYS 158^GLU 68^VAL 21^TYR 161^ASN	0.0.0.0			peptidase activity hydrolase activity
3gd4B apoptosis-inducing factor 1, mitochondrial	[pdb]	2.44 0.00437	458^VAL 476^TRP 481^PHE 440^CYS 425^GLU 467^ASN 475^TYR	0.0.0.0	DNA fragmentation involved in apoptotic nuclear change apoptosis apoptotic mitochondrial changes apoptotic chromosome condensation cell redox homeostasis neuron apoptosis oxidation-reduction process	soluble fraction nucleus cytoplasm mitochondrion mitochondrial outer membrane mitochondrial intermembrane space microsome cytosol	DNA binding electron-transferring-flavoprotein dehydrogenase activity protein binding oxidoreductase activity flavin adenine dinucleotide binding
2o1zA ribonucleotide reductase subunit r2	[pdb]	2.44 0.00451	199^PHE 204^TRP 264^CYS 83^GLU 90^VAL 205^PHE 81^ASP	0.0.0.0	deoxyribonucleoside diphosphate metabolic process oxidation-reduction process		ribonucleoside-diphosphate reductase activity oxidoreductase activity transition metal ion binding
2iqxB phosphatidylethanolamine-binding protein 1	[pdb]	2.45 0.00466	84^TRP 133^CYS 152^GLU 87^PHE 67^VAL 149^PHE 18^ASP	0.0.0.0	MAPKKK cascade regulation of neurotransmitter levels negative regulation of protein phosphorylation regulation of the force of heart contraction response to stress response to oxidative stress spermatid development brain development aging response to heat response to wounding response to toxin response to organic substance response to organic nitrogen response to organic cyclic compound response to activity response to drug eating behavior negative regulation of MAPKKK cascade positive regulation of cAMP-mediated signaling response to ethanol positive regulation of mitosis response to corticosterone stimulus response to cAMP response to calcium ion response to electrical stimulus positive regulation of acetylcholine metabolic process	extracellular space soluble fraction cytoplasm mitochondrion mitochondrial outer membrane rough endoplasmic reticulum Golgi apparatus synaptic vesicle cell surface membrane synaptosome neuronal cell body axon terminus apical part of cell	nucleotide binding serine-type endopeptidase inhibitor activity receptor binding protein binding ATP binding lipid binding kinase binding protein kinase binding peptidase inhibitor activity mitogen-activated protein kinase binding
1cf2Q protein (glyceraldehyde-3-phosphatedehydrogenase)	[pdb]	2.45 0.00466	240^PHE 281^TRP 291^GLU 146^CYS 239^VAL 294^TYR 290^ASN	1.2.1.59	glycolysis metabolic process oxidation-reduction process	cytoplasm	catalytic activity binding glyceraldehyde-3-phosphate dehydrogenase activity oxidoreductase activity glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity NADP binding NAD binding
1pciB procaricain	[pdb]	2.45 0.00466	28^PHE 56^CYS 67^TYR 26^TRP 73^GLU 31^VAL 96^ARG	3.4.22.30	proteolysis		cysteine-type endopeptidase activity peptidase activity cysteine-type peptidase activity hydrolase activity
3hnnB putative diflavin flavoprotein a 5	[pdb]	2.45 0.00466	181^CYS 186^PHE 190^TRP 195^GLU 235^VAL 193^PHE 202^ASN	0.0.0.0	transport electron transport chain oxidation-reduction process		electron carrier activity FMN binding oxidoreductase activity hydrolase activity
3eb7B insecticidal delta-endotoxin cry8ea1	[pdb]	2.47 0.00496	111^TRP 119^GLU 188^VAL 245^CYS 186^PHE 114^PHE 123^ASN	0.0.0.0	defense response pathogenesis sporulation resulting in formation of a cellular spore		receptor binding
2couA ect2 protein	[pdb]	2.48 0.00528	16^CYS 72^PHE 78^TRP 32^GLU 73^VAL 79^PHE 25^ASP	0.0.0.0	cell morphogenesis regulation of Rho protein signal transduction	intracellular	guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity protein binding Rho GTPase binding
1j0tA molt-inhibiting hormone	[pdb]	2.48 0.00528	45^PHE 49^TRP 60^GLU 27^CYS 61^ASP 50^PHE 20^VAL	0.0.0.0	neuropeptide signaling pathway	extracellular region	hormone activity neuropeptide hormone activity
1qjsB hemopexin	[pdb]	2.48 0.00545	131^CYS 147^TRP 156^GLU 78^PHE 124^VAL 146^PHE 142^ASN	0.0.0.0	positive regulation of immunoglobulin production positive regulation of humoral immune response mediated by circulating immunoglobulin transport hemoglobin metabolic process heme metabolic process positive regulation of tyrosine phosphorylation of Stat1 protein regulation of protein metabolic process positive regulation of response to interferon-gamma positive regulation of interferon-gamma-mediated signaling pathway	extracellular region	heme binding metal ion binding
2vraB roundabout 1	[pdb]	2.48 0.00545	77^CYS 89^TRP 108^PHE 129^GLU 106^VAL 90^PHE 126^ASP	0.0.0.0	startle response axon guidance epithelial cell migration open tracheal system salivary gland boundary specification neuron recognition entrainment of circadian clock axon midline choice point recognition positive regulation of cell-cell adhesion locomotion involved in locomotory behavior embryonic heart tube development dendrite morphogenesis brain morphogenesis	plasma membrane axon dendrite vesicle neuronal cell body protein complex	receptor activity protein binding heparin binding
1oz7B echicetin b-chain echicetin a-chain	[pdb]	2.48 0.00545	17^PHE 99^TYR 121^CYS 65^TRP 47^GLU 16^VAL 49^ASP	0.0.0.0		extracellular region extracellular region	binding sugar binding binding sugar binding
3a9sA d-arabinose isomerase	[pdb]	2.49 0.00562	66^CYS 95^TRP 100^GLU 115^PHE 91^VAL 103^ASP 97^TYR	0.0.0.0	monosaccharide metabolic process fucose metabolic process fucose catabolic process	cytoplasm	L-fucose isomerase activity isomerase activity intramolecular oxidoreductase activity interconverting aldoses and ketoses
1dzlA late major capsid protein l1	[pdb]	2.49 0.00562	106^GLU 247^PHE 312^TRP 102^CYS 331^VAL 311^TYR 308^ASN	0.0.0.0		virion viral capsid virion viral capsid host cell nucleus	structural molecule activity structural molecule activity
1h4pB glucan 1,3-beta-glucosidase i/ii	[pdb]	2.49 0.00562	299^VAL 345^TRP 372^CYS 300^PHE 418^GLU 67^TYR 420^ASP	3.2.1.58	carbohydrate metabolic process cellular glucan metabolic process cellular cell wall organization metabolic process	extracellular region cell wall fungal-type cell wall	catalytic activity glucan exo-1,3-beta-glucosidase activity hydrolase activity hydrolyzing O-glycosyl compounds hydrolase activity hydrolase activity
1i2lA 4-amino-4-deoxychorismate lyase	[pdb]	2.5 0.0058	173^GLU 247^CYS 252^PHE 181^TRP 244^VAL 180^PHE 236^ASN	4.1.3.38	metabolic process folic acid biosynthetic process		catalytic activity 4-amino-4-deoxychorismate lyase activity lyase activity pyridoxal phosphate binding
1fbvA signal transduction protein cbl ubiquitin-conjugating enzyme e12-18 kda ubch7 zap-70 peptide	[pdb]	2.5 0.0058	202^TRP 232^CYS 238^VAL 241^PHE 113^GLU 235^TYR 112^ASN	0.0.0.0	protein polyubiquitination protein modification process ubiquitin-dependent protein catabolic process regulation of S phase of mitotic cell cycle cell proliferation protein ubiquitination regulation of gene-specific transcription post-translational protein modification regulation of protein metabolic process protein K11-linked ubiquitination cellular response to steroid hormone stimulus cellular response to glucocorticoid stimulus cell surface receptor linked signaling pathway epidermal growth factor receptor signaling pathway protein ubiquitination positive regulation of receptor-mediated endocytosis	ubiquitin ligase complex nucleus cytoplasm nucleus cytoplasm cytosol plasma membrane flotillin complex	nucleotide binding transcription coactivator activity ubiquitin-protein ligase activity protein binding ATP binding ligase activity small conjugating protein ligase activity enzyme binding sequence-specific DNA binding transcription factor activity ubiquitin-protein ligase activity signal transducer activity calcium ion binding protein binding zinc ion binding ligase activity SH3 domain binding metal ion binding
3ejxC diaminopimelate epimerase, chloroplastic	[pdb]	2.5 0.0058	174^VAL 232^GLU 244^TRP 183^CYS 216^PHE 230^PHE 201^ASN	5.1.1.7	cellular amino acid biosynthetic process lysine biosynthetic process lysine biosynthetic process via diaminopimelate	cytoplasm chloroplast plastid	diaminopimelate epimerase activity isomerase activity
2ahnA thaumatin-like protein	[pdb]	2.5 0.00599	5^PHE 52^TRP 92^GLU 132^CYS 118^VAL 51^PHE 94^ASN	3.2.1.39	metabolic process	extracellular region	hydrolase activity hydrolase activity acting on glycosyl bonds IgE binding
1fuiE l-fucose isomerase	[pdb]	2.51 0.00599	61^CYS 90^TRP 95^GLU 110^PHE 86^VAL 92^TYR 98^ASP	5.3.1.25	carbohydrate metabolic process monosaccharide metabolic process fucose metabolic process fucose catabolic process D-arabinose catabolic process L-fucose catabolic process	cytoplasm cytosol	protein binding L-fucose isomerase activity arabinose isomerase activity isomerase activity intramolecular oxidoreductase activity interconverting aldoses and ketoses manganese ion binding
1sznA alpha-galactosidase	[pdb]	2.51 0.00599	147^CYS 175^TRP 211^PHE 143^GLU 210^VAL 173^TYR 142^ASP	0.0.0.0	carbohydrate metabolic process metabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds alpha-galactosidase activity hydrolase activity hydrolase activity
3fg6A adseverin	[pdb]	2.51 0.00599	530^VAL 551^TYR 575^CYS 553^TRP 513^PHE 588^GLU 591^ASN	0.0.0.0	negative regulation of cell proliferation calcium ion-dependent exocytosis positive regulation of apoptosis actin nucleation positive regulation of megakaryocyte differentiation actin filament severing positive regulation of secretion actin filament capping	cytoplasm cytoskeleton cell cortex protein complex	phosphatidylserine binding actin binding calcium ion binding 1-phosphatidylinositol binding phosphatidylinositol-4,5-bisphosphate binding actin filament binding
3hwwA 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	[pdb]	2.51 0.00599	377^CYS 514^TRP 521^PHE 369^GLU 463^VAL 469^ASN 367^PHE	2.2.1.9	menaquinone biosynthetic process		catalytic activity transferase activity thiamine pyrophosphate binding metal ion binding 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity
1wb4B endo-1,4-beta-xylanase y	[pdb]	2.51 0.00599	962^TYR 967^CYS 996^GLU 961^TRP 974^PHE 1010^VAL 992^ASN	3.2.1.8	polysaccharide catabolic process carbohydrate metabolic process metabolic process xylan catabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds protein binding hydrolase activity hydrolase activity acting on glycosyl bonds
3qanC 1-pyrroline-5-carboxylate dehydrogenase 1	[pdb]	2.51 0.00599	181^TRP 256^PHE 320^CYS 136^GLU 285^VAL 183^PHE 139^ASP		proline biosynthetic process metabolic process oxidation-reduction process		1-pyrroline-5-carboxylate dehydrogenase activity oxidoreductase activity
1f9oA endo-1,4-beta-glucanase f	[pdb]	2.51 0.00618	55^GLU 497^CYS 611^TRP 616^PHE 618^VAL 610^PHE 232^ASP	3.2.1.4	polysaccharide catabolic process carbohydrate metabolic process metabolic process cellulose catabolic process		catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds cellulase activity hydrolase activity
2ezyA barrier-to-autointegration factor	[pdb]	2.52 0.00618	39^PHE 45^VAL 62^TRP 77^CYS 56^GLU 59^PHE 55^ASP	0.0.0.0	response to virus DNA integration provirus integration initiation of viral infection interspecies interaction between organisms	nucleus chromosome cytoplasm cytosol	DNA binding
3hdxA susd superfamily protein	[pdb]	2.52 0.00618	95^GLU 106^VAL 163^TRP 72^CYS 112^PHE 491^TYR 97^ASN	0.0.0.0
2g59A receptor-type tyrosine-protein phosphatase o	[pdb]	2.52 0.00638	128^CYS 140^TRP 184^PHE 105^GLU 123^VAL 139^TYR 109^ASP	3.1.3.48	protein dephosphorylation dephosphorylation	integral to plasma membrane membrane integral to membrane	phosphoprotein phosphatase activity protein tyrosine phosphatase activity receptor activity transmembrane receptor protein tyrosine phosphatase activity protein binding hydrolase activity phosphatase activity
2qc8J glutamine synthetase	[pdb]	2.52 0.00638	130^TRP 349^PHE 359^CYS 338^GLU 351^VAL 256^PHE 339^ASP	6.3.1.2	glutamine biosynthetic process nitrogen compound metabolic process cell proliferation response to glucose stimulus	intracellular cytoplasm mitochondrion Golgi apparatus cytosol	nucleotide binding catalytic activity glutamate decarboxylase activity glutamate-ammonia ligase activity ATP binding lyase activity ligase activity identical protein binding
2kc5A hydrogenase-2 operon protein hybe	[pdb]	2.52 0.00638	45^PHE 52^TRP 108^CYS 98^GLU 42^VAL 67^PHE 100^ASP	0.0.0.0	protein maturation		protein binding preprotein binding
2id0A exoribonuclease 2	[pdb]	2.52 0.00638	86^PHE 112^CYS 127^TRP 121^GLU 129^VAL 122^PHE 119^ASN	3.1.13.1	RNA catabolic process RNA metabolic process	cytoplasm	nucleic acid binding RNA binding nuclease activity exonuclease activity ribonuclease activity protein binding exoribonuclease II activity hydrolase activity
3mlwL hiv-1 gp120 third variable region (v3) crown human monoclonal anti-hiv-1 gp120 v3 antibody 1006-15d fablight chain human monoclonal anti-hiv-1 gp120 v3 antibody 1006-15d fabheavy chain	[pdb]	2.52 0.00638	23^LYS 29^PHE 98^SER 35^ALA 97^TYR 34^ILE 30^THR	0.0.0.0	apoptosis initiation of viral infection evasion by virus of host immune response interspecies interaction between organisms	membrane integral to membrane virion viral envelope host cell plasma membrane host cell membrane host cell endosome host cell endosome membrane virion membrane	structural molecule activity
1cjaB protein (actin-fragmin kinase)	[pdb]	2.52 0.00638	106^GLU 315^TRP 334^PHE 113^CYS 200^VAL 108^PHE 102^ASN	2.7.11.1		cytoplasm	nucleotide binding protein serine/threonine kinase activity protein binding ATP binding kinase activity transferase activity phosphotransferase activity
2uu7J glutamine synthetase	[pdb]	2.53 0.00659	130^TRP 349^PHE 359^CYS 338^GLU 351^VAL 256^PHE 339^ASP	6.3.1.2	glutamine biosynthetic process nitrogen compound metabolic process cell proliferation response to glucose stimulus	intracellular cytoplasm mitochondrion Golgi apparatus	nucleotide binding catalytic activity glutamate decarboxylase activity glutamate-ammonia ligase activity ATP binding lyase activity ligase activity identical protein binding
2cbgA fengycin synthetase	[pdb]	2.53 0.0068	57^GLU 93^VAL 151^TRP 26^CYS 91^PHE 147^TYR 59^ASP	0.0.0.0	metabolic process biosynthetic process		acyl carrier activity catalytic activity hydrolase activity acting on ester bonds ligase activity phosphopantetheine binding
2c1uA di-haem cytochrome c peroxidase	[pdb]	2.53 0.0068	108^TRP 214^CYS 249^VAL 274^PHE 256^GLU 259^PHE 254^ASP
2pi7B protein tyrosine phosphatase cryp-2	[pdb]	2.53 0.0068	1067^GLU 1090^CYS 1102^TRP 1146^PHE 1085^VAL 1101^TYR 1071^ASP	0.0.0.0	protein dephosphorylation dephosphorylation		phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding hydrolase activity phosphatase activity
3oaeB late major capsid protein l1	[pdb]	2.54 0.00702	102^CYS 247^PHE 312^TRP 106^GLU 331^VAL 311^TYR 371^ASP	0.0.0.0		virion viral capsid	structural molecule activity
3gzaB putative alpha-l-fucosidase	[pdb]	2.54 0.00702	197^TRP 213^GLU 223^CYS 234^PHE 283^VAL 198^PHE 204^ASP	0.0.0.0	carbohydrate metabolic process cell adhesion		catalytic activity alpha-L-fucosidase activity cation binding
2v5oA cation-independent mannose-6-phosphate receptor	[pdb]	2.55 0.00702	1695^CYS 1787^PHE 1789^TRP 1739^GLU 1786^VAL 1764^PHE 1734^ASN	0.0.0.0	liver development transport receptor-mediated endocytosis signal transduction G-protein coupled receptor protein signaling pathway spermatogenesis post-embryonic development organ regeneration response to retinoic acid regulation of apoptosis positive regulation of apoptosis	extracellular space membrane fraction nucleus nuclear envelope lumen cytoplasm lysosome lysosomal membrane endosome trans-Golgi network integral to plasma membrane cell surface membrane integral to membrane endocytic vesicle trans-Golgi network transport vesicle perinuclear region of cytoplasm	glycoprotein binding G-protein alpha-subunit binding retinoic acid binding receptor activity G-protein coupled receptor activity insulin-like growth factor receptor activity transporter activity protein binding insulin-like growth factor binding mannose binding enzyme binding insulin-like growth factor II binding phosphoprotein binding
2ippB cathepsin b	[pdb]	2.55 0.00724	214^TYR 231^PHE 240^CYS 215^TRP 157^GLU 217^VAL 159^ASP	3.4.22.1	proteolysis autophagy response to stress skeletal muscle tissue development response to wounding response to mechanical stimulus response to glucose stimulus response to organic cyclic compound response to amine stimulus regulation of apoptosis response to peptide hormone stimulus response to ethanol regulation of catalytic activity response to protein stimulus negative regulation of cell death response to interleukin-4	extracellular region extracellular space intracellular soluble fraction cytoplasm mitochondrion lysosome caveola external side of plasma membrane cell surface apical plasma membrane sarcolemma melanosome perinuclear region of cytoplasm	endopeptidase activity cysteine-type endopeptidase activity protein binding peptidase activity cysteine-type peptidase activity hydrolase activity kininogen binding protein complex binding peptide binding
2r5jL major capsid protein l1	[pdb]	2.55 0.00724	102^CYS 247^PHE 310^TRP 106^GLU 329^VAL 309^TYR 369^ASP	0.0.0.0		virion viral capsid	structural molecule activity
3eiiC protein gh61e	[pdb]	2.55 0.00724	31^VAL 95^TRP 175^PHE 156^CYS 100^GLU 96^PHE 200^ASN	0.0.0.0
2ivkB endonuclease i 5'-d(gpapaptptpcpgpaptpcpgpapaptpt)-3' 5'-d(apaptptpcpgpaptpcpgpapaptptpc)-3' 5'-d(gpapaptptpcpgpaptpcpgpapaptptpc)-3'	[pdb]	2.55 0.00747	44^CYS 135^PHE 196^TRP 206^GLU 81^VAL 200^TYR 210^ASP	0.0.0.0			nuclease activity endonuclease activity
1zceA hypothetical protein atu2648	[pdb]	2.56 0.00747	5^TRP 134^CYS 147^ASP 52^PHE 4^TYR 65^VAL 127^GLU	0.0.0.0
3ilvA glutamine-dependent nad(+) synthetase	[pdb]	2.56 0.00747	108^PHE 129^TRP 163^CYS 122^GLU 97^VAL 126^PHE 54^ASP	0.0.0.0	nitrogen compound metabolic process NAD biosynthetic process		nucleotide binding NAD+ synthase (glutamine-hydrolyzing) activity ATP binding hydrolase activity acting on carbon-nitrogen (but not peptide) bonds
2p1qB auxin-responsive protein iaa7 transport inhibitor response 1 protein skp1-like protein 1a	[pdb]	2.56 0.00771	53^HOH 79^PHE 512^TRP 536^GLU 85^VAL 557^PHE 575^ASN	0.0.0.0	ubiquitin-dependent protein catabolic process chromosome segregation multicellular organismal development auxin mediated signaling pathway ethylene mediated signaling pathway interspecies interaction between organisms negative regulation of DNA recombination response to cadmium ion response to molecule of bacterial origin defense response cell cycle multicellular organismal development response to auxin stimulus auxin mediated signaling pathway ethylene mediated signaling pathway pollen maturation lateral root formation cellular response to phosphate starvation stamen development response to water deprivation response to wounding gravitropism response to auxin stimulus auxin mediated signaling pathway response to jasmonic acid stimulus	nucleus cytoplasm spindle cytoskeleton plasma membrane phragmoplast nucleus SCF ubiquitin ligase complex nucleus	protein binding inositol hexakisphosphate binding ubiquitin-protein ligase activity protein binding auxin binding protein binding protein dimerization activity
2qcjB tyrosine-protein phosphatase non-receptor type22	[pdb]	2.57 0.00796	112^ASP 129^CYS 143^TRP 188^PHE 140^GLU 126^VAL 142^TYR	3.1.3.48	protein dephosphorylation signal transduction dephosphorylation negative regulation of T cell receptor signaling pathway	cytoplasm	phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding hydrolase activity phosphatase activity
3qmzA glutathione-s-transferase cytoplasmic dynein heavy chain	[pdb]	2.57 0.00796	1793^CYS 1809^PHE 1844^TRP 1849^GLU 1806^VAL 1847^PHE 1821^ASN		mitotic spindle elongation mitotic sister chromatid segregation establishment of mitotic spindle orientation karyogamy microtubule-based movement nuclear migration along microtubule	astral microtubule cytoplasm spindle pole body cytoplasmic dynein complex microtubule cytoplasmic microtubule cell cortex dynein complex	glutathione transferase activity transferase activity nucleotide binding motor activity microtubule motor activity protein binding ATP binding ATPase activity nucleoside-triphosphatase activity
3dueA putative periplasmic protein	[pdb]	2.57 0.00796	38^PHE 80^TRP 85^CYS 116^GLU 121^ASP 74^PHE 94^VAL	0.0.0.0
1xvlB mn transporter	[pdb]	2.57 0.00796	238^TRP 246^PHE 251^VAL 268^CYS 234^GLU 236^TYR 261^ASN	0.0.0.0	transport cell adhesion metal ion transport		metal ion binding
1m6iA programmed cell death protein 8	[pdb]	2.57 0.00796	441^CYS 459^VAL 477^TRP 482^PHE 426^GLU 468^ASN 476^TYR	0.0.0.0	DNA fragmentation involved in apoptotic nuclear change apoptosis DNA damage response signal transduction resulting in induction of apoptosis apoptotic chromosome condensation cell redox homeostasis neuron apoptosis	soluble fraction nucleus cytoplasm mitochondrion mitochondrial intermembrane space microsome	DNA binding protein binding electron carrier activity oxidoreductase activity flavin adenine dinucleotide binding
2pa5A tyrosine-protein phosphatase non-receptor type 9	[pdb]	2.57 0.00796	412^CYS 415^TYR 416^TRP 463^PHE 380^GLU 399^VAL 385^ASP	3.1.3.48	protein dephosphorylation dephosphorylation	cytoplasm	phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity protein binding hydrolase activity phosphatase activity
2ppqA homoserine kinase	[pdb]	2.57 0.00796	79^CYS 109^TRP 195^PHE 205^GLU 121^VAL 201^PHE 204^ASP	2.7.1.39	cellular amino acid biosynthetic process threonine biosynthetic process		nucleotide binding homoserine kinase activity ATP binding kinase activity transferase activity
2nygA yokd protein	[pdb]	2.57 0.00821	224^PHE 254^GLU 262^TRP 183^CYS 227^VAL 258^PHE 236^ASN	0.0.0.0	response to antibiotic		acyltransferase activity transferase activity aminoglycoside 3-N-acetyltransferase activity
1nfpA luxf gene product	[pdb]	2.58 0.00821	177^CYS 194^PHE 199^GLU 96^TRP 8^VAL 131^PHE 27^ASN	0.0.0.0	bioluminescence oxidation-reduction process		monooxygenase activity
3a6pF gtp-binding nuclear protein ran exportin-5 pre-microrna 13-mer peptide	[pdb]	2.58 0.00847	465^TRP 533^GLU 551^CYS 509^PHE 513^VAL 468^TYR 530^ASP		transport intracellular protein transport nucleocytoplasmic transport cell cycle mitosis signal transduction protein transport cell division transport protein transport gene silencing by RNA	nucleus cytoplasm melanosome nucleus cytoplasm nucleolus	nucleotide binding GTPase activity protein binding GTP binding tRNA binding RNA binding binding protein binding
2xlyA cloq	[pdb]	2.58 0.00847	255^VAL 264^CYS 284^TYR 53^TRP 252^PHE 9^GLU 7^ASP	0.0.0.0
1yydA peroxidase manganese-dependent i	[pdb]	2.59 0.00847	243^PHE 258^PHE 319^CYS 255^TRP 316^GLU 259^VAL 314^ASP	1.11.1.13	response to oxidative stress hydrogen peroxide catabolic process lignin catabolic process oxidation-reduction process	extracellular region	peroxidase activity oxidoreductase activity manganese peroxidase activity heme binding metal ion binding
2ozoA tyrosine-protein kinase zap-70	[pdb]	2.59 0.00875	458^VAL 505^TRP 509^GLU 575^CYS 480^PHE 506^TYR 512^ASN	2.7.10.2	protein phosphorylation immune response intracellular protein kinase cascade peptidyl-tyrosine phosphorylation T cell differentiation beta selection positive thymic T cell selection negative thymic T cell selection thymic T cell selection positive regulation of T cell differentiation positive regulation of alpha-beta T cell differentiation positive regulation of alpha-beta T cell proliferation protein autophosphorylation positive regulation of calcium-mediated signaling T cell receptor signaling pathway	immunological synapse cytoplasm cytosol plasma membrane membrane T cell receptor complex	nucleotide binding phosphotyrosine binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding kinase activity transferase activity
2i3yA epididymal secretory glutathione peroxidase	[pdb]	2.59 0.00875	73^CYS 108^GLU 181^TRP 183^PHE 69^VAL 104^PHE 111^ASP	1.11.1.9	lipid metabolic process response to oxidative stress oxidation-reduction process	extracellular region	peroxidase activity glutathione peroxidase activity oxidoreductase activity
2dq6A aminopeptidase n	[pdb]	2.59 0.00875	264^GLU 303^TRP 325^PHE 310^CYS 324^VAL 300^PHE 269^ASN	3.4.11.2	proteolysis peptide catabolic process	plasma membrane membrane	aminopeptidase activity peptidase activity metallopeptidase activity zinc ion binding hydrolase activity metal ion binding
2c7sA receptor-type tyrosine-protein phosphatase kappa	[pdb]	2.59 0.00875	965^GLU 996^CYS 1000^TRP 1044^PHE 983^VAL 999^TYR 969^ASP	3.1.3.48	protein dephosphorylation cell adhesion signal transduction transforming growth factor beta receptor signaling pathway negative regulation of cell proliferation negative regulation of keratinocyte proliferation dephosphorylation cell migration negative regulation of cell migration protein localization at cell surface cellular response to reactive oxygen species cellular response to UV negative regulation of cell cycle focal adhesion assembly	plasma membrane integral to plasma membrane cell-cell junction adherens junction cell surface membrane integral to membrane cell junction leading edge membrane	phosphoprotein phosphatase activity protein tyrosine phosphatase activity receptor activity transmembrane receptor protein tyrosine phosphatase activity protein binding beta-catenin binding hydrolase activity phosphatase activity protein kinase binding gamma-catenin binding
3daoB putative phosphatse	[pdb]	2.6 0.00875	98^GLU 150^PHE 170^TRP 158^CYS 152^VAL 166^PHE 97^ASP	0.0.0.0	metabolic process		catalytic activity hydrolase activity
2gtqA aminopeptidase n	[pdb]	2.6 0.00903	260^GLU 299^TRP 320^VAL 306^CYS 321^PHE 296^PHE 265^ASN	0.0.0.0	proteolysis		aminopeptidase activity metallopeptidase activity zinc ion binding hydrolase activity
1h7zB adenovirus fibre protein	[pdb]	2.6 0.00903	194^GLU 290^TRP 310^PHE 143^CYS 171^VAL 288^PHE 274^ASN	0.0.0.0	cell adhesion cell recognition pathogenesis viral infectious cycle
2a3lA amp deaminase	[pdb]	2.6 0.00903	725^PHE 731^VAL 759^TRP 767^CYS 751^GLU 752^TYR 736^ASP	3.5.4.6	nucleotide metabolic process purine ribonucleoside monophosphate biosynthetic process embryo development ending in seed dormancy	nucleus microsome cytosol membrane integral to membrane	nucleotide binding AMP deaminase activity protein binding ATP binding hydrolase activity deaminase activity protein histidine kinase binding metal ion binding
2h2wA homoserine o-succinyltransferase	[pdb]	2.6 0.00903	142^CYS 187^TRP 215^GLU 283^PHE 168^TYR 214^ASP 220^VAL	2.3.1.46	cellular amino acid biosynthetic process methionine biosynthetic process L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine	cytoplasm	acyltransferase activity homoserine O-succinyltransferase activity transferase activity
1h49A beta-glucosidase	[pdb]	2.6 0.00932	53^TRP 198^VAL 216^CYS 195^PHE 62^GLU 56^PHE 66^ASP	3.2.1.21	carbohydrate metabolic process metabolic process cytokinin mediated signaling pathway	chloroplast plastid	catalytic activity hydrolase activity hydrolyzing O-glycosyl compounds beta-glucosidase activity hydrolase activity hydrolase activity
2dcaA cathepsin b	[pdb]	2.61 0.00932	30^TRP 32^PHE 71^CYS 66^GLU 35^VAL 75^PHE 81^ASN	3.4.22.1	proteolysis regulation of catalytic activity	mitochondrion lysosome melanosome	cysteine-type endopeptidase activity protein binding peptidase activity cysteine-type peptidase activity hydrolase activity
3c7tB ecdysteroid-phosphate phosphatase	[pdb]	2.61 0.00932	82^GLU 133^TRP 139^VAL 161^CYS 168^PHE 134^PHE 318^ASN	0.0.0.0
1u2hA aortic preferentially expressed protein 1	[pdb]	2.61 0.00932	53^TRP 67^PHE 76^CYS 105^GLU 37^VAL 91^TYR 28^ASP	2.7.11.1	protein phosphorylation muscle organ development negative regulation of cell proliferation cell differentiation muscle cell differentiation	nucleus	nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding kinase activity transferase activity
3mqoB transcriptional regulator, luxr family	[pdb]	2.61 0.00932	31^GLU 50^VAL 109^TRP 91^CYS 48^PHE 111^PHE 30^ASP	0.0.0.0	two-component signal transduction system (phosphorelay) regulation of transcription DNA-dependent	intracellular	two-component response regulator activity DNA binding sequence-specific DNA binding transcription factor activity signal transducer activity sequence-specific DNA binding
2xsxA beta-enolase	[pdb]	2.61 0.00932	296^PHE 307^PHE 337^CYS 304^TRP 293^GLU 311^VAL 245^ASP	4.2.1.11	glycolysis aging response to drug skeletal muscle tissue regeneration	phosphopyruvate hydratase complex membrane fraction cytoplasm	magnesium ion binding phosphopyruvate hydratase activity lyase activity protein homodimerization activity metal ion binding protein heterodimerization activity
3a5dK v-type atp synthase subunit d v-type atp synthase beta chain v-type atp synthase subunit f v-type atp synthase alpha chain	[pdb]	2.61 0.00932	205^GLU 438^ILE 507^CYS 449^GLY 218^VAL 439^ALA 452^LYS	3.6.3.14	ATP biosynthetic process transport ion transport ATP synthesis coupled proton transport proton transport ATP metabolic process ATP biosynthetic process transport ion transport ATP synthesis coupled proton transport proton transport ATP biosynthetic process transport ion transport ATP synthesis coupled proton transport proton transport ATP biosynthetic process transport ion transport ATP synthesis coupled proton transport proton transport ATP metabolic process	proton-transporting two-sector ATPase complex proton-transporting two-sector ATPase complex catalytic domain proton-transporting two-sector ATPase complex catalytic domain proton-transporting two-sector ATPase complex	hydrolase activity acting on acid anhydrides catalyzing transmembrane movement of substances hydrogen ion transporting ATP synthase activity rotational mechanism proton-transporting ATPase activity rotational mechanism hydrogen ion transporting ATP synthase activity rotational mechanism proton-transporting ATPase activity rotational mechanism ATPase activity coupled to transmembrane movement of substances
1jmzA amine dehydrogenase	[pdb]	2.61 0.00961	103^HOH 125^HOH 130^HOH 134^HOH 123^HOH 135^HOH 143^THR	0.0.0.0	transport electron transport chain oxidation-reduction process	periplasmic space	oxidoreductase activity oxidoreductase activity acting on the CH-NH2 group of donors iron ion binding electron carrier activity